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MANPLHGPSTGPSVAEILASHAGGTGSPTKTAARVADAIAARGDDGTWLSTVPRDQLIAAAEAIERRPAA RTLPLYGVPFGVKDSIDVEGRPTTLSCPDYAYIATATAPAVQKLLDAGALYVGKTNLDQFATGLNGTRTP HTVPRSVYGSDLISGGSSSGSALAVALGQVPFAVATDTAGSGRVPAALNGVIGFKPSRGLISTVGLVPAC KSLDCLSVMAGCIDDVDRVLDIMVGRDDDDPWSRERGPRHRNAAIRVGLPPDSELEFFGDDEMRMAHNAF RAQLRRTHTVVEVSLEPFLAAGTLLYQGPWVAERLVEFGDFLTAHPDSIHPVVREIFEGGRSYTAVDAFA ALQKLQQLKAVVGRLWQHMDVLVVPTIGTTFTVDQVLAAPIDCNTKLGHYTHFGNLLDLLGAAIPLGATA DGRPCSAMLLGNALSDDTVLQLAAEILDEPRSTHQEATVPLAAQERL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3052 | - | - | 100% (467) | amidase |
| M. vanbaalenii PYR-1 | Mvan_4052 | - | 1e-64 | 38.24% (421) | amidase |
| M. vanbaalenii PYR-1 | Mvan_3824 | - | 2e-27 | 29.17% (480) | amidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2384 | amiA2 | 1e-31 | 30.77% (442) | amidase |
| M. gilvum PYR-GCK | Mflv_4246 | gatA | 1e-29 | 29.00% (462) | aspartyl/glutamyl-tRNA amidotransferase subunit A |
| M. tuberculosis H37Rv | Rv2363 | amiA2 | 1e-31 | 30.77% (442) | amidase |
| M. leprae Br4923 | MLBr_01702 | gatA | 5e-25 | 27.77% (461) | aspartyl/glutamyl-tRNA amidotransferase subunit A |
| M. abscessus ATCC 19977 | MAB_1558c | - | 5e-73 | 40.98% (410) | allophanate hydrolase |
| M. marinum M | MMAR_3673 | amiA2 | 2e-28 | 29.31% (481) | amidase AmiA2 |
| M. avium 104 | MAV_2032 | - | 1e-30 | 30.47% (466) | amidase |
| M. smegmatis MC2 155 | MSMEG_2189 | atzF | 1e-66 | 37.41% (417) | allophanate hydrolase |
| M. thermoresistible (build 8) | TH_0712 | - | 2e-69 | 42.07% (397) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3616 | amiA2 | 3e-28 | 29.11% (481) | amidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2384|M.bovis_AF2122/97 MVGASGSDAGAISGSGNQRLPTLTDLLYQLATRAVTSEELVRRSLRAIDV
Rv2363|M.tuberculosis_H37Rv MVGASGSDAGAISGSGNQRLPTLTDLLYQLATRAVTSEELVRRSLRAIDV
MMAR_3673|M.marinum_M MVGASGFASGAVSGSGGPRLPTLTDLLYQLASGSVTSVELTRRSLREIEV
MUL_3616|M.ulcerans_Agy99 MVGASGFASGAVSGSGGPRLPTLTDLLYQLASGSVTSVELTRRSLREIEV
MAV_2032|M.avium_104 ----------------------------------------MGRSLHAIHA
Mflv_4246|M.gilvum_PYR-GCK --------------MSELIKLDAATLADKISSKEVSSAEVTQAFLDQIAA
MLBr_01702|M.leprae_Br4923 ----------MIGSLHEIIRLDASTLAAKIVAKELSSVEITQACLDQIEA
MAB_1558c|M.abscessus_ATCC_199 ----------------------------------------MGQGTRTLLD
MSMEG_2189|M.smegmatis_MC2_155 ------------------------------------MTGKIDEIYRRIEQ
TH_0712|M.thermoresistible__bu -------------------------------MSAPSAVERVHAAYAAIER
Mvan_3052|M.vanbaalenii_PYR-1 ---------MANPLHGPSTGPSVAEILASHAGGTGSPTKTAARVADAIAA
:
Mb2384|M.bovis_AF2122/97 SQPTLNAFRVVLTESALADAAAADKRRAAGDTAP--LLGIPIAVKDDVDV
Rv2363|M.tuberculosis_H37Rv SQPTLNAFRVVLTESALADAAAADKRRAAGDTAP--LLGIPIAVKDDVDV
MMAR_3673|M.marinum_M SQSTLNAFRVVLTESALADAAAADRRRAAGDAAP--LLGIPIAVKDDVDV
MUL_3616|M.ulcerans_Agy99 SQSTLNAFRVVLTESALADAAAADRRRAAGDAAP--LLGIPIAVKDDVDV
MAV_2032|M.avium_104 SQPTLNAFRVVLTESALADAAEADRRRAAGDTAP--LLGIPIAVKDDVDI
Mflv_4246|M.gilvum_PYR-GCK TDGDYHAFLHVGAEQALAAAQTVDRAVAAGEHLPSPLAGVPLALKDVFTT
MLBr_01702|M.leprae_Br4923 TDDTYRAFLHVAAEKALSAAAAVDKAVAAGGQLSSTLAGVPLALKDVFTT
MAB_1558c|M.abscessus_ATCC_199 ---MTVWIMRRPEDD-------IAAELEAS-SGP--LAGVRLAVKDNVDV
MSMEG_2189|M.smegmatis_MC2_155 SGRSEVFIHLRPRDQ-------VEADHASATSGP--LAGLVLAVKDNVDV
TH_0712|M.thermoresistible__bu VDRPEIWITLRPLADALADAVRVDAAARTGAELP--LAGLVAAVKNNIDV
Mvan_3052|M.vanbaalenii_PYR-1 RGDDGTWLSTVPRDQLIAAAEAIERRPAAR-TLP--LYGVPFGVKDSIDV
: . : . * *: .:*: .
Mb2384|M.bovis_AF2122/97 AGVPTAFGTQGYVAP-ATDDCEVVRRLKAAGAVIVGKTNTCELGQWPFTS
Rv2363|M.tuberculosis_H37Rv AGVPTAFGTQGYVAP-ATDDCEVVRRLKAAGAVIVGKTNTCELGQWPFTS
MMAR_3673|M.marinum_M AGVPTAFGTQGYVRP-AAHDSEVVRRLKAAGAVIIGKTNTCELGQWPFTS
MUL_3616|M.ulcerans_Agy99 AGVPTAFGTQGYVQP-AAHDSEVVRRLKAAGAVIIGKTNTCELGQWPFTS
MAV_2032|M.avium_104 AGVPTAFGTEGSVPP-ATHDAEVVRRLKAAGAVIVGKTNTCELGQWPFTS
Mflv_4246|M.gilvum_PYR-GCK TDMPTTCGSKVLEGWTSPYDATVTAKLRSAGIPILGKTNMDEFAMGSSTE
MLBr_01702|M.leprae_Br4923 VDMPTTCGSKILQGWHSPYDATVTTRLRAAGIPILGKTNMDEFAMGSSTE
MAB_1558c|M.abscessus_ATCC_199 GGVPTTAACPEYA-YVPDQDAPAVAALRAAGAVVVGKTNLDQFATGLVGT
MSMEG_2189|M.smegmatis_MC2_155 AGLPTTAACPGYS-FVPDTDAPVVAVLKAAGAVVIGKTNLDQFATGLVGT
TH_0712|M.thermoresistible__bu AGIPTTAGCPTFATCAATADAPAVARLRTAGAVVIGATNLDQFATGLVGT
Mvan_3052|M.vanbaalenii_PYR-1 EGRPTTLSCPDYA-YIATATAPAVQKLLDAGALYVGKTNLDQFATGLNGT
. **: . . . .. * ** :* ** ::.
Mb2384|M.bovis_AF2122/97 GPGFGHTRNPWSRRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRIPAA
Rv2363|M.tuberculosis_H37Rv GPGFGHTRNPWSRRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRIPAA
MMAR_3673|M.marinum_M GPGFGHTRNPWARRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRVPAA
MUL_3616|M.ulcerans_Agy99 GPGFGHTRNPWARRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRVPAA
MAV_2032|M.avium_104 GPGFGHTRNPWSRRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRIPAA
Mflv_4246|M.gilvum_PYR-GCK NSAYGPTRNPWDTERVPGGSGGGSAAALAAFQAPLAIGTDTGGSIRQPAA
MLBr_01702|M.leprae_Br4923 NSAYGPTRNPWNVDRVPGGSGGGSAAALAAFQAPLAIGSDTGGSIRQPAA
MAB_1558c|M.abscessus_ATCC_199 RSPYGAVSDSRRPEYISGGSSSGSAVAVATGQADIAIGTDTAGSGRVPAG
MSMEG_2189|M.smegmatis_MC2_155 RSPYGPVRNAQRPEYISGGSSSGSAVAVALGFADIAIGTDTAGSGRVPAG
TH_0712|M.thermoresistible__bu RSPYGAVRDARRPDRISGGSSSGSAVAVALGLVDVALGTDTAGSGRVPAA
Mvan_3052|M.vanbaalenii_PYR-1 RTPHTVPRSVYGSDLISGGSSSGSALAVALGQVPFAVATDTAGSGRVPAA
. . . .***..*** *:* . *:.:* .** * **.
Mb2384|M.bovis_AF2122/97 WTHLVGIKPQRGRISTWPLPEAFNGVTVNGVLARTVEDAALVLDAASGNV
Rv2363|M.tuberculosis_H37Rv WTHLVGIKPQRGRISTWPLPEAFNGVTVNGVLARTVEDAALVLDAASGNV
MMAR_3673|M.marinum_M WTHLVGIKPQRGRISTWPWPETFNGITVNGVLARTVADAALVLDAASGNV
MUL_3616|M.ulcerans_Agy99 WTHLVGIKPQRGRISTWPWPETFNGITVNGVLARTVADAALVLDAASGNA
MAV_2032|M.avium_104 WTHLVGIKPQRGRISTWPLPEAFNGITVNGVLARTVADAALVLDAASGNV
Mflv_4246|M.gilvum_PYR-GCK LTATVGVKPTYGTVSRYGLVACASSLDQGGPCARTVLDTALLHQVIAGHD
MLBr_01702|M.leprae_Br4923 LTATVGVKPTYGTVSRYGLVACASSLDQGGPCARTVLDTALLHAVIAGHD
MAB_1558c|M.abscessus_ATCC_199 LQGIVGIKPTVGVISTEGVVPACESYDCVTIFAPSLTTANAAMAAMGAAA
MSMEG_2189|M.smegmatis_MC2_155 LQGIVGIKPTLGVVPNTGVVPACASYDCVTIFAADLPTAQAAMGVMATAE
TH_0712|M.thermoresistible__bu LQGIVGIKPTIGVVPTDGVVPACRSYDCVTVFARDLDTADAAMGVLAGGG
Mvan_3052|M.vanbaalenii_PYR-1 LNGVIGFKPSRGLISTVGLVPACKSLDCLSVMAGCIDDVDRVLDIMVGRD
:*.** * :. . * : .
Mb2384|M.bovis_AF2122/97 EGD---RHQPPPVTVSDFVGIAPGPLKIALSTHFPYTGFRAKLHPEILAA
Rv2363|M.tuberculosis_H37Rv EGD---RHQPPPVTVSDFVGIAPGPLKIALSTHFPYTGFRAKLHPEILAA
MMAR_3673|M.marinum_M EGD---LHKPAPLTASDYVGIAPGPLKIAMSTRFPYTGFRAKLHPEILAA
MUL_3616|M.ulcerans_Agy99 EGD---LHKPAPLTASDYVGIAPGPLKIAMSTRFPYTGFRAKLHPEILAS
MAV_2032|M.avium_104 DGD---RHKPPPITASDYVGKAPGPLNIALSTRFPYTGFRPKLHPEILAA
Mflv_4246|M.gilvum_PYR-GCK PLDSTSVEAPVPDVVAAARTGAGGDLTGVRIGVVKQLRSGEGYQAGVLAS
MLBr_01702|M.leprae_Br4923 ARDSTSVEAAVPDIVGAAKAGESGDLHGVRVGVVRQLR-GEGYQSGVLAS
MAB_1558c|M.abscessus_ATCC_199 GPRLWPANTRLAAP-PQPTIAVP--RELPALDEVWCNAFRGAVDDLRAAG
MSMEG_2189|M.smegmatis_MC2_155 PHRAWPADLMLAAP-PAPRVAVP--AQVPELDVAWQAAFTEAVQRAQAAG
TH_0712|M.thermoresistible__bu --RPFPPDAPLTVP-PTTRVAVP--GRLPGLSPAWRQAFESACERLAGNG
Mvan_3052|M.vanbaalenii_PYR-1 DDDPWSRERGPRHRNAAIRVGLPPDSELEFFGDDEMRMAHNAFRAQLRRT
.
Mb2384|M.bovis_AF2122/97 TQRVGDQLELLGHTVVKGNP---DYGLRLSWNFLARSTAG------LWEW
Rv2363|M.tuberculosis_H37Rv TQRVGDQLELLGHTVVKGNP---DYGLRLSWNFLARSTAG------LWEW
MMAR_3673|M.marinum_M TRRVGEQLQLLGHTVERGNP---DYGLRLSWDFLARSTAG------LWEW
MUL_3616|M.ulcerans_Agy99 TRRVGEQLQLLGHTVERGNP---DYGLRLSWDFLARSTAG------LWEW
MAV_2032|M.avium_104 TRAVGKQLELLGHTVVPGNP---DYGMRLSWDFLARSTAG------LRDW
Mflv_4246|M.gilvum_PYR-GCK FNAAVDQLTALGAEVTEVDCPHFDYSLPAYYLILPSEVSSNLAKFDGMRY
MLBr_01702|M.leprae_Br4923 FQAAVEQLIALGATVSEVDCPHFDYALAAYYLILPSEVSSNLARFDAMRY
MAB_1558c|M.abscessus_ATCC_199 ATIIEIDLTPFLAAAKLLYE---GALVSERYAAVGEFID-----------
MSMEG_2189|M.smegmatis_MC2_155 FETVPIDMTPFFAAADLLYN---GALVAERWDAVGEFIES----------
TH_0712|M.thermoresistible__bu IELVEVDLTPFLQAATLLYD---GGLVAERHAAVGTFVDEH---------
Mvan_3052|M.vanbaalenii_PYR-1 HTVVEVSLEPFLAAGTLLYQ---GPWVAERLVEFGDFLT-----------
.: : . : .
Mb2384|M.bovis_AF2122/97 AERLGDEVTLDRRTVSNLRMGHVLSQAILR-------------------S
Rv2363|M.tuberculosis_H37Rv AERLGDEVTLDRRTVSNLRMGHVLSQAILR-------------------S
MMAR_3673|M.marinum_M AECLGDGVTLDPRTVTNMRAGHALSQAILR-------------------N
MUL_3616|M.ulcerans_Agy99 AECLGNGVTLDPRTVTNMRAGHALSQAILR-------------------N
MAV_2032|M.avium_104 EERLGDGVVLDPRTVANLRLGHLLGQAILR-------------------S
Mflv_4246|M.gilvum_PYR-GCK GLRAGDDGTHSAEEVMALTRAAGFGPEVKRRIMIGAYALSAGYYDAYYNQ
MLBr_01702|M.leprae_Br4923 GLRVGDDGSRSAEEVIALTRAAGFGPEVKRRIMIGAYALSAGYYDSYYSQ
MAB_1558c|M.abscessus_ATCC_199 ---AHPEASLDPTVAQIISGARDIPAHRLVH-------------------
MSMEG_2189|M.smegmatis_MC2_155 ---AGPGAGLDPTVSAIISAAGRHSAADLLR-------------------
TH_0712|M.thermoresistible__bu --LAAGDPALDPTVAQIISAAGAVPATTLLR-------------------
Mvan_3052|M.vanbaalenii_PYR-1 ----AHPDSIHPVVREIFEGGRSYTAVDAFA-------------------
: .
Mb2384|M.bovis_AF2122/97 ARRHEAADQRRVGSIFDIVDVVLAPTTAQPPPMARAFDRLGSFGTDRAII
Rv2363|M.tuberculosis_H37Rv ARRHEAADQRRVGSIFDIVDVVLAPTTAQPPPMARAFDRLGSFGTDRAII
MMAR_3673|M.marinum_M ARHHEAAAQRRVGSIFDIVDVVLAPTTAQPPPLARAFDDMGGLATDRAII
MUL_3616|M.ulcerans_Agy99 ARHHEAAAQRRVGSIFDIVDVVLAPTTAQPPPLARAFDDMGGLATDRAII
MAV_2032|M.avium_104 ARRHEAADQRRVGSIFDIVDVVLAPTTAQPPPLARAFDRLSGFGTDRAMI
Mflv_4246|M.gilvum_PYR-GCK AQKVRTLIARDLDAAYQKVDVLVSPATP-----TTAFRLGEKVDDPLSMY
MLBr_01702|M.leprae_Br4923 AQKVRTLIARDLDKAYRSVDVLVSPATP-----TTAFSLGEKADDPLAMY
MAB_1558c|M.abscessus_ATCC_199 DRAEVQRLREQAMTSLAGADALLVPTAPLHPTIEQVNANPIGVNATMGTY
MSMEG_2189|M.smegmatis_MC2_155 DRRRVEHLRDEAFAALAGCDALLVPTAPEHPRIADVAADPIGVNARMGRF
TH_0712|M.thermoresistible__bu DRARLAELTASALARLGDCAALLIPTTTEHPSIAEVAADPVGVNSRLGTY
Mvan_3052|M.vanbaalenii_PYR-1 ALQKLQQLKAVVGRLWQHMDVLVVPTIGTTFTVDQVLAAPIDCNTKLGHY
.:: *: . .
Mb2384|M.bovis_AF2122/97 AACPSTWPWNLLGWPSINVPAGFTSDG-LPIGVQLMGPANSEGMLISLAA
Rv2363|M.tuberculosis_H37Rv AACPSTWPWNLLGWPSINVPAGFTSDG-LPIGVQLMGPANSEGMLISLAA
MMAR_3673|M.marinum_M AACPLTWPWNLLGWPSINVPAGFTVDG-LPIGVQLMGPAESEGLLISLAA
MUL_3616|M.ulcerans_Agy99 AACPLTWPWNLLGWPSINVPAGFTVDG-LPIGVQLMGPAESEGLLISLAA
MAV_2032|M.avium_104 AACPLTFPWNVLGWPSINVPAGFTSDG-LPIGVQLMGPANSEGMLISLAA
Mflv_4246|M.gilvum_PYR-GCK LFDLCTLPLNLAGHCGMSVPSGLSADDNLPVGLQIMAPALADDRLYRVGA
MLBr_01702|M.leprae_Br4923 LFDLCTLPLNLAGHCGMSVPSGLSSDDDLPVGLQIMAPALADDRLYRVGA
MAB_1558c|M.abscessus_ATCC_199 TN-----FCNLFDLCAVSVPAGTAGD--AQFGVTVIARAFDDAVAFDIAA
MSMEG_2189|M.smegmatis_MC2_155 TN-----FCNLFDMCAIAIPAGTTSDG-AQFGITLLAPAFGDAVVADLAA
TH_0712|M.thermoresistible__bu TN-----FCNLMDLCAVAVPAGTTSDG-AQFGVTVLGRAGADALALDLAR
Mvan_3052|M.vanbaalenii_PYR-1 TH-----FGNLLDLLGAAIPLGATADG-RPCSAMLLGNALSDDTVLQLAA
*: . . :* * : * . ::. * : :.
Mb2384|M.bovis_AF2122/97 ELEAVSGWATKQPQVWWTS-------------------------------
Rv2363|M.tuberculosis_H37Rv ELEAVSGWATKQPQVWWTS-------------------------------
MMAR_3673|M.marinum_M ELEAVSGWATKQPKVWWNTGTSTPPIHSVRPPRR----------------
MUL_3616|M.ulcerans_Agy99 ELEAVSGWATKQPKVWWNTGTSTPPIHSVRPPRR----------------
MAV_2032|M.avium_104 ELEAVSGWASKQPQPWWDQSADTPPAPGQPAPTG----------------
Mflv_4246|M.gilvum_PYR-GCK AYEAARGPLPTAL-------------------------------------
MLBr_01702|M.leprae_Br4923 AYEAARGPLPSAI-------------------------------------
MAB_1558c|M.abscessus_ATCC_199 LATGAPAGQDV--WPAAITLSHELA-VFGAHLK-----GGPLEFQLTDLG
MSMEG_2189|M.smegmatis_MC2_155 RFLAVPAAAS---WAEAATEVTEIA-VFGAHLR-----GQPLEHELTGRG
TH_0712|M.thermoresistible__bu LVSAPVDGAAPPGVPAPPTPAVPWPXXXAADLTDDDHLGRPRGDTETGQR
Mvan_3052|M.vanbaalenii_PYR-1 EILDE---------PRSTHQEATVPLAAQERL------------------
Mb2384|M.bovis_AF2122/97 --------------------------------------------------
Rv2363|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3673|M.marinum_M --------------------------------------------------
MUL_3616|M.ulcerans_Agy99 --------------------------------------------------
MAV_2032|M.avium_104 --------------------------------------------------
Mflv_4246|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01702|M.leprae_Br4923 --------------------------------------------------
MAB_1558c|M.abscessus_ATCC_199 ARWVGPIRTATKYRMSALRTTPPKPGLTRSEENGVS---IGGEVWRLSPA
MSMEG_2189|M.smegmatis_MC2_155 ARWGGPVVTAPHYRLFALDTEPPKPGLVRVDSDGSA---IEGERWVLSPA
TH_0712|M.thermoresistible__bu LELLAHLVTGGTRAPATVLAAVVHGELLALAPFGTADGVVARAASRLVTM
Mvan_3052|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2384|M.bovis_AF2122/97 --------------------------------------------------
Rv2363|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3673|M.marinum_M --------------------------------------------------
MUL_3616|M.ulcerans_Agy99 --------------------------------------------------
MAV_2032|M.avium_104 --------------------------------------------------
Mflv_4246|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01702|M.leprae_Br4923 --------------------------------------------------
MAB_1558c|M.abscessus_ATCC_199 ALGTFLAQLPEPMLLGKVECDD-GLWRTGFGCDG-AAAQAGVDISEHGSW
MSMEG_2189|M.smegmatis_MC2_155 ALGEFLAELPAPMLLGKVELSD-GRWVTGFGCDH-AAPAHGRDITEFGGW
TH_0712|M.thermoresistible__bu ASGLDPHGLGVPEVFWMTQQRDYRAAAQGFASGTRDGLTTWLMLTARALH
Mvan_3052|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2384|M.bovis_AF2122/97 -----------------
Rv2363|M.tuberculosis_H37Rv -----------------
MMAR_3673|M.marinum_M -----------------
MUL_3616|M.ulcerans_Agy99 -----------------
MAV_2032|M.avium_104 -----------------
Mflv_4246|M.gilvum_PYR-GCK -----------------
MLBr_01702|M.leprae_Br4923 -----------------
MAB_1558c|M.abscessus_ATCC_199 PAAIAAGAV--------
MSMEG_2189|M.smegmatis_MC2_155 LRAQSALSAR-------
TH_0712|M.thermoresistible__bu AGAREAISIAEAQAEAN
Mvan_3052|M.vanbaalenii_PYR-1 -----------------