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VQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTASIEEIRARQPVALVLSGGPASVY ADGAPKLDPALLDLGVPVLGICYGFQAMAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSH GDAVTAAPDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGAQWTPANI ANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGA NLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLVQGTLYPDVVESGGGSGT ANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLGIRIVGEVTAKRLD TLRHADSIVREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYE VLERISTRITNEVAEVNRVVLDITSKPPATIEWE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3396c | guaA | - | 100% (525) | bifunctional GMP synthase/glutamine amidotransferase protein |
| M. tuberculosis H37Rv | Rv1383 | carA | 1e-08 | 29.07% (172) | carbamoyl phosphate synthase small subunit |
| M. tuberculosis H37Rv | Rv0013 | trpG | 2e-06 | 27.98% (193) | para-aminobenzoate synthase component II |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3429c | guaA | 0.0 | 100.00% (525) | GMP synthase |
| M. gilvum PYR-GCK | Mflv_4903 | guaA | 0.0 | 88.57% (516) | bifunctional GMP synthase/glutamine amidotransferase protein |
| M. leprae Br4923 | MLBr_00395 | guaA | 0.0 | 86.39% (529) | GMP synthase |
| M. abscessus ATCC 19977 | MAB_3718c | - | 0.0 | 82.79% (517) | GMP synthase |
| M. marinum M | MMAR_1148 | guaA | 0.0 | 89.90% (525) | GMP synthase, GuaA |
| M. avium 104 | MAV_4348 | guaA | 0.0 | 90.37% (509) | bifunctional GMP synthase/glutamine amidotransferase protein |
| M. smegmatis MC2 155 | MSMEG_1610 | guaA | 0.0 | 85.91% (518) | bifunctional GMP synthase/glutamine amidotransferase protein |
| M. thermoresistible (build 8) | TH_0484 | guaA | 0.0 | 86.10% (518) | PROBABLE GMP SYNTHASE |
| M. ulcerans Agy99 | MUL_0913 | guaA | 0.0 | 89.71% (525) | GMP synthase |
| M. vanbaalenii PYR-1 | Mvan_1516 | guaA | 0.0 | 88.12% (522) | bifunctional GMP synthase/glutamine amidotransferase protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4903|M.gilvum_PYR-GCK --MES--------AHPRPVLIVDFGAQYAQLIARRVREARVFSEVIPHTA
Mvan_1516|M.vanbaalenii_PYR-1 --MES--------ATPRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTT
MSMEG_1610|M.smegmatis_MC2_155 --MAS--------ESPRPVLVIDYGAQYAQLIARRVREARVYSEVVPHTA
TH_0484|M.thermoresistible__bu --VSSSADV----NTSRPVLVIDFGAQYAQLIARRIREARVYSEVVPHTA
Rv3396c|M.tuberculosis_H37Rv --MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTA
Mb3429c|M.bovis_AF2122/97 --MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTA
MMAR_1148|M.marinum_M --MAEPVDLDVAGPVGRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTT
MUL_0913|M.ulcerans_Agy99 MPVAEPVDLDVAGPVGRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTT
MLBr_00395|M.leprae_Br4923 --MADSAGLDQPEPSPRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTT
MAV_4348|M.avium_104 ------------------MLVVDFGAQYAQLIARRVREARVFSEVIPHTA
MAB_3718c|M.abscessus_ATCC_199 --MAQTEQ-----HGDRPVLVIDFGAQYAQLIARRVREARVFSEVIPHSA
:*::*:***********:*****:***:**::
Mflv_4903|M.gilvum_PYR-GCK SIEEIKARDPRAVVLSGGPSSVYADGAPQLDPALFDLDIPVFGICYGFQA
Mvan_1516|M.vanbaalenii_PYR-1 SVEEIKARNPRAVVLSGGPASVYADGAPQLDPALFDLDVPVFGICYGFQA
MSMEG_1610|M.smegmatis_MC2_155 GVEEIKAKDPQAIVLSGGPASVYSEGAPQLDPGLFDLDVPVFGICYGFQA
TH_0484|M.thermoresistible__bu TVEEIKAKDPQAIVLSGGPASVYAEDAPRLDPGLFDLGVPVFGICYGFQA
Rv3396c|M.tuberculosis_H37Rv SIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQA
Mb3429c|M.bovis_AF2122/97 SIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQA
MMAR_1148|M.marinum_M SIEEIKARDPLALVLSGGPASVYAPGAPQLDPALFDLGLPVFGICYGFQV
MUL_0913|M.ulcerans_Agy99 SIEEIKARDPLALVLSGGPASVYAPGAPQLDPALFDLGLPVFGICYGFQV
MLBr_00395|M.leprae_Br4923 SIEEITARDPLAIVLSGGPASVYTEGAPQLDPALFDLGLPVFGICYGFQA
MAV_4348|M.avium_104 TIEEIKARQPRALVLSGGPSSVYEPGAPQLDPAVFDLGVPVFGICYGFQA
MAB_3718c|M.abscessus_ATCC_199 SVEEIKGRNPRAIVLSGGPSSVYEEGAPQLDPGVFDLDVPVFGICYGFQA
:*** .::* *:******:*** .**:***.::**.:**:*******.
Mflv_4903|M.gilvum_PYR-GCK MAQALGGTVARTGTSEYGRTELKVAGGELHSDLPEVQPVWMSHGDAVTEA
Mvan_1516|M.vanbaalenii_PYR-1 MAQALGGTVAHTGTSEYGRTELKVAGGQLHTDLPETQPVWMSHGDAVTAA
MSMEG_1610|M.smegmatis_MC2_155 MAQALGGTVERTGTSEFGRTELQVTGGDLHSELPATQPVWMSHGDAVTAA
TH_0484|M.thermoresistible__bu MAQALGGTVTRTGTREYGRTELTVLGGQLHSDLPERQPVWMSHADAVTEA
Rv3396c|M.tuberculosis_H37Rv MAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAA
Mb3429c|M.bovis_AF2122/97 MAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAA
MMAR_1148|M.marinum_M MAQALGGTVAHTGTSEYGRTELKVLGGDLHSDLPDIQPVWMSHGDAVTAA
MUL_0913|M.ulcerans_Agy99 MAQALGGTVAHTGTSEYGRTELKVLGGDLHSDLPDIQPVWMSHGDAVTAA
MLBr_00395|M.leprae_Br4923 MAQVLGGTVARTKTSEYGRTELKVLGGDLHSGLPGVQPVWMSHGDAVTAA
MAV_4348|M.avium_104 MAQALGGTVAHTGTSEYGRTELKVLGGELHSGLPGVQPVWMSHGDAVTAA
MAB_3718c|M.abscessus_ATCC_199 MAQVLGGTVAHTGTSEYGRTELTVAGGDLHEGLPDVQPVWMSHGDAVTEA
***.*** * :* * *:***** * **.** ** *******.**** *
Mflv_4903|M.gilvum_PYR-GCK PSGFEVVATSVGAPVAAFENRARRLAGVQYHPEVMHSPHGQQVLSRFLHE
Mvan_1516|M.vanbaalenii_PYR-1 PEGFEVVATSAGAPVAAFENRARRLAGVQYHPEVMHSPHGQQVLSRFLHE
MSMEG_1610|M.smegmatis_MC2_155 PEGFDVVASSAGAPVAGFENRARRLAGVQYHPEVLHSPHGQQVLSRFLHD
TH_0484|M.thermoresistible__bu PAGFEVVATSPGSPVAAFEDPARRLAGVQYHPEVIHSPHGQQVLGRFLHE
Rv3396c|M.tuberculosis_H37Rv PDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHD
Mb3429c|M.bovis_AF2122/97 PDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHD
MMAR_1148|M.marinum_M PDGFEVVASSAGAAVAAFENRERRLAGVQYHPEVMHTPHGQQILGRFLHD
MUL_0913|M.ulcerans_Agy99 PDGFEVVASSAGAAVAAFENRERRLAGVQYHPEVMHTPHGQQILGRFLHD
MLBr_00395|M.leprae_Br4923 PDGFDVAASSSGAPVAAFENRDRRLAGVQYHPEVMHTPHGQQVLSRFLHD
MAV_4348|M.avium_104 PDGFEVVASSPGAVVAAFENRARRLAGVQYHPEVMHTPHGQQVLSRFLHD
MAB_3718c|M.abscessus_ATCC_199 PQGFTVVASSEGAPVAAFENRERRLAGVQYHPEVLHSPHGQQVLSRFLHE
* ** *.*:* *: **.** ************:*:*****:*.****:
Mflv_4903|M.gilvum_PYR-GCK FAGIDAAWTPANIAEALVEQVRNQIGDGRAICGLSGGVDSAVAAALVQRA
Mvan_1516|M.vanbaalenii_PYR-1 FAGIDATWTPANIAEALVEQVRTQIGDGRAICGLSGGVDSAVAAALVQRA
MSMEG_1610|M.smegmatis_MC2_155 FAGIDATWTPANIADQLIEAVREQIGDGRAICGLSGGVDSAVAAALVQRA
TH_0484|M.thermoresistible__bu FAGIGASWTPANIAESLIEQVREQIGDGRAICGLSGGVDSAVAAALVQRA
Rv3396c|M.tuberculosis_H37Rv FAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRA
Mb3429c|M.bovis_AF2122/97 FAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRA
MMAR_1148|M.marinum_M FAGIGARWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRA
MUL_0913|M.ulcerans_Agy99 FAGIGARWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRV
MLBr_00395|M.leprae_Br4923 FAGLDADWTAANIAGVLVEQVRAQIGNGHAICGLSGGVDSAVAAALVQRA
MAV_4348|M.avium_104 FAGLGADWTAANIAGVLVEQVRAQIGDGHAICGLSGGVDSAVAAALVQRA
MAB_3718c|M.abscessus_ATCC_199 FAGIESAWTAANIAETLVEQVRTQIGEGRALCALSGGVDSAVAAALVQRA
***: : **.**** *:* ** ***:*:*:*.****************.
Mflv_4903|M.gilvum_PYR-GCK IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDVADRFLEALSG
Mvan_1516|M.vanbaalenii_PYR-1 IGDRLTCVFVDHGLLRSGERAQVQRDFVAATGANLVTVDVADRFLEALSG
MSMEG_1610|M.smegmatis_MC2_155 IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGAKLVTVDVADRFLEALTG
TH_0484|M.thermoresistible__bu IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGAKLVTVDTSERFLEALSG
Rv3396c|M.tuberculosis_H37Rv IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSG
Mb3429c|M.bovis_AF2122/97 IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSG
MMAR_1148|M.marinum_M IGDRLTCVFVDHGLLRAGERAQVERDFVAATKANLVTVDVADTFLAALSG
MUL_0913|M.ulcerans_Agy99 IGDRLTCVFVDHGLLRAGERAQVERDFVAATKANLVTVDVADTFLAALSG
MLBr_00395|M.leprae_Br4923 IGDRLTCIFVDHGLLRDGERGQVQRDFVAATGAKLVTVDAAETFLQALSG
MAV_4348|M.avium_104 IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAADTFLQALAG
MAB_3718c|M.abscessus_ATCC_199 IGDRLTCVFVDHGLLRSGERAQVEHDFVAATGATLVTVDASETFLGELAG
*******:******** ***.**::****** *.*****.:: ** *:*
Mflv_4903|M.gilvum_PYR-GCK VTNPEGKRKIIGREFIRAFEGAVRDTVERSDGS-DVPVEFLVQGTLYPDV
Mvan_1516|M.vanbaalenii_PYR-1 VTNPEGKRKIIGREFIRAFEGAVRDALESQDGS-DVPVEFLVQGTLYPDV
MSMEG_1610|M.smegmatis_MC2_155 VTNPEGKRKIIGREFIRAFEGAVRDLVEDEGSG---DIDFLVQGTLYPDV
TH_0484|M.thermoresistible__bu VTNPEGKRKIIGREFIRAFEGAVREALGENAAANDDEVEFLVQGTLYPDV
Rv3396c|M.tuberculosis_H37Rv VSAPEGKRKIIGRQFIRAFEGAVRDVLDG------KTAEFLVQGTLYPDV
Mb3429c|M.bovis_AF2122/97 VSAPEGKRKIIGRQFIRAFEGAVRDVLDG------KTAEFLVQGTLYPDV
MMAR_1148|M.marinum_M VTDPEGKRKIIGRQFIRAFEGAVRDVLDG------RDIEFLVQGTLYPDV
MUL_0913|M.ulcerans_Agy99 VTDPEGKRKIIGRQFIRAFEGAVRDVLDG------RDVEFLVQGTLYPDV
MLBr_00395|M.leprae_Br4923 VTNPEGKRKIIGRQFIRAFEGAVRDLLGDSTFD--SGIEFLVQGTLYPDV
MAV_4348|M.avium_104 VTNPEGKRKIIGRQFIRAFEGAVRDVLGD------KPVEFLVQGTLYPDV
MAB_3718c|M.abscessus_ATCC_199 VTDPEAKRKIIGREFIRSFEGAVSDVVGDSRRDDTAGIQFLVQGTLYPDV
*: **.*******:***:***** : : :***********
Mflv_4903|M.gilvum_PYR-GCK VESGGGSGTANIKSHHNVGGLPDDLKFALVEPLRLLFKDEVRAVGRELGL
Mvan_1516|M.vanbaalenii_PYR-1 VESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
MSMEG_1610|M.smegmatis_MC2_155 VESGGGSGTANIKSHHNVGGLPDDLKFKLVEPLRLLFKDEVRAVGRELGL
TH_0484|M.thermoresistible__bu VESGGGAGTANIKSHHNVGGLPDDLKFKLVEPLRLLFKDEVRAVGRELGL
Rv3396c|M.tuberculosis_H37Rv VESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
Mb3429c|M.bovis_AF2122/97 VESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
MMAR_1148|M.marinum_M VESGGGSGTANIKSHHNVGGLPDDLKFALVEPLRLLFKDEVRAVGRELGL
MUL_0913|M.ulcerans_Agy99 VESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
MLBr_00395|M.leprae_Br4923 VESGGGSGTANIKSHHNVGGLPDNLRFKLVEPLRLLFKDEVRAVGRQLDL
MAV_4348|M.avium_104 VESGRGSGTANIKSHHNVGGLPGDLKFTLVEPLRLLFKDEVRAVGRELGL
MAB_3718c|M.abscessus_ATCC_199 VESGGGSGTANIKSHHNVGGLPEDLTFTLVEPLRLLFKDEVRAVGRELGL
**** *:*************** :* * ******************:*.*
Mflv_4903|M.gilvum_PYR-GCK PEEIVARQPFPGPGLGIRIIGEVTSDRLDTLRRADVIAREELTAAGLDHQ
Mvan_1516|M.vanbaalenii_PYR-1 PEEIVARQPFPGPGLGIRIVGEVTAERLDTLRRADAIAREELTSAGLDHQ
MSMEG_1610|M.smegmatis_MC2_155 PEEIVARQPFPGPGLGIRIVGEVTAERLETLRRADAIAREELTAAGLDNQ
TH_0484|M.thermoresistible__bu PEEIVARQPFPGPGLAIRIVGEVTAERLETLRRADAIVREELTAAGLDHQ
Rv3396c|M.tuberculosis_H37Rv PEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQ
Mb3429c|M.bovis_AF2122/97 PEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQ
MMAR_1148|M.marinum_M PEEIVARQPFPGPGLGIRIVGEVTGQRLDTLRRADSIAREELTAAGLDNQ
MUL_0913|M.ulcerans_Agy99 PEEIVARQPFPGPGLGIRIVGEVTGQRLDTLRRADSIARKELTAAGLDNQ
MLBr_00395|M.leprae_Br4923 PEEIVARQPFPGPGLGIRIVGEVTAERLDTLRRADSIAREELTTAGLDYQ
MAV_4348|M.avium_104 PEEIVARQPFPGPGLGIRIVGEVTATRLDTLRRADSIAREELTAAGLDSL
MAB_3718c|M.abscessus_ATCC_199 PEEIVGRQPFPGPGLAIRIVGEVTPDRLDTLRRADAIAREELTAAGQDRN
*****.*********.***:**** **:***:** *.*:***:** *
Mflv_4903|M.gilvum_PYR-GCK IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
Mvan_1516|M.vanbaalenii_PYR-1 IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
MSMEG_1610|M.smegmatis_MC2_155 IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
TH_0484|M.thermoresistible__bu IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYDV
Rv3396c|M.tuberculosis_H37Rv IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
Mb3429c|M.bovis_AF2122/97 IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
MMAR_1148|M.marinum_M IWQCPVVLLADVRSVGVQGDNRTYGHPIVLRPVSSEDAMTADWTRVPFEV
MUL_0913|M.ulcerans_Agy99 IWQCPVVLLADVRSVGVQGDNRTYGHPIVLRPVSSEDAMTADWTRVPFEV
MLBr_00395|M.leprae_Br4923 IWQCPVVLLADVRSVGVQGDNRSYGHPIVLRPVSSEDAMTADWTWVPYEV
MAV_4348|M.avium_104 IWQCPVVLLGEVRSVGVQGDNRTYGHPIVLRPVTSEDAMTADWTRVPYEV
MAB_3718c|M.abscessus_ATCC_199 IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRLPYEV
*********.:*********.*:**********:********** :*::*
Mflv_4903|M.gilvum_PYR-GCK LERISTRITNEVPEVNRVVLDITSKPPGTIEWE
Mvan_1516|M.vanbaalenii_PYR-1 LERISTRITNEVREVNRVVLDVTSKPPGTIEWE
MSMEG_1610|M.smegmatis_MC2_155 LERISTRITNEVREVNRVVLDITSKPPGTIEWE
TH_0484|M.thermoresistible__bu LERISTRITNEVAEVNRVVLDITSKPPATIEWE
Rv3396c|M.tuberculosis_H37Rv LERISTRITNEVAEVNRVVLDITSKPPATIEWE
Mb3429c|M.bovis_AF2122/97 LERISTRITNEVAEVNRVVLDITSKPPATIEWE
MMAR_1148|M.marinum_M LERISTRITNEVPEVNRVVLDVTSKPPGTIEWE
MUL_0913|M.ulcerans_Agy99 LERISTRITNEVPEVNRVVLDVTSKPPGTIEWE
MLBr_00395|M.leprae_Br4923 LECISTRITNEVAEVNRVVLDITNKPPGTIEWE
MAV_4348|M.avium_104 LERISTRITNEVPEVNRVVLDITSKPPGTIEWE
MAB_3718c|M.abscessus_ATCC_199 LERISTRITNEVPEVNRVVLDITSKPPGTIEWE
** ********* ********:*.***.*****