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MKVLVTGGTGFVGAWTAKAAQQAGHQVRFLVRNPDRLTTSAEKIGVDISDHAVGDIADAAATAAALDGCD AVIHCAAMVSTDPSRADEMLHTNLEGARNVLGEAARVGIDPIVHVSSFTALFRPDLDVLHADLPVVGGSD GYGRSKAVVEAYARGLQDGGAPVNITYPGMVLGPPAGDQFGEAAEGVEASVKMRGVPGRSAAWIVIDVRD LADLHVALLEPGRGPRRYMAGGQRVPVDMLASMIGTAAGRSLAVYPVPDVALRSAGRLLDVVGPFLPFET PINSAAMQYYTQMPESDDTPSRRDLGITQRDPAETIADTVEGLRRVGRL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3375 | - | - | 100% (329) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_5194 | - | 2e-50 | 36.22% (312) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_4271 | - | 6e-13 | 28.27% (329) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3752 | - | 1e-129 | 66.36% (327) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3154 | - | 1e-170 | 89.36% (329) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv3725 | - | 4e-98 | 68.57% (245) | oxidoreductase |
| M. leprae Br4923 | MLBr_01942 | - | 5e-11 | 28.50% (207) | putative cholesterol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2971c | - | 1e-125 | 67.28% (324) | putative oxidoreductase |
| M. marinum M | MMAR_5252 | - | 1e-126 | 65.94% (323) | oxidoreductase |
| M. avium 104 | MAV_1849 | - | 2e-14 | 26.52% (313) | dihydroflavonol-4-reductase family protein |
| M. smegmatis MC2 155 | MSMEG_5909 | - | 3e-53 | 37.92% (327) | oxidoreductase |
| M. thermoresistible (build 8) | TH_2143 | - | 2e-14 | 26.75% (329) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4328 | - | 1e-126 | 65.94% (323) | oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3375|M.vanbaalenii_PYR-1 ------------------MKVLVTGGTGFVGAWTAKAAQQAGHQVRFLVR
Mflv_3154|M.gilvum_PYR-GCK MYPPSTAGSLRLGIDGGQMKVLITGGTGFVGAWTAKAAQDAGHQVRFLVR
Mb3752|M.bovis_AF2122/97 -------------MQNATMRVLVTGGTGFVGGWTAKAIADAGHSVRFLVR
Rv3725|M.tuberculosis_H37Rv -------------MQNATMRVLVTGGTGFVGGWTAKAIADAGHSVRFLVR
MMAR_5252|M.marinum_M -------------MHNRCMHVLVTGGTGFVGGWTAKAIADAGHSVRFLVR
MUL_4328|M.ulcerans_Agy99 -------------MHNRCMHVLVTGGTGFVGGWTAKAIADAGHSVRFLVR
MAB_2971c|M.abscessus_ATCC_199 ------------------MRVLVTGGTGFVGGWTAKAMAEAGHKVRFLVR
MSMEG_5909|M.smegmatis_MC2_155 -------------MSEESVRIAVTGGTGYVGAHTVRGLLTAGHEVRLLVA
MAV_1849|M.avium_104 -----------------MAVKLVIGASGFLGSHVTRQLVERGERVRVLLR
TH_2143|M.thermoresistible__bu ----------------VAKKKLVIGASGFLGSHVTRQLVREGHDVRVMVR
MLBr_01942|M.leprae_Br4923 ----MLRGVGNASLTTELGRVLVTGGSGFVGANLVTALLERGYQVRSFDR
: *.:*::*. . * ** :
Mvan_3375|M.vanbaalenii_PYR-1 NPDRLTTSAEKIG-VDISDHAVGDIADAAATAAALDGCDAVIHCAAMVST
Mflv_3154|M.gilvum_PYR-GCK NPDRLTTSAAEIG-ADISDHVIGDIADGEATAAALDGCDAVIHCAAMVST
Mb3752|M.bovis_AF2122/97 NPARLKTSVAKLG-VDVSDFAVADISDRDSVREALNGCDAVVHSAALVAT
Rv3725|M.tuberculosis_H37Rv NPARLKTSVAKLG-VDVSDFAVADISDRDSVREALNGCDAVVHSAALVAT
MMAR_5252|M.marinum_M NPAKLESSVAKLG-VDVSDFIIGDIKDRDLVREALTGCDAVVHSAALVAT
MUL_4328|M.ulcerans_Agy99 NPAKLESSVAKLG-VDVSDFIIGDIKDRDLVREALTGCDAVVHSAALVAT
MAB_2971c|M.abscessus_ATCC_199 KEARLHTTVATLG-VDVSDYAVGDITDRASVEAALDGCDAVVHSAAMVST
MSMEG_5909|M.smegmatis_MC2_155 PGCEGEPVIDKLAEAGEVETLVGDIRDSGTVDRLIKGCDSVIHAAGVVGT
MAV_1849|M.avium_104 RTS-STVALDDLD----IERRYGDVFDDAVLRDALDGCDDVYYCVVDTRA
TH_2143|M.thermoresistible__bu TTS-MTRGIDDLD----VERCHGDVFDDAALRAAMTGVDDVYYCVVDARM
MLBr_01942|M.leprae_Br4923 APMPLPQHP-------QLEVLQGDITDATVCTTAMDSIDTVFHTAAIIEL
: .*: * : . * * : .
Mvan_3375|M.vanbaalenii_PYR-1 D------PSRADEMLHTNLEGARNVLGEAARVGIDPIVHVSSFTALFRP-
Mflv_3154|M.gilvum_PYR-GCK D------PSRADEMLHTNLEGARNILGGAAHAGIDPIVHVSSFTALFRP-
Mb3752|M.bovis_AF2122/97 D------PRETSRMLSTNMAGAQNVLGQAVELGMDPIVHVSSFTALFRP-
Rv3725|M.tuberculosis_H37Rv D------PRETSRMLSTNMAGAQNVLGQAVELGMDPIVHVSSFTALFRP-
MMAR_5252|M.marinum_M D------QRQTQDMLSTNMEGARNVLGQAVALGLDPIVHVSSFTALFHP-
MUL_4328|M.ulcerans_Agy99 D------QRQTQDMLSTNMEGARNVLGQAVALGLDPIVHVSSFTALFHP-
MAB_2971c|M.abscessus_ATCC_199 D------PAEADRMMAINLEGTRNVLGAAVDRGLDPIVHVSSITALFRP-
MSMEG_5909|M.smegmatis_MC2_155 D------KSRTQLMWEINAHATEAVLIRAAEAGLDPIVSVSSYSSLFPP-
MAV_1849|M.avium_104 W------LRDPAPLFRTNVEGLRQVLDTAVGADLRRFVFTSTIGTIALSE
TH_2143|M.thermoresistible__bu W------LRDPAPLFRTNVEGLRHVLDAAVEADLNRFLFTSTTGTMAIN-
MLBr_01942|M.leprae_Br4923 MGGASVTDEYRQRSYTVNVGGTENLLRAGQKSGVKRFVYTASNSVVMGGT
* . . :* . .: :: .:: :
Mvan_3375|M.vanbaalenii_PYR-1 DLDVLHADLPVVGGSDGYGRSKAVVEAYARGLQDG---GAPVN--ITYPG
Mflv_3154|M.gilvum_PYR-GCK DLDRLHADLPVVGGSDGYGRSKAAVEAYARGLQDG---GAPVN--ITYPG
Mb3752|M.bovis_AF2122/97 NLATLSADLPVAGGTDGYGQSKAQIEIYARGLQDA---GAPVN--ITYPG
Rv3725|M.tuberculosis_H37Rv NLATLSADLPVAGGTDGYGQSKAQIEIYARGLQDA---GAPVN--ITYPG
MMAR_5252|M.marinum_M GLQTLSADLPVVGGSDGYGTSKAQVEIYARGLQDA---GAPVN--ITYPG
MUL_4328|M.ulcerans_Agy99 GLQTLSADLPVVGGSDGYGTSKAQVEIYARGLQDA---GAPVN--ITYPG
MAB_2971c|M.abscessus_ATCC_199 GLETFAADLPAAGGSDGYGQSKARVELYVRALQDS---GAPVT--ITYPG
MSMEG_5909|M.smegmatis_MC2_155 PDGVISADTPPVAGRSPYAQTKAYADRAARRLQDT---GAPVV--VTYPS
MAV_1849|M.avium_104 DGLPVSEDEPFNWADRGGGYIRSRVEAENLVLQYARERGLPAV--AMCVS
TH_2143|M.thermoresistible__bu PYRPVTEDDPHNWT-EGGAYIEARVAAEQLVLRYARERGLPAV--ALCIS
MLBr_01942|M.leprae_Br4923 PITGGDETMPYTKRFNDLYTETKVVAEKFVLSQNGVPDGETMLTCSIRPS
* : * . .
Mvan_3375|M.vanbaalenii_PYR-1 MVLGPPAGDQFGEAAEGVEASVKMRGVPGRSAAWIVIDVRDLADLHVALL
Mflv_3154|M.gilvum_PYR-GCK MVLGPPAGDQFGEAADGVEASVKMRGVPGRGAGWIVIDVRDLADLHVALL
Mb3752|M.bovis_AF2122/97 MVLGPPVGDQFGEAGEGVRSALWMHVIPGRGAAWLIVDVRDVAALHAALL
Rv3725|M.tuberculosis_H37Rv MVLGPPVGDQFGEAGEGVRSALWMHVIPGRGAAWLIVDVRDVAALHAALL
MMAR_5252|M.marinum_M MVLGPPVGNQFGEAGEGVKAALEIRTIPGRNAAWLIIDVRDVAAVHAALL
MUL_4328|M.ulcerans_Agy99 MVLGPPVGNQFGEAGEGVKAALEIRTIPGRNAAWLIIDVRDVAAVHAALL
MAB_2971c|M.abscessus_ATCC_199 MVLGPPVGDQFGEAAEGVRWVLLTRSVPGRSAAWLVVDVRDLAALHTALL
MSMEG_5909|M.smegmatis_MC2_155 SVVGPAWFTAPGVTERGWGPIVKARVAPRLRGGMQMIDVRDVADVHVALM
MAV_1849|M.avium_104 NTYGPGDFQPTPHGSLVAAAGKGKMPVYVKDMSMEVVGIEDAARALILAA
TH_2143|M.thermoresistible__bu TTYGPGDWQPTPHGRLLAMVATGRFPFYLG-WSAEVVGIEDAARAMLLAA
MLBr_01942|M.leprae_Br4923 GIWGRGDQTMFRKAFESVVSGHVKVLIGSKNAKLDNSYVHNLVHGLILAA
* :.: .
Mvan_3375|M.vanbaalenii_PYR-1 E------PGRGPRRYMAGGQRVPVDMLASMIGTAAGRSLAVYPVPDVALR
Mflv_3154|M.gilvum_PYR-GCK E------PGRGPRRYMAGGQRVSVSELASMIGNAADQSILVYPVPDVALR
Mb3752|M.bovis_AF2122/97 E------SGRGPRRYTAGGHRIPVPELAKILGEVAGTTMLAVPVPDSALR
Rv3725|M.tuberculosis_H37Rv E------SGRGPRRYTAGGHRIPVPELAKILGGSPAPRCWPSRCPIPRCV
MMAR_5252|M.marinum_M E------PGRGPRRYMVGGHRIPVPELAKMLGQVAETPIVSVPIPDSVLR
MUL_4328|M.ulcerans_Agy99 E------PGRGPRRYMVGGHRIPVPELAKMLGQVAETPIVSVPIPDSVLR
MAB_2971c|M.abscessus_ATCC_199 E------PSRGPRRYTAGGHRLEVGELVDLLTEAAGSAVLAVPVPDSLLR
MSMEG_5909|M.smegmatis_MC2_155 K------PGRGPHRYVCGGVLVSFNEWIDILEQGVGRPIRRIPLSPAMFH
MAV_1849|M.avium_104 E------KGRVGERYIVSERYISARELYTTAAEAGGARPPRIGIPLKVMY
TH_2143|M.thermoresistible__bu E------QGRVGERYIISDRYLHTREVHAIAAEAVGRRAPWFGLPLPVLS
MLBr_01942|M.leprae_Br4923 EHLVPGGTAPGQAYFINDGEPINFFDFMGPIIKACGENWPRVRISGRLVR
: . : . : .
Mvan_3375|M.vanbaalenii_PYR-1 -SAGRLLDVVGPFLPFETPINSAAMQYYTQMPESDDTPSRRDLGITQRD-
Mflv_3154|M.gilvum_PYR-GCK -SAGRLLDVVGPYLPFETPINSAAMQYYTQMPESDDTPGARDFGLTQRD-
Mb3752|M.bovis_AF2122/97 -VAGSVLDQAGPYLPFNTPFTAAGMQYYTQMPEPDDSPSEKELGITYRD-
Rv3725|M.tuberculosis_H37Rv -SRDRCWIKPGP-------------ICLSILRSPRQVCS-----TTHRC-
MMAR_5252|M.marinum_M -VAGSLLDLAGPYLPFDNPFTAAGMQYYTQMPDSDDSPSELELGVTYRD-
MUL_4328|M.ulcerans_Agy99 -VAGSLLDLAGPYLPFDNPFTAAGMQYYTQMPDSDDSPSELELGVTYRD-
MAB_2971c|M.abscessus_ATCC_199 -AAGTVMDQIGRYVPWETPMTEAGMQYYTQMPASDDTPSERELGITYRD-
MSMEG_5909|M.smegmatis_MC2_155 -AIGWVSDLLGNVLPLGDGISYEAAMLLTAATPTDDAKTLADLGIPAWRS
MAV_1849|M.avium_104 -ALGLCGDVAAKVLRRDMLLSTLSVRLMHIMSPMDHSKAERELGWRPEP-
TH_2143|M.thermoresistible__bu -VAARGNDLAARLLRRDLMFAHVGLKMAELMSPLDHSKAERELGFKPEP-
MLBr_01942|M.leprae_Br4923 NVMAVWQRLHFGFGLPKPPMEPLAVERVYLDNYFSIEKAHKELGYRPLFT
Mvan_3375|M.vanbaalenii_PYR-1 PAETIADTVEGLRRVGRL-------------------
Mflv_3154|M.gilvum_PYR-GCK PAVTIADTFAGLRAVGRL-------------------
Mb3752|M.bovis_AF2122/97 PRDTVADTVTALRGLGS--------------------
Rv3725|M.tuberculosis_H37Rv RSPTIRRAKKN--------------------------
MMAR_5252|M.marinum_M PRTTLADTVAALTA-----------------------
MUL_4328|M.ulcerans_Agy99 PRTTLADTVAALTA-----------------------
MAB_2971c|M.abscessus_ATCC_199 PRETLADTVVSLRAGRTTSKLWGLWPFSE--------
MSMEG_5909|M.smegmatis_MC2_155 PRAAVLESFGR--------------------------
MAV_1849|M.avium_104 IHDAIRRAVAFYQTR----------------------
TH_2143|M.thermoresistible__bu VEDSIAKAARFFLEQHR--------------------
MLBr_01942|M.leprae_Br4923 TEQAMAECLPYYTELFEQIKVAAKPHLASIAATPRPE
::