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VADAAFLLLSIRGEDEAADDEYAAMMRFAGLDESGMRRIRLTHRGLGYIDLTQWSGIILGGGPYNVSDDP ASKSPTQMRVEEEMAGLLAEVIARDFPFLGCCYGIGTVGAAIGAVIDRSHSEPVGGVTVDLTDHGRRDPL FCVLPDTFDAFGGHKEAVSSLPGGAVSLASSADCPVQAFRVGANVYATQFHPELDVDGLCTRIEVYKHHG YFAPETAESLKHDARQRTVTHPMAVLRGFVQRYGRGAGLPVSSRVPPRPD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2980 | - | - | 100% (260) | glutamine amidotransferase |
| M. vanbaalenii PYR-1 | Mvan_1516 | guaA | 8e-08 | 28.06% (139) | bifunctional GMP synthase/glutamine amidotransferase protein |
| M. vanbaalenii PYR-1 | Mvan_1852 | - | 4e-06 | 27.85% (158) | peptidase C26 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3429c | guaA | 5e-08 | 27.34% (139) | GMP synthase |
| M. gilvum PYR-GCK | Mflv_3263 | - | 1e-107 | 76.13% (243) | glutamine amidotransferase |
| M. tuberculosis H37Rv | Rv3396c | guaA | 5e-08 | 27.34% (139) | GMP synthase |
| M. leprae Br4923 | MLBr_00395 | guaA | 8e-06 | 25.18% (139) | GMP synthase |
| M. abscessus ATCC 19977 | MAB_3718c | - | 5e-07 | 29.50% (139) | GMP synthase |
| M. marinum M | MMAR_1148 | guaA | 4e-05 | 25.90% (139) | GMP synthase, GuaA |
| M. avium 104 | MAV_4348 | guaA | 6e-05 | 25.85% (147) | bifunctional GMP synthase/glutamine amidotransferase protein |
| M. smegmatis MC2 155 | MSMEG_1610 | guaA | 9e-09 | 29.50% (139) | bifunctional GMP synthase/glutamine amidotransferase protein |
| M. thermoresistible (build 8) | TH_0484 | guaA | 6e-07 | 29.50% (139) | PROBABLE GMP SYNTHASE |
| M. ulcerans Agy99 | MUL_0913 | guaA | 2e-05 | 25.90% (139) | GMP synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1148|M.marinum_M --MAEPVDLDVAGPVGRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTT
MUL_0913|M.ulcerans_Agy99 MPVAEPVDLDVAGPVGRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTT
Mb3429c|M.bovis_AF2122/97 --MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTA
Rv3396c|M.tuberculosis_H37Rv --MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTA
MLBr_00395|M.leprae_Br4923 --MADSAGLDQPEPSPRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTT
MAV_4348|M.avium_104 ------------------MLVVDFGAQYAQLIARRVREARVFSEVIPHTA
MSMEG_1610|M.smegmatis_MC2_155 --MAS--------ESPRPVLVIDYGAQYAQLIARRVREARVYSEVVPHTA
TH_0484|M.thermoresistible__bu --VSSSADV----NTSRPVLVIDFGAQYAQLIARRIREARVYSEVVPHTA
MAB_3718c|M.abscessus_ATCC_199 --MAQTEQHG-----DRPVLVIDFGAQYAQLIARRVREARVFSEVIPHSA
Mvan_2980|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3263|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1148|M.marinum_M SIEEIKARDPLALVLSGGPASVYAPGAPQLDPALFDLGLPVFGICYGFQV
MUL_0913|M.ulcerans_Agy99 SIEEIKARDPLALVLSGGPASVYAPGAPQLDPALFDLGLPVFGICYGFQV
Mb3429c|M.bovis_AF2122/97 SIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQA
Rv3396c|M.tuberculosis_H37Rv SIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQA
MLBr_00395|M.leprae_Br4923 SIEEITARDPLAIVLSGGPASVYTEGAPQLDPALFDLGLPVFGICYGFQA
MAV_4348|M.avium_104 TIEEIKARQPRALVLSGGPSSVYEPGAPQLDPAVFDLGVPVFGICYGFQA
MSMEG_1610|M.smegmatis_MC2_155 GVEEIKAKDPQAIVLSGGPASVYSEGAPQLDPGLFDLDVPVFGICYGFQA
TH_0484|M.thermoresistible__bu TVEEIKAKDPQAIVLSGGPASVYAEDAPRLDPGLFDLGVPVFGICYGFQA
MAB_3718c|M.abscessus_ATCC_199 SVEEIKGRNPRAIVLSGGPSSVYEEGAPQLDPGVFDLDVPVFGICYGFQA
Mvan_2980|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3263|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1148|M.marinum_M MAQALGGTVAHTGTSEYGRTELKVLGGDLHSDLPDIQPVWMSHGDAVTAA
MUL_0913|M.ulcerans_Agy99 MAQALGGTVAHTGTSEYGRTELKVLGGDLHSDLPDIQPVWMSHGDAVTAA
Mb3429c|M.bovis_AF2122/97 MAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAA
Rv3396c|M.tuberculosis_H37Rv MAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAA
MLBr_00395|M.leprae_Br4923 MAQVLGGTVARTKTSEYGRTELKVLGGDLHSGLPGVQPVWMSHGDAVTAA
MAV_4348|M.avium_104 MAQALGGTVAHTGTSEYGRTELKVLGGELHSGLPGVQPVWMSHGDAVTAA
MSMEG_1610|M.smegmatis_MC2_155 MAQALGGTVERTGTSEFGRTELQVTGGDLHSELPATQPVWMSHGDAVTAA
TH_0484|M.thermoresistible__bu MAQALGGTVTRTGTREYGRTELTVLGGQLHSDLPERQPVWMSHADAVTEA
MAB_3718c|M.abscessus_ATCC_199 MAQVLGGTVAHTGTSEYGRTELTVAGGDLHEGLPDVQPVWMSHGDAVTEA
Mvan_2980|M.vanbaalenii_PYR-1 --------------------------------MADAAFLLLSIRGEDEAA
Mflv_3263|M.gilvum_PYR-GCK --------------------------------MADAPFLLLSIRDEDEAA
:. : :* . *
MMAR_1148|M.marinum_M PDGFEVVASSAGAAVAAFENRERRLAGVQYHPEVMHTPHGQQILGRFLHD
MUL_0913|M.ulcerans_Agy99 PDGFEVVASSAGAAVAAFENRERRLAGVQYHPEVMHTPHGQQILGRFLHD
Mb3429c|M.bovis_AF2122/97 PDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHD
Rv3396c|M.tuberculosis_H37Rv PDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHD
MLBr_00395|M.leprae_Br4923 PDGFDVAASSSGAPVAAFENRDRRLAGVQYHPEVMHTPHGQQVLSRFLHD
MAV_4348|M.avium_104 PDGFEVVASSPGAVVAAFENRARRLAGVQYHPEVMHTPHGQQVLSRFLHD
MSMEG_1610|M.smegmatis_MC2_155 PEGFDVVASSAGAPVAGFENRARRLAGVQYHPEVLHSPHGQQVLSRFLHD
TH_0484|M.thermoresistible__bu PAGFEVVATSPGSPVAAFEDPARRLAGVQYHPEVIHSPHGQQVLGRFLHE
MAB_3718c|M.abscessus_ATCC_199 PQGFTVVASSEGAPVAAFENRERRLAGVQYHPEVLHSPHGQQVLSRFLHE
Mvan_2980|M.vanbaalenii_PYR-1 DDEYAAMMRFAGLDESGMRRIR-----------LTHRGLGYIDLT----Q
Mflv_3263|M.gilvum_PYR-GCK DDEYRAVLRFGGLDEAGLHRIG-----------LTHCELGAVDLS----Q
: . * :.:. : * * * :
MMAR_1148|M.marinum_M FAGIGARWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRA
MUL_0913|M.ulcerans_Agy99 FAGIGARWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRV
Mb3429c|M.bovis_AF2122/97 FAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRA
Rv3396c|M.tuberculosis_H37Rv FAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRA
MLBr_00395|M.leprae_Br4923 FAGLDADWTAANIAGVLVEQVRAQIGNGHAICGLSGGVDSAVAAALVQRA
MAV_4348|M.avium_104 FAGLGADWTAANIAGVLVEQVRAQIGDGHAICGLSGGVDSAVAAALVQRA
MSMEG_1610|M.smegmatis_MC2_155 FAGIDATWTPANIADQLIEAVREQIGDGRAICGLSGGVDSAVAAALVQRA
TH_0484|M.thermoresistible__bu FAGIGASWTPANIAESLIEQVREQIGDGRAICGLSGGVDSAVAAALVQRA
MAB_3718c|M.abscessus_ATCC_199 FAGIESAWTAANIAETLVEQVRTQIGEGRALCALSGGVDSAVAAALVQRA
Mvan_2980|M.vanbaalenii_PYR-1 WSGIILGGGPYNVSDDPASKSPTQMR------------VEEEMAGLLAEV
Mflv_3263|M.gilvum_PYR-GCK WSGIILGGGPYNVSDDAAGKSATQVR------------VEAELAALLREV
::*: . *:: *: . *.*: ..
MMAR_1148|M.marinum_M IGDRLTCVFVDHGLLRAGERAQVERDFVAATKANLVTVDVADTFLAALSG
MUL_0913|M.ulcerans_Agy99 IGDRLTCVFVDHGLLRAGERAQVERDFVAATKANLVTVDVADTFLAALSG
Mb3429c|M.bovis_AF2122/97 IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSG
Rv3396c|M.tuberculosis_H37Rv IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSG
MLBr_00395|M.leprae_Br4923 IGDRLTCIFVDHGLLRDGERGQVQRDFVAATGAKLVTVDAAETFLQALSG
MAV_4348|M.avium_104 IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAADTFLQALAG
MSMEG_1610|M.smegmatis_MC2_155 IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGAKLVTVDVADRFLEALTG
TH_0484|M.thermoresistible__bu IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGAKLVTVDTSERFLEALSG
MAB_3718c|M.abscessus_ATCC_199 IGDRLTCVFVDHGLLRSGERAQVEHDFVAATGATLVTVDASETFLGELAG
Mvan_2980|M.vanbaalenii_PYR-1 IARDFPFLGCCYGIGTVGAAIGAVIDRSHSEPVGGVTVDLTD--------
Mflv_3263|M.gilvum_PYR-GCK IDVDFPFLGCCYGVGTVGTAVGAVIDRAHSEPVGGVTVQVTP--------
* :. : :*: * . * : . ***: :
MMAR_1148|M.marinum_M VTDPEGKRKIIGRQFIRAFEGAVRDVLDG------RDIEFLVQGTLYPDV
MUL_0913|M.ulcerans_Agy99 VTDPEGKRKIIGRQFIRAFEGAVRDVLDG------RDVEFLVQGTLYPDV
Mb3429c|M.bovis_AF2122/97 VSAPEGKRKIIGRQFIRAFEGAVRDVLDG------KTAEFLVQGTLYPDV
Rv3396c|M.tuberculosis_H37Rv VSAPEGKRKIIGRQFIRAFEGAVRDVLDG------KTAEFLVQGTLYPDV
MLBr_00395|M.leprae_Br4923 VTNPEGKRKIIGRQFIRAFEGAVRDLLGDSTFD--SGIEFLVQGTLYPDV
MAV_4348|M.avium_104 VTNPEGKRKIIGRQFIRAFEGAVRDVLGD------KPVEFLVQGTLYPDV
MSMEG_1610|M.smegmatis_MC2_155 VTNPEGKRKIIGREFIRAFEGAVRDLVEDEGSG---DIDFLVQGTLYPDV
TH_0484|M.thermoresistible__bu VTNPEGKRKIIGREFIRAFEGAVREALGENAAANDDEVEFLVQGTLYPDV
MAB_3718c|M.abscessus_ATCC_199 VTDPEAKRKIIGREFIRSFEGAVSDVVGDSRRDDTAGIQFLVQGTLYPDV
Mvan_2980|M.vanbaalenii_PYR-1 ----HGRR------------------------------------------
Mflv_3263|M.gilvum_PYR-GCK ----EGRA------------------------------------------
..:
MMAR_1148|M.marinum_M VESGGGSGTANIKSHHNVGGLPDDLKFALVEPLRLLFKDEVRAVGRELGL
MUL_0913|M.ulcerans_Agy99 VESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
Mb3429c|M.bovis_AF2122/97 VESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
Rv3396c|M.tuberculosis_H37Rv VESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
MLBr_00395|M.leprae_Br4923 VESGGGSGTANIKSHHNVGGLPDNLRFKLVEPLRLLFKDEVRAVGRQLDL
MAV_4348|M.avium_104 VESGRGSGTANIKSHHNVGGLPGDLKFTLVEPLRLLFKDEVRAVGRELGL
MSMEG_1610|M.smegmatis_MC2_155 VESGGGSGTANIKSHHNVGGLPDDLKFKLVEPLRLLFKDEVRAVGRELGL
TH_0484|M.thermoresistible__bu VESGGGAGTANIKSHHNVGGLPDDLKFKLVEPLRLLFKDEVRAVGRELGL
MAB_3718c|M.abscessus_ATCC_199 VESGGGSGTANIKSHHNVGGLPEDLTFTLVEPLRLLFKDEVRAVGRELGL
Mvan_2980|M.vanbaalenii_PYR-1 ------------------------------DPLFCVLPDTFDAFGG----
Mflv_3263|M.gilvum_PYR-GCK ------------------------------DPLFAGLPDTFDAYGG----
:** : * . * *
MMAR_1148|M.marinum_M PEEIVARQPFPGPGLGIRIVGEVTGQRLDTLRRADSIAREELTAAGLDNQ
MUL_0913|M.ulcerans_Agy99 PEEIVARQPFPGPGLGIRIVGEVTGQRLDTLRRADSIARKELTAAGLDNQ
Mb3429c|M.bovis_AF2122/97 PEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQ
Rv3396c|M.tuberculosis_H37Rv PEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQ
MLBr_00395|M.leprae_Br4923 PEEIVARQPFPGPGLGIRIVGEVTAERLDTLRRADSIAREELTTAGLDYQ
MAV_4348|M.avium_104 PEEIVARQPFPGPGLGIRIVGEVTATRLDTLRRADSIAREELTAAGLDSL
MSMEG_1610|M.smegmatis_MC2_155 PEEIVARQPFPGPGLGIRIVGEVTAERLETLRRADAIAREELTAAGLDNQ
TH_0484|M.thermoresistible__bu PEEIVARQPFPGPGLAIRIVGEVTAERLETLRRADAIVREELTAAGLDHQ
MAB_3718c|M.abscessus_ATCC_199 PEEIVGRQPFPGPGLAIRIVGEVTPDRLDTLRRADAIAREELTAAGQDRN
Mvan_2980|M.vanbaalenii_PYR-1 HKEAVSSLPGGAVSLASSADCPVQAFRVGANVYATQFH-PELDVDGLCTR
Mflv_3263|M.gilvum_PYR-GCK HKEAATSLPPGVVRLATSPVCPVQAFRVGANVYATQFH-PELDLDGVCTR
:* . * *. * *: : * : ** *
MMAR_1148|M.marinum_M IWQCPVVLLADVRSVGVQGDNRTYGHPIVLRPVSSEDAMTADWTRVPFEV
MUL_0913|M.ulcerans_Agy99 IWQCPVVLLADVRSVGVQGDNRTYGHPIVLRPVSSEDAMTADWTRVPFEV
Mb3429c|M.bovis_AF2122/97 IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
Rv3396c|M.tuberculosis_H37Rv IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
MLBr_00395|M.leprae_Br4923 IWQCPVVLLADVRSVGVQGDNRSYGHPIVLRPVSSEDAMTADWTWVPYEV
MAV_4348|M.avium_104 IWQCPVVLLGEVRSVGVQGDNRTYGHPIVLRPVTSEDAMTADWTRVPYEV
MSMEG_1610|M.smegmatis_MC2_155 IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
TH_0484|M.thermoresistible__bu IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYDV
MAB_3718c|M.abscessus_ATCC_199 IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRLPYEV
Mvan_2980|M.vanbaalenii_PYR-1 IEVY-----------------KHHGYFAPETAESLKHDARQRTVTHPMAV
Mflv_3263|M.gilvum_PYR-GCK IDVY-----------------KNHGYFAPETTESLKDAARGHAVTHPMAI
* : :*: . : :. . * :
MMAR_1148|M.marinum_M LERISTRITNEVPEVNRVVLDVTSKPPGTIEWE
MUL_0913|M.ulcerans_Agy99 LERISTRITNEVPEVNRVVLDVTSKPPGTIEWE
Mb3429c|M.bovis_AF2122/97 LERISTRITNEVAEVNRVVLDITSKPPATIEWE
Rv3396c|M.tuberculosis_H37Rv LERISTRITNEVAEVNRVVLDITSKPPATIEWE
MLBr_00395|M.leprae_Br4923 LECISTRITNEVAEVNRVVLDITNKPPGTIEWE
MAV_4348|M.avium_104 LERISTRITNEVPEVNRVVLDITSKPPGTIEWE
MSMEG_1610|M.smegmatis_MC2_155 LERISTRITNEVREVNRVVLDITSKPPGTIEWE
TH_0484|M.thermoresistible__bu LERISTRITNEVAEVNRVVLDITSKPPATIEWE
MAB_3718c|M.abscessus_ATCC_199 LERISTRITNEVPEVNRVVLDITSKPPGTIEWE
Mvan_2980|M.vanbaalenii_PYR-1 LRGFVQRYG------RGAGLPVSSRVPPRPD--
Mflv_3263|M.gilvum_PYR-GCK LRSFVERY-------------TARR--------
*. : * : :