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PEPDQRIRAAIDVESWVCPAPLRDAPNIVMGHGGGGAMSGELIEHLFLPAFGPAADAAMGDAAVVEIGGT RLAFSTDSFVVKPMVFPGGSIGDLAVNGTVNDLAMAGAVPQVLSTAFILEEGTPLDELARVAQAVGTAAM AAGVRLVTGDTKVVDSGHGDGVYINTAGIGLVDDRTDIRPQRAAPGDAVIVSGDIGVHGVAVLSCREGLE FGTAVASDTAPLHGLVAAMVATGADVHALRDPTRGGMAATLNEIAKAAKVGVTIDERALPIPSEVRDACS MLGLDPLYVANEGKLVAFVPAADAGKVLAAMRAHPLGAHAVIIGACVADHPGMVVAKTALGGTRVVDLPI GEQLPRIC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2404 | - | - | 100% (359) | hydrogenase expression/formation protein HypE |
| M. vanbaalenii PYR-1 | Mvan_2362 | - | e-116 | 59.83% (351) | hydrogenase expression/formation protein HypE |
| M. vanbaalenii PYR-1 | Mvan_1220 | - | 1e-06 | 26.32% (285) | GCN5-related N-acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0832 | purM | 7e-07 | 29.13% (103) | phosphoribosylaminoimidazole synthetase |
| M. gilvum PYR-GCK | Mflv_3982 | - | 1e-174 | 84.21% (361) | hydrogenase expression/formation protein HypE |
| M. tuberculosis H37Rv | Rv0809 | purM | 7e-07 | 29.13% (103) | phosphoribosylaminoimidazole synthetase |
| M. leprae Br4923 | MLBr_02205 | purM | 6e-07 | 25.12% (207) | phosphoribosylaminoimidazole synthetase |
| M. abscessus ATCC 19977 | MAB_0728 | - | 1e-05 | 24.17% (211) | phosphoribosylaminoimidazole synthetase |
| M. marinum M | MMAR_1859 | hypE | 6e-84 | 46.55% (333) | hydrogenase maturation factor, HypE |
| M. avium 104 | MAV_0748 | purM | 5e-07 | 26.70% (176) | phosphoribosylaminoimidazole synthetase |
| M. smegmatis MC2 155 | MSMEG_2276 | hypE | 1e-115 | 58.29% (350) | hydrogenase expression/formation protein HypE |
| M. thermoresistible (build 8) | TH_0225 | hypE | 2e-90 | 50.30% (332) | hydrogenase expression/formation protein HypE |
| M. ulcerans Agy99 | MUL_0418 | purM | 1e-06 | 24.64% (207) | phosphoribosylaminoimidazole synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0748|M.avium_104 ------------------------MTDPGKSP---GRHSGSQGITYASAG
MUL_0418|M.ulcerans_Agy99 ----MRGARVADTGGERRPVAFIAMTDPEKSPESSGRGPASQGVTYAAAG
MLBr_02205|M.leprae_Br4923 ------------------------MMDPGKSP---GGQLGNHGITYASTG
Mb0832|M.bovis_AF2122/97 ------------------------MTDLAKGP---GKDPGSRGITYASAG
Rv0809|M.tuberculosis_H37Rv ------------------------MTDLAKGP---GKDPGSRGITYASAG
MAB_0728|M.abscessus_ATCC_1997 ------------------------MPDMSERA----DKPSN---SYAAAG
Mvan_2404|M.vanbaalenii_PYR-1 MP--EPDQRIR------------AAIDVESWV-----CPAPLRDAPNIVM
Mflv_3982|M.gilvum_PYR-GCK MPDTEPEASIETEPEASIETEPEASIDMESWV-----CPLPLRDAPAIVT
MSMEG_2276|M.smegmatis_MC2_155 ----MSDAPVT--------------IDPSDWV-----CPLPLRETKRIVM
MMAR_1859|M.marinum_M ----MSKSAGEYLSSGPRFAEGDVIGRIESFR-----RRRPRLLDEHVTL
TH_0225|M.thermoresistible__bu ----MAE------------AEARVIERIESFR-----RRRPRLRDEIVTL
. .
MAV_0748|M.avium_104 VDIEAGDRAVELFKPLATKATRPEVRGGLGGFAGLFALRGEYREPLLAAS
MUL_0418|M.ulcerans_Agy99 VDIEAGDRAVELFKPLATRATRPEVRGGLGGFAGLFALRNDYREPVLAAS
MLBr_02205|M.leprae_Br4923 VDIEAGDRSVELFKPMAVKAIRTEVLGGLGGFAGLFALRSGYREPVLAAS
Mb0832|M.bovis_AF2122/97 VDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTLRGDYREPVLAAS
Rv0809|M.tuberculosis_H37Rv VDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTLRGDYREPVLAAS
MAB_0728|M.abscessus_ATCC_1997 VDIEAGDRAVELFKKSVAKTHRPEVLGGIGGFAGLFALKGGYREPVLAAS
Mvan_2404|M.vanbaalenii_PYR-1 GHGGGGAMSGELIEHLFLPAFGPAADAAMGDAAVVEIG-----GTRLAFS
Mflv_3982|M.gilvum_PYR-GCK GHGGGGAMSGELVEHLFLPAFGSAAEAGLADSAVVEIG-----GARLAFS
MSMEG_2276|M.smegmatis_MC2_155 GHGGGGVLSEELIENLFLPAFDTADAGPARDSALLKVG-----AGTVAVT
MMAR_1859|M.marinum_M AHGAGGKASAALIDAVFMEAFRNPLLESLGDGAILTLPS----GERVAMS
TH_0225|M.thermoresistible__bu AHGAGGKASAALVDAVFVEAFRNPLLESLGDGAVLPLPD----GRRMAMS
. .* : *.. : . * : :* :
MAV_0748|M.avium_104 TDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGR
MUL_0418|M.ulcerans_Agy99 TDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGR
MLBr_02205|M.leprae_Br4923 TDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGR
Mb0832|M.bovis_AF2122/97 SDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIAVGR
Rv0809|M.tuberculosis_H37Rv SDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIAVGR
MAB_0728|M.abscessus_ATCC_1997 TDGVGTKIAVAQAMDKRDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGK
Mvan_2404|M.vanbaalenii_PYR-1 TD----SFVVKPMVFPGGSIGDLAVNGTVNDLAMAGAVPQVLSTAFILEE
Mflv_3982|M.gilvum_PYR-GCK TD----SFVVKPMVFPGGTIGDLAVNGTVNDLAMAGAVPAVLSTAFILEE
MSMEG_2276|M.smegmatis_MC2_155 TD----SYVVQPLFFPGGDIGHLAVNGTINDLACSGAQPVALTAGFILEE
MMAR_1859|M.marinum_M TD----SFVVQPRRFPGGSIGELAVHGTCNDLAVAGAVPSWISAAFVLEE
TH_0225|M.thermoresistible__bu TD----SFVVQPLRFPGGSIGHLAVHGTVNDLAMAGAVPSWISAAFVLEE
:* . .: . :* * . :**. .** * : : : .
MAV_0748|M.avium_104 -TVPERLSAIVSGIAEGCVRAGCALLGGETAEHPGLMEPDHYDISATGVG
MUL_0418|M.ulcerans_Agy99 -TVPERVSAIVSGIAEGCVRAGCALLGGETAEHPGLMAPDHYDISATGVG
MLBr_02205|M.leprae_Br4923 -TVPERLSAIVDGIAEGCMLAGCALLGGETAEHPGLMEVDHYDIAATGVG
Mb0832|M.bovis_AF2122/97 -IVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEPDHYDISATGVG
Rv0809|M.tuberculosis_H37Rv -IVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEPDHYDISATGVG
MAB_0728|M.abscessus_ATCC_1997 -VVPERVSELVAGIAEGCAIAGCALLGGETAEHPGLMAPDDFDLSATGVG
Mvan_2404|M.vanbaalenii_PYR-1 GTPLDELARVAQAVGTAAMAAGVRLVTGDTKVVD-SGHGDGVYINTAGIG
Mflv_3982|M.gilvum_PYR-GCK GTALDHLARVAQAVGTAALAAGVKLVTGDTKVVD-SGHGDGVYINTTGIG
MSMEG_2276|M.smegmatis_MC2_155 GLEIDVLGAVAQSMGAAARHAGVRIVTGDTKVVG-KGGADQLFVNTAGVG
MMAR_1859|M.marinum_M GFPIEELKQIVADMADAAAKAGVQIVTGDTKVVP-KGAADGLFITTTGTG
TH_0225|M.thermoresistible__bu GFPVSELKEIVADMADAAAAAGVQIVTGDTKVVA-RGAADGLFVTTAGVG
. : :. :. .. ** :: *:* * : ::* *
MAV_0748|M.avium_104 VVEADDVLGPDRVKPGDVIIAMGSSGLHSNGYSLART-VLLEIDRMNLEG
MUL_0418|M.ulcerans_Agy99 VVEADNVLGPERVKPGDVIIAMGSSGLHSNGYSLARN-VLLEIDRMNLAG
MLBr_02205|M.leprae_Br4923 VVEADDTLGPDRVKPGDVIIALRSSGLHSNGYSLARS-VLLEIDRMNLAG
Mb0832|M.bovis_AF2122/97 VVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRK-VLLEIDRMNLAG
Rv0809|M.tuberculosis_H37Rv VVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRK-VLLEIDRMNLAG
MAB_0728|M.abscessus_ATCC_1997 IVEADRVLGPDRVRPGDVVIAMGSSGLHSNGYSLARH-VLLEIDRMDLFG
Mvan_2404|M.vanbaalenii_PYR-1 LVDDRTDIRPQRAAPGDAVIVSGDIGVHGVAVLSCREGLEFGTAVASDTA
Mflv_3982|M.gilvum_PYR-GCK LVDPRVDIRPQRAAPGDVVIVSGDLGVHGIAVLSCREGLEFATSVASDAA
MSMEG_2276|M.smegmatis_MC2_155 VVPPGVSIGPELVRPGDHILVSGNLGEHGVAIMSVREGIDFGTAVTTDSA
MMAR_1859|M.marinum_M IIPTGRALSADSVRPGDKVLLSGSMGDHGMAVMLARGDLAIEADIHSDTA
TH_0225|M.thermoresistible__bu LIPAGRELSAAAVRPGDRVLISGSMGEHGMAVMLARGDLAIDADICSDTA
:: : . . *** :: . * *. . * : : .
MAV_0748|M.avium_104 YVEEFGRTLGEELLEPTRIYAKDCLALAAETHVRTFCHVTGGGLAGNLAR
MUL_0418|M.ulcerans_Agy99 YVEEFGRTLGEELLEPTRIYAKDCLALTAETHVRTFCHVTGGGLAGNLER
MLBr_02205|M.leprae_Br4923 YVEEFGRTLGEELLEPTRIYAKDCLALAAETHVRTFCHVTGGGLAGNLQR
Mb0832|M.bovis_AF2122/97 HVEEFGRTLGEELLEPTRIYAKDCLALAAETRVRTFCHVTGGGLAGNLQR
Rv0809|M.tuberculosis_H37Rv HVEEFGRTLGEELLEPTRIYAKDCLALAAETRVRTFCHVTGGGLAGNLQR
MAB_0728|M.abscessus_ATCC_1997 QVEEFGRTLGEELLEPTRIYAKDCLALAAETEVRTFCHVTGGGLAGNLAR
Mvan_2404|M.vanbaalenii_PYR-1 PLHGLVAAMVATG--ADVHALRDPTRGGMAATLNEIAKAAKVGVTIDERA
Mflv_3982|M.gilvum_PYR-GCK PLHGLVAAMVETG--ADIHTLRDPTRGGLAATLNEIARAAGVGVSIADTA
MSMEG_2276|M.smegmatis_MC2_155 PLHHLVAAMLATGDPSHVHALRDPTRGGLVASVVEIARAARVGMELDEAN
MMAR_1859|M.marinum_M SVSPLVELLMAAA--PGTRWLRDATRGGVGTVCNELAQACGFGVLLDEQR
TH_0225|M.thermoresistible__bu AVSGLVETLLAAA--PSTRWLRDPTRGGVGTVCNELARAANVGVVLDEER
: : : . :* : :.:. *:
MAV_0748|M.avium_104 VIPHGLVAELDRGTWTPAPVFAMIAQRGRVTREEMEKTFNMGVGMIAVVA
MUL_0418|M.ulcerans_Agy99 VIPHGLVAEIDRGTWTPAPVFAMIAQRGRVVREEMEKTFNMGVGMIAVVA
MLBr_02205|M.leprae_Br4923 VIPHGLVAEVDRGTWTPAPVFAMIAQRGRVAREEMEKTFNMGVGMIAVVA
Mb0832|M.bovis_AF2122/97 VIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFNMGVGMIAVVA
Rv0809|M.tuberculosis_H37Rv VIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFNMGVGMIAVVA
MAB_0728|M.abscessus_ATCC_1997 VIPDGLVAELDRGSWTPGPIFAMIAQRGRIERAEMEKTFNMGVGMVAVVA
Mvan_2404|M.vanbaalenii_PYR-1 LP---IPSEVRDACSMLGLDPLYVANEGKLVAFVPAADAGKVLAAMRAHP
Mflv_3982|M.gilvum_PYR-GCK LP---IPQEVRDACSMLGLDPLYVANEGKLVAFVPAADADEVLAAMHAHP
MSMEG_2276|M.smegmatis_MC2_155 IP---VPESVSSACSFLGLDPLQVANEGKIVAFVDPAHSEAILETMRARP
MMAR_1859|M.marinum_M LP---VAPMVNGACELLGIDPLYVANEGKFIAVVAPEEAEAGLAALQSHP
TH_0225|M.thermoresistible__bu LV---VRPEVAAACEMLGIDLLYVANEGKFLAVVAAEEVDAALAALRAHP
: : : . . :*:.*:. : : .
MAV_0748|M.avium_104 PEDTDRALAILTARHLDCWVLGTVGKGGKAG--PRAKLVGQHPRF-
MUL_0418|M.ulcerans_Agy99 PEDTDRALAILTARHLDCWVLGTVCKGGKEG--PRATLVGQHPRF-
MLBr_02205|M.leprae_Br4923 PEDTDRALAILTARHLDCWVLGTVCKGSKVG--PRAKLVGQHPRF-
Mb0832|M.bovis_AF2122/97 PEDTTRALAVLTARHLDCWVLGTVCKGGKQG--PRAKLVGQHPRF-
Rv0809|M.tuberculosis_H37Rv PEDTTRALAVLTARHLDCWVLGTVCKGGKQG--PRAKLVGQHPRF-
MAB_0728|M.abscessus_ATCC_1997 PEDVDRALAVLTARHIDCWTLGTIKKSGKDSGSESALLVGQHPRF-
Mvan_2404|M.vanbaalenii_PYR-1 LGAHAVIIGACVADHPGMVVAKTALGGTRVV---DLPIGEQLPRIC
Mflv_3982|M.gilvum_PYR-GCK LGAQSAVIGTCVPDHPGMVVAKTALGGNRVV---DLPIGEQLPRIC
MSMEG_2276|M.smegmatis_MC2_155 EGANAAIIGRVVEGHPGMAVGKTPFGTTRVI---ERELGEQLPRIC
MMAR_1859|M.marinum_M LGADAAEVGEIIAEPAETVILRTGFGGTRIV---DMLVGDPLPRIC
TH_0225|M.thermoresistible__bu LGADAAEIGEITTEPAGTVVLRTAFGGSRIV---DMLVGDPLPRIC
:. * : : **: