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AEDLDLETSELLDGLEGDARGERAELIRWLVGRGVGIDQIRGNPAPMLLASRRVIGDDGLYVSARQAAAN AGVDLELFERIQRAMGLPRVDDADAQVFLRADAEAAKFTRDFLDAGIDPDELVQITRLLGDGLSRAAEAM RYAALAAVIRPGATELEIAQQSEALVAGLAPLLGPMIQEVLLLQLRHAIETEAVNATERAEGQHLPGARL VTIGFADLVGFTRLGEAVPPEDLEQLSQRLADMTREFAVAPVRFIKTIGDEVMLVSPEPAPLLDTLLRLV DETEDDDDFPRLRAGVATGLAVSRAGDWFGSPVNLAARVTGAARPGSVLVAEATREAIGEDERFTWSFAG GKHLKGFKSDVKTFRARRTTNL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4452 | - | - | 100% (373) | putative adenylate/guanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_3699 | - | 9e-19 | 37.82% (156) | putative adenylate/guanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_3321 | - | 5e-12 | 32.67% (150) | putative adenylate/guanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1295 | - | 1e-124 | 59.68% (372) | adenylyl cyclase |
| M. gilvum PYR-GCK | Mflv_2243 | - | 1e-176 | 86.74% (362) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1264 | - | 1e-125 | 59.95% (372) | adenylyl cyclase |
| M. leprae Br4923 | MLBr_01399 | - | 3e-10 | 30.15% (136) | hypothetical protein MLBr_01399 |
| M. abscessus ATCC 19977 | MAB_4771 | - | 4e-24 | 28.52% (305) | putative adenylate cyclase |
| M. marinum M | MMAR_4173 | - | 1e-126 | 61.26% (364) | adenylate cyclase |
| M. avium 104 | MAV_1415 | - | 1e-130 | 61.31% (367) | chain A, Myco adenylyl cyclase, holoenzyme, inhibited state |
| M. smegmatis MC2 155 | MSMEG_5018 | - | 1e-134 | 65.85% (369) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_1842 | - | 1e-140 | 67.75% (369) | ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) |
| M. ulcerans Agy99 | MUL_4470 | - | 1e-126 | 61.81% (364) | adenylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1295|M.bovis_AF2122/97 MTD-------HVR---EADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
Rv1264|M.tuberculosis_H37Rv MTD-------HVR---EADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
MMAR_4173|M.marinum_M MED-------SVDRAPEPAGQNTDDLLEGLEGAARAERAELIDWLFGQGI
MUL_4470|M.ulcerans_Agy99 MED-------SVDRAPEPAGQNTDDLLEGLEGAARAERAELIDWLFGQGI
MAV_1415|M.avium_104 MTSHDGLPALYVDDVHDGDDRDIEDLLDGLQGTARTERAELVRWLLAQGI
Mvan_4452|M.vanbaalenii_PYR-1 --------------MAEDLDLETSELLDGLEGDARGERAELIRWLVGRGV
Mflv_2243|M.gilvum_PYR-GCK --------------------METSGLLDGLEGAARAERAELIGWLLDRGV
TH_1842|M.thermoresistible__bu --------------MADDVDIEASGLLDDLTGEAREQRAELIAWLIERGY
MSMEG_5018|M.smegmatis_MC2_155 -------------MVSQQVQPDIQPLLEGLDGAARSQREELINWLLSRGI
MAB_4771|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01399|M.leprae_Br4923 --------------------------------------------------
Mb1295|M.bovis_AF2122/97 TPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAV
Rv1264|M.tuberculosis_H37Rv TPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAV
MMAR_4173|M.marinum_M TAAEIRTTNPPLLLATRHVIGDDGTYVSSREISETYGIDLDLLQRVQRAV
MUL_4470|M.ulcerans_Agy99 TAAEIRTTNPPLLLATRHVIGDDGTYVSSREISETYGIDLDLLQRVQRAV
MAV_1415|M.avium_104 TAEEIRTTNPPLLLATRHLIGDDGTYVSTREISETYGIDMALLQRVQRAI
Mvan_4452|M.vanbaalenii_PYR-1 GIDQIRGNPAPMLLASRRVIGDDGLYVSARQAAANAGVDLELFERIQRAM
Mflv_2243|M.gilvum_PYR-GCK AVDEIRGNPAPMLLASRRVIGDDGEYVSARQAADRAGVELELFERIQRAM
TH_1842|M.thermoresistible__bu SIEEIRESVSPMLLASRRLIGDDSRYVSAAEISRSTGMDLGLLQRMLRAL
MSMEG_5018|M.smegmatis_MC2_155 SVDQIGQAITPMLLASRRVAGDDGTYVSAREISEQTGLDLDLLQRLQRAM
MAB_4771|M.abscessus_ATCC_1997 -MPESDELNAVVDAAVEQVLLGGPRRYTRSQVSQLSGVPVERARTLWVAL
MLBr_01399|M.leprae_Br4923 -----------------MPPSAKSTYPGQVEGAPHDGTPSAPQEPDEDTV
: : * . ::
Mb1295|M.bovis_AF2122/97 GLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQ-VVLVVRVLAEGLS
Rv1264|M.tuberculosis_H37Rv GLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQ-VVLVVRVLAEGLS
MMAR_4173|M.marinum_M GLARVDDPDAVVYMRADGEAAAYTQRFIELGLNPDQ-IVLVVRVLAEGLS
MUL_4470|M.ulcerans_Agy99 GLARVDDPDAVVYMRADGEAAAYTQRFIELGLNPDQ-IVLVVRVLAEGLS
MAV_1415|M.avium_104 GLVRVDDPDAAVHMRADGEAAAFTQRFVDVGLDPDQ-VVLVAQVLAEGLS
Mvan_4452|M.vanbaalenii_PYR-1 GLPRVDDADAQVFLRADAEAAKFTRDFLDAGIDPDE-LVQITRLLGDGLS
Mflv_2243|M.gilvum_PYR-GCK GLPRVEDPDAEVFLRADAEAAKFTRDFLDVGIGLDE-LVQITRLLGDGLA
TH_1842|M.thermoresistible__bu GLPRVDDPDAVVHLRADAEAAARAQRFIEAGVDPDQ-MVQIAAVLSEGLA
MSMEG_5018|M.smegmatis_MC2_155 GLPAVEDPDAAVLLRADAEAVTFSQQFIDLGIDADQ-VVLITRVLAEGLS
MAB_4771|M.abscessus_ATCC_1997 GFAAADSDDEVAFTDADVSAIRTFAALGSATAANQQSQIAAARTLGQAMA
MLBr_01399|M.leprae_Br4923 TVP------APALIRRSSVSMPNAAQWLHTTNRSPR-LVAMVRRARRLLP
. . . : . : . :.
Mb1295|M.bovis_AF2122/97 HAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQ
Rv1264|M.tuberculosis_H37Rv HAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQ
MMAR_4173|M.marinum_M RAAEVMRYTALEAIMHPGVTELDIAKGSKALVSQIAPLLGPMIQEMLFMQ
MUL_4470|M.ulcerans_Agy99 RAAEVMRYTALEAIMHPGATELDIAKGSKALVSQIAPLLGPMIQEMLFMQ
MAV_1415|M.avium_104 RAAEVMRYSALSAIMRPGATELEIAKASKALVTQIAPLLGPMIQQMLFMQ
Mvan_4452|M.vanbaalenii_PYR-1 RAAEAMRYAALAAVIRPGATELEIAQQSEALVAGLAPLLGPMIQEVLLLQ
Mflv_2243|M.gilvum_PYR-GCK RAAEAMRYAALAAVIRPAATELETAKASEELVGNVAPLLGPMIQEVLLLQ
TH_1842|M.thermoresistible__bu KAAELMRSTVVAAVLQPGKTELQIAQDAEALVRRLAPLLGPMIQDLLLLQ
MSMEG_5018|M.smegmatis_MC2_155 RAAEVMRAAALAAVLEPGASELETAKAAEGLVAEAAPLLGPMIQDMLFVQ
MAB_4771|M.abscessus_ATCC_1997 RLAEWQ-----ADLLTREVGGRLAAEGDDASAESSANAATQTIATLTALQ
MLBr_01399|M.leprae_Br4923 GDPDFGDPLSTAGEGGP----RAAARAADRLLGDRG--AASREVSLSVLQ
.: *. . : :*
Mb1295|M.bovis_AF2122/97 LRHMMETEAVNAGECAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELG
Rv1264|M.tuberculosis_H37Rv LRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELG
MMAR_4173|M.marinum_M LRHMMETEAVNAGERAAGKPLPGAREVSVAFADLVGFTKLGEVVSAEELG
MUL_4470|M.ulcerans_Agy99 LRHMMETEAVNAGERAAGKPLPGAREVSVAFADLVGFTKLGEVVSAEELG
MAV_1415|M.avium_104 LRHMMETEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSPEELG
Mvan_4452|M.vanbaalenii_PYR-1 LRHAIETEAVNATERAEGQHLPGARLVTIGFADLVGFTRLGEAVPPEDLE
Mflv_2243|M.gilvum_PYR-GCK LRHAIETEAINATERAEGQHLPGARLVTIGFADLVGFTRLGEALPPEDLE
TH_1842|M.thermoresistible__bu LRHAMETEAVSVTERAQGVPLPGARLVSIAFADLVGFTRLGEAVPPEELE
MSMEG_5018|M.smegmatis_MC2_155 LRHAMETEAVDASERAEGVPLPGARLVTVAFADIVGFTRLGEVVPPEQLE
MAB_4771|M.abscessus_ATCC_1997 N-YAWQRHLAAALHRAN-ETGSTTRQLLVGFADMVGYTRLSRHLDPDELA
MLBr_01399|M.leprae_Br4923 VWQALTEAIARR---------PVNPEVTLVFTDLVGFSGWSLQAGDEATL
. : : *:*:**:: . :
Mb1295|M.bovis_AF2122/97 HLAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPDPAP----LLDTVLKL
Rv1264|M.tuberculosis_H37Rv HLAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPDPAP----LLDTVLKL
MMAR_4173|M.marinum_M QLAGRLADLARELTAPP-VRFIKTIGDAVMLVCPDPAP----LLDTVLNL
MUL_4470|M.ulcerans_Agy99 QLAGRLADLARELTAPP-VRFIKTIGDAVMLVCPDPAP----LLDTVLNL
MAV_1415|M.avium_104 QLANRLAILARDVTVPP-VRFVKTIGDAVMFVCPEPRP----LLDVVLKL
Mvan_4452|M.vanbaalenii_PYR-1 QLSQRLADMTREFAVAP-VRFIKTIGDEVMLVSPEPAP----LLDTLLRL
Mflv_2243|M.gilvum_PYR-GCK RLAQRLADLTREIAVAP-VRFIKTIGDEVMLVSPEPAP----LLETMLRL
TH_1842|M.thermoresistible__bu QLAARLADLAREVAEPP-VRFIKTIGDAVMLVSVDPAE----LLAAMLEL
MSMEG_5018|M.smegmatis_MC2_155 QLANSLAEATRDVVRPP-VRLIKTIGDAVMLVSPEPAA----LLDAVLNL
MAB_4771|M.abscessus_ATCC_1997 SLLETFETALTEAITTHGGWVIKNVGDEVMFAAASAAAGARIAVAMNTAI
MLBr_01399|M.leprae_Br4923 ALLRQVARAVESPLLDAGGHIVKRMGDGIMAVFRDPSVAVQ-AVLAATEA
* . . .:* :** :* . .. :
Mb1295|M.bovis_AF2122/97 VEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVL
Rv1264|M.tuberculosis_H37Rv VEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVL
MMAR_4173|M.marinum_M VEVVDTDDAFPRLRAGVACGRAVSRAGDWFGSPVNAASRITGVARPGTVL
MUL_4470|M.ulcerans_Agy99 VEVVDTDDAFPRLRAGVACGRAVSRAGDWFGSPVNAASRITGVARPGTVL
MAV_1415|M.avium_104 VEAVDTDNEFPRLRAGVASGTAVSRAGDWFGSPVNVASRVTAVARPGTVL
Mvan_4452|M.vanbaalenii_PYR-1 VDETEDDDDFPRLRAGVATGLAVSRAGDWFGSPVNLAARVTGAARPGSVL
Mflv_2243|M.gilvum_PYR-GCK VEETEGDDDFPRLRAGVATGMAVSRAGDWFGSPVNLAARMTGAARPGTVL
TH_1842|M.thermoresistible__bu IDGTGADQDFPRVRAGMATGMAVSRAGDWYGSPVNLASRVTGVARPGSVL
MSMEG_5018|M.smegmatis_MC2_155 VAATEADPEFPGLRVGLATGMAVSRAGDWFGSPVNLASRVTGVARPGTVL
MAB_4771|M.abscessus_ATCC_1997 TEAAQTIPDMPQIRVGLAYGQVLSRFGDLYGTVVNIAARLTGVARPGTIL
MLBr_01399|M.leprae_Br4923 MKSVEVGGYTPRIRVGIHTGRPQRLAADWLGVDVNIAARVMERATKGGIM
. * :*.*: * .* * ** *:*: * * ::
Mb1295|M.bovis_AF2122/97 VADSVREALGDAPEADG--FQWSFAGPRRLRGIRG---DVRLFRVRRGAT
Rv1264|M.tuberculosis_H37Rv VADSVREALGDAPEADG--FQWSFAGPRRLRGIRG---DVRLFRVRRGAT
MMAR_4173|M.marinum_M AADSVCDAVRDTAAGAG--FEWSFAGPRRLKGIKN---ETKLFRVRRNLA
MUL_4470|M.ulcerans_Agy99 AADSVCDAIRDTAAGAG--FEWSFAGPRRLKGIKN---ETKLFRVRRNLA
MAV_1415|M.avium_104 VADSVWDVIGDNGE-----FSGSFAGARRLKGIKN---EVKLFRVRRGG-
Mvan_4452|M.vanbaalenii_PYR-1 VAEATREAIGE-DER----FTWSFAGGKHLKGFKS---DVKTFRARRTTN
Mflv_2243|M.gilvum_PYR-GCK VAEAAREAIGE-DDR----FAWSFAGAKHLKGIKS---DVKSFRARWAPA
TH_1842|M.thermoresistible__bu VAEATREAIGD-DER----FRWSFAGSRRLKGIKG---EVKLYRARRAE-
MSMEG_5018|M.smegmatis_MC2_155 VAESTRQAIAAADDR----FRWSFAGARRLKGIKG---DVKMFRARMRDQ
MAB_4771|M.abscessus_ATCC_1997 LDDGAAAALGDDGE-----FSLRHLRGVRVKGFSRL--GSHVLRARKR--
MLBr_01399|M.leprae_Br4923 ISGPTLDLIPQSDLKELGIITRRVRKPMFTSKFTGIPPDMVIYRIKARRE
. : : : * :
Mb1295|M.bovis_AF2122/97 RTGSGGAAQDDDLAGSSP
Rv1264|M.tuberculosis_H37Rv RTGSGGAAQDDDLAGSSP
MMAR_4173|M.marinum_M DLAADTATEGR-------
MUL_4470|M.ulcerans_Agy99 DLAADTATEGR-------
MAV_1415|M.avium_104 ------------------
Mvan_4452|M.vanbaalenii_PYR-1 L-----------------
Mflv_2243|M.gilvum_PYR-GCK DSH---------------
TH_1842|M.thermoresistible__bu ------------------
MSMEG_5018|M.smegmatis_MC2_155 ------------------
MAB_4771|M.abscessus_ATCC_1997 ------------------
MLBr_01399|M.leprae_Br4923 LTASDETAQTNSLT----