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PDFDADFDVVVAGSGGGIAGAYTAAREGLSVLLVEATDKFGGTTAYSGGGGTWYPCNPVLRRAGTDDTIA AALDYFHAVVGDRTPRDLQDTYVRGGAPFIEYLEQDPGFEFMVLPWPDYYGSAPGARDDGYRHIIPLPLP DSDLGRYAGQVRGPLDTERLGTPAPDVLAGGRALVGRFLAALDKLPNVTCWRNAPLEELITDDGRVVGAM IVHDGTPVRIRTRRGVLLASGGFEQNADMRTAYGVPGSANDTMGGPGSTGGAHRAAIAVGADLDLMDQAW WSPGMTHPDGRSAFALWFTGGIFVNQDGHRFVNESAPYDRLGREVIRQIDSGATTPPFWMVYDDRAGDIP PVSATNVSMVEAAQYREAGLWHTADTIEGLAEAIGVPPAELKYTIERFNTLAAAGVDEDFGRGGEAYDRV FTGGSSPLVPIDTPPYHAAAFGLSDLGTKGGLRTDTRARVLTADGTPIPGLYAAGNTMAAVSGTTYPGGG NPIGASMLFSHLAALDMTGSPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2865 | - | - | 100% (513) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5210 | - | 0.0 | 66.67% (510) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4243 | - | 2e-81 | 37.39% (575) | 3-ketosteroid-delta-1-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3567 | - | 6e-78 | 36.82% (554) | 3-ketosteroid-delta-1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1547 | - | 0.0 | 65.69% (510) | 3-ketosteroid-delta-1-dehydrogenase |
| M. tuberculosis H37Rv | Rv3537 | - | 7e-78 | 36.82% (554) | 3-ketosteroid-delta-1-dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0622c | - | 7e-81 | 38.10% (559) | 3-ketosteroid-delta-1-dehydrogenase |
| M. marinum M | MMAR_5024 | - | 1e-79 | 37.19% (562) | dehydrogenase |
| M. avium 104 | MAV_4249 | - | 0.0 | 69.11% (505) | 3-ketosteroid-delta-1-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2867 | - | 0.0 | 80.59% (505) | 3-ketosteroid-delta-1-dehydrogenase |
| M. thermoresistible (build 8) | TH_3671 | - | 1e-161 | 82.87% (321) | PUTATIVE fumarate reductase/succinate dehydrogenase |
| M. ulcerans Agy99 | MUL_4098 | - | 3e-80 | 37.37% (562) | 3-ketosteroid-delta-1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2865|M.vanbaalenii_PYR-1 MPD-----------FDADFDVVVAGSG-GGIAGAYTAAREGLSVLLVEAT
MSMEG_2867|M.smegmatis_MC2_155 MPDQRSE----SGRFDVEVDVLVAGSG-GGVAGAYTAAREGLSVLLVEAT
Mflv_1547|M.gilvum_PYR-GCK MAPLESPGEEPTTTWDEVTDVLVAGSGAGGVTGAYTAAREGLDVILVEAT
MAV_4249|M.avium_104 MG---------TVQWTAECDVLVAGSGAGGVTGAYTAAREGLEVLLVEAT
TH_3671|M.thermoresistible__bu MSD------------DIVVDVLVAGSG-GGLAGVYTAARAGLSVLLVEAT
Mb3567|M.bovis_AF2122/97 -------------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKA
Rv3537|M.tuberculosis_H37Rv -------------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKA
MMAR_5024|M.marinum_M ----------MFYMTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKA
MUL_4098|M.ulcerans_Agy99 -------------MTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKA
MAB_0622c|M.abscessus_ATCC_199 -------------MTEQEYDVVVVGSGGAGMVAALTAAHNGLSTVLIEKA
**:*.*** .*:... .**: **..:::* :
Mvan_2865|M.vanbaalenii_PYR-1 DKFGGTTAYSGGGGTWYPCNPVLRRAGTDDTIAAALDYFHAVVG----DR
MSMEG_2867|M.smegmatis_MC2_155 DKFGGTTAFSGGGGMWFPCNPVLERAGTDDTLDEALKYFHAVVG----DR
Mflv_1547|M.gilvum_PYR-GCK EKFGGTTAYSGGGGMWFPCNPVLMRAGVDDTIEDALEYYTSVVG----DR
MAV_4249|M.avium_104 SKFGGTTAYSGGGGVWFPCNPVLIRAGTDDTIEDALTYYHAVVG----DR
TH_3671|M.thermoresistible__bu DKFGGTTAYSGGGGMWYPCNPVVRRAGTDDTIADALEYFHAVVG----DR
Mb3567|M.bovis_AF2122/97 PHYGGSTARSGGG-VWIPNNEVLKRRGVRDTPEAARTYLHGIVG----EI
Rv3537|M.tuberculosis_H37Rv PHYGGSTARSGGG-VWIPNNEVLKRRGVRDTPEAARTYLHGIVG----EI
MMAR_5024|M.marinum_M AHYGGSTARSGGG-VWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVSG
MUL_4098|M.ulcerans_Agy99 AHYGGSTARSGGG-VWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVSG
MAB_0622c|M.abscessus_ATCC_199 PHFGGSTARSGGG-VWIPNNEVLKKARQTDTPEAAREYLYSIIG----DV
::**:** **** * * * :: : ** * * .::* .
Mvan_2865|M.vanbaalenii_PYR-1 TPRDLQDTYVRGGAPFIEYLEQDPGFEFMVLP-WPDYYGSAPGARDDGYR
MSMEG_2867|M.smegmatis_MC2_155 TPQELQDAYVTGGAGFIAYLEQDHGFEFAVLP-WPDYYGSVPGARNDGYR
Mflv_1547|M.gilvum_PYR-GCK TPRALQETYVRSGAPLVEYLEADELINFSLLP-WPDYFGAAPKARADGMR
MAV_4249|M.avium_104 TPRELQETYVRGGAPLIEYLEADPHLAFVPLP-WPDYYGKAPKARLDGQR
TH_3671|M.thermoresistible__bu TPRDLQDAYVTGGAGFIEFLEQDPHFEFTVLP-WPDYYGSAPGARNDGYR
Mb3567|M.bovis_AF2122/97 VEPERIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGG-R
Rv3537|M.tuberculosis_H37Rv VEPERIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGG-R
MMAR_5024|M.marinum_M VEPERIDTYLERGPEMLSFVLEHTPLKMCWVPGYSDYYPEAPGGRSGG-R
MUL_4098|M.ulcerans_Agy99 VEPERIDTYLERGPEMLSFVLEHTPLKMCWVPGYSDYYSEAPGGRSGG-R
MAB_0622c|M.abscessus_ATCC_199 VPREKIDTYLDRGPEMLSFVLANSPLKLDWVPNYSDYYPEAPGGRAAG-R
. ::*: *. :: :: . : : :* :.**: .* .* * *
Mvan_2865|M.vanbaalenii_PYR-1 HIIPLPLPD----------------------------SDLGRYAGQVRGP
MSMEG_2867|M.smegmatis_MC2_155 HIVPKPLPD----------------------------SALGSYQGLVRGP
Mflv_1547|M.gilvum_PYR-GCK HIAAKPWKV----------------------------AAAPHLRELVRGP
MAV_4249|M.avium_104 HIAAKPLPV----------------------------AAAPEFRTVIRGP
TH_3671|M.thermoresistible__bu HIVPVPLPD----------------------------DALGRHAGLVRGP
Mb3567|M.bovis_AF2122/97 SIEPKPFNARKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGV
Rv3537|M.tuberculosis_H37Rv SIEPKPFNARKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGV
MMAR_5024|M.marinum_M SIEPKPFDARKLGADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGV
MUL_4098|M.ulcerans_Agy99 SIEPKPFDARKLGADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGV
MAB_0622c|M.abscessus_ATCC_199 SVEPKPFDAKKLGDELPNLEPPYGKVPLNVVVRQQDYVRLNQLKRHPRGV
: . * **
Mvan_2865|M.vanbaalenii_PYR-1 LDTERLGTPAP-DVLAG------GRALVGRFLAALDKLPNVTCWRNAPLE
MSMEG_2867|M.smegmatis_MC2_155 LDTERLGAPAP-DTLIG------GRALVGRFLAALDKLPNADCWCEAPLT
Mflv_1547|M.gilvum_PYR-GCK LDSDRLGAPQPDDYFVG------GRALIARLLAAAQRHPNSSARLNTALV
MAV_4249|M.avium_104 LDTDRLGAEPPSDYYLG------GRALIARFLRAIGEFPTATLRRDTALV
TH_3671|M.thermoresistible__bu LDTERLGTPAP-DVLVG------GRALVGRFLAALGGFPDVTCWRNTPLT
Mb3567|M.bovis_AF2122/97 LRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRA-GVPVELNTAFT
Rv3537|M.tuberculosis_H37Rv LRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRA-GVPVELNTAFT
MMAR_5024|M.marinum_M LRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRK-GVPVQLNTALT
MUL_4098|M.ulcerans_Agy99 LRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRK-GVPVQLNTALT
MAB_0622c|M.abscessus_ATCC_199 LRSLRVGVRTFWAQGTGKKLVGMGRALSAALRIGLRDA-GVPVKLNTALT
* : ::*. * **** . : . ::.:
Mvan_2865|M.vanbaalenii_PYR-1 ELITDDGRVVGAMIVHDGT-----PVRIRTRRGVLLASGGFEQNADMRTA
MSMEG_2867|M.smegmatis_MC2_155 ELITESGRVVGAIVERGGE-----RLRVCARRGVLLASGGFEQNADMRGR
Mflv_1547|M.gilvum_PYR-GCK ELVVEDGAVVGAVVDADGE-----RRSIRTRRGVLLAAGGFEHNDDMRAR
MAV_4249|M.avium_104 ELVRTDGRVVGAVVETGGE-----RRAVRARRGVLLAAGGFEANPDLRRA
TH_3671|M.thermoresistible__bu ELICDGDRVVGAVVVRDGT-----PVRVRARRGVLLAAGGFERNADMRAR
Mb3567|M.bovis_AF2122/97 DLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIK
Rv3537|M.tuberculosis_H37Rv DLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIK
MMAR_5024|M.marinum_M DLYLEDGMVRGIYVRSTDAQESEEPQLIRARKGVILACGGFDHNEQMRVK
MUL_4098|M.ulcerans_Agy99 DLYLEDGVVRGIYVRSTDAHESEEPQLIRARKGVILACGGFDHNEQMRVK
MAB_0622c|M.abscessus_ATCC_199 DLYIEDGTVRGVYVRETGAPEASEPTLIRGRRGVILASGGFEHNEQMRVK
:* .. * * : : *:**:**.***: * ::*
Mvan_2865|M.vanbaalenii_PYR-1 YG-VPGSANDTMGGPGSTGGAHRAAIAVGADLDLMDQAWWSPGMTHPDGR
MSMEG_2867|M.smegmatis_MC2_155 YG-VPGSATDTMGGPGSTGAAHRAAMAVGADVDLMDQAWWSPGLTHPDGR
Mflv_1547|M.gilvum_PYR-GCK YG-VPGSSRDTMGPWGNRGLAHQAGIAVGADTDLMDQAWWSPGLTHPDGT
MAV_4249|M.avium_104 YG-VPGQARDTMGGPGSRGLALQAGIAVGADTDLLDQAWWSPGLTHPDGR
TH_3671|M.thermoresistible__bu YG-VPGDATDTMGAPGNTGAAHLAAIAAGADTDLMDQAWWSPGLTHPDGR
Mb3567|M.bovis_AF2122/97 YQRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGP-TVPLVGK
Rv3537|M.tuberculosis_H37Rv YQRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGP-TVPLVGK
MMAR_5024|M.marinum_M YQRAPITTDWTVGAKANTGDGIVAAEKLGAALDLMEDAWWGP-TVPLVGR
MUL_4098|M.ulcerans_Agy99 YQRAPITTDWTVGAKANTGDGIVAAEKLGAALDLMEDAWWGP-TVPLVGR
MAB_0622c|M.abscessus_ATCC_199 YQRAPITTEWTVGAKANTGDGILAAEKLGAALEFMEDSWWGP-TVPLVGR
* .* : *:* .. * . *. ** ::::::**.* . *
Mvan_2865|M.vanbaalenii_PYR-1 SAFALWFT---GGIFVNQDGHRFVNESAPYDRLGREVIRQIDSGA----T
MSMEG_2867|M.smegmatis_MC2_155 SAFALWFT---GGIFVDQDGKRFVNESAPYDRLGRAVIERLESGR----L
Mflv_1547|M.gilvum_PYR-GCK SAFALWFT---GGIFVDDHGRRFVNESAAYDRLGRAVLAAVDDGR----V
MAV_4249|M.avium_104 SAFALWFT---GGIFVNQSADRFVNESMAYDRAGRQILAHLRDGS----L
TH_3671|M.thermoresistible__bu SAFALWFT---GGIFVDQNGRRFVNESAPYDRLGREGXXXAGGHR----V
Mb3567|M.bovis_AF2122/97 PWFALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGE
Rv3537|M.tuberculosis_H37Rv PWFALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGE
MMAR_5024|M.marinum_M PWFALSERNSPGSIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGE
MUL_4098|M.ulcerans_Agy99 PWFALSERNSPGSIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGE
MAB_0622c|M.abscessus_ATCC_199 PWFALSERNSPGSIIVNSSGKRFMNESLPYVEATHRMYGGQYGQGPGPGE
. *** *.*:*: . **:*** .* . : .
Mvan_2865|M.vanbaalenii_PYR-1 TPPFWMVYD---DRAGDIPPVSATNVSMVEAAQYREAGLWHTADTIEGLA
MSMEG_2867|M.smegmatis_MC2_155 TLPYWMVYD---SRAGDVPPVGATNVSMVDPAEYRAAGLWRSAETISGLA
Mflv_1547|M.gilvum_PYR-GCK TLPFWMIYDSAGDRDGVVPPVKATNVSMVEPEKYIAAGLWRSADTLEELA
MAV_4249|M.avium_104 RLPYWMIYD---DKEGAVPPVKATNVSLVETEKYVAAGLWHTADSLPELA
TH_3671|M.thermoresistible__bu GEP----------GQRGAAAVHAEHLGRDLPVDHPAEELH--ADRAHQGS
Mb3567|M.bovis_AF2122/97 NIPAWLVFD---QRYRDRYIFAGLQPGQRIPSRWLDSGVIVQADTLAELA
Rv3537|M.tuberculosis_H37Rv NIPAWLVFD---QRYRDRYIFAGLQPGQRIPSRWLDSGVIVQADTLAELA
MMAR_5024|M.marinum_M NIPAWLVFD---QRYRDRYIFAGLQPGQRIPRKWLDSGVIVMADTLEELA
MUL_4098|M.ulcerans_Agy99 NIPAWLVFD---QRYRDRYIFAGLQPGQRIPRKWLDSGVIVMADTLEELA
MAB_0622c|M.abscessus_ATCC_199 NLPAWLVFD---QEYRNRYIFAGLQPGQKIPSKWIESGVIVKADTIEELA
* . . : . . : *: :
Mvan_2865|M.vanbaalenii_PYR-1 EAIGVPPAELKYTIERFNTLAAAGVDEDFGRGGEAYDRVFTGGS----SP
MSMEG_2867|M.smegmatis_MC2_155 EEIGVPADALEATIQRFNEMATAGHDDDFGRGDEAYDRVFTGGA----SP
Mflv_1547|M.gilvum_PYR-GCK VQIGVPPDNLVDSVARFNDFVRRGVDEDFGRGDEPYDRAFSGGV----PP
MAV_4249|M.avium_104 AKIGVPAQRLTATVLRFNGFAAAGVDEDFGRGDEAFDRAFSAGA----SP
TH_3671|M.thermoresistible__bu GERIVDHGILGAARQRAG-------GRHHGRGG-----ADAGGQ----VP
Mb3567|M.bovis_AF2122/97 GKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPN
Rv3537|M.tuberculosis_H37Rv GKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPN
MMAR_5024|M.marinum_M AKAGLPVDELTSTVSRFNGFARSGVDEDYHRGESAYDRYYGDPTNKPNPN
MUL_4098|M.ulcerans_Agy99 AKAGLPVDELTSTVSRFNGFARSGVDEDYHRGESAYDRYYGDPTNKPNPN
MAB_0622c|M.abscessus_ATCC_199 KKANLPVEELRATIERFNGFARSGVDEDFGRGKSAYDRYYGDPTNKPNPN
: * : * . . .. **
Mvan_2865|M.vanbaalenii_PYR-1 LVPIDTPPYHAAAFGLSDLGTKGGLRTDTRARVLTADGTPIPGLYAAGNT
MSMEG_2867|M.smegmatis_MC2_155 LVPIDTPPYHAAAFGLSDLGTKGGLRTDTRARVRGRDGEPIPGLYAAGNT
Mflv_1547|M.gilvum_PYR-GCK LYAIEKGPFHAAAFGVSDLGTKGGLRTDTAARVLDRADNVIPGLYAAGNT
MAV_4249|M.avium_104 LVPIDTPPYHAAAFGVSDLGTKGGLRTDTAARVLDTAGRPIPGVYAAGNT
TH_3671|M.thermoresistible__bu GVVVGTRHRRPLTDQCTNPELVS--CHNSSSRLYARFRGPVRAMRASGMT
Mb3567|M.bovis_AF2122/97 LGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
Rv3537|M.tuberculosis_H37Rv LGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
MMAR_5024|M.marinum_M LGEINHAPYYAAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
MUL_4098|M.ulcerans_Agy99 LGEINHAPYYAAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV
MAB_0622c|M.abscessus_ATCC_199 LGALTKAPFYAAKMVPGDLGTKGGVRTDVKGRVLRDDNSVIEGLYAAGNV
: : . : .* : .: *:* .
Mvan_2865|M.vanbaalenii_PYR-1 MAAVSG--TTYPGGGNPIGASMLFSHLAALDMTGSPR--
MSMEG_2867|M.smegmatis_MC2_155 MAAVSG--TTYPGGGNPIGASMLFSHFAALDMAAEGTTA
Mflv_1547|M.gilvum_PYR-GCK MAAPSG--TVYPGGGNPIGTSMVFSHLAVLDMVKGTTP-
MAV_4249|M.avium_104 MAAPSG--TTYPGGGNPIGTSMLFSHLAVLDMRDRRP--
TH_3671|M.thermoresistible__bu TVTLIDCLTRDSAGCASVRAPYLTYRNAGTDQPVWHAAL
Mb3567|M.bovis_AF2122/97 SAPVMG--HTYPGPGGTIGPAMTFGYLAALHIADQAGKR
Rv3537|M.tuberculosis_H37Rv SAPVMG--HTYPGPGGTIGPAMTFGYLAALHIADQAGKR
MMAR_5024|M.marinum_M SAPVMG--HTYPGPGGTIGPAMTFGYLAALHIAGDR---
MUL_4098|M.ulcerans_Agy99 SAPVMG--HTYPGPGGTIGPAMTFGYLAALHIAGDR---
MAB_0622c|M.abscessus_ATCC_199 STPVMG--HTYAGPGATIGPAMTWGYLAALDIAGK----
.. . .. .: .. * .