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MPDTPVSVDPADWVCPLPLRETRRVVLGHGGGGVLSEELIENLFLPAFGSQPGPSRDSAVLDTGSGRIAL TTDSYVVQPLFFPGGNIGDLAVNGTINDLACSGAQPIGITAGFILEEGLEIDVLGTVAATMGRAAAEAGV PIVTGDTKVVGKGGADQLFINTAGVGVVPPGVVIGPERARPGDVVIVSGDIGEHGVAIMSVREGIDFGTV VTTDSAPLHRLVGAMLAAGAPDAVHTLRDPTRGGLVASVVEIARAASVGVDLDEAAIPVPETVASACSFL GLDPLQVANEGKMVAFVAPEHAEAVLAAMRGCPEGVGAAVIGRVVADHPGMAVARTPFGTTRVVERELGE QLPRIC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2362 | - | - | 100% (356) | hydrogenase expression/formation protein HypE |
| M. vanbaalenii PYR-1 | Mvan_2404 | - | e-116 | 59.83% (351) | hydrogenase expression/formation protein HypE |
| M. vanbaalenii PYR-1 | Mvan_5111 | - | 9e-08 | 25.32% (233) | phosphoribosylaminoimidazole synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0832 | purM | 8e-10 | 27.43% (237) | phosphoribosylaminoimidazole synthetase |
| M. gilvum PYR-GCK | Mflv_3982 | - | 1e-116 | 59.54% (351) | hydrogenase expression/formation protein HypE |
| M. tuberculosis H37Rv | Rv0809 | purM | 8e-10 | 27.43% (237) | phosphoribosylaminoimidazole synthetase |
| M. leprae Br4923 | MLBr_01676 | thiL | 3e-07 | 23.77% (244) | thiamine monophosphate kinase |
| M. abscessus ATCC 19977 | MAB_0728 | - | 4e-10 | 26.18% (233) | phosphoribosylaminoimidazole synthetase |
| M. marinum M | MMAR_1859 | hypE | 1e-80 | 49.40% (334) | hydrogenase maturation factor, HypE |
| M. avium 104 | MAV_3829 | thiL | 1e-12 | 26.43% (280) | thiamine monophosphate kinase |
| M. smegmatis MC2 155 | MSMEG_2276 | hypE | 1e-165 | 79.55% (357) | hydrogenase expression/formation protein HypE |
| M. thermoresistible (build 8) | TH_0225 | hypE | 2e-81 | 50.30% (334) | hydrogenase expression/formation protein HypE |
| M. ulcerans Agy99 | MUL_0418 | purM | 2e-09 | 24.52% (261) | phosphoribosylaminoimidazole synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2362|M.vanbaalenii_PYR-1 --------------------MPDTP------------------VSVDPAD
MSMEG_2276|M.smegmatis_MC2_155 --------------------MSDAP------------------VTIDPSD
Mflv_3982|M.gilvum_PYR-GCK --------------------MPDTEPEASIETEPEASIETEPEASIDMES
MMAR_1859|M.marinum_M --------------------MSKSAGEYL----SSGPRFAEGDVIGRIES
TH_0225|M.thermoresistible__bu --------------------MAE----------------AEARVIERIES
MLBr_01676|M.leprae_Br4923 --------------------------------------------------
MAV_3829|M.avium_104 --------------------------------------------------
Mb0832|M.bovis_AF2122/97 --------------------MTDLAKGP---------GKDPGSRGITYAS
Rv0809|M.tuberculosis_H37Rv --------------------MTDLAKGP---------GKDPGSRGITYAS
MUL_0418|M.ulcerans_Agy99 MRGARVADTGGERRPVAFIAMTDPEKSPE------SSGRGPASQGVTYAA
MAB_0728|M.abscessus_ATCC_1997 --------------------MPDMSERA----------DKPSN---SYAA
Mvan_2362|M.vanbaalenii_PYR-1 WVCPLPLRETRRVVLGHGGGGVLSEELIENLFLPAFG-SQPGPSRDSAVL
MSMEG_2276|M.smegmatis_MC2_155 WVCPLPLRETKRIVMGHGGGGVLSEELIENLFLPAFDTADAGPARDSALL
Mflv_3982|M.gilvum_PYR-GCK WVCPLPLRDAPAIVTGHGGGGAMSGELVEHLFLPAFGSAAEAGLADSAVV
MMAR_1859|M.marinum_M FRRRRPRLLDEHVTLAHGAGGKASAALIDAVFMEAFRNPLLESLGDGAIL
TH_0225|M.thermoresistible__bu FRRRRPRLRDEIVTLAHGAGGKASAALVDAVFVEAFRNPLLESLGDGAVL
MLBr_01676|M.leprae_Br4923 MCNHECGALGESVTLEQLGEFAVIDRLVRGRRQPAVVALGPGD--DAAVV
MAV_3829|M.avium_104 --------MRDESTLRQLGEFGVIDRLVAGRRQPAAVTLGPGD--DAALV
Mb0832|M.bovis_AF2122/97 AGVDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTLRGDYREPVLA
Rv0809|M.tuberculosis_H37Rv AGVDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTLRGDYREPVLA
MUL_0418|M.ulcerans_Agy99 AGVDIEAGDRAVELFKPLATRATRPEVRGGLGGFAGLFALRNDYREPVLA
MAB_0728|M.abscessus_ATCC_1997 AGVDIEAGDRAVELFKKSVAKTHRPEVLGGIGGFAGLFALKGGYREPVLA
: * : .:
Mvan_2362|M.vanbaalenii_PYR-1 DTGSG-RIALTTDSYVVQPLF----FPGGNIGDLAVNGTINDLACSGAQP
MSMEG_2276|M.smegmatis_MC2_155 KVGAG-TVAVTTDSYVVQPLF----FPGGDIGHLAVNGTINDLACSGAQP
Mflv_3982|M.gilvum_PYR-GCK EIGGA-RLAFSTDSFVVKPMV----FPGGTIGDLAVNGTVNDLAMAGAVP
MMAR_1859|M.marinum_M TLPSGERVAMSTDSFVVQPRR----FPGGSIGELAVHGTCNDLAVAGAVP
TH_0225|M.thermoresistible__bu PLPDGRRMAMSTDSFVVQPLR----FPGGSIGHLAVHGTVNDLAMAGAVP
MLBr_01676|M.leprae_Br4923 TASDG-RIVVSTDVLVQDRHFRLDWSTPHDVGRKAIAQNAADIEAMGARA
MAV_3829|M.avium_104 TTGDG-RVVVSTDMLVQDRHFRLDWSTPHDIGRKAIAQNAADIEAMGARP
Mb0832|M.bovis_AF2122/97 ASSDG----VGTKLAIAQAMD-----KHDTVGLDLVAMVVDDLVVCGAEP
Rv0809|M.tuberculosis_H37Rv ASSDG----VGTKLAIAQAMD-----KHDTVGLDLVAMVVDDLVVCGAEP
MUL_0418|M.ulcerans_Agy99 ASTDG----VGTKLAVAQAMD-----KHDTVGLDLVAMVVDDLVVCGAEP
MAB_0728|M.abscessus_ATCC_1997 ASTDG----VGTKIAVAQAMD-----KRDTVGLDLVAMVVDDLVVCGAEP
. . *. : . :* : *: ** .
Mvan_2362|M.vanbaalenii_PYR-1 IGITAGFILEEGLEIDVLGTVAATMGRAAAEAGVPIVTGDTKVVGKGGA-
MSMEG_2276|M.smegmatis_MC2_155 VALTAGFILEEGLEIDVLGAVAQSMGAAARHAGVRIVTGDTKVVGKGGA-
Mflv_3982|M.gilvum_PYR-GCK AVLSTAFILEEGTALDHLARVAQAVGTAALAAGVKLVTGDTKVVDSGHG-
MMAR_1859|M.marinum_M SWISAAFVLEEGFPIEELKQIVADMADAAAKAGVQIVTGDTKVVPKGAA-
TH_0225|M.thermoresistible__bu SWISAAFVLEEGFPVSELKEIVADMADAAAAAGVQIVTGDTKVVARGAA-
MLBr_01676|M.leprae_Br4923 TTFVVGLGAPGDTPVAQVDALVDGLWDEAGRIGAGIVGGDLVSCP-----
MAV_3829|M.avium_104 TAFVVGFGAPGQTAAAQVDALVDGMWDEAQRVGAGIAGGDLVSCP-----
Mb0832|M.bovis_AF2122/97 -LFLLDYIAVGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEP
Rv0809|M.tuberculosis_H37Rv -LFLLDYIAVGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEP
MUL_0418|M.ulcerans_Agy99 -LFLQDYIAVGRTVPERVSAIVSGIAEGCVRAGCALLGGETAEHPGLMAP
MAB_0728|M.abscessus_ATCC_1997 -LFLQDYIAVGKVVPERVSELVAGIAEGCAIAGCALLGGETAEHPGLMAP
: : :. : . * : *:
Mvan_2362|M.vanbaalenii_PYR-1 DQLFINTAGVGVVPPGVVIGPERARPGDVVIVSGDIGEHGVAIMSVREGI
MSMEG_2276|M.smegmatis_MC2_155 DQLFVNTAGVGVVPPGVSIGPELVRPGDHILVSGNLGEHGVAIMSVREGI
Mflv_3982|M.gilvum_PYR-GCK DGVYINTTGIGLVDPRVDIRPQRAAPGDVVIVSGDLGVHGIAVLSCREGL
MMAR_1859|M.marinum_M DGLFITTTGTGIIPTGRALSADSVRPGDKVLLSGSMGDHGMAVMLARGDL
TH_0225|M.thermoresistible__bu DGLFVTTAGVGLIPAGRELSAAAVRPGDRVLISGSMGEHGMAVMLARGDL
MLBr_01676|M.leprae_Br4923 -QWVLSVTVLGDLDGRAPVLRSGAKNGSMVAVAGALGRSAAGYALWHKGI
MAV_3829|M.avium_104 -QWVISVTALGELDGRSPVCRAGAEPGALIAVAGDLGRSAAGFDLWRNQI
Mb0832|M.bovis_AF2122/97 DHYDISATGVGVVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRKVL
Rv0809|M.tuberculosis_H37Rv DHYDISATGVGVVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRKVL
MUL_0418|M.ulcerans_Agy99 DHYDISATGVGVVEADNVLGPERVKPGDVIIAMGSSGLHSNGYSLARNVL
MAB_0728|M.abscessus_ATCC_1997 DDFDLSATGVGIVEADRVLGPDRVRPGDVVIAMGSSGLHSNGYSLARHVL
:..: * : : . * : * * . . : :
Mvan_2362|M.vanbaalenii_PYR-1 D-FGTVVTTDSAPLHR-------------LVGAMLAAGAPDAVHTLRDPT
MSMEG_2276|M.smegmatis_MC2_155 D-FGTAVTTDSAPLHH-------------LVAAMLATGDPSHVHALRDPT
Mflv_3982|M.gilvum_PYR-GCK E-FATSVASDAAPLHG-------------LVAAMVETG--ADIHTLRDPT
MMAR_1859|M.marinum_M A-IEADIHSDTASVSP-------------LVELLMAAAP--GTRWLRDAT
TH_0225|M.thermoresistible__bu A-IDADICSDTAAVSG-------------LVETLLAAAP--STRWLRDPT
MLBr_01676|M.leprae_Br4923 DGFDDLRRRHLVPEPP-------------YGKGVAAAAC--GAQAMIDVS
MAV_3829|M.avium_104 GGFDELRRRHAVPQPP-------------YGQGAVAAAG--GAQAMIDVS
Mb0832|M.bovis_AF2122/97 LEIDRMNLAGHVEEFGRTLGEELLEPTRIYAKDCLALAAETRVRTFCHVT
Rv0809|M.tuberculosis_H37Rv LEIDRMNLAGHVEEFGRTLGEELLEPTRIYAKDCLALAAETRVRTFCHVT
MUL_0418|M.ulcerans_Agy99 LEIDRMNLAGYVEEFGRTLGEELLEPTRIYAKDCLALTAETHVRTFCHVT
MAB_0728|M.abscessus_ATCC_1997 LEIDRMDLFGQVEEFGRTLGEELLEPTRIYAKDCLALAAETEVRTFCHVT
: . : : . :
Mvan_2362|M.vanbaalenii_PYR-1 RGGLVASVVEIARAASVGVDLDEAAIPVP-ETVASACSFLGLDPLQVANE
MSMEG_2276|M.smegmatis_MC2_155 RGGLVASVVEIARAARVGMELDEANIPVP-ESVSSACSFLGLDPLQVANE
Mflv_3982|M.gilvum_PYR-GCK RGGLAATLNEIARAAGVGVSIADTALPIP-QEVRDACSMLGLDPLYVANE
MMAR_1859|M.marinum_M RGGVGTVCNELAQACGFGVLLDEQRLPVA-PMVNGACELLGIDPLYVANE
TH_0225|M.thermoresistible__bu RGGVGTVCNELARAANVGVVLDEERLVVR-PEVAAACEMLGIDLLYVANE
MLBr_01676|M.leprae_Br4923 DG-LIADLRHVARASGVSIDLSTAALAADHAALIAAATAVGGDPWPWVLG
MAV_3829|M.avium_104 DG-LIADLRHVAEASGVGMDVSTAALAADRDAVAAAAAAVGVDAWPWVLT
Mb0832|M.bovis_AF2122/97 GGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFN
Rv0809|M.tuberculosis_H37Rv GGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFN
MUL_0418|M.ulcerans_Agy99 GGGLAGNLERVIPHGLVAEIDRGTWTPAPVFAMIAQRGRVVREEMEKTFN
MAB_0728|M.abscessus_ATCC_1997 GGGLAGNLARVIPDGLVAELDRGSWTPGPIFAMIAQRGRIERAEMEKTFN
* : .: .. : : .
Mvan_2362|M.vanbaalenii_PYR-1 GKMVAFVAPEHAEAVLAAMRGCPEGVGAAVIGRVVADHPGMAVARTPFGT
MSMEG_2276|M.smegmatis_MC2_155 GKIVAFVDPAHSEAILETMRARPEGANAAIIGRVVEGHPGMAVGKTPFGT
Mflv_3982|M.gilvum_PYR-GCK GKLVAFVPAADADEVLAAMHAHPLGAQSAVIGTCVPDHPGMVVAKTALGG
MMAR_1859|M.marinum_M GKFIAVVAPEEAEAGLAALQSHPLGADAAEVGEIIAEPAETVILRTGFGG
TH_0225|M.thermoresistible__bu GKFLAVVAAEEVDAALAALRAHPLGADAAEIGEITTEPAGTVVLRTAFGG
MLBr_01676|M.leprae_Br4923 G---------GEDHALVACFAGTALSGWRIIGRVFDGPARVLVDGQEWRG
MAV_3829|M.avium_104 G---------GEDHALVACFPGPAPAGWRIIGRVLDGPARVLVDEREWSG
Mb0832|M.bovis_AF2122/97 MGVGMIAVVAPEDTTRALAVLTARHLDCWVLGTVCKGGKQG--PRAKLVG
Rv0809|M.tuberculosis_H37Rv MGVGMIAVVAPEDTTRALAVLTARHLDCWVLGTVCKGGKQG--PRAKLVG
MUL_0418|M.ulcerans_Agy99 MGVGMIAVVAPEDTDRALAILTARHLDCWVLGTVCKGGKEG--PRATLVG
MAB_0728|M.abscessus_ATCC_1997 MGVGMVAVVAPEDVDRALAVLTARHIDCWTLGTIKKSGKDSGSESALLVG
: . :*
Mvan_2362|M.vanbaalenii_PYR-1 TRVVERELGEQLPRIC
MSMEG_2276|M.smegmatis_MC2_155 TRVIERELGEQLPRIC
Mflv_3982|M.gilvum_PYR-GCK NRVVDLPIGEQLPRIC
MMAR_1859|M.marinum_M TRIVDMLVGDPLPRIC
TH_0225|M.thermoresistible__bu SRIVDMLVGDPLPRIC
MLBr_01676|M.leprae_Br4923 HAGWQSFGG-------
MAV_3829|M.avium_104 PAGWQSY---------
Mb0832|M.bovis_AF2122/97 QHPRF-----------
Rv0809|M.tuberculosis_H37Rv QHPRF-----------
MUL_0418|M.ulcerans_Agy99 QHPRF-----------
MAB_0728|M.abscessus_ATCC_1997 QHPRF-----------