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ATDSATVESKSIDWIPLGERRGKPSMLFPLWFMSNANLTTLATGMVGASLGASFLTSLVAIVLGAAVGTV FTAFHSAQGPQLGLPQMIQSRAQFGYRGVVVICAVVIFSIVGFNIFNQILAGDVLTMTTGVDARNLWFVI ITALALALAIYGYHWIHRVQNWLTWLFLATFGVFTVVALVTLHLPHGQFGFAGFSWPAFLVQFAAAAAYA LGWAPYVSDYSRYLPPQTSPGKALFYTYGGVFVGSSWLMILGAFVAALFADVSPLEAVRQAADGILPGAG LWLLVAALPGLVTVITVNIYASSIELITIIDSFRAVSPTRRLRVGACVVIGLAGLLGAVLSTGEFLDNFG SFLVILLYLLVPWTSVNLVDYYFVRRGRYAIGEIFVPRGGVYGTWGWRGLAAYAIGIIAMIPFVVTVWYT GPVANALGGVDVALFVGLFASAVAYLLMARSLDLAAEQAKAQSDAREHGFEAVSFASPRTGAGTASLTDG GQSS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5653 | - | - | 100% (495) | cytosine/purine/uracil/thiamine/allantoin permease family protein |
| M. smegmatis MC2 155 | MSMEG_1683 | - | 1e-72 | 34.74% (475) | cytosine/purine/uracil/thiamine/allantoin permease family |
| M. smegmatis MC2 155 | MSMEG_1177 | - | 2e-72 | 34.12% (466) | cytosine/purines/uracil/thiamine/allantoin permease family |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3483 | - | 3e-07 | 23.61% (360) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_0055 | - | 6e-25 | 25.11% (438) | permease for cytosine/purines, uracil, thiamine, allantoin |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2025 | - | 4e-25 | 23.68% (473) | purine/cytosine permease |
| M. marinum M | MMAR_1096 | - | 5e-08 | 25.14% (362) | hypothetical protein MMAR_1096 |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3383 | - | 5e-41 | 29.93% (451) | permease for cytosine/purines, uracil, thiamine, allantoin |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3483|M.bovis_AF2122/97 ----MPGVITNSESPTA-ADHDRITATRETLEDYTLRLAPRSYRRWPPAV
MMAR_1096|M.marinum_M ----MQDTDVSQVSPSAPADLAEITAAKETLEDYTLRFAPRSYRRWSPAV
MSMEG_5653|M.smegmatis_MC2_155 -----------------------MATDSATVESKSIDWIPLGERRGKPSM
Mvan_3383|M.vanbaalenii_PYR-1 MPQTSPGSTTGALTGEVFSGHQPSGVGDLSVETHGIAPISGDHRYGSPGR
Mflv_0055|M.gilvum_PYR-GCK ----------------------------MHDLEAELTVIPESAKTTDLRG
MAB_2025|M.abscessus_ATCC_1997 ---MDEIQACCSATSLIASRESVGRDRVGAIERAGIDYLPEAARGSSPKN
: . :
Mb3483|M.bovis_AF2122/97 VGISALGGIAYLADFAIGANVGITWGTANALCGIAIFALVVFVTGLPLAY
MMAR_1096|M.marinum_M VGISALGGIAYLADFAIGANIGITWGTTNALWGIAIFAAVVFTTGLPLAY
MSMEG_5653|M.smegmatis_MC2_155 LFPLWFMSNANLTTLATG-MVGASLGASFLTSLVAIVLGAAVGTVFTAFH
Mvan_3383|M.vanbaalenii_PYR-1 LFTVWFAPQVNMSGVFTG-TLAIVLGLGFWLGLLAMVIGTVLGSLVVGYL
Mflv_0055|M.gilvum_PYR-GCK QFWIWAGANIAPINWILG-ALGVTMGLGLFETIAVLVVGNAIGMSLFGTF
MAB_2025|M.abscessus_ATCC_1997 LFAVFVGGNLAFSTIIFG-WLPIVMGLTFWQAVSSSVTGLLIGLMLTAPM
* : * . . .
Mb3483|M.bovis_AF2122/97 YAARYNIDLDLITRG-SGFGYYGSVVTNVIFATFTFIFFALEGSIMAQGL
MMAR_1096|M.marinum_M YAARYNIDLDLITRG-SGFGYYGSVVTNVIFATFTFIFFALEGSIMAQGL
MSMEG_5653|M.smegmatis_MC2_155 SAQGPQLGLPQMIQSRAQFGYRGVVVICAVVIFSIVGFNIFNQILAGDVL
Mvan_3383|M.vanbaalenii_PYR-1 STWGPRTGTGQLPNARMAFGGT-VVVPAALQWLSSIAWDALVGLFGGEAL
Mflv_0055|M.gilvum_PYR-GCK VVIGQKTGVTGMVLSRMVFGRRGAYVPAAVQAALCIGWCAVNTWIVLDLV
MAB_2025|M.abscessus_ATCC_1997 SLFGPRTGTNNPVSSGAHFGVRGRLIGSSLTLMFALVYAAIAVWTSGEAL
. . . ** : : . : . : :
Mb3483|M.bovis_AF2122/97 KLGLH-----------IPLW-AGYACSTLIIFPLVVYGMKVLSQLQLWTT
MMAR_1096|M.marinum_M NLGLH-----------IPLW-LGYAFSTLLIFPLVIYGMKVLSQLQLWTT
MSMEG_5653|M.smegmatis_MC2_155 TMTTG-----------VDARNLWFVIITALALALAIYGYHWIHRVQNWLT
Mvan_3383|M.vanbaalenii_PYR-1 SVLLG-----------IPFW-VAVLIVLGVQGVVGFFGYELIHRLQAVLT
Mflv_0055|M.gilvum_PYR-GCK MALLGRIGLVDPELSNHAARIVVAGIIMTTQVVIAWFGYRLIAAFERWTV
MAB_2025|M.abscessus_ATCC_1997 IAGASRLFG---APQNHVAFLLGYGVIALEVILIALYGHATIVWAQKIII
: :* : :
Mb3483|M.bovis_AF2122/97 PLWLILMAAPFGYLVVSHPDSIGQFFSYAGKDGHGGLSFGSVLLAAGV-C
MMAR_1096|M.marinum_M PLWLILMVAPFGYLLISHPESVAQFFAYAGKDGRATASIGSALMAAGV-C
MSMEG_5653|M.smegmatis_MC2_155 ----WLFLATFGVFTVVALVTLHLPHGQFGFAGFSWPAFLVQFAAAAA-Y
Mvan_3383|M.vanbaalenii_PYR-1 ----VVLFVTFLVFTAKLVAGHEIVVPAAVSGPDLVGAFVLEVTIAFS-L
Mflv_0055|M.gilvum_PYR-GCK PPTVAVLVAMTAVAWFGLDVDWGYTGDAALTGAEHFTAITAVMTAIGIGW
MAB_2025|M.abscessus_ATCC_1997 PLAVVVLALGVLAYAPNFHPMGSAQHGYALQEFWPTWLFAVTVSVGGP--
:: : .
Mb3483|M.bovis_AF2122/97 LSLIAQIAEQIDYLRFMPPRTPENANRWWTWTLLAGPGWVAFGATKQIIG
MMAR_1096|M.marinum_M LALIAQIAEQIDYLRFMPPRTPKNSRRWWAWMLLAGPGWVIFGAAKQIIG
MSMEG_5653|M.smegmatis_MC2_155 ALGWAPYVS--DYSRYLPPQTSPGKALFYTY------GGVFVGSSWLMIL
Mvan_3383|M.vanbaalenii_PYR-1 AISWATYAA--DFSRYLPADVSPVRVFGFST------AGLALGYVFVQGV
Mflv_0055|M.gilvum_PYR-GCK GITWLGYAG--DYSRFVSSSVPARKLFAASA------LGQFIPVVWLGAL
MAB_2025|M.abscessus_ATCC_1997 -LSYAPSVG--DYTRRISRSRYSDRQIAVAVS-----AGIFLGLFSTATF
. *: * :. : .
Mb3483|M.bovis_AF2122/97 LFLAVYLMANIPGSSTIANQPVHQFMQIYRTFVPG-WLALTLAVILVILS
MMAR_1096|M.marinum_M LFLAVYLLSNVAGAADFANQPVHQFMQIYRNFMPG-WLALTLAVILVVLS
MSMEG_5653|M.smegmatis_MC2_155 GAFVAALFADVS--------PLEAVRQAADGILPGAGLWLLVAALPGLVT
Mvan_3383|M.vanbaalenii_PYR-1 GIAAAGVVGEHT---------VEGVRSVMGGGLLG-----GLALLVIAVA
Mflv_0055|M.gilvum_PYR-GCK GATLATLSASSD--------PGEIIVDAYGVLAIP-------VLLLVVHG
MAB_2025|M.abscessus_ATCC_1997 GAFTASTFSAPTAS-----YVADMVATAPGWYVVP-------LLILAVLG
. . . . :
Mb3483|M.bovis_AF2122/97 QIKINVTNAYSGSLAWTNSFTRLT---KHYPGRVVFLGVNLAIALILMEA
MMAR_1096|M.marinum_M QVKINVTNAYSGSLAWTNSFTRVT---KHYPGRVMFLGVNLTIALILMEA
MSMEG_5653|M.smegmatis_MC2_155 VITVNIYASSIELITIIDSFRAVSPTRRLRVGACVVIGLAGLLGAVLSTG
Mvan_3383|M.vanbaalenii_PYR-1 SIGSGVMNDYSGSLALQTLGVRVR----RPVSAVIVTVLAFALILWLHAA
Mflv_0055|M.gilvum_PYR-GCK PLATNILNIYTCAVSTQALDIHVN---RRVLNIVIGVVAMAWVVYFVLNG
MAB_2025|M.abscessus_ATCC_1997 GCGQGVISIYSSGLDLESIVPRLN---RTQTTLIASGIAVVLMYLGVVVT
.: : : : :
Mb3483|M.bovis_AF2122/97 NMFDFLNTILGCYANCGMAWVVAVASDIGFNKYLLGLSPKTPEFRRG---
MMAR_1096|M.marinum_M NMFDFLNTILGFYANCGMAWVVTVASDIVFNKFLLGLSPKTPEFRRG---
MSMEG_5653|M.smegmatis_MC2_155 EFLDNFGSFLVILLYLLVPWTSVNLVDYYFVRRGRYAIGEIFVPRGG---
Mvan_3383|M.vanbaalenii_PYR-1 DTATRFTDVLLLVSYWIPAFVAVVVVDWWRRAEGR----PTVDPAAE---
Mflv_0055|M.gilvum_PYR-GCK DFAATIDAWLVGIVGWLAPWAAVMLVHWFGVARRQVDPATLLTPPNES--
MAB_2025|M.abscessus_ATCC_1997 DAIDSVTGMTVVLNSFAGSWVAINICGFFKANRGQYDPKALQRFGQDGRG
: . .:.
Mb3483|M.bovis_AF2122/97 ----MLYAINPVGFGSLLLAAGLSIVTFFGGL-GAALQPYSPLVAIVTAL
MMAR_1096|M.marinum_M ----MLYAINPVGFGSMLLAAGLSIVAFFGGL-GETLRPYSPLVAISVAL
MSMEG_5653|M.smegmatis_MC2_155 ----VYGTWGWRGLAAYAIGI-IAMIPFVVTV-WYTGPVANALGGVDVAL
Mvan_3383|M.vanbaalenii_PYR-1 ----VTGRRDAVVALVVFVVSYLAAIPFMNTS-LIQGPVAMAWHGADIAY
Mflv_0055|M.gilvum_PYR-GCK ----TLPAVRPSALISLAVGIVFTWLFMYGMVPMMQGPIAVALGGVDLSW
MAB_2025|M.abscessus_ATCC_1997 GLYWFSHGFNVRAVVPFIAGSGLGLLTVQNDL--YQAPFANIAGGIDVSL
: : . . :
Mb3483|M.bovis_AF2122/97 VMPPILAAATKG-KYYLRRTHDGIDLPMYDEHGNPSAAVLTCHVCHQDFE
MMAR_1096|M.marinum_M VMPPILAIATKG-KYYLRRTHDGIELPMYDEHGNPSAEHLNCHVCRQNFE
MSMEG_5653|M.smegmatis_MC2_155 FVG--LFASAVA-YLLMARSLD-----LAAEQAKAQSDAREHGFEAVSFA
Mvan_3383|M.vanbaalenii_PYR-1 FVNLAVAAVLYGGYRLMSRD------------------------------
Mflv_0055|M.gilvum_PYR-GCK LAGGLAAGSLYAALEIPKARRA----------------------------
MAB_2025|M.abscessus_ATCC_1997 LLSVVVGGGLYWLAQVSWPAPRVVSSGSSA--------------------
.
Mb3483|M.bovis_AF2122/97 RPDMLACQTHGAHVCSLCLSTDKQAEHVLPGLARAHIPGDQVP
MMAR_1096|M.marinum_M RPDMAACQTHDAHVCSLCLSTDKQAEHVLS----AHP------
MSMEG_5653|M.smegmatis_MC2_155 SP------RTGAGTASLTDGGQSS-------------------
Mvan_3383|M.vanbaalenii_PYR-1 -------------------------------------------
Mflv_0055|M.gilvum_PYR-GCK -------------------------------------------
MAB_2025|M.abscessus_ATCC_1997 -------------------------------------------