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TEQEYDVVVVGSGGAGMVAALTAAHNGLSTVLIEKAPHFGGSTARSGGGVWIPNNEVLKKARQTDTPEAA REYLYSIIGDVVPREKIDTYLDRGPEMLSFVLANSPLKLDWVPNYSDYYPEAPGGRAAGRSVEPKPFDAK KLGDELPNLEPPYGKVPLNVVVRQQDYVRLNQLKRHPRGVLRSLRVGVRTFWAQGTGKKLVGMGRALSAA LRIGLRDAGVPVKLNTALTDLYIEDGTVRGVYVRETGAPEASEPTLIRGRRGVILASGGFEHNEQMRVKY QRAPITTEWTVGAKANTGDGILAAEKLGAALEFMEDSWWGPTVPLVGRPWFALSERNSPGSIIVNSSGKR FMNESLPYVEATHRMYGGQYGQGPGPGENLPAWLVFDQEYRNRYIFAGLQPGQKIPSKWIESGVIVKADT IEELAKKANLPVEELRATIERFNGFARSGVDEDFGRGKSAYDRYYGDPTNKPNPNLGALTKAPFYAAKMV PGDLGTKGGVRTDVKGRVLRDDNSVIEGLYAAGNVSTPVMGHTYAGPGATIGPAMTWGYLAALDIAGK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0622c | - | - | 100% (559) | 3-ketosteroid-delta-1-dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0081 | - | e-117 | 41.31% (564) | 3-ketosteroid-delta-1-dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0623 | - | 1e-21 | 26.06% (591) | hypothetical protein MAB_0623 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3567 | - | 0.0 | 77.92% (557) | 3-ketosteroid-delta-1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1519 | - | 0.0 | 80.82% (558) | 3-ketosteroid-delta-1-dehydrogenase |
| M. tuberculosis H37Rv | Rv3537 | - | 0.0 | 77.92% (557) | 3-ketosteroid-delta-1-dehydrogenase |
| M. leprae Br4923 | MLBr_01226 | nadB | 6e-05 | 34.52% (84) | L-aspartate oxidase |
| M. marinum M | MMAR_5024 | - | 0.0 | 79.54% (562) | dehydrogenase |
| M. avium 104 | MAV_0624 | - | 0.0 | 81.22% (559) | 3-ketosteroid-delta-1-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5941 | - | 0.0 | 81.69% (557) | 3-ketosteroid-delta-1-dehydrogenase |
| M. thermoresistible (build 8) | TH_0368 | - | 0.0 | 79.24% (525) | PROBABLE DEHYDROGENASE |
| M. ulcerans Agy99 | MUL_4098 | - | 0.0 | 79.36% (562) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5237 | - | 0.0 | 82.47% (559) | 3-ketosteroid-delta-1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1519|M.gilvum_PYR-GCK -----MAQQEYDVVVVGSGAAGMVAALTAAHQGLSTIVVEKAPHYGGSTA
TH_0368|M.thermoresistible__bu --------------------------------------VEKAPHYGGSTA
Mvan_5237|M.vanbaalenii_PYR-1 -----MTEQEYDVVVVGSGAAGMVAALTAAHQGLSTIVVEKAPHYGGSTA
MSMEG_5941|M.smegmatis_MC2_155 -----MTGQEYDVVVVGSGAAGMVAALTAAHQGLSTVVVEKAPHYGGSTA
Mb3567|M.bovis_AF2122/97 -----MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTA
Rv3537|M.tuberculosis_H37Rv -----MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTA
MMAR_5024|M.marinum_M --MFYMTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKAAHYGGSTA
MUL_4098|M.ulcerans_Agy99 -----MTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKAAHYGGSTA
MAV_0624|M.avium_104 -----MSAQEYDVVVVGSGGAGMVAALTAAHRGLSTIVIEKAPHFGGSTA
MAB_0622c|M.abscessus_ATCC_199 -----MTEQEYDVVVVGSGGAGMVAALTAAHNGLSTVLIEKAPHFGGSTA
MLBr_01226|M.leprae_Br4923 MMAVPDWKHAADVVVIGTGVAGLAAALAAHRAGRNVVVLTKADQRRGETA
: ** : *.**
Mflv_1519|M.gilvum_PYR-GCK RSGGGVWIPNNEVLKRDGVKDTTEAARTYLHSIVG----DAVPAEKIDTY
TH_0368|M.thermoresistible__bu RSGGGVWIPNNEVLKRDGVTDTPEEARRYLHAIVG----DVVPAEKIDTY
Mvan_5237|M.vanbaalenii_PYR-1 RSGGGVWIPNNEVLKRDGVKDTADAARTYLHAIIG----DVVPAEKIDTY
MSMEG_5941|M.smegmatis_MC2_155 RSGGGVWIPNNEILKRDGVKDTPDEARKYLHAIIG----DVVPAEKIDTY
Mb3567|M.bovis_AF2122/97 RSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----EIVEPERIDAY
Rv3537|M.tuberculosis_H37Rv RSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----EIVEPERIDAY
MMAR_5024|M.marinum_M RSGGGVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVSGVEPERIDTY
MUL_4098|M.ulcerans_Agy99 RSGGGVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVSGVEPERIDTY
MAV_0624|M.avium_104 RSGGGVWIPNNEVLKRDGVKDTPEAARTYLHGIIG----DVVEPERIDTY
MAB_0622c|M.abscessus_ATCC_199 RSGGGVWIPNNEVLKKARQTDTPEAAREYLYSIIG----DVVPREKIDTY
MLBr_01226|M.leprae_Br4923 THYAQGGIA---VVLPGSDDSVDAHASDTLAAGAG-----MCNLDTVYSI
. *. :: .. * * . * : : :
Mflv_1519|M.gilvum_PYR-GCK LDRGPEMLSFVLKHSPLKLCWVPGYSDYYPETPGGKPTGRSVEPKPFNAK
TH_0368|M.thermoresistible__bu LDRGPEMLSFVLKHTPLKLCWVPGYSDYYPETPGGKPTGRSVEPRPFDAK
Mvan_5237|M.vanbaalenii_PYR-1 LQRGPEMLSFVLKHSPLKLCWVPGYSDYYPETPGGKATGRSVEPKPFDAK
MSMEG_5941|M.smegmatis_MC2_155 LDRGPEMLSFVLKHSPLKLCWVPGYSDYYPETPGGKPTGRSVEPKPFDAN
Mb3567|M.bovis_AF2122/97 LDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNAR
Rv3537|M.tuberculosis_H37Rv LDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNAR
MMAR_5024|M.marinum_M LERGPEMLSFVLEHTPLKMCWVPGYSDYYPEAPGGRSGGRSIEPKPFDAR
MUL_4098|M.ulcerans_Agy99 LERGPEMLSFVLEHTPLKMCWVPGYSDYYSEAPGGRSGGRSIEPKPFDAR
MAV_0624|M.avium_104 LERGPEMLSFVLKHTPLKMCWVPRYSDYYPESPGGRAEGRSIEPKPFNAR
MAB_0622c|M.abscessus_ATCC_199 LDRGPEMLSFVLANSPLKLDWVPNYSDYYPEAPGGRAAGRSVEPKPFDAK
MLBr_01226|M.leprae_Br4923 VAEGYHAVTELVGYGARFDESIPGR--WAVTCEGGHSRRRIVH-------
: .* . :: :: . :* : **:. * :.
Mflv_1519|M.gilvum_PYR-GCK KLGPDEKGLEPPYGKVPLNMVVMQQDYVRLNQLKRHPRGVLRSLKVGVRS
TH_0368|M.thermoresistible__bu KLGPDMDTLEPPYGKVPMNMVVMQQDYVRLNQLKRHPRGVLRSLKVGIRS
Mvan_5237|M.vanbaalenii_PYR-1 KLGEDLPGLEPPYGKVPMNMVVMQQDYVRLNQLKRHPRGVLRSLRVGIRS
MSMEG_5941|M.smegmatis_MC2_155 KLGPDLKGLEPPYGKVPMNMVVMQQDYVRLNQLKRHPRGVLRSLKVGIRA
Mb3567|M.bovis_AF2122/97 KLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGART
Rv3537|M.tuberculosis_H37Rv KLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGART
MMAR_5024|M.marinum_M KLGADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGART
MUL_4098|M.ulcerans_Agy99 KLGADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGART
MAV_0624|M.avium_104 KLGPDEAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSLKVGART
MAB_0622c|M.abscessus_ATCC_199 KLGDELPNLEPPYGKVPLNVVVRQQDYVRLNQLKRHPRGVLRSLRVGVRT
MLBr_01226|M.leprae_Br4923 -AGGDATGAEVQR-ALDHAADVLDIRTSHLALRVLHDGTVVNGVSVLNPN
* : * : * : :* * *:..: *
Mflv_1519|M.gilvum_PYR-GCK VWANATGKNLVGMGRALIAPLRIGLQKAGVPVLLNTALTDLHVEDGVVTG
TH_0368|M.thermoresistible__bu MWANATGKNLVGMGRALIAPLRIGLREAGVPLLLNTAMTDLYVEDGVVRG
Mvan_5237|M.vanbaalenii_PYR-1 VWANTTGKNLVGMGRALIAPLRIGLREAGVPVRLNTAMTDLYVEDGVVRG
MSMEG_5941|M.smegmatis_MC2_155 TWGKVSGKNLVGMGRALIAPLRIGLREAGVPVLLNTALTDLYVEDGRVLG
Mb3567|M.bovis_AF2122/97 MWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVSG
Rv3537|M.tuberculosis_H37Rv MWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVSG
MMAR_5024|M.marinum_M MWAKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTALTDLYLEDGMVRG
MUL_4098|M.ulcerans_Agy99 MWAKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTALTDLYLEDGVVRG
MAV_0624|M.avium_104 MWAKATGKNLVGMGRALIGPLRIGLQRAGVPVVLNTALTDLYLEDGVVRG
MAB_0622c|M.abscessus_ATCC_199 FWAQGTGKKLVGMGRALSAALRIGLRDAGVPVKLNTALTDLYIEDGTVRG
MLBr_01226|M.leprae_Br4923 GWGIVSAPSVILASGGLGHLYGATTNPEGS--------TGDGIALALWAG
*. :. .:: . .* . * *. : . *
Mflv_1519|M.gilvum_PYR-GCK IYVVATGDSVNAEPQLIRARRAVILGSGGFEHNEQMRVKYQRAPITTEWT
TH_0368|M.thermoresistible__bu IYVVDARDPESAEPRLIRARRGVILGSGGFEHNEQMRVKYQRPPITTEWT
Mvan_5237|M.vanbaalenii_PYR-1 IYVRDTTAPESAEPQLIRARRGVILGSGGFEHNEQMRVKYQRAPITTEWT
MSMEG_5941|M.smegmatis_MC2_155 IYVRDTTAGDDAEPRLIRARHGVILGSGGFEHNEQMRVKYQRAPITTEWT
Mb3567|M.bovis_AF2122/97 VYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEWT
Rv3537|M.tuberculosis_H37Rv VYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEWT
MMAR_5024|M.marinum_M IYVRSTDAQESEEPQLIRARKGVILACGGFDHNEQMRVKYQRAPITTDWT
MUL_4098|M.ulcerans_Agy99 IYVRSTDAHESEEPQLIRARKGVILACGGFDHNEQMRVKYQRAPITTDWT
MAV_0624|M.avium_104 VYVRDSQAAESAEPRLIRARRGVILASGGFEHNEQMRVKYQRAPITTEWT
MAB_0622c|M.abscessus_ATCC_199 VYVRETGAPEASEPTLIRGRRGVILASGGFEHNEQMRVKYQRAPITTEWT
MLBr_01226|M.leprae_Br4923 VAVSDLEFIQFHPTMLFAAGTG--TGGRRPLVTEAIRGEGAILLDSKGNS
: * . *: . . . .* :* : :. :
Mflv_1519|M.gilvum_PYR-GCK VGAVANTGDGILAAEKLGAALEIMEDAWWGPTVPLEGAPWFALSERNSPG
TH_0368|M.thermoresistible__bu VGAKANTGDGILAAEKLGAALEIMEDAWWGPTIPLPGAPWFALSERNSPG
Mvan_5237|M.vanbaalenii_PYR-1 VGAKANTGDGILAAEKLGAALDVMEDAWWGPTVPLVDAPWFALSERNSPG
MSMEG_5941|M.smegmatis_MC2_155 VGAVANTGDGIVAAEKLGAALELMEDAWWGPTVPLVGAPWFALSERNSPG
Mb3567|M.bovis_AF2122/97 VGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSPG
Rv3537|M.tuberculosis_H37Rv VGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSPG
MMAR_5024|M.marinum_M VGAKANTGDGIVAAEKLGAALDLMEDAWWGPTVPLVGRPWFALSERNSPG
MUL_4098|M.ulcerans_Agy99 VGAKANTGDGIVAAEKLGAALDLMEDAWWGPTVPLVGRPWFALSERNSPG
MAV_0624|M.avium_104 VGAKANTGDGILAAEKLGAALELMEDAWWGPTVPLVGAPWFALSERNSPG
MAB_0622c|M.abscessus_ATCC_199 VGAKANTGDGILAAEKLGAALEFMEDSWWGPTVPLVGRPWFALSERNSPG
MLBr_01226|M.leprae_Br4923 VTSGVHPLGDLAPRDVVAAAIDARLKATGDSCVYLDARGIDGFASRFPTV
* : .:. ..: . : :.**:: .: .. : * .::.* ..
Mflv_1519|M.gilvum_PYR-GCK SIIVNMAGKRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLIFDQQY
TH_0368|M.thermoresistible__bu SIIVNMAGKRFMNESMPYVEACHHMYGGEYGQGPGPGENIPAWLIFDQRY
Mvan_5237|M.vanbaalenii_PYR-1 SIIVNMAGKRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLVFDQRY
MSMEG_5941|M.smegmatis_MC2_155 SIIVNMSGKRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLIFDQQY
Mb3567|M.bovis_AF2122/97 SIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRY
Rv3537|M.tuberculosis_H37Rv SIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRY
MMAR_5024|M.marinum_M SIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLVFDQRY
MUL_4098|M.ulcerans_Agy99 SIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLVFDQRY
MAV_0624|M.avium_104 SIIVNMSGKRFMNESMPYVEACHHMYGGEYGQGPGPGENIPAWLVFDQQY
MAB_0622c|M.abscessus_ATCC_199 SIIVNSSGKRFMNESLPYVEATHRMYGGQYGQGPGPGENLPAWLVFDQEY
MLBr_01226|M.leprae_Br4923 TAACRTVGIDPAREPIPVVPGAHYSCGGIVTDAYGQTELAGLFAAGEVAR
: . * .*.:* * . * ** :. * * : :
Mflv_1519|M.gilvum_PYR-GCK RDRYIFAGLQPGQRIPSKWLESGVIVKADTLDELAARTGLPTDAFKATVD
TH_0368|M.thermoresistible__bu RDRYLFAGLQPGQRIPKKWLDSGVIVKADTLAELAARIGVPEQDFLATVE
Mvan_5237|M.vanbaalenii_PYR-1 RDRYIFAGLQPGQRIPKKWLESGVIVKADTLEELAAKTGLPVDAFKTTVQ
MSMEG_5941|M.smegmatis_MC2_155 RDRYIFAGLQPGQRIPSKWLESGVIVKADTLVELAEKTGLPADQFTSTIE
Mb3567|M.bovis_AF2122/97 RDRYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQ
Rv3537|M.tuberculosis_H37Rv RDRYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQ
MMAR_5024|M.marinum_M RDRYIFAGLQPGQRIPRKWLDSGVIVMADTLEELAAKAGLPVDELTSTVS
MUL_4098|M.ulcerans_Agy99 RDRYIFAGLQPGQRIPRKWLDSGVIVMADTLEELAAKAGLPVDELTSTVS
MAV_0624|M.avium_104 RDRYIFAGLQPGQRIPRKWLESGVIIQAETLEELASKAGLPVDEFLATVQ
MAB_0622c|M.abscessus_ATCC_199 RNRYIFAGLQPGQKIPSKWIESGVIVKADTIEELAKKANLPVEELRATIE
MLBr_01226|M.leprae_Br4923 ------TGMHGANRLASNSLLEGLVVGGRAGRAAAAHAAAAGRAYVSKLE
:*:: .:::. . : .*::: . : * : . :.:.
Mflv_1519|M.gilvum_PYR-GCK RFNGFARSGRDEDFKRGESAYDRYYGDPTNKPNPNLGEITQGPFYAAKMV
TH_0368|M.thermoresistible__bu RFNGFARAGVDQDFRRGESAYDRYYGDPTNKPNPNLGEIDQAPFYAAKMV
Mvan_5237|M.vanbaalenii_PYR-1 RFNGFARSGVDEDFKRGESAYDRYYGDPTNKPNPNLGEISQGPFYAAKMV
MSMEG_5941|M.smegmatis_MC2_155 RFNGFARSGVDEDFHRGESAYDRYYGDPTNKPNPNLGEIKHGPFYAAKMV
Mb3567|M.bovis_AF2122/97 RFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMV
Rv3537|M.tuberculosis_H37Rv RFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMV
MMAR_5024|M.marinum_M RFNGFARSGVDEDYHRGESAYDRYYGDPTNKPNPNLGEINHAPYYAAKMV
MUL_4098|M.ulcerans_Agy99 RFNGFARSGVDEDYHRGESAYDRYYGDPTNKPNPNLGEINHAPYYAAKMV
MAV_0624|M.avium_104 RFNGFARTGIDEDYHRGESAYDRYYGDPTNKPNPNLGEISHPPYYAAKMV
MAB_0622c|M.abscessus_ATCC_199 RFNGFARSGVDEDFGRGKSAYDRYYGDPTNKPNPNLGALTKAPFYAAKMV
MLBr_01226|M.leprae_Br4923 PVTHHALKRRELQRVMSRDAAVMRNAAGLQRLSDTLAEAP------IRHV
.. .* : : ...* . :: . .*. : *
Mflv_1519|M.gilvum_PYR-GCK PGDLGTKGGIRTDVHGRALRDDGSVIEGLYAAGNVSSPVMGHTYPGPGGT
TH_0368|M.thermoresistible__bu PGDLGTKGGIRTDVHGRALRDDGSVIDGLYAAGNVSSPVMGHTYPGPGGT
Mvan_5237|M.vanbaalenii_PYR-1 PGDLGTKGGIVTDVQGRALRDDGSIIEGLYAAGNASAPVMGHTYPGPGGT
MSMEG_5941|M.smegmatis_MC2_155 PGDLGTKGGIRTDVRGRALRDDDSVIEGLYAAGNVSSPVMGHTYPGPGGT
Mb3567|M.bovis_AF2122/97 PGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGT
Rv3537|M.tuberculosis_H37Rv PGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGT
MMAR_5024|M.marinum_M PGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGT
MUL_4098|M.ulcerans_Agy99 PGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGT
MAV_0624|M.avium_104 PGDLGTKGGIRTDIHGRALRDDGSIIEGLYAAGNVSAPVMGHTYPGPGGT
MAB_0622c|M.abscessus_ATCC_199 PGDLGTKGGVRTDVKGRVLRDDNSVIEGLYAAGNVSTPVMGHTYAGPGAT
MLBr_01226|M.leprae_Br4923 TGRRDFED-VALTLTARAVAAAALARNESRGCHHCTEYPDTAPEHARSTV
.* . :. : : .*.: : .. : : . . . .
Mflv_1519|M.gilvum_PYR-GCK IGPAMTFGYLAALHIAGAAPAATSSSGKG
TH_0368|M.thermoresistible__bu IGPAMTFGYLAALHVAGAA-TATSDPGKS
Mvan_5237|M.vanbaalenii_PYR-1 IGPAMTFGYLAALDIARKD----------
MSMEG_5941|M.smegmatis_MC2_155 IGPAMTFGYLAALDIAATAAASRKG----
Mb3567|M.bovis_AF2122/97 IGPAMTFGYLAALHIADQAGKR-------
Rv3537|M.tuberculosis_H37Rv IGPAMTFGYLAALHIADQAGKR-------
MMAR_5024|M.marinum_M IGPAMTFGYLAALHIAGDR----------
MUL_4098|M.ulcerans_Agy99 IGPAMTFGYLAALHIAGDR----------
MAV_0624|M.avium_104 IGPAMTFGYLAALHIAGEN----------
MAB_0622c|M.abscessus_ATCC_199 IGPAMTWGYLAALDIAGK-----------
MLBr_01226|M.leprae_Br4923 IRLADDQNLVRAEALATVG----------
* * . : * :*