For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VADAPFLLLSIRDEDEAADDEYRAVLRFGGLDEAGLHRIGLTHCELGAVDLSQWSGIILGGGPYNVSDDA AGKSATQVRVEAELAALLREVIDVDFPFLGCCYGVGTVGTAVGAVIDRAHSEPVGGVTVQVTPEGRADPL FAGLPDTFDAYGGHKEAATSLPPGVVRLATSPVCPVQAFRVGANVYATQFHPELDLDGVCTRIDVYKNHG YFAPETTESLKDAARGHAVTHPMAILRSFVERYTARR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3263 | - | - | 100% (247) | glutamine amidotransferase |
| M. gilvum PYR-GCK | Mflv_4903 | guaA | 9e-10 | 29.50% (139) | bifunctional GMP synthase/glutamine amidotransferase protein |
| M. gilvum PYR-GCK | Mflv_3000 | - | 8e-05 | 32.43% (111) | glutamine amidotransferase class-I |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3429c | guaA | 4e-09 | 27.34% (139) | GMP synthase |
| M. tuberculosis H37Rv | Rv3396c | guaA | 4e-09 | 27.34% (139) | GMP synthase |
| M. leprae Br4923 | MLBr_00395 | guaA | 5e-08 | 26.62% (139) | GMP synthase |
| M. abscessus ATCC 19977 | MAB_3718c | - | 4e-09 | 28.78% (139) | GMP synthase |
| M. marinum M | MMAR_1148 | guaA | 7e-06 | 25.90% (139) | GMP synthase, GuaA |
| M. avium 104 | MAV_4348 | guaA | 3e-08 | 28.06% (139) | bifunctional GMP synthase/glutamine amidotransferase protein |
| M. smegmatis MC2 155 | MSMEG_1610 | guaA | 5e-10 | 30.22% (139) | bifunctional GMP synthase/glutamine amidotransferase protein |
| M. thermoresistible (build 8) | TH_0484 | guaA | 4e-09 | 29.50% (139) | PROBABLE GMP SYNTHASE |
| M. ulcerans Agy99 | MUL_0017 | trpG | 2e-06 | 31.61% (155) | para-aminobenzoate synthase component II |
| M. vanbaalenii PYR-1 | Mvan_2980 | - | 1e-107 | 76.13% (243) | glutamine amidotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3429c|M.bovis_AF2122/97 MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTASI
Rv3396c|M.tuberculosis_H37Rv MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTASI
MMAR_1148|M.marinum_M MAEPVDLDVAGPVGRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTTSI
MLBr_00395|M.leprae_Br4923 MADSAGLDQPEPSPRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTTSI
MAV_4348|M.avium_104 ----------------MLVVDFGAQYAQLIARRVREARVFSEVIPHTATI
MSMEG_1610|M.smegmatis_MC2_155 MAS--------ESPRPVLVIDYGAQYAQLIARRVREARVYSEVVPHTAGV
TH_0484|M.thermoresistible__bu VSSSADV----NTSRPVLVIDFGAQYAQLIARRIREARVYSEVVPHTATV
MAB_3718c|M.abscessus_ATCC_199 MAQTEQHG-----DRPVLVIDFGAQYAQLIARRVREARVFSEVIPHSASV
Mflv_3263|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2980|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_0017|M.ulcerans_Agy99 --------------------------------------------------
Mb3429c|M.bovis_AF2122/97 EEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMA
Rv3396c|M.tuberculosis_H37Rv EEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMA
MMAR_1148|M.marinum_M EEIKARDPLALVLSGGPASVYAPGAPQLDPALFDLGLPVFGICYGFQVMA
MLBr_00395|M.leprae_Br4923 EEITARDPLAIVLSGGPASVYTEGAPQLDPALFDLGLPVFGICYGFQAMA
MAV_4348|M.avium_104 EEIKARQPRALVLSGGPSSVYEPGAPQLDPAVFDLGVPVFGICYGFQAMA
MSMEG_1610|M.smegmatis_MC2_155 EEIKAKDPQAIVLSGGPASVYSEGAPQLDPGLFDLDVPVFGICYGFQAMA
TH_0484|M.thermoresistible__bu EEIKAKDPQAIVLSGGPASVYAEDAPRLDPGLFDLGVPVFGICYGFQAMA
MAB_3718c|M.abscessus_ATCC_199 EEIKGRNPRAIVLSGGPSSVYEEGAPQLDPGVFDLDVPVFGICYGFQAMA
Mflv_3263|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2980|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_0017|M.ulcerans_Agy99 --------------------------------------------------
Mb3429c|M.bovis_AF2122/97 QALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPD
Rv3396c|M.tuberculosis_H37Rv QALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPD
MMAR_1148|M.marinum_M QALGGTVAHTGTSEYGRTELKVLGGDLHSDLPDIQPVWMSHGDAVTAAPD
MLBr_00395|M.leprae_Br4923 QVLGGTVARTKTSEYGRTELKVLGGDLHSGLPGVQPVWMSHGDAVTAAPD
MAV_4348|M.avium_104 QALGGTVAHTGTSEYGRTELKVLGGELHSGLPGVQPVWMSHGDAVTAAPD
MSMEG_1610|M.smegmatis_MC2_155 QALGGTVERTGTSEFGRTELQVTGGDLHSELPATQPVWMSHGDAVTAAPE
TH_0484|M.thermoresistible__bu QALGGTVTRTGTREYGRTELTVLGGQLHSDLPERQPVWMSHADAVTEAPA
MAB_3718c|M.abscessus_ATCC_199 QVLGGTVAHTGTSEYGRTELTVAGGDLHEGLPDVQPVWMSHGDAVTEAPQ
Mflv_3263|M.gilvum_PYR-GCK ------------------------------MADAPFLLLSIRDEDEAADD
Mvan_2980|M.vanbaalenii_PYR-1 ------------------------------MADAAFLLLSIRGEDEAADD
MUL_0017|M.ulcerans_Agy99 ------------------------------------MPILVVDNYDSFVF
: : .
Mb3429c|M.bovis_AF2122/97 GFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFA
Rv3396c|M.tuberculosis_H37Rv GFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFA
MMAR_1148|M.marinum_M GFEVVASSAGAAVAAFENRERRLAGVQYHPEVMHTPHGQQILGRFLHDFA
MLBr_00395|M.leprae_Br4923 GFDVAASSSGAPVAAFENRDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFA
MAV_4348|M.avium_104 GFEVVASSPGAVVAAFENRARRLAGVQYHPEVMHTPHGQQVLSRFLHDFA
MSMEG_1610|M.smegmatis_MC2_155 GFDVVASSAGAPVAGFENRARRLAGVQYHPEVLHSPHGQQVLSRFLHDFA
TH_0484|M.thermoresistible__bu GFEVVATSPGSPVAAFEDPARRLAGVQYHPEVIHSPHGQQVLGRFLHEFA
MAB_3718c|M.abscessus_ATCC_199 GFTVVASSEGAPVAAFENRERRLAGVQYHPEVLHSPHGQQVLSRFLHEFA
Mflv_3263|M.gilvum_PYR-GCK EYRAVLRFGGLDEAGLHRIG-----------LTHCELGAVDLS----QWS
Mvan_2980|M.vanbaalenii_PYR-1 EYAAMMRFAGLDESGMRRIR-----------LTHRGLGYIDLT----QWS
MUL_0017|M.ulcerans_Agy99 NLVQYLGQLGVRAEVWRNDDPR-----------------------LCDEA
* . : :
Mb3429c|M.bovis_AF2122/97 GLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRAIG
Rv3396c|M.tuberculosis_H37Rv GLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRAIG
MMAR_1148|M.marinum_M GIGARWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRAIG
MLBr_00395|M.leprae_Br4923 GLDADWTAANIAGVLVEQVRAQIGNGHAICGLSGGVDSAVAAALVQRAIG
MAV_4348|M.avium_104 GLGADWTAANIAGVLVEQVRAQIGDGHAICGLSGGVDSAVAAALVQRAIG
MSMEG_1610|M.smegmatis_MC2_155 GIDATWTPANIADQLIEAVREQIGDGRAICGLSGGVDSAVAAALVQRAIG
TH_0484|M.thermoresistible__bu GIGASWTPANIAESLIEQVREQIGDGRAICGLSGGVDSAVAAALVQRAIG
MAB_3718c|M.abscessus_ATCC_199 GIESAWTAANIAETLVEQVRTQIGEGRALCALSGGVDSAVAAALVQRAIG
Mflv_3263|M.gilvum_PYR-GCK GIILGGGPYNVSDDAAGKSATQVR------------VEAELAALLREVID
Mvan_2980|M.vanbaalenii_PYR-1 GIILGGGPYNVSDDPASKSPTQMR------------VEEEMAGLLAEVIA
MUL_0017|M.ulcerans_Agy99 AIAAQFDGVLLSPGPGTPER-----------------AGASVSLVRACAE
.: :: ..*:
Mb3429c|M.bovis_AF2122/97 DRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSGVS
Rv3396c|M.tuberculosis_H37Rv DRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSGVS
MMAR_1148|M.marinum_M DRLTCVFVDHGLLRAGERAQVERDFVAATKANLVTVDVADTFLAALSGVT
MLBr_00395|M.leprae_Br4923 DRLTCIFVDHGLLRDGERGQVQRDFVAATGAKLVTVDAAETFLQALSGVT
MAV_4348|M.avium_104 DRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAADTFLQALAGVT
MSMEG_1610|M.smegmatis_MC2_155 DRLTCVFVDHGLLRAGERAQVQRDFVAATGAKLVTVDVADRFLEALTGVT
TH_0484|M.thermoresistible__bu DRLTCVFVDHGLLRAGERAQVQRDFVAATGAKLVTVDTSERFLEALSGVT
MAB_3718c|M.abscessus_ATCC_199 DRLTCVFVDHGLLRSGERAQVEHDFVAATGATLVTVDASETFLGELAGVT
Mflv_3263|M.gilvum_PYR-GCK VDFPFLGCCYGVGTVGTAVGAVIDRAHSEPVGGVTVQVTP------EGRA
Mvan_2980|M.vanbaalenii_PYR-1 RDFPFLGCCYGIGTVGAAIGAVIDRSHSEPVGGVTVDLTD------HGRR
MUL_0017|M.ulcerans_Agy99 ARTPLLGVCLGHQAIGVAFGATVDRAPELLHGKTSS--------------
. : * * . * .:
Mb3429c|M.bovis_AF2122/97 APEGKRKIIGRQFIRAFEGAVRDVLDG------KTAEFLVQGTLYPDVVE
Rv3396c|M.tuberculosis_H37Rv APEGKRKIIGRQFIRAFEGAVRDVLDG------KTAEFLVQGTLYPDVVE
MMAR_1148|M.marinum_M DPEGKRKIIGRQFIRAFEGAVRDVLDG------RDIEFLVQGTLYPDVVE
MLBr_00395|M.leprae_Br4923 NPEGKRKIIGRQFIRAFEGAVRDLLGDSTFD--SGIEFLVQGTLYPDVVE
MAV_4348|M.avium_104 NPEGKRKIIGRQFIRAFEGAVRDVLGD------KPVEFLVQGTLYPDVVE
MSMEG_1610|M.smegmatis_MC2_155 NPEGKRKIIGREFIRAFEGAVRDLVEDEGSG---DIDFLVQGTLYPDVVE
TH_0484|M.thermoresistible__bu NPEGKRKIIGREFIRAFEGAVREALGENAAANDDEVEFLVQGTLYPDVVE
MAB_3718c|M.abscessus_ATCC_199 DPEAKRKIIGREFIRSFEGAVSDVVGDSRRDDTAGIQFLVQGTLYPDVVE
Mflv_3263|M.gilvum_PYR-GCK DP--------------------------------------LFAGLPDTFD
Mvan_2980|M.vanbaalenii_PYR-1 DP--------------------------------------LFCVLPDTFD
MUL_0017|M.ulcerans_Agy99 -------------------------------------------VYHTNVG
.
Mb3429c|M.bovis_AF2122/97 SGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPE
Rv3396c|M.tuberculosis_H37Rv SGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPE
MMAR_1148|M.marinum_M SGGGSGTANIKSHHNVGGLPDDLKFALVEPLRLLFKDEVRAVGRELGLPE
MLBr_00395|M.leprae_Br4923 SGGGSGTANIKSHHNVGGLPDNLRFKLVEPLRLLFKDEVRAVGRQLDLPE
MAV_4348|M.avium_104 SGRGSGTANIKSHHNVGGLPGDLKFTLVEPLRLLFKDEVRAVGRELGLPE
MSMEG_1610|M.smegmatis_MC2_155 SGGGSGTANIKSHHNVGGLPDDLKFKLVEPLRLLFKDEVRAVGRELGLPE
TH_0484|M.thermoresistible__bu SGGGAGTANIKSHHNVGGLPDDLKFKLVEPLRLLFKDEVRAVGRELGLPE
MAB_3718c|M.abscessus_ATCC_199 SGGGSGTANIKSHHNVGGLPEDLTFTLVEPLRLLFKDEVRAVGRELGLPE
Mflv_3263|M.gilvum_PYR-GCK AYGG--------------------------------------------HK
Mvan_2980|M.vanbaalenii_PYR-1 AFGG--------------------------------------------HK
MUL_0017|M.ulcerans_Agy99 VLQG-------------------------------------------LPD
* .
Mb3429c|M.bovis_AF2122/97 EIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQIW
Rv3396c|M.tuberculosis_H37Rv EIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQIW
MMAR_1148|M.marinum_M EIVARQPFPGPGLGIRIVGEVTGQRLDTLRRADSIAREELTAAGLDNQIW
MLBr_00395|M.leprae_Br4923 EIVARQPFPGPGLGIRIVGEVTAERLDTLRRADSIAREELTTAGLDYQIW
MAV_4348|M.avium_104 EIVARQPFPGPGLGIRIVGEVTATRLDTLRRADSIAREELTAAGLDSLIW
MSMEG_1610|M.smegmatis_MC2_155 EIVARQPFPGPGLGIRIVGEVTAERLETLRRADAIAREELTAAGLDNQIW
TH_0484|M.thermoresistible__bu EIVARQPFPGPGLAIRIVGEVTAERLETLRRADAIVREELTAAGLDHQIW
MAB_3718c|M.abscessus_ATCC_199 EIVGRQPFPGPGLAIRIVGEVTPDRLDTLRRADAIAREELTAAGQDRNIW
Mflv_3263|M.gilvum_PYR-GCK EAATSLPPGVVRLATSPVCPVQAFRVGANVYATQFH-PELDLDGVCTRID
Mvan_2980|M.vanbaalenii_PYR-1 EAVSSLPGGAVSLASSADCPVQAFRVGANVYATQFH-PELDVDGLCTRIE
MUL_0017|M.ulcerans_Agy99 PFTATRYHSLTILPDSLPAELEATAHTRSGVIMGVRHTELPIHG------
. * : . ** *
Mb3429c|M.bovis_AF2122/97 QCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLE
Rv3396c|M.tuberculosis_H37Rv QCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLE
MMAR_1148|M.marinum_M QCPVVLLADVRSVGVQGDNRTYGHPIVLRPVSSEDAMTADWTRVPFEVLE
MLBr_00395|M.leprae_Br4923 QCPVVLLADVRSVGVQGDNRSYGHPIVLRPVSSEDAMTADWTWVPYEVLE
MAV_4348|M.avium_104 QCPVVLLGEVRSVGVQGDNRTYGHPIVLRPVTSEDAMTADWTRVPYEVLE
MSMEG_1610|M.smegmatis_MC2_155 QCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLE
TH_0484|M.thermoresistible__bu QCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYDVLE
MAB_3718c|M.abscessus_ATCC_199 QCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRLPYEVLE
Mflv_3263|M.gilvum_PYR-GCK VY-----------------KNHGYFAPETTESLKDAARGHAVTHPMAILR
Mvan_2980|M.vanbaalenii_PYR-1 VY-----------------KHHGYFAPETAESLKHDARQRTVTHPMAVLR
MUL_0017|M.ulcerans_Agy99 --------------------VQFHPESILTEGGHRMLANWLAYCGWARDD
: . . .
Mb3429c|M.bovis_AF2122/97 RISTRITNEVAEVNRVVLDITSKPPATIEWE
Rv3396c|M.tuberculosis_H37Rv RISTRITNEVAEVNRVVLDITSKPPATIEWE
MMAR_1148|M.marinum_M RISTRITNEVPEVNRVVLDVTSKPPGTIEWE
MLBr_00395|M.leprae_Br4923 CISTRITNEVAEVNRVVLDITNKPPGTIEWE
MAV_4348|M.avium_104 RISTRITNEVPEVNRVVLDITSKPPGTIEWE
MSMEG_1610|M.smegmatis_MC2_155 RISTRITNEVREVNRVVLDITSKPPGTIEWE
TH_0484|M.thermoresistible__bu RISTRITNEVAEVNRVVLDITSKPPATIEWE
MAB_3718c|M.abscessus_ATCC_199 RISTRITNEVPEVNRVVLDITSKPPGTIEWE
Mflv_3263|M.gilvum_PYR-GCK SFVERY-------------TARR--------
Mvan_2980|M.vanbaalenii_PYR-1 GFVQRYG------RGAGLPVSSRVPPRPD--
MUL_0017|M.ulcerans_Agy99 TLVRRLENEVASAIRPHLPVEAGTTDRTSA-
: *