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PQTSPGSTTGALTGEVFSGHQPSGVGDLSVETHGIAPISGDHRYGSPGRLFTVWFAPQVNMSGVFTGTLA IVLGLGFWLGLLAMVIGTVLGSLVVGYLSTWGPRTGTGQLPNARMAFGGTVVVPAALQWLSSIAWDALVG LFGGEALSVLLGIPFWVAVLIVLGVQGVVGFFGYELIHRLQAVLTVVLFVTFLVFTAKLVAGHEIVVPAA VSGPDLVGAFVLEVTIAFSLAISWATYAADFSRYLPADVSPVRVFGFSTAGLALGYVFVQGVGIAAAGVV GEHTVEGVRSVMGGGLLGGLALLVIAVASIGSGVMNDYSGSLALQTLGVRVRRPVSAVIVTVLAFALILW LHAADTATRFTDVLLLVSYWIPAFVAVVVVDWWRRAEGRPTVDPAAEVTGRRDAVVALVVFVVSYLAAIP FMNTSLIQGPVAMAWHGADIAYFVNLAVAAVLYGGYRLMSRD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3383 | - | - | 100% (463) | permease for cytosine/purines, uracil, thiamine, allantoin |
| M. vanbaalenii PYR-1 | Mvan_0862 | - | 9e-27 | 25.46% (436) | permease for cytosine/purines, uracil, thiamine, allantoin |
| M. vanbaalenii PYR-1 | Mvan_0160 | - | 2e-21 | 25.68% (475) | permease for cytosine/purines, uracil, thiamine, allantoin |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_0055 | - | 5e-29 | 24.77% (436) | permease for cytosine/purines, uracil, thiamine, allantoin |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2025 | - | 1e-19 | 23.52% (455) | purine/cytosine permease |
| M. marinum M | MMAR_1212 | - | 2e-05 | 21.66% (471) | hypothetical protein MMAR_1212 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_5653 | - | 5e-41 | 29.93% (451) | cytosine/purine/uracil/thiamine/allantoin permease family |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2680 | - | 4e-06 | 23.36% (274) | hypothetical protein MUL_2680 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1212|M.marinum_M MIDTTAPHSPVHSPSHGAGPANIKPDYHPRLTNDDLAPLREQTWG--TYN
MUL_2680|M.ulcerans_Agy99 MIDTTAPHSPVHSPSHGAGPANIKPDYHPRLTNDDLAPLREQTWG--TYN
MAB_2025|M.abscessus_ATCC_1997 ---MDEIQACCSATSLIASRESVGRDRVGAIERAGIDYLPEAARGSSPKN
Mvan_3383|M.vanbaalenii_PYR-1 MPQTSPGSTTGALTGEVFSGHQPSGVGDLSVETHGIAPISGDHRYGSPGR
MSMEG_5653|M.smegmatis_MC2_155 -----------------------MATDSATVESKSIDWIPLGERRGKPSM
Mflv_0055|M.gilvum_PYR-GCK ----------------------------MHDLEAELTVIPESAKTTDLRG
: :
MMAR_1212|M.marinum_M IFAFWMSDVHSVGGYVTAGSLFALGLASWQVLVSLVIAITIVYFLCNLVA
MUL_2680|M.ulcerans_Agy99 IFAFWMSDVHSVGGYVTAGSLFALGLASWQVLVSLVIAITIVYFLCNLVA
MAB_2025|M.abscessus_ATCC_1997 LFAVFVGGNLAFSTIIFGWLPIVMGLTFWQAVSSSVTGLLIGLMLTAPMS
Mvan_3383|M.vanbaalenii_PYR-1 LFTVWFAPQVNMSGVFTGTLAIVLGLGFWLGLLAMVIGTVLGSLVVGYLS
MSMEG_5653|M.smegmatis_MC2_155 LFPLWFMSNANLTTLATGMVGASLGASFLTSLVAIVLGAAVGTVFTAFHS
Mflv_0055|M.gilvum_PYR-GCK QFWIWAGANIAPINWILGALGVTMGLGLFETIAVLVVGNAIGMSLFGTFV
* .: . :* : * . : .
MMAR_1212|M.marinum_M RPSQATGVPYPVICRTAFGVLGANIPAIIRGLIAVAWYGIQTYLASAALD
MUL_2680|M.ulcerans_Agy99 RPSQATGVPYPVICRTAFGVLGANIPAIIRGLIAVAWYGIQTYLASAALD
MAB_2025|M.abscessus_ATCC_1997 LFGPRTGTNNPVSSGAHFGVRGRLIGSSLTLMFALVYAAIAVWTSGEALI
Mvan_3383|M.vanbaalenii_PYR-1 TWGPRTGTGQLPNARMAFGGT-VVVPAALQWLSSIAWDALVGLFGGEALS
MSMEG_5653|M.smegmatis_MC2_155 AQGPQLGLPQMIQSRAQFGYRGVVVICAVVIFSIVGFNIFNQILAGDVLT
Mflv_0055|M.gilvum_PYR-GCK VIGQKTGVTGMVLSRMVFGRRGAYVPAAVQAALCIGWCAVNTWIVLDLVM
. * . ** : . : : : . :
MMAR_1212|M.marinum_M VVMIKLFPG-LARYAVVEDYGFLGLPALGWASYLILWVLQACVFWRGMEA
MUL_2680|M.ulcerans_Agy99 VVMIKLFPG-LARYAVVEDYGFLGLPALGWASYLILWVLQACVFWRGMEA
MAB_2025|M.abscessus_ATCC_1997 AGASRLFGAPQNHVAFLLGYGVIALEVI-----LIALYGHATIVWAQKII
Mvan_3383|M.vanbaalenii_PYR-1 VLLGIPFWV-----AVLIVLGVQG---------VVGFFGYELIHRLQ---
MSMEG_5653|M.smegmatis_MC2_155 MTTGVDARN-----LWFVIITALAL--------ALAIYGYHWIHRVQN--
Mflv_0055|M.gilvum_PYR-GCK ALLGRIGLVDPELSNHAARIVVAGIIMT--TQVVIAWFGYRLIAAFERWT
. : :
MMAR_1212|M.marinum_M IRKFIDFCGPAVYVVMFALSGYLISKAGWAAIDLNLGDVRYSGWDAIPVM
MUL_2680|M.ulcerans_Agy99 IRKFIDFCGPAVYVVIFALSGYLISTAGWAAIDLNLGDVRYSGWDAIPVM
MAB_2025|M.abscessus_ATCC_1997 IP---------LAVVVLALG-VLAYAPNFHPMGS--AQHGYALQEFWPTW
Mvan_3383|M.vanbaalenii_PYR-1 -----------AVLTVVLFVTFLVFTAKLVAGHEIVVPAAVSGPDLVGAF
MSMEG_5653|M.smegmatis_MC2_155 -----------WLTWLFLATFGVFTVVALVTLHLPHGQFGFAG-FSWPAF
Mflv_0055|M.gilvum_PYR-GCK VP---------PTVAVLVAMTAVAWFGLDVDWGYTGDAALTGAEHFTAIT
:. : .
MMAR_1212|M.marinum_M LGAIALVVSYFSGPMLNFGDFSRYGRSFGAVRKGNFLGLPLNFLLFSLLV
MUL_2680|M.ulcerans_Agy99 LGAIALVVSYFSGPMLNFGDFSRYGRSFGAVRKGNFLGLPLNFLLFSLLV
MAB_2025|M.abscessus_ATCC_1997 LFAVTVSVGGPLSYAPSVGDYTRRISRSRYSDRQIAVAVSAGIFLGLFST
Mvan_3383|M.vanbaalenii_PYR-1 VLEVTIAFSLAISWATYAADFSRYLP-ADVSPVRVFGFSTAGLALGYVFV
MSMEG_5653|M.smegmatis_MC2_155 LVQFAAAAAYALGWAPYVSDYSRYLP-PQTSPGKALFYTYGGVFVGSSWL
Mflv_0055|M.gilvum_PYR-GCK AVMTAIGIGWGITWLGYAGDYSRFVS-SSVPARKLFAASALGQFIPVVWL
: . .*::* . :
MMAR_1212|M.marinum_M VVTASLTVPVFGELITDPVQTVARIDSTFAIILGASTFTIATIGINIVAN
MUL_2680|M.ulcerans_Agy99 VVTASLTVPVFGELITDPVQTVARIDSTFAIILGASTFTIATIGINIVAN
MAB_2025|M.abscessus_ATCC_1997 ATFGAFTASTFSAPTASYVADMVATAPGWYVVPLLILAVLGGCGQGVIS-
Mvan_3383|M.vanbaalenii_PYR-1 QGVGIAAAGVVGEHTVEGVRSVMGGG--LLGGLALLVIAVASIGSGVMN-
MSMEG_5653|M.smegmatis_MC2_155 MILGAFVAALFADVSPLEAVRQAADGILPGAGLWLLVAALPGLVTVITVN
Mflv_0055|M.gilvum_PYR-GCK GALGATLATLSASSDPG---EIIVDAYGVLAIPVLLLVVHGPLATNILN-
. . . . :
MMAR_1212|M.marinum_M FISPAFDFSNVNPQRISWRTGGMIAAVGSALITP-------WNLYNHPDV
MUL_2680|M.ulcerans_Agy99 FISPAFDFSNVNPQRIGWRTGGMIAAVGSALITP-------WNLYNHPDV
MAB_2025|M.abscessus_ATCC_1997 IYSSGLDLESIVPRLNRTQTTLIASGIAVVLMYLG------VVVTDAIDS
Mvan_3383|M.vanbaalenii_PYR-1 DYSGSLALQTLGVRVRRPVSAVIVTVLAFALILW-------LHAADTATR
MSMEG_5653|M.smegmatis_MC2_155 IYASSIELITIIDSFRAVSPTRRLRVGACVVIGLAGLLGAVLSTGEFLDN
Mflv_0055|M.gilvum_PYR-GCK IYTCAVSTQALDIHVNRRVLNIVIGVVAMAWVVYF------VLNGDFAAT
: .. : . . : :
MMAR_1212|M.marinum_M IHYTLETLGAFIGPLFGVLIADYYLVRKQHVVVDDLFSLSHDG---TYWY
MUL_2680|M.ulcerans_Agy99 IHYTLETLGAFIGPLFGVLIADYYLVRKQHVVVDDLFSLSHDG---TYWY
MAB_2025|M.abscessus_ATCC_1997 VTGMTVVLNSFAGSWVAINICGFFKANRGQYDPKALQRFGQDGRGGLYWF
Mvan_3383|M.vanbaalenii_PYR-1 FTDVLLLVSYWIPAFVAVVVVDWWRRAEGRPTVDPAAEVTGRR-------
MSMEG_5653|M.smegmatis_MC2_155 FGSFLVILLYLLVPWTSVNLVDYYFVRRGRYAIGEIFVPRGGVYG-----
Mflv_0055|M.gilvum_PYR-GCK IDAWLVGIVGWLAPWAAVMLVHWFGVARRQVDPATLLTPPNES------T
. : . .: : :: . :
MMAR_1212|M.marinum_M RKGYNPAAVIATAVSAAIAMVPVL--ASDVYGMYTAAEYSWFIGCGVALV
MUL_2680|M.ulcerans_Agy99 RKGYNPAAVIATAVSAAIAMAPVL--ASDV--------------------
MAB_2025|M.abscessus_ATCC_1997 SHGFNVRAVVPFIAGSGLGLLTVQ--NDLYQAPFANIAGGIDVSLLLSVV
Mvan_3383|M.vanbaalenii_PYR-1 ---DAVVALVVFVVSYLAAIPFMN--TSLIQGPVAMAWHGADIAYFVNLA
MSMEG_5653|M.smegmatis_MC2_155 --TWGWRGLAAYAIGIIAMIPFVV--TVWYTGPVANALGGVDVALFVGLF
Mflv_0055|M.gilvum_PYR-GCK LPAVRPSALISLAVGIVFTWLFMYGMVPMMQGPIAVALGGVDLSWLAGGL
.: . :
MMAR_1212|M.marinum_M VYYLLATRGRLAIAPPYHPVGAG---------------------------
MUL_2680|M.ulcerans_Agy99 --------------------------------------------------
MAB_2025|M.abscessus_ATCC_1997 VGGGLYWLAQVSWPAPRVVSSGSSA-------------------------
Mvan_3383|M.vanbaalenii_PYR-1 VAAVLYGGYRLMSRD-----------------------------------
MSMEG_5653|M.smegmatis_MC2_155 ASAVAYLLMARSLDLAAEQAKAQSDAREHGFEAVSFASPRTGAGTASLTD
Mflv_0055|M.gilvum_PYR-GCK AAGSLYAALEIPKARRA---------------------------------
MMAR_1212|M.marinum_M -----
MUL_2680|M.ulcerans_Agy99 -----
MAB_2025|M.abscessus_ATCC_1997 -----
Mvan_3383|M.vanbaalenii_PYR-1 -----
MSMEG_5653|M.smegmatis_MC2_155 GGQSS
Mflv_0055|M.gilvum_PYR-GCK -----