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RALLEAQHTIRLLVLPQEQDAPVIRRLRSLGDVSVIVGDVRAESTVTALLTGVDAVVHAAGVVGTDERRA QLMWDINAYATEQVLTRAVELGLDPVVSVSSYSALFPPPDGIISADSPTSSGRSSYAKTKGYADRVARRL QDAGAPVVVTYPSSVVGPAFGTAAGVTERGWEPIVRARVAPRVRAGMQMIDVRDVADVHVRLMRPGRGPR RYVCGGVMLTFDEMIDALEAGLGRPVRRVPLSPKVLLAVGRLSDAVGRYVPLGDGLSYEAALLLTSATPT DDRATTEDLGLHWRSPRQAIIESFGVAGRLGDPVS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5194 | - | - | 100% (316) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_3375 | - | 2e-50 | 36.22% (312) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_0338 | - | 1e-09 | 23.90% (272) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3752 | - | 2e-48 | 36.10% (313) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1564 | - | 1e-150 | 85.44% (309) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv3725 | - | 9e-40 | 40.87% (230) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2971c | - | 4e-53 | 38.36% (305) | putative oxidoreductase |
| M. marinum M | MMAR_5252 | - | 2e-52 | 39.02% (305) | oxidoreductase |
| M. avium 104 | MAV_5157 | - | 2e-08 | 24.27% (309) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_5909 | - | 1e-121 | 68.40% (307) | oxidoreductase |
| M. thermoresistible (build 8) | TH_2143 | - | 3e-07 | 21.59% (301) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_4328 | - | 2e-52 | 39.02% (305) | oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5194|M.vanbaalenii_PYR-1 ---------------------MRALLEAQHTIRLLVLPQEQDAPVIRRLR
Mflv_1564|M.gilvum_PYR-GCK -MEGTIHIAVTGGIGYLGAHTVRALLEAGHSVRLLVLPQEQDAPVIDRLR
MSMEG_5909|M.smegmatis_MC2_155 MSEESVRIAVTGGTGYVGAHTVRGLLTAGHEVRLLVAPGCEGEPVIDKLA
MMAR_5252|M.marinum_M MHNRCMHVLVTGGTGFVGGWTAKAIADAGHSVRFLVRNPAKLESSVAKLG
MUL_4328|M.ulcerans_Agy99 MHNRCMHVLVTGGTGFVGGWTAKAIADAGHSVRFLVRNPAKLESSVAKLG
Mb3752|M.bovis_AF2122/97 MQNATMRVLVTGGTGFVGGWTAKAIADAGHSVRFLVRNPARLKTSVAKLG
Rv3725|M.tuberculosis_H37Rv MQNATMRVLVTGGTGFVGGWTAKAIADAGHSVRFLVRNPARLKTSVAKLG
MAB_2971c|M.abscessus_ATCC_199 -----MRVLVTGGTGFVGGWTAKAMAEAGHKVRFLVRKEARLHTTVATLG
MAV_5157|M.avium_104 --MSGKPKLVIGANGFLGSHVTRQLVADGAQVRAMVRAGANTR-GIDDLS
TH_2143|M.thermoresistible__bu ---VAKKKLVIGASGFLGSHVTRQLVREGHDVRVMVRTTSMTR-GIDDLD
: : :* :* : *
Mvan_5194|M.vanbaalenii_PYR-1 SLGDVSVIVGDVRAESTVTALLTGVDAVVHAAGVVGTDERRAQLMWDINA
Mflv_1564|M.gilvum_PYR-GCK ALGEVSVVVGDIRSESTVTELLSGADAVLHAAGVVGTDERRSQLMWDINA
MSMEG_5909|M.smegmatis_MC2_155 EAGEVETLVGDIRDSGTVDRLIKGCDSVIHAAGVVGTDKSRTQLMWEINA
MMAR_5252|M.marinum_M -VDVSDFIIGDIKDRDLVREALTGCDAVVHSAALVATDQRQTQDMLSTNM
MUL_4328|M.ulcerans_Agy99 -VDVSDFIIGDIKDRDLVREALTGCDAVVHSAALVATDQRQTQDMLSTNM
Mb3752|M.bovis_AF2122/97 -VDVSDFAVADISDRDSVREALNGCDAVVHSAALVATDPRETSRMLSTNM
Rv3725|M.tuberculosis_H37Rv -VDVSDFAVADISDRDSVREALNGCDAVVHSAALVATDPRETSRMLSTNM
MAB_2971c|M.abscessus_ATCC_199 -VDVSDYAVGDITDRASVEAALDGCDAVVHSAAMVSTDPAEADRMMAINL
MAV_5157|M.avium_104 ----LTRFHGDVFDTAVLSEAMDGVDDVYYCVVDTRAWVRDTSPLFRTNV
TH_2143|M.thermoresistible__bu ----VERCHGDVFDDAALRAAMTGVDDVYYCVVDARMWLRDPAPLFRTNV
.*: : : * * * :.. . . : *
Mvan_5194|M.vanbaalenii_PYR-1 YATEQVLTRAV-ELGLDPVVSVSSYSALFPPPDGIISADSPTSS-GRSSY
Mflv_1564|M.gilvum_PYR-GCK YATEQILTRAV-DLGLDPVVSVSSYSALFPPKNGVISADSPTAD-GRSSY
MSMEG_5909|M.smegmatis_MC2_155 HATEAVLIRAA-EAGLDPIVSVSSYSSLFPPPDGVISADTPPVA-GRSPY
MMAR_5252|M.marinum_M EGARNVLGQAV-ALGLDPIVHVSSFTALFHPGLQTLSADLPVVG-GSDGY
MUL_4328|M.ulcerans_Agy99 EGARNVLGQAV-ALGLDPIVHVSSFTALFHPGLQTLSADLPVVG-GSDGY
Mb3752|M.bovis_AF2122/97 AGAQNVLGQAV-ELGMDPIVHVSSFTALFRPNLATLSADLPVAG-GTDGY
Rv3725|M.tuberculosis_H37Rv AGAQNVLGQAV-ELGMDPIVHVSSFTALFRPNLATLSADLPVAG-GTDGY
MAB_2971c|M.abscessus_ATCC_199 EGTRNVLGAAV-DRGLDPIVHVSSITALFRPGLETFAADLPAAG-GSDGY
MAV_5157|M.avium_104 EGLRNVLDVAVTQPELRKFIFTSTYATVGRRRGHVATEDDVIGTRGLSDY
TH_2143|M.thermoresistible__bu EGLRHVLDAAV-EADLNRFLFTSTTGTMAINPYRPVTEDDPHNWTEGGAY
. . :* *. : .: .*: :: : * . *
Mvan_5194|M.vanbaalenii_PYR-1 AKTKGYADRVARRLQ-DAGAPVVVTYPSSVVGP-AFG-TAAGVTERGWEP
Mflv_1564|M.gilvum_PYR-GCK AKTKGYADRAARRLQ-DAGAPVVVTYPSSVVGA-AFGGTASGVTERGWAP
MSMEG_5909|M.smegmatis_MC2_155 AQTKAYADRAARRLQ-DTGAPVVVTYPSSVVGP-AWF-TAPGVTERGWGP
MMAR_5252|M.marinum_M GTSKAQVEIYARGLQ-DAGAPVNITYPGMVLGP-PVG-NQFGEAGEGVKA
MUL_4328|M.ulcerans_Agy99 GTSKAQVEIYARGLQ-DAGAPVNITYPGMVLGP-PVG-NQFGEAGEGVKA
Mb3752|M.bovis_AF2122/97 GQSKAQIEIYARGLQ-DAGAPVNITYPGMVLGP-PVG-DQFGEAGEGVRS
Rv3725|M.tuberculosis_H37Rv GQSKAQIEIYARGLQ-DAGAPVNITYPGMVLGP-PVG-DQFGEAGEGVRS
MAB_2971c|M.abscessus_ATCC_199 GQSKARVELYVRALQ-DSGAPVTITYPGMVLGP-PVG-DQFGEAAEGVRW
MAV_5157|M.avium_104 VKSRVQAENLVMRYVAEAGLPAVAMCVSTTYGSGDWGRTPHGAFIAGAVF
TH_2143|M.thermoresistible__bu IEARVAAEQLVLRYARERGLPAVALCISTTYGPGDWQPTPHGRLLAMVAT
:: : . : * *. . . *. *
Mvan_5194|M.vanbaalenii_PYR-1 IVRARVAPRVRAGMQMIDVRDVADVHVRLMRPGRGPRRYVCGGVMLTFDE
Mflv_1564|M.gilvum_PYR-GCK IVRARVAPRVRAGMQMIDVRDVADVHTRLMSPGRGPHRYVCGGVMLTFDE
MSMEG_5909|M.smegmatis_MC2_155 IVKARVAPRLRGGMQMIDVRDVADVHVALMKPGRGPHRYVCGGVLVSFNE
MMAR_5252|M.marinum_M ALEIRTIPGRNAAWLIIDVRDVAAVHAALLEPGRGPRRYMVGGHRIPVPE
MUL_4328|M.ulcerans_Agy99 ALEIRTIPGRNAAWLIIDVRDVAAVHAALLEPGRGPRRYMVGGHRIPVPE
Mb3752|M.bovis_AF2122/97 ALWMHVIPGRGAAWLIVDVRDVAALHAALLESGRGPRRYTAGGHRIPVPE
Rv3725|M.tuberculosis_H37Rv ALWMHVIPGRGAAWLIVDVRDVAALHAALLESGRGPRRYTAGGHRIPVPE
MAB_2971c|M.abscessus_ATCC_199 VLLTRSVPGRSAAWLVVDVRDLAALHTALLEPSRGPRRYTAGGHRLEVGE
MAV_5157|M.avium_104 GKLPFTMEG--IQLEVVGVTDAAKAMVLAADRGRVGERYLISERMIALKE
TH_2143|M.thermoresistible__bu GRFPFYLG---WSAEVVGIEDAARAMLLAAEQGRVGERYIISDRYLHTRE
::.: * * .* .** . : *
Mvan_5194|M.vanbaalenii_PYR-1 MIDALEAGLGRPVRRVPLSPKVLLAVGRLSDAVGRYVPLGDGLSYEAALL
Mflv_1564|M.gilvum_PYR-GCK MIDALEEGLGRPVRRIPMSPKALLAVGRISDVAGRYVPLGDGLSYEAALL
MSMEG_5909|M.smegmatis_MC2_155 WIDILEQGVGRPIRRIPLSPAMFHAIGWVSDLLGNVLPLGDGISYEAAML
MMAR_5252|M.marinum_M LAKMLGQVAETPIVSVPIPDSVLRVAGSLLDLAGPYLPFDNPFTAAGMQY
MUL_4328|M.ulcerans_Agy99 LAKMLGQVAETPIVSVPIPDSVLRVAGSLLDLAGPYLPFDNPFTAAGMQY
Mb3752|M.bovis_AF2122/97 LAKILGEVAGTTMLAVPVPDSALRVAGSVLDQAGPYLPFNTPFTAAGMQY
Rv3725|M.tuberculosis_H37Rv LAKILGGSPAPRCWPSRCPIPRCVSRDRCWIKPGP-------------IC
MAB_2971c|M.abscessus_ATCC_199 LVDLLTEAAGSAVLAVPVPDSLLRAAGTVMDQIGRYVPWETPMTEAGMQY
MAV_5157|M.avium_104 VVRIAADEAGVPPPRRSISVPTLYALGALGDLRARLTGKDAELSLASVRM
TH_2143|M.thermoresistible__bu VHAIAAEAVGRRAPWFGLPLPVLSVAARGNDLAARLLRRDLMFAHVGLKM
. .
Mvan_5194|M.vanbaalenii_PYR-1 LTSATPTDDRATTEDLGL-HWRSPRQAIIESFGVAGR-LGDPVS------
Mflv_1564|M.gilvum_PYR-GCK LTSATPTDDSVTRQDLGL-SWRSPRAAIVESFAAARVSAGRGIA------
MSMEG_5909|M.smegmatis_MC2_155 LTAATPTDDAKTLADLGIPAWRSPRAAVLESFGR----------------
MMAR_5252|M.marinum_M YTQMPDSDDSPSELELGVTYRDP-RTTLADTVAALTA-------------
MUL_4328|M.ulcerans_Agy99 YTQMPDSDDSPSELELGVTYRDP-RTTLADTVAALTA-------------
Mb3752|M.bovis_AF2122/97 YTQMPEPDDSPSEKELGITYRDP-RDTVADTVTALRGLGS----------
Rv3725|M.tuberculosis_H37Rv LSILRSPRQVCS-----TTHRCR-SPTIRRAKKN----------------
MAB_2971c|M.abscessus_ATCC_199 YTQMPASDDTPSERELGITYRDP-RETLADTVVSLRAGRTTSKLWGLWPF
MAV_5157|M.avium_104 MRAEAPVDHSKAVRELGWQPRPVEESIREAARFWAAMRNAKGKSATPR--
TH_2143|M.thermoresistible__bu AELMSPLDHSKAERELGFKPEPVEDSIAKAARFFLEQHR-----------
. : :
Mvan_5194|M.vanbaalenii_PYR-1 --
Mflv_1564|M.gilvum_PYR-GCK --
MSMEG_5909|M.smegmatis_MC2_155 --
MMAR_5252|M.marinum_M --
MUL_4328|M.ulcerans_Agy99 --
Mb3752|M.bovis_AF2122/97 --
Rv3725|M.tuberculosis_H37Rv --
MAB_2971c|M.abscessus_ATCC_199 SE
MAV_5157|M.avium_104 --
TH_2143|M.thermoresistible__bu --