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HEHTVRVRTASGTVEGFTRDGVHRWRSIPYARPPVGRLRYRAPEPVQPWSGVRHCHGFLSCAPQHRRYTL IGVRKYQPTSEDCLTLNVVAPEGAASAGEPLPVMFFIHGGGYILGSSATPLYDGAALARRGCVYVSVNYR LGPLGCMDLSSLSTPENPIDDNLFLRDLVMALRWVRDNVAAFGGDPDKVTIFGESAGAHAVATLLATPQA KGLFAQAISESPASGMVRSTEMAAKFASRFADLVANDGGDAAAALMSASPHALIAALDDLVANGFKDMPG AFPVGPTYGTEYLPKDPVEAMRDGTAHRVPLIVGTNAEEGRLFTRFLPLLPTTEQTIEIMLGDTDAEVRN RIMSAYPDYPKPDACVQIGGDFTFSTAAWQIGEAHSRHAPTFVYRYDYAPRPLHWSGMGATHATELLAVF DIYRTMPGALLTLAGDWRSARRVSKDVQRRWSSFSRTGVPGADWPRYSAEDRPVMVFDRHPRLEYDPHAH RRQAWEGFSLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3408 | - | - | 100% (502) | carboxylesterase, type B |
| M. vanbaalenii PYR-1 | Mvan_2609 | - | 2e-85 | 38.82% (492) | carboxylesterase, type B |
| M. vanbaalenii PYR-1 | Mvan_3172 | - | 1e-74 | 37.30% (504) | carboxylesterase, type B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 0.0 | 69.92% (502) | carboxylesterase LipT |
| M. gilvum PYR-GCK | Mflv_3125 | - | 0.0 | 69.64% (504) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv2045c | lipT | 0.0 | 69.92% (502) | carboxylesterase LipT |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3453c | - | 1e-167 | 59.44% (498) | carboxylesterase LipT |
| M. marinum M | MMAR_3020 | lipT | 0.0 | 69.52% (502) | carboxylesterase, LipT |
| M. avium 104 | MAV_2466 | - | 0.0 | 71.74% (506) | LppT protein |
| M. smegmatis MC2 155 | MSMEG_3848 | - | 0.0 | 71.71% (502) | para-nitrobenzyl esterase |
| M. thermoresistible (build 8) | TH_0737 | lipT | 0.0 | 74.85% (501) | Probable carboxylesterase LipT |
| M. ulcerans Agy99 | MUL_2261 | lipT | 0.0 | 69.52% (502) | carboxylesterase, LipT |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2071c|M.bovis_AF2122/97 ----MALESATVGSMHERTVRARTATGIVEGFTRDGVHRWRSIPYARAPV
Rv2045c|M.tuberculosis_H37Rv ----MALESATVGSMHERTVRARTATGIVEGFTRDGVHRWRSIPYARAPV
MMAR_3020|M.marinum_M --------------MHERTVRARTATGIVEGFTRDGVHRWRSIPYARAPI
MUL_2261|M.ulcerans_Agy99 --------------MHERTVRARTATGVVEGFTRDGVHRWRSIPYARAPI
MAV_2466|M.avium_104 --------------MHDRTVRARTATGIVEGFTRDGVHRWRSIPYARPPV
Mvan_3408|M.vanbaalenii_PYR-1 --------------MHEHTVRVRTASGTVEGFTRDGVHRWRSIPYARPPV
TH_0737|M.thermoresistible__bu -------------VMHEHRVRVQISTGTIEGFTRDGVHRWRAIPYAKPPV
MSMEG_3848|M.smegmatis_MC2_155 --------------MHERTVRAEISTGIIEGFTRDGVHRWRSIPYARAPI
Mflv_3125|M.gilvum_PYR-GCK MVRQAGREFDTVGRMHEHTVRVKIASGTVEGFTRDGVHRWRSIPYARPPV
MAB_3453c|M.abscessus_ATCC_199 ----------MASGSKTPTVRVTTPNGIVEGFVRGGVRRFRSIPYARPPI
: **. ..* :***.*.**:*:*:****:.*:
Mb2071c|M.bovis_AF2122/97 GSLRFRAPQPAQPWPGVRHCHTFANCAPQQRRYTVMGIG----RYQTRSE
Rv2045c|M.tuberculosis_H37Rv GSLRFRAPQPAQPWPGVRHCHTFANCAPQQRRYTVMGIG----RYQTRSE
MMAR_3020|M.marinum_M GPLRFRAPRPPQPWSGVRHCHGFTHCSPQQRRYTMLGLG----KYQPMSE
MUL_2261|M.ulcerans_Agy99 GLLRFRAPRPPQPWSGVRHCHGFTHCSPQQRRYTMLGLG----KYQPMSE
MAV_2466|M.avium_104 GDLRFRAPQPAQPWSGVRHCHGFANCAPQQRRYTLLGLSGLGGRYQPMSE
Mvan_3408|M.vanbaalenii_PYR-1 GRLRYRAPEPVQPWSGVRHCHGFLSCAPQHRRYTLIGVR----KYQPTSE
TH_0737|M.thermoresistible__bu GPLRLRAPEPADPWPGVRHCHGFGNCAPQERKYTLIGLG----KYQPMGE
MSMEG_3848|M.smegmatis_MC2_155 GPLRLRAPQPAEPWPGVRYCHGFGFCAPQQRRYTLLGVG----KYQPTSE
Mflv_3125|M.gilvum_PYR-GCK GPLRYRAPRPVQPWPGVRYCHGFGACAPQQRMYTLLAPG----RYQPMSE
MAB_3453c|M.abscessus_ATCC_199 GLLRLRAPQPALPWEGVRDCTEFGAAAPQRRRYRVLGPG----RVQRASE
* ** ***.* ** *** * * .:**.* * ::. : * .*
Mb2071c|M.bovis_AF2122/97 DCLTLNVVTPEEPATQ----PLPVMVFIHGGGYILGSSATPIYDGAALAR
Rv2045c|M.tuberculosis_H37Rv DCLTLNVVTPEEPATQ----PLPVMVFIHGGGYILGSSATPIYDGAALAR
MMAR_3020|M.marinum_M DCLTLNVVAPEAPSHR----PLPVMVFIHGGGYILGSSATPIYDGAALAR
MUL_2261|M.ulcerans_Agy99 DCLTLNVVAPEAPTHR----PLPVMVFIHGGGYILGSSATPIYDGAALAR
MAV_2466|M.avium_104 DCLTLNVVTPEAPAEG----PLPVMVFIHGGGYFLGSSATPLYDGAALAR
Mvan_3408|M.vanbaalenii_PYR-1 DCLTLNVVAPEGAASAGE--PLPVMFFIHGGGYILGSSATPLYDGAALAR
TH_0737|M.thermoresistible__bu DCLTLNVVAPEHPPDS----PMPVLVFIHGGGYLLGSSATPIYDGAALAR
MSMEG_3848|M.smegmatis_MC2_155 DCLTLNVVAPEKPHDG----PLPVMFFVHGGGYVLGSSATPIYDGAALAR
Mflv_3125|M.gilvum_PYR-GCK DCLTLNVVAPADAEARAADGPLPVMVFIHGGGYLLGSSATPVYDGASLAR
MAB_3453c|M.abscessus_ATCC_199 DCLTVNVVTPDRPSNE----PLPVMFFIYGGGYLLGSSATPLYDGAALAR
****:***:* . *:**:.*::****.*******:****:***
Mb2071c|M.bovis_AF2122/97 RGCVYVSVNYRLGALGCLDLSSLSTPQITLDSNVYLRDLVLALRWVHDNI
Rv2045c|M.tuberculosis_H37Rv RGCVYVSVNYRLGALGCLDLSSLSTPQITLDSNVYLRDLVLALRWVHDNI
MMAR_3020|M.marinum_M RGCVYVSVNYRLGALGCLDLSSLSTPDIAIDGNLYLRDLVMALQWIQDNI
MUL_2261|M.ulcerans_Agy99 RGCVYVSVNYRLGALGCLDLSSLSTPDIAIDGNLYLRDLVMALQWIQDNI
MAV_2466|M.avium_104 RGCVYVSVNYRLGALGCVDFSSLSTPEIPLESNLYLRDLVLALQWVRDNI
Mvan_3408|M.vanbaalenii_PYR-1 RGCVYVSVNYRLGPLGCMDLSSLSTPENPIDDNLFLRDLVMALRWVRDNV
TH_0737|M.thermoresistible__bu RGCVYVSVNYRLGALGCMDLSSLSTRRHPIDSNLFLRDLVLALQWVRDNI
MSMEG_3848|M.smegmatis_MC2_155 RGCVYVSVNYRLGVLGAMELSSLSTPEHPIDDNLFLRDLVLALQWVRDNI
Mflv_3125|M.gilvum_PYR-GCK KGCVYISVNYRLGALGCLELSSLSTPEAPIDDNLFLRDLVMALRWVRDNV
MAB_3453c|M.abscessus_ATCC_199 RGCVYVSVNYRVGALGALDLSSLSDRDHTIDGNLFLRDVVLALQWVHDNI
:****:*****:* **.:::**** .::.*::***:*:**:*::**:
Mb2071c|M.bovis_AF2122/97 AEFGGDPGNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRS
Rv2045c|M.tuberculosis_H37Rv AEFGGDPGNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRS
MMAR_3020|M.marinum_M AEFGGDPDNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRP
MUL_2261|M.ulcerans_Agy99 AEFGGDPDNVTIFGESAGAHITATLLAVPAAKGLFARAISESPAAGMVRP
MAV_2466|M.avium_104 AEFGGDPDNVTIFGESAGACITATLLAVPAAKGLFAQAISESPASGLVRS
Mvan_3408|M.vanbaalenii_PYR-1 AAFGGDPDKVTIFGESAGAHAVATLLATPQAKGLFAQAISESPASGMVRS
TH_0737|M.thermoresistible__bu SVFGGDPGNVTIFGESAGAHAVATLMAVPAAKGLFSQAISQSPASGMVRS
MSMEG_3848|M.smegmatis_MC2_155 AVFGGDPDNVTIFGESAGAHAVATLLAVPAARGLFARVISESPASGMVSS
Mflv_3125|M.gilvum_PYR-GCK AAFGGDPGNVTIFGESAGAHAVSTLVATPEAEGLFAQAIAQSPASGMISD
MAB_3453c|M.abscessus_ATCC_199 GTFGGDPGNVTIFGESAGAHCVETLMATPAAAGLFHRAICQSTASGMAVP
. *****.:********** . **:*.* * *** :.*.:*.*:*:
Mb2071c|M.bovis_AF2122/97 REVAAEFAARFANLIGARTQDAANALMQASPAQLVEAQHHLIRQGMRKRL
Rv2045c|M.tuberculosis_H37Rv REVAAEFAARFANLIGARTQDAANALMQASPAQLVEAQHHLIRQGMRKRL
MMAR_3020|M.marinum_M REIAAEFATRFARLLGARKHDAASALMRATAAQLVQTQHRLIDQGMQKRL
MUL_2261|M.ulcerans_Agy99 REIAAEFATRFARLLGARKHDAASALMRATAAQLVQTQHRLIDQGMQKRL
MAV_2466|M.avium_104 QEVAAEFANRFANLLGVRRQDAANALMQASAAQLVKTQHRLIDEGMQDRL
Mvan_3408|M.vanbaalenii_PYR-1 TEMAAKFASRFADLVANDGGDAAAALMSASPHALIAALDDLVANGFKDMP
TH_0737|M.thermoresistible__bu ADVAAEFARRFADLLG-AGRDPAAALMAASPADLVRALDELISRGMTDMP
MSMEG_3848|M.smegmatis_MC2_155 ADTAARLAGQYAGIIGHGGRDAAEALKTLSPAQLGRALEELINRGMTDMP
Mflv_3125|M.gilvum_PYR-GCK ADIAADYAQRFARQLGADGKDGARALLAARPADLVDALERLIVEGQRDLV
MAB_3453c|M.abscessus_ATCC_199 ADSAAMYAQKFAQILGATTQSAAETVLRSSPAELGAALNMLIADIVTNMP
: ** * ::* :. . * :: . * : . *: .
Mb2071c|M.bovis_AF2122/97 G-AFPIGPVFGDDYLPMDPVEAMRSGRVHAVPLIVGTNAEEGRLFTRFLG
Rv2045c|M.tuberculosis_H37Rv G-AFPIGPVFGDDYLPMDPVEAMRSGRVHAVPLIVGTNAEEGRLFTRFLG
MMAR_3020|M.marinum_M G-AFPIGPTFGDDCLPLDPVEAMRAGQSHKVPLIVGTNADEGRLFTRFLK
MUL_2261|M.ulcerans_Agy99 G-AFPIGPTFGDDCLPLDPVEAMRAGQSHKVPLIVGTNADEGRLFTRFLK
MAV_2466|M.avium_104 G-AFPIGPVVGDDILPTDPVEAMRRGEAHRVPLIVGTNAEEGRLFTRFLA
Mvan_3408|M.vanbaalenii_PYR-1 G-AFPVGPTYGTEYLPKDPVEAMRDGTAHRVPLIVGTNAEEGRLFTRFLP
TH_0737|M.thermoresistible__bu G-AFAVGPSYGDDCLPRHPVEAMRDGRAHDVPLIVGTNAEEGRLFRRFLP
MSMEG_3848|M.smegmatis_MC2_155 G-AFPVGPTYGTEFLPTDPVEAMAAGSAHRVPLIVGNNAEEGRLFTRFLP
Mflv_3125|M.gilvum_PYR-GCK G-AFAIGPTYGTEYLPEDPVEAMRSGRAHPVPLIVGTNADEGRLFTRFLK
MAB_3453c|M.abscessus_ATCC_199 GGSFAIGPCIDGHYLPRHPIEAMEHGEAHRVPLIVGHNADEAKLFTRVLK
* :*.:** . . ** .*:*** * * ****** **:*.:** *.*
Mb2071c|M.bovis_AF2122/97 MLPTNEPMVEELLSGMKPADRERITAAYPNYPAPSACIQLGGDFAFSSAA
Rv2045c|M.tuberculosis_H37Rv MLPTNEPMVEELLSGMKPADRERITAAYPNYPAPSACIQLGGDFAFSSAA
MMAR_3020|M.marinum_M MLPTNKAMIDELLADTEPATRERITAAYPNYPESAACIQLGGDFAFNAAA
MUL_2261|M.ulcerans_Agy99 MLPTNKAMIDELLADTEPATRERITAAYPNYPESAACIQLGGDFAFNAAA
MAV_2466|M.avium_104 MLPTNESMVEELLADAEPAVRERITAAYPDYPDRSACIQLGGDFAFGSAA
Mvan_3408|M.vanbaalenii_PYR-1 LLPTTEQTIEIMLGDTDAEVRNRIMSAYPDYPKPDACVQIGGDFTFSTAA
TH_0737|M.thermoresistible__bu LLPISEPMIEALFGDTDAEVRDRIIAAYPGYPDADACIRLGGDFAFGTAA
MSMEG_3848|M.smegmatis_MC2_155 LLPTNEPMIEKLFADADPEHRERILSAYPGYPDRDVCVRLGGDFAFGSAT
Mflv_3125|M.gilvum_PYR-GCK LLPTNEQAIEQLLSAVEPEARQRVLAAYPKYPAVDACVAFGGDFIFGSAV
MAB_3453c|M.abscessus_ATCC_199 MMPLSESALEGMLARGGPGHRDRIVAAYPGYPERSARVKLAGDMNFSTAA
::* .: :: ::. . *:*: :*** ** . : :.**: *.:*.
Mb2071c|M.bovis_AF2122/97 WQIAEAHGANAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFG
Rv2045c|M.tuberculosis_H37Rv WQIAEAHGANAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFG
MMAR_3020|M.marinum_M WQIAEAQGAHAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFG
MUL_2261|M.ulcerans_Agy99 WQIAEAQGVHAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFG
MAV_2466|M.avium_104 WQIAEAHCAHAPTYLYRYDYAPRTLRWSGFGATHATELLAVFDVYRTRFG
Mvan_3408|M.vanbaalenii_PYR-1 WQIGEAHSRHAPTFVYRYDYAPRPLHWSGMGATHATELLAVFDIYRTMPG
TH_0737|M.thermoresistible__bu WEISEAHSRHAPTYVYRYDYAPRMLHWSGIGATHATELLAVFGTYRTRPG
MSMEG_3848|M.smegmatis_MC2_155 WQVAEAHSRHAPTYVYRYDYAPRALRWSGLGATHAMELLAVFDTYRTRYG
Mflv_3125|M.gilvum_PYR-GCK WQIAHAHSAFAPTYVYRYDYATAALRLSGMGATHATELLAVFDVYRSRFG
MAB_3453c|M.abscessus_ATCC_199 WQMAEAHHRYAPVYFYRYDYAPGALRIAGMGATHATELLAVFDSYRGAMG
*::..*: **.:.******. *: :*:***** **:***. ** *
Mb2071c|M.bovis_AF2122/97 ALLTAAADRRAALRVSNEVQRRWRCFSQIGVPGDDWPAYTQDDRAVLVFD
Rv2045c|M.tuberculosis_H37Rv ALLTAAADRRAALRVSNEVQRRWRCFSQIGVPGDDWPAYTQDDRAVLVFD
MMAR_3020|M.marinum_M ALLTAAADRRHALRVSDEVIRRWRSFSQTGTPGEDWPAYTHTRRAVMVID
MUL_2261|M.ulcerans_Agy99 ALLTAAADRRHALRVSDEVIRRWRSFSQTGTPGEDWPAYTHTRRAVMVID
MAV_2466|M.avium_104 ALLTAAADRRAALRVSNQVQRRWRAFSRTGVPGEDWPRYTAADRAVLVFD
Mvan_3408|M.vanbaalenii_PYR-1 ALLTLAGDWRSARRVSKDVQRRWSSFSRTGVPGADWPRYSAEDRPVMVFD
TH_0737|M.thermoresistible__bu RLLTLAGDWVSAQRVSSDLQRRWLAFGRTGVPGDDWPAYTAEHRPVRVFD
MSMEG_3848|M.smegmatis_MC2_155 SMLTAMADRRSARRVSRDIQTRWRDFSRAGVPGDGWPAYRHDERAVYVFD
Mflv_3125|M.gilvum_PYR-GCK KLLAAGLDSRSAKKVTDDVQKRWLGFAERAVPGGDWPQYTRDERAVLVLD
MAB_3453c|M.abscessus_ATCC_199 TVMAGALGRRDAVRVSNDVQRRWLAFARSGVPGDGWPTYGPPDRAVMVFD
::: . * :*: :: ** *.. ..** .** * *.* *:*
Mb2071c|M.bovis_AF2122/97 RRCRIEFDPHQHRRIAWDGFSLAN----
Rv2045c|M.tuberculosis_H37Rv RRCRIEFDPHQHRRIAWDGFSLAN----
MMAR_3020|M.marinum_M RKSRVEIDPHQHRRLAWDGFSLAR----
MUL_2261|M.ulcerans_Agy99 RKSRVEIDPHRHRRLAWDGFSLAR----
MAV_2466|M.avium_104 RKSRVEFDPHPHRRMAWDGFSLAR----
Mvan_3408|M.vanbaalenii_PYR-1 RHPRLEYDPHAHRRQAWEGFSLA-----
TH_0737|M.thermoresistible__bu RNPRVEYDPDAHRRQAWQGFTLTRPDRN
MSMEG_3848|M.smegmatis_MC2_155 TRPRVEYDPDADRRLAWEGFSLAQR---
Mflv_3125|M.gilvum_PYR-GCK RRRRVEFDPHSERRQAWEGFFLATR---
MAB_3453c|M.abscessus_ATCC_199 HATRVELDPEAARRAAWEGFSLTL----
*:* **. ** **:** *: