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SLEEHKRRERANAIGLFRYQLICPALEDGLSTRQRGRLVREIAERRHIDPFGTQVQIARATLDRWIRRYR GGGFEALVPEPRRLATRTDTQVLELAASLKRENPARTVAQVARILRTATGWAPSESTLLRHFHRCELMGP AAGQSAEVFGRFEAADPNELWVGDALHGPRVGDRKTYLFAFLDDHSRLVVGHRFGFAEDTVRLAAALKPA LAARGVPAGIYVDNGSAFVDAWLLRACAKLGIRLVHSAPGRPQGRGKIERFFRTVREQFLVEVTDTTAED LTAAGVDHTGALLELNRLFMAWVETEYHRRTHTETGQSPLARWETGWDRLGALPALPTAADLTEAFLWSE FRVVTKTATVSLHSNIYRVDPALAGRRVELVFSPFDLQAIEVRHQDRSYGPAVAHTITRHAHPKARPETR GEAPPAATGIDYLALTAANHHAQLRDDERIGYHALYGTQAATDDTAGDDQVLGQLSITDLEPGGRTGASA DHEGEVSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2928 | - | - | 100% (499) | integrase catalytic subunit |
| M. vanbaalenii PYR-1 | Mvan_2501 | - | 0.0 | 100.00% (499) | integrase catalytic subunit |
| M. vanbaalenii PYR-1 | Mvan_1688 | - | 0.0 | 100.00% (499) | integrase catalytic subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2836 | - | 8e-84 | 60.29% (277) | transposase |
| M. gilvum PYR-GCK | Mflv_3183 | - | 1e-08 | 26.38% (235) | integrase catalytic subunit |
| M. tuberculosis H37Rv | Rv2812 | - | 1e-158 | 61.26% (475) | transposase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4893c | - | 2e-13 | 26.74% (258) | integrase/transposase |
| M. marinum M | MMAR_4106 | - | 3e-20 | 25.29% (435) | transposase for ISMyma05 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_6888 | - | 2e-07 | 29.27% (164) | transposase subunit |
| M. thermoresistible (build 8) | TH_3163 | - | 2e-09 | 23.94% (259) | PUTATIVE putative Integrase, catalytic region |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2836|M.bovis_AF2122/97 --------------------------------------------------
Rv2812|M.tuberculosis_H37Rv -------------------------------------------------M
Mvan_2928|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4106|M.marinum_M --------------------------------------------------
TH_3163|M.thermoresistible__bu --------------------------------------------------
MAB_4893c|M.abscessus_ATCC_199 MTAGAERFGIGTRFVYEGQIIDVVQLRSTPKGPEVIASNGLEVMHVALKE
Mflv_3183|M.gilvum_PYR-GCK ------------------------------------MLWSVEALEGVPEE
MSMEG_6888|M.smegmatis_MC2_155 --------------------------------------------------
Mb2836|M.bovis_AF2122/97 --------------------------------------------------
Rv2812|M.tuberculosis_H37Rv AVGDDEEKVRAERARAIGLFRYQLIWEAADAAHSTKQRGKMVRELASREH
Mvan_2928|M.vanbaalenii_PYR-1 --MSLEEHKRRERANAIGLFRYQLICPALEDGLSTRQRGRLVREIAERRH
MMAR_4106|M.marinum_M ---------------------------MLQELRMSEMRYRAVLEVLDGAP
TH_3163|M.thermoresistible__bu ---------------------------MAQKVTAMDIR-MAAAVAGEIDN
MAB_4893c|M.abscessus_ATCC_199 LLQSSRARLIPTEDGPSADDEQETAAMMLAQLSKAELKTVRERAAHVREV
Mflv_3183|M.gilvum_PYR-GCK VADRARWWEQHIVEVLTGRRPESPPGQPIRPEFDPAVRSLRQRELTKLEE
MSMEG_6888|M.smegmatis_MC2_155 -------------------------------------------MTCR---
Mb2836|M.bovis_AF2122/97 --------------------------------------------------
Rv2812|M.tuberculosis_H37Rv TDPFGR------------------------------RVRISRQTIDRWIR
Mvan_2928|M.vanbaalenii_PYR-1 IDPFGT------------------------------QVQIARATLDRWIR
MMAR_4106|M.marinum_M VTAVAR------------------------------RFGVSRQTVHAWLR
TH_3163|M.thermoresistible__bu VAEFCR------------------------------RRKISRQTFYKFRR
MAB_4893c|M.abscessus_ATCC_199 LTGFRRGSEHIKEPDEPRPGFDPCGALADRYKAKAEQLNTSVRTVQRWVS
Mflv_3183|M.gilvum_PYR-GCK LRAAGH--------------------------------DLALITLQRQRS
MSMEG_6888|M.smegmatis_MC2_155 ------------------------------------VLKLARQPYYRWRA
Mb2836|M.bovis_AF2122/97 --------------------------------------------------
Rv2812|M.tuberculosis_H37Rv GWRAG----GFDALVPNPRQCTPRTPAEVLELAVALR-----------RE
Mvan_2928|M.vanbaalenii_PYR-1 RYRGG----GFEALVPEPRRLATRTDTQVLELAASLK-----------RE
MMAR_4106|M.marinum_M RYAEEGAALNLEDRSSRPHRCPHQMPVEVEARVLTLR-----------DA
TH_3163|M.thermoresistible__bu RFRDSG-IEGLQELSRRPLTSPGQTPVEVEDLIVLRRK-----Q--LIEQ
MAB_4893c|M.abscessus_ATCC_199 NYRRFGEAGLVDHRKPRQLGVDQRWVDEALAVMVERTN-----ESRCTRK
Mflv_3183|M.gilvum_PYR-GCK RYEAKGLLGLVDGRYLAKRPVLGRVDERVVAVVRRLIDNETELSTGTVSR
MSMEG_6888|M.smegmatis_MC2_155 N-------PITDAEIIEAYRANALFDAHRDDPEFGYR---------YLVE
Mb2836|M.bovis_AF2122/97 --------------------------------------------------
Rv2812|M.tuberculosis_H37Rv NPQR-TAAAIRRILRTQLGWAPDERTLQR----------NFHRLGLTGAT
Mvan_2928|M.vanbaalenii_PYR-1 NPAR-TVAQVARILRTATGWAPSESTLLR----------HFHRCELMGPA
MMAR_4106|M.marinum_M HPRWGPTRIVYELQRDVVPVVPGRSSVYR----------ALVRNGRIDPA
TH_3163|M.thermoresistible__bu GRDHGAQSIVWSFERDGVTVPSVSTVWQRGW-------QILSRRGAITPQ
MAB_4893c|M.abscessus_ATCC_199 LVMWEATKRIEQRYGTGSVQIPSKTTAYKVLKILETRYPAFRLSAARNRD
Mflv_3183|M.gilvum_PYR-GCK LQRKLEKALLAEYGPDDAPKAPSQATFYRLVKRLEEG-KHTFGSARTRRS
MSMEG_6888|M.smegmatis_MC2_155 EARDAGETMAERTAWRICSQNRLWSVFGK------------KRGKNGKVG
Mb2836|M.bovis_AF2122/97 --------------------------------------------------
Rv2812|M.tuberculosis_H37Rv TG-SAPAVFGRFEAEHPNALWTGD------VLHGIRIDL-RKTYLFAFLD
Mvan_2928|M.vanbaalenii_PYR-1 AG-QSAEVFGRFEAADPNELWVGD------ALHGPRVGD-RKTYLFAFLD
MMAR_4106|M.marinum_M KRRRRRSDYKRWERGRPMELWQMD------VVGGLHLRDGIEVKVVTGID
TH_3163|M.thermoresistible__bu PQKRPKSATKRFVFSCPNECWQSD------WTG-WVLADGSPAGIAGSLD
MAB_4893c|M.abscessus_ATCC_199 IAGRPQEPYGKLKPTRPGEFMLMDTTPLDVFAYDPATSRSIRVELTVAMD
Mflv_3183|M.gilvum_PYR-GCK LAKQPDGPFGTVTAARPGEMVEIDSTP-LDVRVVLDDGVVDRVELTAMVD
MSMEG_6888|M.smegmatis_MC2_155 PPVHDDLVERDFTAGGPNQLWLSD--------ITEHRTDEGKLYLCAIKD
Mb2836|M.bovis_AF2122/97 ------------------MRLAAALRPALA---------------SRGVP
Rv2812|M.tuberculosis_H37Rv DHSRLVPGYRWGH-AEDTVRLAAALRPALA---------------SRGVP
Mvan_2928|M.vanbaalenii_PYR-1 DHSRLVVGHRFGF-AEDTVRLAAALKPALA---------------ARGVP
MMAR_4106|M.marinum_M DNSRFVVSAKVVA-RATARPVCAALLEALR---------------RHGVP
TH_3163|M.thermoresistible__bu DHSRYVPALRACAGDADAQLVWETMLAGIA---------------ECGIP
MAB_4893c|M.abscessus_ATCC_199 WYTRCITALRLTPVSTKAVDVAAVLYQLYRPLPAGPNWPDHACWPEHGVP
Mflv_3183|M.gilvum_PYR-GCK NVTRSIPAAVLRP-TTKAVDAALLLAKALTPEPMRPGWSDALRLSRSVLP
MSMEG_6888|M.smegmatis_MC2_155 VFSNRIVGYSIDARMKSRLATTALSSAVAR---------------RGDVA
:.
Mb2836|M.bovis_AF2122/97 NAVYVD------NGSPYV--------------------------------
Rv2812|M.tuberculosis_H37Rv NAVYVD------NGSPYV--------------------------------
Mvan_2928|M.vanbaalenii_PYR-1 AGIYVD------NGSAFV--------------------------------
MMAR_4106|M.marinum_M EQILTD------NGKVFTGRFGPGG----------------------SSA
TH_3163|M.thermoresistible__bu SMSLTD------NGIVYTG----RF----------------------HAH
MAB_4893c|M.abscessus_ATCC_199 RSVLIDPDAIDYTGAKYPQKHEQQAGPPTRSGGPAIVPETIVIDHGKIYV
Mflv_3183|M.gilvum_PYR-GCK HRRLTDIDQRLADAAARPVIAPETIVCDHG----------------KAFL
MSMEG_6888|M.smegmatis_MC2_155 GCILHS-----DRGSQFR--------------------------------
. .
Mb2836|M.bovis_AF2122/97 DAWLLRACAKLGVRLVHSTPGRPQGRGKIERFFRTVREQFLVEITG----
Rv2812|M.tuberculosis_H37Rv DAWLLRACAKLGVRLVHSTPGRPQGRGKIERFFRTVREQFLVEITG----
Mvan_2928|M.vanbaalenii_PYR-1 DAWLLRACAKLGIRLVHSAPGRPQGRGKIERFFRTVREQFLVEVTDTT--
MMAR_4106|M.marinum_M EVLFDRVCVENGIGHLLTAPRSPTTTGKVERLHKTMRAEIFAEVDG----
TH_3163|M.thermoresistible__bu QSAFETNLRALGVQTINATPFHPQTCGKIERFWQTLKKWLTARDPA----
MAB_4893c|M.abscessus_ATCC_199 SEHINSVCARMGISIQPVRLGEGRDKGPVERFFRSVRQGVLEFLPGYAGP
Mflv_3183|M.gilvum_PYR-GCK SKTFEQACCSLGINLQPAHPDQPTDKPKVERTLQSVGTLFAQYVAGYVGS
MSMEG_6888|M.smegmatis_MC2_155 SRRFVRVLGRHEMVGSMGRVGAAGDNAAMESFFALLQKNVLDRRRWR---
. : : :* : .
Mb2836|M.bovis_AF2122/97 ----EPDVVGRHYVADLAELNRLFTAWVETVYHRSVHS-------ETGQT
Rv2812|M.tuberculosis_H37Rv ----EPDVVGRHYVADLAELNRLFTAWVETVYHRSVHS-------ETGQT
Mvan_2928|M.vanbaalenii_PYR-1 --AEDLTAAGVDHTGALLELNRLFMAWVETEYHRRTHT-------ETGQS
MMAR_4106|M.marinum_M ------------VFDAIAELQAAIDRWVQYYNTARPHQ-------SLGMV
TH_3163|M.thermoresistible__bu --------------TTIAELNALLEQFRTFYNHQRPHR-------AHRGA
MAB_4893c|M.abscessus_ATCC_199 DIASRGLDPQAQAELYIDELEELLRQWVAVYYHHRPHSGLVDPHLPSARM
Mflv_3183|M.gilvum_PYR-GCK SVERRGKNADQDAVWSLVELQALLDEWLVAVWQNRPHDGLRDPVTPGKAL
MSMEG_6888|M.smegmatis_MC2_155 ---------------TREELRIAIVTWIERTYHRRRRQ------AGLGRL
**. : : :
Mb2836|M.bovis_AF2122/97 -PLARWSAG--------GPIP-LPAPETLTEAFLWEEHR-----------
Rv2812|M.tuberculosis_H37Rv -PLARWSAG--------GPIP-LPAPETLTEAFLWEEHR-----------
Mvan_2928|M.vanbaalenii_PYR-1 -PLARWETGW----DRLGALPALPTAADLTEAFLWSEFR-----------
MMAR_4106|M.marinum_M APAARFALAAGPDLSVVEPVAAVPAEGQHPGALVDLRDAGVR--------
TH_3163|M.thermoresistible__bu LPAEVFAAG----------DKARPADRPVPAPVIVSRHT-----------
MAB_4893c|M.abscessus_ATCC_199 SPAQMYEHGLAG-----AGFIEIPRDPDLAYEFLRPELRTIQPYGVQVDN
Mflv_3183|M.gilvum_PYR-GCK TPNEKFAALVEV-----AGYVPVPLSADAYIELLPATWRTIGSAG-----
MSMEG_6888|M.smegmatis_MC2_155 TPIEFEAIMT------------TPASQAA---------------------
* *
Mb2836|M.bovis_AF2122/97 ---RVTKTATVSLHGNRYEIDPALVG--RKVELVFDPFDLTRIEVRLAGA
Rv2812|M.tuberculosis_H37Rv ---RVTKTATVSLHGNRYEIDPALVG--RKVELVFDPFDLTRIEVRLAGA
Mvan_2928|M.vanbaalenii_PYR-1 ---VVTKTATVSLHSNIYRVDPALAG--RRVELVFSPFDLQAIEVRHQDR
MMAR_4106|M.marinum_M --RWVNRHGSISVAGFRYRVPIVLAG--EPVSVVVADN---LVSIYHHDV
TH_3163|M.thermoresistible__bu ---VGPTSGYVFVAPYKVNVGLRWAG--HECDIIRDGQ---HITILSGTT
MAB_4893c|M.abscessus_ATCC_199 RIYRGLPQDETHILGELANLPSPYGR--HRWPVYSDPDDIRYVYVRHPDN
Mflv_3183|M.gilvum_PYR-GCK -IRVNHRTYDARALNPYRRVDSGVRSRNGRWEVHYDPYDVSQIWVRNHHD
MSMEG_6888|M.smegmatis_MC2_155 --------------------------------------------------
Mb2836|M.bovis_AF2122/97 P--------MGRAIPYHIGRHSHPKAKPETP-TAPPKPSGIDYAQLIE--
Rv2812|M.tuberculosis_H37Rv P--------MRRAIPYHIGRHSHPKAKPETP-TAPPKPSGIDYAQLIE--
Mvan_2928|M.vanbaalenii_PYR-1 S--------YGPAVAHTITRHAHPKARPETRGEAPPAATGIDYLALTA--
MMAR_4106|M.marinum_M L--------VASHVQHRKTDNTTGVVRQGRR-TARPVTSGIVVTRVVD--
TH_3163|M.thermoresistible__bu L--------VRSFTADPTRNYQRGDKTTRTYRTREPKPPS----------
MAB_4893c|M.abscessus_ATCC_199 RRWHTLTWELADALNMPMSDERLSYLRRQAAQQHEEFDDRLILDELLSGW
Mflv_3183|M.gilvum_PYR-GCK DGWITATWTHMRTAAVPFGDTVWKQAQAIVAERGADPVTEAEIAAAADAL
MSMEG_6888|M.smegmatis_MC2_155 --------------------------------------------------
Mb2836|M.bovis_AF2122/97 ------TAHAAELARG--VNYTALTG---------AADQIPGQLDL----
Rv2812|M.tuberculosis_H37Rv ------TAHAAELARG--VNYTALTG---------AADQIPGQLDL----
Mvan_2928|M.vanbaalenii_PYR-1 ------ANHHAQLRDDERIGYHALYGTQAATDDTAGDDQVLGQLSIT---
MMAR_4106|M.marinum_M ------SNGDVSFAGTMYRAGRVWRGKQVEVSIVAESVQIACAGAIVRTH
TH_3163|M.thermoresistible__bu --------------------------------------------------
MAB_4893c|M.abscessus_ATCC_199 NLSMGTSTTEKRIALRMSRPHATLSYQIQQIGPRPSRPETGQLAPDTAPE
Mflv_3183|M.gilvum_PYR-GCK LDRAERGPDTQQDPPAARRAAARARSIPEPSWPHPSVEGTNQNQEPS---
MSMEG_6888|M.smegmatis_MC2_155 --------------------------------------------------
Mb2836|M.bovis_AF2122/97 --------LTGQEAQPK---------------------------------
Rv2812|M.tuberculosis_H37Rv --------LTGQEAQPK---------------------------------
Mvan_2928|M.vanbaalenii_PYR-1 --DLEPGGRTGASADHEGEVSA----------------------------
MMAR_4106|M.marinum_M AIRHDRAKEHGAFATPHGRPRKPRQDAPDGPGAKATPLRGRPEGRALTPA
TH_3163|M.thermoresistible__bu --------------------------------------------------
MAB_4893c|M.abscessus_ATCC_199 PLLAQGTSAIAADIQIEGTAARCRAAAQASDDDDDDELDDFYAGALEEA-
Mflv_3183|M.gilvum_PYR-GCK --------EVSTDRPANSDDDDLADVIPLPVFDARKEAEQWHW-------
MSMEG_6888|M.smegmatis_MC2_155 --------------------------------------------------
Mb2836|M.bovis_AF2122/97 -
Rv2812|M.tuberculosis_H37Rv -
Mvan_2928|M.vanbaalenii_PYR-1 -
MMAR_4106|M.marinum_M P
TH_3163|M.thermoresistible__bu -
MAB_4893c|M.abscessus_ATCC_199 -
Mflv_3183|M.gilvum_PYR-GCK -
MSMEG_6888|M.smegmatis_MC2_155 -