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VSRPLVAVVGRRAAQVPILRFSATLAAEAICEAVWAGGGEPVVLHGPAADPLTEMPRRLARFDGVLLPGG ADVEPRRYGAEPAPETTGVVAFQDEFDLGVIRAVIDLDMPALAICRGMQILNVALGGTLIQHVVETDTVH HNAIHQVHVKRGTRLHGIVGTQSIDVSSYHHQAVDRLAPGLVVCALAADGVIEAVEHRRADVVAVQWHPE DRHADSITDAALFADLVDRARKRKESSR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1852 | - | - | 100% (238) | peptidase C26 |
| M. vanbaalenii PYR-1 | Mvan_2279 | - | 2e-33 | 39.68% (247) | peptidase C26 |
| M. vanbaalenii PYR-1 | Mvan_1853 | - | 3e-29 | 40.10% (192) | peptidase C26 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2884c | - | 3e-32 | 40.67% (209) | amidotransferase |
| M. gilvum PYR-GCK | Mflv_4064 | - | 7e-33 | 39.92% (248) | peptidase C26 |
| M. tuberculosis H37Rv | Rv2859c | - | 4e-32 | 40.67% (209) | amidotransferase |
| M. leprae Br4923 | MLBr_01573 | - | 2e-31 | 38.76% (209) | putative amidotransferase |
| M. abscessus ATCC 19977 | MAB_3718c | - | 5e-08 | 28.73% (181) | GMP synthase |
| M. marinum M | MMAR_1844 | - | 1e-31 | 37.23% (231) | amidotransferase |
| M. avium 104 | MAV_3717 | - | 9e-30 | 41.81% (177) | class I glutamine amidotransferase, putative |
| M. smegmatis MC2 155 | MSMEG_6691 | - | 1e-106 | 76.69% (236) | glutamine amidotransferase |
| M. thermoresistible (build 8) | TH_0292 | pabA | 1e-07 | 31.01% (158) | POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE |
| M. ulcerans Agy99 | MUL_2093 | - | 3e-31 | 36.80% (231) | amidotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1852|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6691|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01573|M.leprae_Br4923 --------------------------------------------------
MAV_3717|M.avium_104 --------------------------------------------------
Mb2884c|M.bovis_AF2122/97 MDLSASRSDGGDPLRPASPRLRSPVSDGGDPLRPASPRLRSPVSDGGDPL
Rv2859c|M.tuberculosis_H37Rv MDLSASRSDGGDPLRPASPRLRSPVSDGGDPLRPASPRLRSPVSDGGDPL
MMAR_1844|M.marinum_M --------------------------------------------------
MUL_2093|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4064|M.gilvum_PYR-GCK --------------------------------------------------
TH_0292|M.thermoresistible__bu --------------------------------------------------
MAB_3718c|M.abscessus_ATCC_199 ----MAQTEQHGDRPVLVIDFGAQYAQLIARRVREARVFSEVIPHSASVE
Mvan_1852|M.vanbaalenii_PYR-1 ------------MSRPLVAVVGRRAAQVP-ILRFSATLA--------AEA
MSMEG_6691|M.smegmatis_MC2_155 -MAADPRLPLRRVNRPLIAVPGRRAESVP-ILRFSATLA--------AEA
MLBr_01573|M.leprae_Br4923 --------MDLSGSRPVVGLTAYLEQVHTGLWDVPAGYL--------PAD
MAV_3717|M.avium_104 -----------------MGLTAYLERVQTGIWDIPAGYL--------PAD
Mb2884c|M.bovis_AF2122/97 RPASPRLRSPLGASRPVVGLTAYLEQVRTGVWDIPAGYL--------PAD
Rv2859c|M.tuberculosis_H37Rv RPASPRLRSPLGASRPVVGLTAYLEQVRTGVWDIPAGYL--------PAD
MMAR_1844|M.marinum_M ------MVLNAAGPGPIVGMTTYLDQAKTGVWDVSASFL--------PAS
MUL_2093|M.ulcerans_Agy99 ------MVLNAAGPGPIVGMTTYLDQAKTGVWDVSASFL--------PAS
Mflv_4064|M.gilvum_PYR-GCK --------MSVS-SRPVIGLTTYLQQAQTGVWDVRASFL--------PAI
TH_0292|M.thermoresistible__bu ------------------VQILVVDNYDSFVFNLVQYLG--------QLG
MAB_3718c|M.abscessus_ATCC_199 EIKGRNPRAIVLSGGPSSVYEEGAPQLDPGVFDLDVPVFGICYGFQAMAQ
. : .
Mvan_1852|M.vanbaalenii_PYR-1 ICEAVWAGGGEPVVLHGPAADPLTEMPRRLARFDGVLLPGGADVEPRRYG
MSMEG_6691|M.smegmatis_MC2_155 ICEAVWAAGGEPVILHGPAADPLAELPQRLAAFDGALLPGGADVDPCRYG
MLBr_01573|M.leprae_Br4923 YFQGVAMAGGIAVLLPPQPVDPEIAG-LALDGLDGLVITGGYDVDPATYG
MAV_3717|M.avium_104 YFEGVTRAGGIAVLLPPQPVDTGIVG-SLLDGLHALVITGGYDLDPAGYG
Mb2884c|M.bovis_AF2122/97 YFEGITMAGGVAVLLPPQPVDPESVG-CVLDSLHALVITGGYDLDPAAYG
Rv2859c|M.tuberculosis_H37Rv YFEGITMAGGVAVLLPPQPVDPESVG-CVLDSLHALVITGGYDLDPAAYG
MMAR_1844|M.marinum_M YFDGVTMAGGIAVLLPPQRADADAAN-RVLDSLDALVITGGKDVDPAAYG
MUL_2093|M.ulcerans_Agy99 YFDGVTMAGGIAVLLPPQRADADAAN-RVLDSLDALVITGGKDVDPAAYG
Mflv_4064|M.gilvum_PYR-GCK YFEGVGMAGGIASLLPPQPVDDTIAE-RVLDGIDGLIITGGRDVDPSTYG
TH_0292|M.thermoresistible__bu VDAQVWRNDDARLGTEAAIAD-------AVAAVDGVLLSPGPGT-PERAG
MAB_3718c|M.abscessus_ATCC_199 VLGGTVAHTGTSEYGRTELTVAGGDLHEGLPDVQPVWMSHGDAVTEAPQG
. . : .. :. * *
Mvan_1852|M.vanbaalenii_PYR-1 AEPAPETTGVVAF-------------------------------------
MSMEG_6691|M.smegmatis_MC2_155 ADPAPETKDTVAF-------------------------------------
MLBr_01573|M.leprae_Br4923 QRPHPSTDEPRTT-------------------------------------
MAV_3717|M.avium_104 QRPHPSTDAPRTD-------------------------------------
Mb2884c|M.bovis_AF2122/97 QEPHPATDHPRPG-------------------------------------
Rv2859c|M.tuberculosis_H37Rv QEPHPATDHPRPG-------------------------------------
MMAR_1844|M.marinum_M QQAHPATDEPAPI-------------------------------------
MUL_2093|M.ulcerans_Agy99 QQAHPATDEPAPI-------------------------------------
Mflv_4064|M.gilvum_PYR-GCK AQRHPRTDEPDTDSRA----------------------------------
TH_0292|M.thermoresistible__bu AS------------------------------------------------
MAB_3718c|M.abscessus_ATCC_199 FTVVASSEGAPVAAFENRERRLAGVQYHPEVLHSPHGQQVLSRFLHEFAG
Mvan_1852|M.vanbaalenii_PYR-1 -----------------------------------QDEFDLGVIRAVIDL
MSMEG_6691|M.smegmatis_MC2_155 -----------------------------------QDDFDLGLTRAVLEL
MLBr_01573|M.leprae_Br4923 -----------------------------------RDSWEFALFEAALQR
MAV_3717|M.avium_104 -----------------------------------RDAWEFALLRGALQR
Mb2884c|M.bovis_AF2122/97 -----------------------------------RDAWEFALLRGALQR
Rv2859c|M.tuberculosis_H37Rv -----------------------------------RDAWEFALLRGALQR
MMAR_1844|M.marinum_M -----------------------------------RDSWEFALLRGALQR
MUL_2093|M.ulcerans_Agy99 -----------------------------------RDSWEFALLRGALQR
Mflv_4064|M.gilvum_PYR-GCK -----------------------------------RDAFEFALVRAALRR
TH_0292|M.thermoresistible__bu ----------------------------------------IPVVRACAAA
MAB_3718c|M.abscessus_ATCC_199 IESAWTAANIAETLVEQVRTQIGEGRALCALSGGVDSAVAAALVQRAIGD
: .
Mvan_1852|M.vanbaalenii_PYR-1 DMPALAICRGMQILN----------VALGGTLIQHVV------ETDTVHH
MSMEG_6691|M.smegmatis_MC2_155 DLPTLAICRGLQVLN----------VALGGTLVQHIT------ETTTAHH
MLBr_01573|M.leprae_Br4923 GLPVLGICRGAQLLN----------IALGGTLHQHLP------EVIGHSK
MAV_3717|M.avium_104 GLPVLGICRGAQVLN----------VAFGGTLHQHLP------DVLGHGG
Mb2884c|M.bovis_AF2122/97 GMPVLGICRGTQVLN----------VALGGTLHQHLP------DILGHSG
Rv2859c|M.tuberculosis_H37Rv GMPVLGICRGTQVLN----------VALGGTLHQHLP------DILGHSG
MMAR_1844|M.marinum_M GLPVLGICRGAQVLN----------VAFGGTLHQHLP------DVLGHNG
MUL_2093|M.ulcerans_Agy99 GLPVLGICRGAQVLN----------VAFGGTPHQHLP------DVLGHNG
Mflv_4064|M.gilvum_PYR-GCK AMPVLGICRGAQVLN----------VALGGTLHQHVP------DVVGHTR
TH_0292|M.thermoresistible__bu GTPLLGVCLGHQAIG----------VAFGATVDRAPE------LLHG---
MAB_3718c|M.abscessus_ATCC_199 RLTCVFVDHGLLRSGERAQVEHDFVAATGATLVTVDASETFLGELAGVTD
. : : * . * *.*
Mvan_1852|M.vanbaalenii_PYR-1 N-------AIHQVHVKRGTRLHGIVGT-----------------------
MSMEG_6691|M.smegmatis_MC2_155 N-------AIHPVWVVTGSRLHSIVGT-----------------------
MLBr_01573|M.leprae_Br4923 HWVGNAVFNNLLVRTVPGTRLAAVLG------------------------
MAV_3717|M.avium_104 HRAGNGVFSTLPVRTVAGTRLAALLG------------------------
Mb2884c|M.bovis_AF2122/97 HRAGNGVFTRLPVHTASGTRLAELIG------------------------
Rv2859c|M.tuberculosis_H37Rv HRAGNGVFTRLPVHTASGTRLAELIG------------------------
MMAR_1844|M.marinum_M HRAGNAVFSSLPVRTVPGTRLATLIG------------------------
MUL_2093|M.ulcerans_Agy99 HRAGNAVFSSLPVRTVPGTRLATLIG------------------------
Mflv_4064|M.gilvum_PYR-GCK HQQGNAVFTTSSIATVPGSRVAALVG------------------------
TH_0292|M.thermoresistible__bu --------KTSTVHHTDVGVLQGLPDP-----------------------
MAB_3718c|M.abscessus_ATCC_199 PEAKRKIIGREFIRSFEGAVSDVVGDSRRDDTAGIQFLVQGTLYPDVVES
: : .
Mvan_1852|M.vanbaalenii_PYR-1 --QSIDVSSYHHQAVDRLAPGLVVCALAADGVIEAVEHRR--------AD
MSMEG_6691|M.smegmatis_MC2_155 --ETVDVSSYHHQGIDRLGADLTVTAVAADGVIEAVEHRR--------AD
MLBr_01573|M.leprae_Br4923 --EFVEARCYHHQSIDKLGDGLVVSAWDADGVVEAVELPG-------DAF
MAV_3717|M.avium_104 --ETVDAPCYHHQAIDKLGDGLVVSAWDPDGVVEAVELPG-------DAF
Mb2884c|M.bovis_AF2122/97 --ESADVPCYHHQAIDQVGEGLVVSAVDVDGVIEALELPG-------DTF
Rv2859c|M.tuberculosis_H37Rv --ESADVPCYHHQAIDQVGEGLVVSAVDVDGVIEALELPG-------DTF
MMAR_1844|M.marinum_M --ESAQVRCYHHQAVAEVGEGLVVSAWDVDGVVEALELPG-------ENF
MUL_2093|M.ulcerans_Agy99 --ESAQVRCYHHQAVAEVGEGLVVSAFDVDGVVEALELPG-------ENF
Mflv_4064|M.gilvum_PYR-GCK --PDTEAQCYHHQAIDRLGDGLVVSASDTDGVIEAVEVDLS---AHPDHW
TH_0292|M.thermoresistible__bu --FTATRYHSLTILPQTLPAELEVTARTAGGVIMGVRHREL---P-----
MAB_3718c|M.abscessus_ATCC_199 GGGSGTANIKSHHNVGGLPEDLTFTLVEPLRLLFKDEVRAVGRELGLPEE
: * . :: .
Mvan_1852|M.vanbaalenii_PYR-1 VVAVQWHPEDRHAD--------------SITDAALFADLVDRARKRKESS
MSMEG_6691|M.smegmatis_MC2_155 ILAVQWHPEDRHAT--------------ADSDAALFADLVDRARKRKESR
MLBr_01573|M.leprae_Br4923 VLGVQWHPEK------------------ALSDLRLFTAIVDAACRYANSR
MAV_3717|M.avium_104 VLAVQWHPEQ------------------SLHDLRLFTAIVDAARSYAGVA
Mb2884c|M.bovis_AF2122/97 VLAVQWHPEK------------------SLDDLRLFKALVDAASGYAGRQ
Rv2859c|M.tuberculosis_H37Rv VLAVQWHPEK------------------SLDDLRLFKALVDAASGYAGRQ
MMAR_1844|M.marinum_M VLAVQWHPEE------------------SLEDLRLFSAVVDAARSRRSG-
MUL_2093|M.ulcerans_Agy99 VLAVQWHPEE------------------SLEDLRLFSAVVDAARSRRSG-
Mflv_4064|M.gilvum_PYR-GCK VIAVQWHPEE------------------RLDDLRLFAGLVGAAGVYATQK
TH_0292|M.thermoresistible__bu IHGVQFHPESILTEGGHRMLANWLGFCGAAPDDALVRRLEDEVAETVRAA
MAB_3718c|M.abscessus_ATCC_199 IVGRQPFPGPGLAIRIVGEVTPDRLDTLRRADAIAREELTAAGQDRNIWQ
: . * .* * :
Mvan_1852|M.vanbaalenii_PYR-1 R-------------------------------------------------
MSMEG_6691|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01573|M.leprae_Br4923 CVEYS---------------------------------------------
MAV_3717|M.avium_104 R-------------------------------------------------
Mb2884c|M.bovis_AF2122/97 SQAEPR--------------------------------------------
Rv2859c|M.tuberculosis_H37Rv SQAEPR--------------------------------------------
MMAR_1844|M.marinum_M --------------------------------------------------
MUL_2093|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4064|M.gilvum_PYR-GCK TQKVNR--------------------------------------------
TH_0292|M.thermoresistible__bu TTRSSA--------------------------------------------
MAB_3718c|M.abscessus_ATCC_199 CPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRLPYEVLER
Mvan_1852|M.vanbaalenii_PYR-1 ------------------------------
MSMEG_6691|M.smegmatis_MC2_155 ------------------------------
MLBr_01573|M.leprae_Br4923 ------------------------------
MAV_3717|M.avium_104 ------------------------------
Mb2884c|M.bovis_AF2122/97 ------------------------------
Rv2859c|M.tuberculosis_H37Rv ------------------------------
MMAR_1844|M.marinum_M ------------------------------
MUL_2093|M.ulcerans_Agy99 ------------------------------
Mflv_4064|M.gilvum_PYR-GCK ------------------------------
TH_0292|M.thermoresistible__bu ------------------------------
MAB_3718c|M.abscessus_ATCC_199 ISTRITNEVPEVNRVVLDITSKPPGTIEWE