For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. thermoresistible (build 8) TH_0484 (guaA)

annotation: PROBABLE GMP SYNTHASE
coordinates: 1020447 - 1022030
length: 528

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0484guaA-100% (528)PROBABLE GMP SYNTHASE
M. thermoresistible (build 8)TH_0817carA4e-0826.35% (167) PROBABLE CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN CARA
M. thermoresistible (build 8)TH_0292pabA4e-0730.25% (119) POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3429cguaA0.086.10% (518) GMP synthase
M. gilvum PYR-GCKMflv_4903guaA0.087.81% (517) bifunctional GMP synthase/glutamine amidotransferase protein
M. tuberculosis H37RvRv3396cguaA0.086.10% (518) GMP synthase
M. leprae Br4923MLBr_00395guaA0.083.37% (517) GMP synthase
M. abscessus ATCC 19977MAB_3718c-0.082.79% (517) GMP synthase
M. marinum MMMAR_1148guaA0.084.53% (517) GMP synthase, GuaA
M. avium 104MAV_4348guaA0.084.47% (515) bifunctional GMP synthase/glutamine amidotransferase protein
M. smegmatis MC2 155MSMEG_1610guaA0.088.39% (517) bifunctional GMP synthase/glutamine amidotransferase protein
M. ulcerans Agy99MUL_0913guaA0.084.33% (517) GMP synthase
M. vanbaalenii PYR-1Mvan_1516guaA0.088.25% (519) bifunctional GMP synthase/glutamine amidotransferase protein

CLUSTAL 2.0.9 multiple sequence alignment


TH_0484|M.thermoresistible__bu      ------VSSSADVNTSRPVLVIDFGAQYAQLIARRIREARVYSEVVPHTA
MSMEG_1610|M.smegmatis_MC2_155      ----------MASESPRPVLVIDYGAQYAQLIARRVREARVYSEVVPHTA
Mflv_4903|M.gilvum_PYR-GCK          ----------MESAHPRPVLIVDFGAQYAQLIARRVREARVFSEVIPHTA
Mvan_1516|M.vanbaalenii_PYR-1       ----------MESATPRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTT
MLBr_00395|M.leprae_Br4923          --MADSAGLDQPEPSPRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTT
MAV_4348|M.avium_104                ------------------MLVVDFGAQYAQLIARRVREARVFSEVIPHTA
Mb3429c|M.bovis_AF2122/97           --MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTA
Rv3396c|M.tuberculosis_H37Rv        --MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTA
MMAR_1148|M.marinum_M               --MAEPVDLDVAGPVGRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTT
MUL_0913|M.ulcerans_Agy99           MPVAEPVDLDVAGPVGRPVLVVDFGAQYAQLIARRVREARVFSEVIPHTT
MAB_3718c|M.abscessus_ATCC_199      -------MAQTEQHGDRPVLVIDFGAQYAQLIARRVREARVFSEVIPHSA
                                                      :*::*:***********:*****:***:**::

TH_0484|M.thermoresistible__bu      TVEEIKAKDPQAIVLSGGPASVYAEDAPRLDPGLFDLGVPVFGICYGFQA
MSMEG_1610|M.smegmatis_MC2_155      GVEEIKAKDPQAIVLSGGPASVYSEGAPQLDPGLFDLDVPVFGICYGFQA
Mflv_4903|M.gilvum_PYR-GCK          SIEEIKARDPRAVVLSGGPSSVYADGAPQLDPALFDLDIPVFGICYGFQA
Mvan_1516|M.vanbaalenii_PYR-1       SVEEIKARNPRAVVLSGGPASVYADGAPQLDPALFDLDVPVFGICYGFQA
MLBr_00395|M.leprae_Br4923          SIEEITARDPLAIVLSGGPASVYTEGAPQLDPALFDLGLPVFGICYGFQA
MAV_4348|M.avium_104                TIEEIKARQPRALVLSGGPSSVYEPGAPQLDPAVFDLGVPVFGICYGFQA
Mb3429c|M.bovis_AF2122/97           SIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQA
Rv3396c|M.tuberculosis_H37Rv        SIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQA
MMAR_1148|M.marinum_M               SIEEIKARDPLALVLSGGPASVYAPGAPQLDPALFDLGLPVFGICYGFQV
MUL_0913|M.ulcerans_Agy99           SIEEIKARDPLALVLSGGPASVYAPGAPQLDPALFDLGLPVFGICYGFQV
MAB_3718c|M.abscessus_ATCC_199      SVEEIKGRNPRAIVLSGGPSSVYEEGAPQLDPGVFDLDVPVFGICYGFQA
                                     :*** .::* *:******:***  .**:***.::**.:**:*******.

TH_0484|M.thermoresistible__bu      MAQALGGTVTRTGTREYGRTELTVLGGQLHSDLPERQPVWMSHADAVTEA
MSMEG_1610|M.smegmatis_MC2_155      MAQALGGTVERTGTSEFGRTELQVTGGDLHSELPATQPVWMSHGDAVTAA
Mflv_4903|M.gilvum_PYR-GCK          MAQALGGTVARTGTSEYGRTELKVAGGELHSDLPEVQPVWMSHGDAVTEA
Mvan_1516|M.vanbaalenii_PYR-1       MAQALGGTVAHTGTSEYGRTELKVAGGQLHTDLPETQPVWMSHGDAVTAA
MLBr_00395|M.leprae_Br4923          MAQVLGGTVARTKTSEYGRTELKVLGGDLHSGLPGVQPVWMSHGDAVTAA
MAV_4348|M.avium_104                MAQALGGTVAHTGTSEYGRTELKVLGGELHSGLPGVQPVWMSHGDAVTAA
Mb3429c|M.bovis_AF2122/97           MAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAA
Rv3396c|M.tuberculosis_H37Rv        MAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAA
MMAR_1148|M.marinum_M               MAQALGGTVAHTGTSEYGRTELKVLGGDLHSDLPDIQPVWMSHGDAVTAA
MUL_0913|M.ulcerans_Agy99           MAQALGGTVAHTGTSEYGRTELKVLGGDLHSDLPDIQPVWMSHGDAVTAA
MAB_3718c|M.abscessus_ATCC_199      MAQVLGGTVAHTGTSEYGRTELTVAGGDLHEGLPDVQPVWMSHGDAVTEA
                                    ***.*** * :* * *:***** * **.**  **  *******.**** *

TH_0484|M.thermoresistible__bu      PAGFEVVATSPGSPVAAFEDPARRLAGVQYHPEVIHSPHGQQVLGRFLHE
MSMEG_1610|M.smegmatis_MC2_155      PEGFDVVASSAGAPVAGFENRARRLAGVQYHPEVLHSPHGQQVLSRFLHD
Mflv_4903|M.gilvum_PYR-GCK          PSGFEVVATSVGAPVAAFENRARRLAGVQYHPEVMHSPHGQQVLSRFLHE
Mvan_1516|M.vanbaalenii_PYR-1       PEGFEVVATSAGAPVAAFENRARRLAGVQYHPEVMHSPHGQQVLSRFLHE
MLBr_00395|M.leprae_Br4923          PDGFDVAASSSGAPVAAFENRDRRLAGVQYHPEVMHTPHGQQVLSRFLHD
MAV_4348|M.avium_104                PDGFEVVASSPGAVVAAFENRARRLAGVQYHPEVMHTPHGQQVLSRFLHD
Mb3429c|M.bovis_AF2122/97           PDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHD
Rv3396c|M.tuberculosis_H37Rv        PDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHD
MMAR_1148|M.marinum_M               PDGFEVVASSAGAAVAAFENRERRLAGVQYHPEVMHTPHGQQILGRFLHD
MUL_0913|M.ulcerans_Agy99           PDGFEVVASSAGAAVAAFENRERRLAGVQYHPEVMHTPHGQQILGRFLHD
MAB_3718c|M.abscessus_ATCC_199      PQGFTVVASSEGAPVAAFENRERRLAGVQYHPEVLHSPHGQQVLSRFLHE
                                    * ** *.*:* *: **.**   ************:*:*****:*.****:

TH_0484|M.thermoresistible__bu      FAGIGASWTPANIAESLIEQVREQIGDGRAICGLSGGVDSAVAAALVQRA
MSMEG_1610|M.smegmatis_MC2_155      FAGIDATWTPANIADQLIEAVREQIGDGRAICGLSGGVDSAVAAALVQRA
Mflv_4903|M.gilvum_PYR-GCK          FAGIDAAWTPANIAEALVEQVRNQIGDGRAICGLSGGVDSAVAAALVQRA
Mvan_1516|M.vanbaalenii_PYR-1       FAGIDATWTPANIAEALVEQVRTQIGDGRAICGLSGGVDSAVAAALVQRA
MLBr_00395|M.leprae_Br4923          FAGLDADWTAANIAGVLVEQVRAQIGNGHAICGLSGGVDSAVAAALVQRA
MAV_4348|M.avium_104                FAGLGADWTAANIAGVLVEQVRAQIGDGHAICGLSGGVDSAVAAALVQRA
Mb3429c|M.bovis_AF2122/97           FAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRA
Rv3396c|M.tuberculosis_H37Rv        FAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRA
MMAR_1148|M.marinum_M               FAGIGARWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRA
MUL_0913|M.ulcerans_Agy99           FAGIGARWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRV
MAB_3718c|M.abscessus_ATCC_199      FAGIESAWTAANIAETLVEQVRTQIGEGRALCALSGGVDSAVAAALVQRA
                                    ***: : **.****  *:* ** ***:*:*:*.****************.

TH_0484|M.thermoresistible__bu      IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGAKLVTVDTSERFLEALSG
MSMEG_1610|M.smegmatis_MC2_155      IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGAKLVTVDVADRFLEALTG
Mflv_4903|M.gilvum_PYR-GCK          IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDVADRFLEALSG
Mvan_1516|M.vanbaalenii_PYR-1       IGDRLTCVFVDHGLLRSGERAQVQRDFVAATGANLVTVDVADRFLEALSG
MLBr_00395|M.leprae_Br4923          IGDRLTCIFVDHGLLRDGERGQVQRDFVAATGAKLVTVDAAETFLQALSG
MAV_4348|M.avium_104                IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAADTFLQALAG
Mb3429c|M.bovis_AF2122/97           IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSG
Rv3396c|M.tuberculosis_H37Rv        IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSG
MMAR_1148|M.marinum_M               IGDRLTCVFVDHGLLRAGERAQVERDFVAATKANLVTVDVADTFLAALSG
MUL_0913|M.ulcerans_Agy99           IGDRLTCVFVDHGLLRAGERAQVERDFVAATKANLVTVDVADTFLAALSG
MAB_3718c|M.abscessus_ATCC_199      IGDRLTCVFVDHGLLRSGERAQVEHDFVAATGATLVTVDASETFLGELAG
                                    *******:******** ***.**::****** *.*****.:: **  *:*

TH_0484|M.thermoresistible__bu      VTNPEGKRKIIGREFIRAFEGAVREALGENAAANDDEVEFLVQGTLYPDV
MSMEG_1610|M.smegmatis_MC2_155      VTNPEGKRKIIGREFIRAFEGAVRDLVEDEGSG---DIDFLVQGTLYPDV
Mflv_4903|M.gilvum_PYR-GCK          VTNPEGKRKIIGREFIRAFEGAVRDTVERSDGS-DVPVEFLVQGTLYPDV
Mvan_1516|M.vanbaalenii_PYR-1       VTNPEGKRKIIGREFIRAFEGAVRDALESQDGS-DVPVEFLVQGTLYPDV
MLBr_00395|M.leprae_Br4923          VTNPEGKRKIIGRQFIRAFEGAVRDLLGDSTFD--SGIEFLVQGTLYPDV
MAV_4348|M.avium_104                VTNPEGKRKIIGRQFIRAFEGAVRDVLGD------KPVEFLVQGTLYPDV
Mb3429c|M.bovis_AF2122/97           VSAPEGKRKIIGRQFIRAFEGAVRDVLDG------KTAEFLVQGTLYPDV
Rv3396c|M.tuberculosis_H37Rv        VSAPEGKRKIIGRQFIRAFEGAVRDVLDG------KTAEFLVQGTLYPDV
MMAR_1148|M.marinum_M               VTDPEGKRKIIGRQFIRAFEGAVRDVLDG------RDIEFLVQGTLYPDV
MUL_0913|M.ulcerans_Agy99           VTDPEGKRKIIGRQFIRAFEGAVRDVLDG------RDVEFLVQGTLYPDV
MAB_3718c|M.abscessus_ATCC_199      VTDPEAKRKIIGREFIRSFEGAVSDVVGDSRRDDTAGIQFLVQGTLYPDV
                                    *: **.*******:***:***** : :           :***********

TH_0484|M.thermoresistible__bu      VESGGGAGTANIKSHHNVGGLPDDLKFKLVEPLRLLFKDEVRAVGRELGL
MSMEG_1610|M.smegmatis_MC2_155      VESGGGSGTANIKSHHNVGGLPDDLKFKLVEPLRLLFKDEVRAVGRELGL
Mflv_4903|M.gilvum_PYR-GCK          VESGGGSGTANIKSHHNVGGLPDDLKFALVEPLRLLFKDEVRAVGRELGL
Mvan_1516|M.vanbaalenii_PYR-1       VESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
MLBr_00395|M.leprae_Br4923          VESGGGSGTANIKSHHNVGGLPDNLRFKLVEPLRLLFKDEVRAVGRQLDL
MAV_4348|M.avium_104                VESGRGSGTANIKSHHNVGGLPGDLKFTLVEPLRLLFKDEVRAVGRELGL
Mb3429c|M.bovis_AF2122/97           VESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
Rv3396c|M.tuberculosis_H37Rv        VESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
MMAR_1148|M.marinum_M               VESGGGSGTANIKSHHNVGGLPDDLKFALVEPLRLLFKDEVRAVGRELGL
MUL_0913|M.ulcerans_Agy99           VESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
MAB_3718c|M.abscessus_ATCC_199      VESGGGSGTANIKSHHNVGGLPEDLTFTLVEPLRLLFKDEVRAVGRELGL
                                    **** *:*************** :* * ******************:*.*

TH_0484|M.thermoresistible__bu      PEEIVARQPFPGPGLAIRIVGEVTAERLETLRRADAIVREELTAAGLDHQ
MSMEG_1610|M.smegmatis_MC2_155      PEEIVARQPFPGPGLGIRIVGEVTAERLETLRRADAIAREELTAAGLDNQ
Mflv_4903|M.gilvum_PYR-GCK          PEEIVARQPFPGPGLGIRIIGEVTSDRLDTLRRADVIAREELTAAGLDHQ
Mvan_1516|M.vanbaalenii_PYR-1       PEEIVARQPFPGPGLGIRIVGEVTAERLDTLRRADAIAREELTSAGLDHQ
MLBr_00395|M.leprae_Br4923          PEEIVARQPFPGPGLGIRIVGEVTAERLDTLRRADSIAREELTTAGLDYQ
MAV_4348|M.avium_104                PEEIVARQPFPGPGLGIRIVGEVTATRLDTLRRADSIAREELTAAGLDSL
Mb3429c|M.bovis_AF2122/97           PEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQ
Rv3396c|M.tuberculosis_H37Rv        PEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQ
MMAR_1148|M.marinum_M               PEEIVARQPFPGPGLGIRIVGEVTGQRLDTLRRADSIAREELTAAGLDNQ
MUL_0913|M.ulcerans_Agy99           PEEIVARQPFPGPGLGIRIVGEVTGQRLDTLRRADSIARKELTAAGLDNQ
MAB_3718c|M.abscessus_ATCC_199      PEEIVGRQPFPGPGLAIRIVGEVTPDRLDTLRRADAIAREELTAAGQDRN
                                    *****.*********.***:****  **:***:** *.*:***:** *  

TH_0484|M.thermoresistible__bu      IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYDV
MSMEG_1610|M.smegmatis_MC2_155      IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
Mflv_4903|M.gilvum_PYR-GCK          IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
Mvan_1516|M.vanbaalenii_PYR-1       IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
MLBr_00395|M.leprae_Br4923          IWQCPVVLLADVRSVGVQGDNRSYGHPIVLRPVSSEDAMTADWTWVPYEV
MAV_4348|M.avium_104                IWQCPVVLLGEVRSVGVQGDNRTYGHPIVLRPVTSEDAMTADWTRVPYEV
Mb3429c|M.bovis_AF2122/97           IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
Rv3396c|M.tuberculosis_H37Rv        IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEV
MMAR_1148|M.marinum_M               IWQCPVVLLADVRSVGVQGDNRTYGHPIVLRPVSSEDAMTADWTRVPFEV
MUL_0913|M.ulcerans_Agy99           IWQCPVVLLADVRSVGVQGDNRTYGHPIVLRPVSSEDAMTADWTRVPFEV
MAB_3718c|M.abscessus_ATCC_199      IWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRLPYEV
                                    *********.:*********.*:**********:********** :*::*

TH_0484|M.thermoresistible__bu      LERISTRITNEVAEVNRVVLDITSKPPATIEWE
MSMEG_1610|M.smegmatis_MC2_155      LERISTRITNEVREVNRVVLDITSKPPGTIEWE
Mflv_4903|M.gilvum_PYR-GCK          LERISTRITNEVPEVNRVVLDITSKPPGTIEWE
Mvan_1516|M.vanbaalenii_PYR-1       LERISTRITNEVREVNRVVLDVTSKPPGTIEWE
MLBr_00395|M.leprae_Br4923          LECISTRITNEVAEVNRVVLDITNKPPGTIEWE
MAV_4348|M.avium_104                LERISTRITNEVPEVNRVVLDITSKPPGTIEWE
Mb3429c|M.bovis_AF2122/97           LERISTRITNEVAEVNRVVLDITSKPPATIEWE
Rv3396c|M.tuberculosis_H37Rv        LERISTRITNEVAEVNRVVLDITSKPPATIEWE
MMAR_1148|M.marinum_M               LERISTRITNEVPEVNRVVLDVTSKPPGTIEWE
MUL_0913|M.ulcerans_Agy99           LERISTRITNEVPEVNRVVLDVTSKPPGTIEWE
MAB_3718c|M.abscessus_ATCC_199      LERISTRITNEVPEVNRVVLDITSKPPGTIEWE
                                    ** ********* ********:*.***.*****