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LFQAISPHRGELSILAGSRPATGGQFLIRLAGAPELRAYHRLRQESFVVEQGMFSGTDRDDLDDDPRTVV LVAVAADGTVLGGVRLAPACAPDIGWWTGSRLVADPAARAAGLGPALVRAACAHAESVGALRFEATVQHR YAPMFVGLGWTDEGGCVVAGRPHVVMRWPLDPVQRVAAATKSFLGEVLDPLRRVPNGLGPKGFVGDDGVP VPGGDVVAACDAIIPSMVERDPEWAGWCSVLVNVNDLSAMGATPTGLLDAVGAPNRSLLTRIVRGVANAS QAWRVPVLGGHTQLGVPASLAVTALGRTADPVPAAGGAAGDALRLTVDLSGRWRPGYHGRQWDSTSARCP DDLARMGSYVAAARPRAAKDVSMAGIAGTAGMLAEAGGVGAEIDVAAVPRPRDADMGSWMTCFPGFGMLT AGGVGAAPLPDGVASRVCGRLTAQPGVRLRWPDGVVTTALPAGVTGLGRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1220 | - | - | 100% (471) | GCN5-related N-acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2404 | - | 2e-06 | 26.32% (285) | hydrogenase expression/formation protein HypE |
| M. vanbaalenii PYR-1 | Mvan_2151 | - | 5e-06 | 25.78% (225) | thiamine monophosphate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3001c | thiL | 9e-07 | 28.76% (226) | thiamine monophosphate kinase |
| M. gilvum PYR-GCK | Mflv_4216 | - | 1e-06 | 28.93% (242) | thiamine monophosphate kinase |
| M. tuberculosis H37Rv | Rv2977c | thiL | 9e-07 | 28.76% (226) | thiamine monophosphate kinase |
| M. leprae Br4923 | MLBr_01676 | thiL | 2e-05 | 27.13% (247) | thiamine monophosphate kinase |
| M. abscessus ATCC 19977 | MAB_3284c | - | 1e-07 | 29.49% (217) | thiamine monophosphate kinase |
| M. marinum M | MMAR_1735 | thiL | 1e-06 | 26.67% (225) | thiamine-monophosphate kinase ThiL |
| M. avium 104 | MAV_3829 | thiL | 4e-11 | 31.30% (246) | thiamine monophosphate kinase |
| M. smegmatis MC2 155 | MSMEG_0567 | - | 0.0 | 69.33% (463) | selenophosphate synthetase |
| M. thermoresistible (build 8) | TH_2051 | thiL | 5e-08 | 28.09% (267) | PROBABLE THIAMINE-MONOPHOSPHATE KINASE THIL |
| M. ulcerans Agy99 | MUL_1978 | thiL | 3e-07 | 27.56% (225) | thiamine monophosphate kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3001c|M.bovis_AF2122/97 --------------------------------------------------
Rv2977c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01676|M.leprae_Br4923 --------------------------------------------------
MAV_3829|M.avium_104 --------------------------------------------------
MMAR_1735|M.marinum_M --------------------------------------------------
MUL_1978|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4216|M.gilvum_PYR-GCK --------------------------------------------------
TH_2051|M.thermoresistible__bu --------------------------------------------------
MAB_3284c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1220|M.vanbaalenii_PYR-1 -MLFQAISPHR-GELSILAGSRPATGGQFLIRLAG-APELRAYHRLRQES
MSMEG_0567|M.smegmatis_MC2_155 MIEFDVSTPSLPGDLSILAGSRPTAP--FLIRPAENADDLASYRRLRRDS
Mb3001c|M.bovis_AF2122/97 --------------------------------------------------
Rv2977c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01676|M.leprae_Br4923 --------------------------------------------------
MAV_3829|M.avium_104 --------------------------------------------------
MMAR_1735|M.marinum_M --------------------------------------------------
MUL_1978|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4216|M.gilvum_PYR-GCK --------------------------------------------------
TH_2051|M.thermoresistible__bu --------------------------------------------------
MAB_3284c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1220|M.vanbaalenii_PYR-1 FVVEQGMFSGTDRDDLDDDPRTVVLVAVAADGTVLGGVRLAPACAPDIGW
MSMEG_0567|M.smegmatis_MC2_155 FVVDQGMFSGSDHDDIDDDPRVVVLIAAAADGSVLGGVRLAPVGGVDLGW
Mb3001c|M.bovis_AF2122/97 -------------MTTKDHSLATESPTLQQLGEFAVIDRLVRGRRQPATV
Rv2977c|M.tuberculosis_H37Rv -------------MTTKDHSLATESPTLQQLGEFAVIDRLVRGRRQPATV
MLBr_01676|M.leprae_Br4923 -------------MCNHECGALGESVTLEQLGEFAVIDRLVRGRRQPAVV
MAV_3829|M.avium_104 ---------------------MRDESTLRQLGEFGVIDRLVAGRRQPAAV
MMAR_1735|M.marinum_M ----------------MGQDTSGQTPTLRELGEFAVIDRLVQGRNQPAVV
MUL_1978|M.ulcerans_Agy99 ----------------MGQDTSGQTPTLRELGEFAVIDRLVQGRNQPAVV
Mflv_4216|M.gilvum_PYR-GCK ---------------MAAEDAD---AKLSELGEFAVIDRLVADRRQPPAV
TH_2051|M.thermoresistible__bu -------MAGDQPRDMAGDEAGGRAETLAAVGEFAVIDRLVAGRRQPGAV
MAB_3284c|M.abscessus_ATCC_199 ------------------------MPNLGDTGEFGVISRLTAGRDLGADV
Mvan_1220|M.vanbaalenii_PYR-1 WTGSRLVADPAARAAGLGPALVRAACAHAESVGALRFEATVQHRYAPMFV
MSMEG_0567|M.smegmatis_MC2_155 WTGSRLVVDRSTRITGIGAALVRAACAYAESAGVLRFEATVQRRYQPMFT
:. . * .
Mb3001c|M.bovis_AF2122/97 LLGPGDDAALVSAG------------------------------------
Rv2977c|M.tuberculosis_H37Rv LLGPGDDAALVSAG------------------------------------
MLBr_01676|M.leprae_Br4923 ALGPGDDAAVVTAS------------------------------------
MAV_3829|M.avium_104 TLGPGDDAALVTTG------------------------------------
MMAR_1735|M.marinum_M ELGPGDDAAVVAAP------------------------------------
MUL_1978|M.ulcerans_Agy99 ELGPGDDAAVVAAP------------------------------------
Mflv_4216|M.gilvum_PYR-GCK SLGPGDDAAVVFAA------------------------------------
TH_2051|M.thermoresistible__bu ALGPGDDAAVVHAA------------------------------------
MAB_3284c|M.abscessus_ATCC_199 LLGPGDDAAVVTVP------------------------------------
Mvan_1220|M.vanbaalenii_PYR-1 GLGWTDEGGCVVAGRPHVVMRWPLDPVQRVAAATKSFLGEVLDPLRRVPN
MSMEG_0567|M.smegmatis_MC2_155 ALGWDPLGDVEIAARPHVWMRRQINPFDALAAATKSFLGAALNPLRAVDG
** . .
Mb3001c|M.bovis_AF2122/97 ----------DGRTVVSTDMLVQDSHFRLDWS--TPQDVGRKAIAQNAAD
Rv2977c|M.tuberculosis_H37Rv ----------DGRTVVSTDMLVQDSHFRLDWS--TPQDVGRKAIAQNAAD
MLBr_01676|M.leprae_Br4923 ----------DGRIVVSTDVLVQDRHFRLDWS--TPHDVGRKAIAQNAAD
MAV_3829|M.avium_104 ----------DGRVVVSTDMLVQDRHFRLDWS--TPHDIGRKAIAQNAAD
MMAR_1735|M.marinum_M ----------DGRTVISTDMLVQDRHFRLDWS--SPHDVGRKAIAQNAAD
MUL_1978|M.ulcerans_Agy99 ----------DGRTVISTDMLVQDRHFRLDWS--SPHDVGRKAIAQNAAD
Mflv_4216|M.gilvum_PYR-GCK ----------DGRTVVCTDMLVEGRHFRLDWS--TPHDIGRKAIAQNAAD
TH_2051|M.thermoresistible__bu ----------DGRTVVCTDMLVQDRHFRLDWS--TPHQVGRKAIAQNAAD
MAB_3284c|M.abscessus_ATCC_199 ----------DGRVVVSTDMLVQDRHFRLEWS--SPSDIGRKAVAQNAAD
Mvan_1220|M.vanbaalenii_PYR-1 GLGPKGFVGDDGVPVPGGDVVAACDAIIPSMVERDPEWAGWCSVLVNVND
MSMEG_0567|M.smegmatis_MC2_155 ALGPAGFVGDDGSPVPGTDLVAACDAIIPSLVERDPEWAGWCSVLVNIND
** * *::. : . * * :: * *
Mb3001c|M.bovis_AF2122/97 IEAMGARATAFVVGFGAPAETPAAQASALVDGMWEEAGRIGAGIVGGDLV
Rv2977c|M.tuberculosis_H37Rv IEAMGARATAFVVGFGAPAETPAAQASALVDGMWEEAGRIGAGIVGGDLV
MLBr_01676|M.leprae_Br4923 IEAMGARATTFVVGLGAPGDTPVAQVDALVDGLWDEAGRIGAGIVGGDLV
MAV_3829|M.avium_104 IEAMGARPTAFVVGFGAPGQTAAAQVDALVDGMWDEAQRVGAGIAGGDLV
MMAR_1735|M.marinum_M IAAMGARPTAFVVSLGAPAHTPVAEVIALLDGMWEEAGRIGTGIVGGDMV
MUL_1978|M.ulcerans_Agy99 IAAMGARPTAFVVSLGAPAHTPVAEVTALLDGMWEEAGRIGTGIVGGDMV
Mflv_4216|M.gilvum_PYR-GCK IEAMGARATAFVVAFGAPGDTPTAAAVQVADGMWHEAALLGAGIVGGDTV
TH_2051|M.thermoresistible__bu IAAMGARSTAFVVAFGAPADTPAAAALALADGLWAEAQSLGAGIVGGDLV
MAB_3284c|M.abscessus_ATCC_199 IEAMGGRVTAFVVAVGAPAQTDIAFLDQLNEGVWAEAALVQAPIVGGDLV
Mvan_1220|M.vanbaalenii_PYR-1 LSAMGATPTGLLDAVGAPNR---SLLTRIVRGVANASQAWRVPVLGGHTQ
MSMEG_0567|M.smegmatis_MC2_155 LSAMGATPTGLLDAVAAPTR---AVLDRIIGGIAAASSAWAVPVLGGHTQ
: ***. * :: ...** : : *: : . : **.
Mb3001c|M.bovis_AF2122/97 SCRQWVVSVTAIGDLDGRAPVLRSGAKAGSVLAVVGELGRSAAGYALWCN
Rv2977c|M.tuberculosis_H37Rv SCRQWVVSVTAIGDLDGRAPVLRSGAKAGSVLAVVGELGRSAAGYALWCN
MLBr_01676|M.leprae_Br4923 SCPQWVLSVTVLGDLDGRAPVLRSGAKNGSMVAVAGALGRSAAGYALWHK
MAV_3829|M.avium_104 SCPQWVISVTALGELDGRSPVCRAGAEPGALIAVAGDLGRSAAGFDLWRN
MMAR_1735|M.marinum_M RCPQWVVSVTVLGDLEGRPPVTRGGAKPGSSVAVAGELGRSAAGYALWHN
MUL_1978|M.ulcerans_Agy99 RCPQWVVSVTVLGDLEGRPPVTRGGAKPGSSVAVAGELGRSAAGYALWHN
Mflv_4216|M.gilvum_PYR-GCK AAPQWVISVAALGDLGGREPVRRDGARPGDTVAVTGVLGRSAAGYELLRN
TH_2051|M.thermoresistible__bu RAPNWVVSVTALGDLEGRPPVPRGGARAGDVVAAVGQLGRSAAGYALWRN
MAB_3284c|M.abscessus_ATCC_199 SARELVVSVTVLGDLQGRAPVTRSGAVVGDTVAICGALGTSAAGYRLWQE
Mvan_1220|M.vanbaalenii_PYR-1 LGVPASLAVTALG--RTADPVPAAGGAAGDALRLTVDLSG------RWRP
MSMEG_0567|M.smegmatis_MC2_155 LGVPAALSVTALG--HTVSPVPAGGGVAGDRVRLTADTTG------RWRR
::*:.:* ** *. * :
Mb3001c|M.bovis_AF2122/97 GIEDFAELRRRHLVPQPPYGHGAAAAAVGAQAMIDVSDG-LLADLRHIAE
Rv2977c|M.tuberculosis_H37Rv GIEDFAELRRRHLVPQPPYGHGAAAAAVGAQAMIDVSDG-LLADLRHIAE
MLBr_01676|M.leprae_Br4923 GIDGFDDLRRRHLVPEPPYGKGVAAAACGAQAMIDVSDG-LIADLRHVAR
MAV_3829|M.avium_104 QIGGFDELRRRHAVPQPPYGQGAVAAAGGAQAMIDVSDG-LIADLRHVAE
MMAR_1735|M.marinum_M EIAGFDELRRRHLVPDPPYGQGVAAAVAGAQAMIDVSDG-LVADLRHIAD
MUL_1978|M.ulcerans_Agy99 EIAGFDELRRRHLVPDPPYGQGVAAAVAGAQAMIDVSDG-LVADLRHIAD
Mflv_4216|M.gilvum_PYR-GCK GIDGFDELRRQHRVPSPPYGQGAIAAQAGATAMTDVSDG-LLADLAHIAS
TH_2051|M.thermoresistible__bu GIKDFPALRERHLVPAPPYRQGPVAASSGATSMIDVSDG-LVADLGHVAE
MAB_3284c|M.abscessus_ATCC_199 QIDEFPDLRRVHLVPAPPYGQGPAAARAGATAMTDVSDG-LLADLAHIAE
Mvan_1220|M.vanbaalenii_PYR-1 GYHGRQWDSTSARCPDDLARMGSYVAAARPRAAKDVSMAGIAGTAGMLAE
MSMEG_0567|M.smegmatis_MC2_155 GYTGRQWDSTTSRNSAELASMAGLVARMAPRAAKDVSMAGVVGTVGMLAE
. . .* . : *** . : . :*
Mb3001c|M.bovis_AF2122/97 ASGVRIDLSAAALAADRDALTAAATALGTDPWPWVLSGGEDHALVACFVG
Rv2977c|M.tuberculosis_H37Rv ASGVRIDLSAAALAADRDALTAAATALGTDPWPWVLSGGEDHALVACFVG
MLBr_01676|M.leprae_Br4923 ASGVSIDLSTAALAADHAALIAAATAVGGDPWPWVLGGGEDHALVACFAG
MAV_3829|M.avium_104 ASGVGMDVSTAALAADRDAVAAAAAAVGVDAWPWVLTGGEDHALVACFPG
MMAR_1735|M.marinum_M SAAVGIDVATAALAQDHRALIAAADAVGADPWGWVLGGGEDHALVACFSG
MUL_1978|M.ulcerans_Agy99 AAAVGIDVATAALAQDHRALIAAADAVGADPCGWVLGGGEDHALVACFSG
Mflv_4216|M.gilvum_PYR-GCK ASGVSIDITLDTLTSDEAAVADAAGATGVDARQWVLGGGEDHALVATFPG
TH_2051|M.thermoresistible__bu SSAVGIDVFTDALAGDHAAVAPAAEVTGADAWSWVLGGGEDHALVATFPG
MAB_3284c|M.abscessus_ATCC_199 LSAVHIDLSSPSLEPYLQPVAGAAGLLGADPWEWVLTGGEDHALVGMFPG
Mvan_1220|M.vanbaalenii_PYR-1 AGGVGAEIDVAAVPRPRDADMGSWMTCFPGFGMLTAGG-VGAAPLPDGVA
MSMEG_0567|M.smegmatis_MC2_155 ASGTGAELDVATIPRPASAGMAPWLTCFPGFGMLTVGGALGSAAVPAGVA
... :: :: . . . . * . * : .
Mb3001c|M.bovis_AF2122/97 PVPAGWRTIG----RVLDGPARVLVDGEEWTGYAGWQSFGEPDNQGSLG
Rv2977c|M.tuberculosis_H37Rv PVPAGWRTIG----RVLDGPARVLVDGEEWTGYAGWQSFGEPDNQGSLG
MLBr_01676|M.leprae_Br4923 TALSGWRIIG----RVFDGPARVLVDGQEWRGHAGWQSFGG--------
MAV_3829|M.avium_104 PAPAGWRIIG----RVLDGPARVLVDEREWSGPAGWQSY----------
MMAR_1735|M.marinum_M AVPDGWRVIG----RVLDGPARVLVDGQQWSGYAGWQSFD---------
MUL_1978|M.ulcerans_Agy99 AVPDGWRVIG----RVLDGPARVLVDGQQWSGYAGWQSFD---------
Mflv_4216|M.gilvum_PYR-GCK AVPPNWRVLGTVAATAADGAPAVTVDGSPWIGNAGWQSF----------
TH_2051|M.thermoresistible__bu EPPPGWRVIG----RVVDGPARVLVDGVAWSGSAGWESFGD--------
MAB_3284c|M.abscessus_ATCC_199 VVPTGWVPIG----RVTVGEPGVTVDGAAWTRATGWDSFRLS-------
Mvan_1220|M.vanbaalenii_PYR-1 SRVCGRLTAQP---GVRLRWPDGVVTTALPAGVTGLGRA----------
MSMEG_0567|M.smegmatis_MC2_155 SSECGSLTAEP---GVRLRWPDGVTTTALTSPVTGLGKA----------
. . . . :*