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MSDAPVTIDPSDWVCPLPLRETKRIVMGHGGGGVLSEELIENLFLPAFDTADAGPARDSALLKVGAGTVA VTTDSYVVQPLFFPGGDIGHLAVNGTINDLACSGAQPVALTAGFILEEGLEIDVLGAVAQSMGAAARHAG VRIVTGDTKVVGKGGADQLFVNTAGVGVVPPGVSIGPELVRPGDHILVSGNLGEHGVAIMSVREGIDFGT AVTTDSAPLHHLVAAMLATGDPSHVHALRDPTRGGLVASVVEIARAARVGMELDEANIPVPESVSSACSF LGLDPLQVANEGKIVAFVDPAHSEAILETMRARPEGANAAIIGRVVEGHPGMAVGKTPFGTTRVIERELG EQLPRIC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2276 | hypE | - | 100% (357) | hydrogenase expression/formation protein HypE |
| M. smegmatis MC2 155 | MSMEG_2705 | hypE | 6e-81 | 47.31% (334) | hydrogenase expression/formation protein HypE |
| M. smegmatis MC2 155 | MSMEG_2398 | thiL | 2e-06 | 24.91% (293) | thiamine monophosphate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3001c | thiL | 2e-07 | 25.51% (247) | thiamine monophosphate kinase |
| M. gilvum PYR-GCK | Mflv_3982 | - | 1e-113 | 55.06% (356) | hydrogenase expression/formation protein HypE |
| M. tuberculosis H37Rv | Rv2977c | thiL | 2e-07 | 25.51% (247) | thiamine monophosphate kinase |
| M. leprae Br4923 | MLBr_02205 | purM | 2e-05 | 23.84% (172) | phosphoribosylaminoimidazole synthetase |
| M. abscessus ATCC 19977 | MAB_3284c | - | 1e-06 | 24.57% (289) | thiamine monophosphate kinase |
| M. marinum M | MMAR_1859 | hypE | 5e-75 | 43.75% (336) | hydrogenase maturation factor, HypE |
| M. avium 104 | MAV_3829 | thiL | 1e-09 | 25.09% (287) | thiamine monophosphate kinase |
| M. thermoresistible (build 8) | TH_0225 | hypE | 5e-78 | 46.71% (334) | hydrogenase expression/formation protein HypE |
| M. ulcerans Agy99 | MUL_0418 | purM | 2e-06 | 23.11% (251) | phosphoribosylaminoimidazole synthetase |
| M. vanbaalenii PYR-1 | Mvan_2362 | - | 1e-165 | 79.55% (357) | hydrogenase expression/formation protein HypE |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3001c|M.bovis_AF2122/97 --------------------------------MTTKDHSLATESPTLQQL
Rv2977c|M.tuberculosis_H37Rv --------------------------------MTTKDHSLATESPTLQQL
MAV_3829|M.avium_104 ---------------------------------------MRDES-TLRQL
MAB_3284c|M.abscessus_ATCC_199 -------------------------------------------MPNLGDT
MSMEG_2276|M.smegmatis_MC2_155 --MSDAP------------------VTIDPSDWVCPLPLRETKRIVMGHG
Mvan_2362|M.vanbaalenii_PYR-1 --MPDTP------------------VSVDPADWVCPLPLRETRRVVLGHG
Mflv_3982|M.gilvum_PYR-GCK --MPDTEPEASIETEPEASIETEPEASIDMESWVCPLPLRDAPAIVTGHG
MMAR_1859|M.marinum_M --MSKSAGEYL----SSGPRFAEGDVIGRIESFRRRRPRLLDEHVTLAHG
TH_0225|M.thermoresistible__bu --MAE----------------AEARVIERIESFRRRRPRLRDEIVTLAHG
MLBr_02205|M.leprae_Br4923 --------------------MMDPGKSP---GGQLGNHGITYASTGVDIE
MUL_0418|M.ulcerans_Agy99 MRGARVADTGGERRPVAFIAMTDPEKSPESSGRGPASQGVTYAAAGVDIE
Mb3001c|M.bovis_AF2122/97 GEFAVIDRLVRGRRQPATVLLGPGD--DAALVSAGDG----RTVVSTDML
Rv2977c|M.tuberculosis_H37Rv GEFAVIDRLVRGRRQPATVLLGPGD--DAALVSAGDG----RTVVSTDML
MAV_3829|M.avium_104 GEFGVIDRLVAGRRQPAAVTLGPGD--DAALVTTGDG----RVVVSTDML
MAB_3284c|M.abscessus_ATCC_199 GEFGVISRLTAGRDLGADVLLGPGD--DAAVVTVPDG----RVVVSTDML
MSMEG_2276|M.smegmatis_MC2_155 GGGVLSEELIENLFLPAFDTADAGPARDSALLKVGAG----TVAVTTDSY
Mvan_2362|M.vanbaalenii_PYR-1 GGGVLSEELIENLFLPAFG-SQPGPSRDSAVLDTGSG----RIALTTDSY
Mflv_3982|M.gilvum_PYR-GCK GGGAMSGELVEHLFLPAFGSAAEAGLADSAVVEIGGA----RLAFSTDSF
MMAR_1859|M.marinum_M AGGKASAALIDAVFMEAFRNPLLESLGDGAILTLPSGE---RVAMSTDSF
TH_0225|M.thermoresistible__bu AGGKASAALVDAVFVEAFRNPLLESLGDGAVLPLPDGR---RMAMSTDSF
MLBr_02205|M.leprae_Br4923 AGDRSVELFKPMAVKAIRTEVLGGLGGFAGLFALRSGYREPVLAASTDGV
MUL_0418|M.ulcerans_Agy99 AGDRAVELFKPLATRATRPEVRGGLGGFAGLFALRNDYREPVLAASTDGV
. : ..:. . :**
Mb3001c|M.bovis_AF2122/97 VQDSHFRLDWSTPQDVGRKAIAQNAADIEAMGARATAFVVGFGAPAETPA
Rv2977c|M.tuberculosis_H37Rv VQDSHFRLDWSTPQDVGRKAIAQNAADIEAMGARATAFVVGFGAPAETPA
MAV_3829|M.avium_104 VQDRHFRLDWSTPHDIGRKAIAQNAADIEAMGARPTAFVVGFGAPGQTAA
MAB_3284c|M.abscessus_ATCC_199 VQDRHFRLEWSSPSDIGRKAVAQNAADIEAMGGRVTAFVVAVGAPAQTDI
MSMEG_2276|M.smegmatis_MC2_155 VVQPLF----FPGGDIGHLAVNGTINDLACSGAQPVALTAGFILEEGLEI
Mvan_2362|M.vanbaalenii_PYR-1 VVQPLF----FPGGNIGDLAVNGTINDLACSGAQPIGITAGFILEEGLEI
Mflv_3982|M.gilvum_PYR-GCK VVKPMV----FPGGTIGDLAVNGTVNDLAMAGAVPAVLSTAFILEEGTAL
MMAR_1859|M.marinum_M VVQPRR----FPGGSIGELAVHGTCNDLAVAGAVPSWISAAFVLEEGFPI
TH_0225|M.thermoresistible__bu VVQPLR----FPGGSIGHLAVHGTVNDLAMAGAVPSWISAAFVLEEGFPV
MLBr_02205|M.leprae_Br4923 GTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEP-LFLQDYIAVGRTVP
MUL_0418|M.ulcerans_Agy99 GTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEP-LFLQDYIAVGRTVP
. :* : *: *. :
Mb3001c|M.bovis_AF2122/97 AQASALVDGMWEEAGRIGAGIVGGDLVSCR------QWVVSVTAIGDLDG
Rv2977c|M.tuberculosis_H37Rv AQASALVDGMWEEAGRIGAGIVGGDLVSCR------QWVVSVTAIGDLDG
MAV_3829|M.avium_104 AQVDALVDGMWDEAQRVGAGIAGGDLVSCP------QWVISVTALGELDG
MAB_3284c|M.abscessus_ATCC_199 AFLDQLNEGVWAEAALVQAPIVGGDLVSAR------ELVVSVTVLGDLQG
MSMEG_2276|M.smegmatis_MC2_155 DVLGAVAQSMGAAARHAGVRIVTGDTKVVGKGGA-DQLFVNTAGVGVVPP
Mvan_2362|M.vanbaalenii_PYR-1 DVLGTVAATMGRAAAEAGVPIVTGDTKVVGKGGA-DQLFINTAGVGVVPP
Mflv_3982|M.gilvum_PYR-GCK DHLARVAQAVGTAALAAGVKLVTGDTKVVDSGHG-DGVYINTTGIGLVDP
MMAR_1859|M.marinum_M EELKQIVADMADAAAKAGVQIVTGDTKVVPKGAA-DGLFITTTGTGIIPT
TH_0225|M.thermoresistible__bu SELKEIVADMADAAAAAGVQIVTGDTKVVARGAA-DGLFVTTAGVGLIPA
MLBr_02205|M.leprae_Br4923 ERLSAIVDGIAEGCMLAGCALLGGETAEHPGLMEVDHYDIAATGVGVVEA
MUL_0418|M.ulcerans_Agy99 ERVSAIVSGIAEGCVRAGCALLGGETAEHPGLMAPDHYDISATGVGVVEA
: : . : *: : .: * :
Mb3001c|M.bovis_AF2122/97 RAPVLRSGAKAGSVLAVVGELGRSAAGYALWCNGIEDFAELRRRHLVPQP
Rv2977c|M.tuberculosis_H37Rv RAPVLRSGAKAGSVLAVVGELGRSAAGYALWCNGIEDFAELRRRHLVPQP
MAV_3829|M.avium_104 RSPVCRAGAEPGALIAVAGDLGRSAAGFDLWRNQIGGFDELRRRHAVPQP
MAB_3284c|M.abscessus_ATCC_199 RAPVTRSGAVVGDTVAICGALGTSAAGYRLWQEQIDEFPDLRRVHLVPAP
MSMEG_2276|M.smegmatis_MC2_155 GVSIGPELVRPGDHILVSGNLGEHGVAIMSVREGIDFGTAVTTDSAPLHH
Mvan_2362|M.vanbaalenii_PYR-1 GVVIGPERARPGDVVIVSGDIGEHGVAIMSVREGIDFGTVVTTDSAPLHR
Mflv_3982|M.gilvum_PYR-GCK RVDIRPQRAAPGDVVIVSGDLGVHGIAVLSCREGLEFATSVASDAAPLHG
MMAR_1859|M.marinum_M GRALSADSVRPGDKVLLSGSMGDHGMAVMLARGDLAIEADIHSDTASVSP
TH_0225|M.thermoresistible__bu GRELSAAAVRPGDRVLISGSMGEHGMAVMLARGDLAIDADICSDTAAVSG
MLBr_02205|M.leprae_Br4923 DDTLGPDRVKPGDVIIALRSSGLHSNGYSLARSVLLEIDRMNLAGYVEEF
MUL_0418|M.ulcerans_Agy99 DNVLGPERVKPGDVIIAMGSSGLHSNGYSLARNVLLEIDRMNLAGYVEEF
: . * : * . . : :
Mb3001c|M.bovis_AF2122/97 --PYGHGAAAAA-VGAQAMIDVSDG-LLADLRHIAEASGVRIDLSAAALA
Rv2977c|M.tuberculosis_H37Rv --PYGHGAAAAA-VGAQAMIDVSDG-LLADLRHIAEASGVRIDLSAAALA
MAV_3829|M.avium_104 --PYGQGAVAAA-GGAQAMIDVSDG-LIADLRHVAEASGVGMDVSTAALA
MAB_3284c|M.abscessus_ATCC_199 --PYGQGPAAAR-AGATAMTDVSDG-LLADLAHIAELSAVHIDLSSPSLE
MSMEG_2276|M.smegmatis_MC2_155 --LVAAMLATGDPSHVHALRDPTRGGLVASVVEIARAARVGMELDEANIP
Mvan_2362|M.vanbaalenii_PYR-1 --LVGAMLAAGAPDAVHTLRDPTRGGLVASVVEIARAASVGVDLDEAAIP
Mflv_3982|M.gilvum_PYR-GCK --LVAAMVETG--ADIHTLRDPTRGGLAATLNEIARAAGVGVSIADTALP
MMAR_1859|M.marinum_M --LVELLMAAAP--GTRWLRDATRGGVGTVCNELAQACGFGVLLDEQRLP
TH_0225|M.thermoresistible__bu --LVETLLAAAP--STRWLRDPTRGGVGTVCNELARAANVGVVLDEERLV
MLBr_02205|M.leprae_Br4923 GRTLGEELLEPTRIYAKDCLALAAETHVRTFCHVTGG-GLAGNLQRVIPH
MUL_0418|M.ulcerans_Agy99 GRTLGEELLEPTRIYAKDCLALTAETHVRTFCHVTGG-GLAGNLERVIPH
: .:: . :
Mb3001c|M.bovis_AF2122/97 ADRDALTAAATALGTDPWPWVLSG---------GEDHALVACFVGPVPAG
Rv2977c|M.tuberculosis_H37Rv ADRDALTAAATALGTDPWPWVLSG---------GEDHALVACFVGPVPAG
MAV_3829|M.avium_104 ADRDAVAAAAAAVGVDAWPWVLTG---------GEDHALVACFPGPAPAG
MAB_3284c|M.abscessus_ATCC_199 PYLQPVAGAAGLLGADPWEWVLTG---------GEDHALVGMFPGVVPTG
MSMEG_2276|M.smegmatis_MC2_155 VP-ESVSSACSFLGLDPLQVANEGKIVAFVDPAHSEAILETMRARPEGAN
Mvan_2362|M.vanbaalenii_PYR-1 VP-ETVASACSFLGLDPLQVANEGKMVAFVAPEHAEAVLAAMRGCPEGVG
Mflv_3982|M.gilvum_PYR-GCK IP-QEVRDACSMLGLDPLYVANEGKLVAFVPAADADEVLAAMHAHPLGAQ
MMAR_1859|M.marinum_M VA-PMVNGACELLGIDPLYVANEGKFIAVVAPEEAEAGLAALQSHPLGAD
TH_0225|M.thermoresistible__bu VR-PEVAAACEMLGIDLLYVANEGKFLAVVAAEEVDAALAALRAHPLGAD
MLBr_02205|M.leprae_Br4923 GLVAEVDRGTWTPAPVFAMIAQRGRVAREEMEKTFNMGVGMIAVVAPEDT
MUL_0418|M.ulcerans_Agy99 GLVAEIDRGTWTPAPVFAMIAQRGRVVREEMEKTFNMGVGMIAVVAPEDT
: . . . * : :
Mb3001c|M.bovis_AF2122/97 WRTIGRVLDGPARVLVDGEEWTGYA-GWQSFGEPDNQGSLG
Rv2977c|M.tuberculosis_H37Rv WRTIGRVLDGPARVLVDGEEWTGYA-GWQSFGEPDNQGSLG
MAV_3829|M.avium_104 WRIIGRVLDGPARVLVDEREWSGPA-GWQSY----------
MAB_3284c|M.abscessus_ATCC_199 WVPIGRVTVGEPGVTVDGAAWTRAT-GWDSFRLS-------
MSMEG_2276|M.smegmatis_MC2_155 AAIIGRVVEGHPGMAVGKTPFGTTR-VIERELGEQLPRIC-
Mvan_2362|M.vanbaalenii_PYR-1 AAVIGRVVADHPGMAVARTPFGTTR-VVERELGEQLPRIC-
Mflv_3982|M.gilvum_PYR-GCK SAVIGTCVPDHPGMVVAKTALGGNR-VVDLPIGEQLPRIC-
MMAR_1859|M.marinum_M AAEVGEIIAEPAETVILRTGFGGTR-IVDMLVGDPLPRIC-
TH_0225|M.thermoresistible__bu AAEIGEITTEPAGTVVLRTAFGGSR-IVDMLVGDPLPRIC-
MLBr_02205|M.leprae_Br4923 DRALAILTARHLDCWVLGTVCKGSKVGPRAKLVGQHPRF--
MUL_0418|M.ulcerans_Agy99 DRALAILTARHLDCWVLGTVCKGGKEGPRATLVGQHPRF--
:. :