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MPDTEPEASIETEPEASIETEPEASIDMESWVCPLPLRDAPAIVTGHGGGGAMSGELVEHLFLPAFGSAA EAGLADSAVVEIGGARLAFSTDSFVVKPMVFPGGTIGDLAVNGTVNDLAMAGAVPAVLSTAFILEEGTAL DHLARVAQAVGTAALAAGVKLVTGDTKVVDSGHGDGVYINTTGIGLVDPRVDIRPQRAAPGDVVIVSGDL GVHGIAVLSCREGLEFATSVASDAAPLHGLVAAMVETGADIHTLRDPTRGGLAATLNEIARAAGVGVSIA DTALPIPQEVRDACSMLGLDPLYVANEGKLVAFVPAADADEVLAAMHAHPLGAQSAVIGTCVPDHPGMVV AKTALGGNRVVDLPIGEQLPRIC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3982 | - | - | 100% (373) | hydrogenase expression/formation protein HypE |
| M. gilvum PYR-GCK | Mflv_4216 | - | 3e-08 | 27.56% (254) | thiamine monophosphate kinase |
| M. gilvum PYR-GCK | Mflv_1636 | - | 4e-08 | 24.50% (298) | phosphoribosylaminoimidazole synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0832 | purM | 1e-07 | 30.09% (113) | phosphoribosylaminoimidazole synthetase |
| M. tuberculosis H37Rv | Rv0809 | purM | 1e-07 | 30.09% (113) | phosphoribosylaminoimidazole synthetase |
| M. leprae Br4923 | MLBr_02205 | purM | 3e-08 | 25.53% (282) | phosphoribosylaminoimidazole synthetase |
| M. abscessus ATCC 19977 | MAB_3284c | - | 1e-06 | 26.04% (288) | thiamine monophosphate kinase |
| M. marinum M | MMAR_1859 | hypE | 7e-80 | 44.28% (332) | hydrogenase maturation factor, HypE |
| M. avium 104 | MAV_0748 | purM | 1e-08 | 25.89% (282) | phosphoribosylaminoimidazole synthetase |
| M. smegmatis MC2 155 | MSMEG_2276 | hypE | 1e-113 | 55.06% (356) | hydrogenase expression/formation protein HypE |
| M. thermoresistible (build 8) | TH_0225 | hypE | 8e-86 | 48.52% (338) | hydrogenase expression/formation protein HypE |
| M. ulcerans Agy99 | MUL_0418 | purM | 4e-08 | 23.84% (302) | phosphoribosylaminoimidazole synthetase |
| M. vanbaalenii PYR-1 | Mvan_2404 | - | 1e-174 | 84.21% (361) | hydrogenase expression/formation protein HypE |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3982|M.gilvum_PYR-GCK MPDTEPEASIETEPEASIETEPEASIDMESWV-----CPLPLRDAPAIVT
Mvan_2404|M.vanbaalenii_PYR-1 MP--EPDQRIR------------AAIDVESWV-----CPAPLRDAPNIVM
MSMEG_2276|M.smegmatis_MC2_155 ----MSDAPVT--------------IDPSDWV-----CPLPLRETKRIVM
MMAR_1859|M.marinum_M ----MSKSAGEYLSSGPRFAEGDVIGRIESFR-----RRRPRLLDEHVTL
TH_0225|M.thermoresistible__bu ----MAE------------AEARVIERIESFR-----RRRPRLRDEIVTL
MAV_0748|M.avium_104 ------------------------MTDPGKSP---GRHSGSQGITYASAG
MUL_0418|M.ulcerans_Agy99 ----MRGARVADTGGERRPVAFIAMTDPEKSPESSGRGPASQGVTYAAAG
Mb0832|M.bovis_AF2122/97 ------------------------MTDLAKGP---GKDPGSRGITYASAG
Rv0809|M.tuberculosis_H37Rv ------------------------MTDLAKGP---GKDPGSRGITYASAG
MLBr_02205|M.leprae_Br4923 ------------------------MMDPGKSP---GGQLGNHGITYASTG
MAB_3284c|M.abscessus_ATCC_199 ------------------------MPNLGDTG-----------EFGVISR
.
Mflv_3982|M.gilvum_PYR-GCK GHGGGGAMSGELVEHLFLPAFGSAAEAGLA-DSAVVEIG-GARLAFSTDS
Mvan_2404|M.vanbaalenii_PYR-1 GHGGGGAMSGELIEHLFLPAFGPAADAAMG-DAAVVEIG-GTRLAFSTDS
MSMEG_2276|M.smegmatis_MC2_155 GHGGGGVLSEELIENLFLPAFDTADAGPAR-DSALLKVG-AGTVAVTTDS
MMAR_1859|M.marinum_M AHGAGGKASAALIDAVFMEAFRNPLLESLG-DGAILTLPSGERVAMSTDS
TH_0225|M.thermoresistible__bu AHGAGGKASAALVDAVFVEAFRNPLLESLG-DGAVLPLPDGRRMAMSTDS
MAV_0748|M.avium_104 VDIEAGDRAVELFKPLATKATRPEVRGGLGGFAGLFALRGEYREPLLAAS
MUL_0418|M.ulcerans_Agy99 VDIEAGDRAVELFKPLATRATRPEVRGGLGGFAGLFALRNDYREPVLAAS
Mb0832|M.bovis_AF2122/97 VDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTLRGDYREPVLAAS
Rv0809|M.tuberculosis_H37Rv VDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTLRGDYREPVLAAS
MLBr_02205|M.leprae_Br4923 VDIEAGDRSVELFKPMAVKAIRTEVLGGLGGFAGLFALRSGYREPVLAAS
MAB_3284c|M.abscessus_ATCC_199 LTAGRDLGADVLLGPGDDAAVVTVPDGRVVVSTDMLVQDRHFRLEWSSPS
. : *. * :. : *
Mflv_3982|M.gilvum_PYR-GCK -------FVVKPMVFPGGTIGDLAVNGTVNDLAMAGAVPAVLSTAFILEE
Mvan_2404|M.vanbaalenii_PYR-1 -------FVVKPMVFPGGSIGDLAVNGTVNDLAMAGAVPQVLSTAFILEE
MSMEG_2276|M.smegmatis_MC2_155 -------YVVQPLFFPGGDIGHLAVNGTINDLACSGAQPVALTAGFILEE
MMAR_1859|M.marinum_M -------FVVQPRRFPGGSIGELAVHGTCNDLAVAGAVPSWISAAFVLEE
TH_0225|M.thermoresistible__bu -------FVVQPLRFPGGSIGHLAVHGTVNDLAMAGAVPSWISAAFVLEE
MAV_0748|M.avium_104 TDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGR
MUL_0418|M.ulcerans_Agy99 TDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGR
Mb0832|M.bovis_AF2122/97 SDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIAVGR
Rv0809|M.tuberculosis_H37Rv SDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIAVGR
MLBr_02205|M.leprae_Br4923 TDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGR
MAB_3284c|M.abscessus_ATCC_199 ------------------DIGRKAVAQNAADIEAMGGRVTAFVVAVGAPA
:* * *: *. : .
Mflv_3982|M.gilvum_PYR-GCK GTALDHLARVAQAVGTAALAAGVKLVTGDTKVVD-SGHGDGVYINTTGIG
Mvan_2404|M.vanbaalenii_PYR-1 GTPLDELARVAQAVGTAAMAAGVRLVTGDTKVVD-SGHGDGVYINTAGIG
MSMEG_2276|M.smegmatis_MC2_155 GLEIDVLGAVAQSMGAAARHAGVRIVTGDTKVVG-KGGADQLFVNTAGVG
MMAR_1859|M.marinum_M GFPIEELKQIVADMADAAAKAGVQIVTGDTKVVP-KGAADGLFITTTGTG
TH_0225|M.thermoresistible__bu GFPVSELKEIVADMADAAAAAGVQIVTGDTKVVA-RGAADGLFVTTAGVG
MAV_0748|M.avium_104 -TVPERLSAIVSGIAEGCVRAGCALLGGETAEHPGLMEPDHYDISATGVG
MUL_0418|M.ulcerans_Agy99 -TVPERVSAIVSGIAEGCVRAGCALLGGETAEHPGLMAPDHYDISATGVG
Mb0832|M.bovis_AF2122/97 -IVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEPDHYDISATGVG
Rv0809|M.tuberculosis_H37Rv -IVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEPDHYDISATGVG
MLBr_02205|M.leprae_Br4923 -TVPERLSAIVDGIAEGCMLAGCALLGGETAEHPGLMEVDHYDIAATGVG
MAB_3284c|M.abscessus_ATCC_199 QTDIAFLDQLNEGVWAEAALVQAPIVGGDLVSAR------ELVVSVTVLG
: : : . . :: *: : .: *
Mflv_3982|M.gilvum_PYR-GCK LVDPRVDIRPQRAAPGDVVIVSGDLGVHGIAVLSCREGLEFATSVASDAA
Mvan_2404|M.vanbaalenii_PYR-1 LVDDRTDIRPQRAAPGDAVIVSGDIGVHGVAVLSCREGLEFGTAVASDTA
MSMEG_2276|M.smegmatis_MC2_155 VVPPGVSIGPELVRPGDHILVSGNLGEHGVAIMSVREGIDFGTAVTTDSA
MMAR_1859|M.marinum_M IIPTGRALSADSVRPGDKVLLSGSMGDHGMAVMLARGDLAIEADIHSDTA
TH_0225|M.thermoresistible__bu LIPAGRELSAAAVRPGDRVLISGSMGEHGMAVMLARGDLAIDADICSDTA
MAV_0748|M.avium_104 VVEADDVLGPDRVKPGDVIIAMGSSGLHSNGYSLART-VLLEIDRMNLEG
MUL_0418|M.ulcerans_Agy99 VVEADNVLGPERVKPGDVIIAMGSSGLHSNGYSLARN-VLLEIDRMNLAG
Mb0832|M.bovis_AF2122/97 VVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRK-VLLEIDRMNLAG
Rv0809|M.tuberculosis_H37Rv VVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRK-VLLEIDRMNLAG
MLBr_02205|M.leprae_Br4923 VVEADDTLGPDRVKPGDVIIALRSSGLHSNGYSLARS-VLLEIDRMNLAG
MAB_3284c|M.abscessus_ATCC_199 DLQGRAPVTRSGAVVGDTVAICGALGTSAAGYRLWQEQIDEFPDLR-RVH
: : . ** : * . . : :
Mflv_3982|M.gilvum_PYR-GCK PLHGLVAAMVETG--ADIHTLRDPTRGGLAATLNEIARAAGVGVSIADTA
Mvan_2404|M.vanbaalenii_PYR-1 PLHGLVAAMVATG--ADVHALRDPTRGGMAATLNEIAKAAKVGVTIDERA
MSMEG_2276|M.smegmatis_MC2_155 PLHHLVAAMLATGDPSHVHALRDPTRGGLVASVVEIARAARVGMELDEAN
MMAR_1859|M.marinum_M SVSPLVELLMAAA--PGTRWLRDATRGGVGTVCNELAQACGFGVLLDEQR
TH_0225|M.thermoresistible__bu AVSGLVETLLAAA--PSTRWLRDPTRGGVGTVCNELARAANVGVVLDEER
MAV_0748|M.avium_104 YVEEFGRTLGEELLEPTRIYAKDCLALAAETHVRTFCHVTGGGLAGNLAR
MUL_0418|M.ulcerans_Agy99 YVEEFGRTLGEELLEPTRIYAKDCLALTAETHVRTFCHVTGGGLAGNLER
Mb0832|M.bovis_AF2122/97 HVEEFGRTLGEELLEPTRIYAKDCLALAAETRVRTFCHVTGGGLAGNLQR
Rv0809|M.tuberculosis_H37Rv HVEEFGRTLGEELLEPTRIYAKDCLALAAETRVRTFCHVTGGGLAGNLQR
MLBr_02205|M.leprae_Br4923 YVEEFGRTLGEELLEPTRIYAKDCLALAAETHVRTFCHVTGGGLAGNLQR
MAB_3284c|M.abscessus_ATCC_199 LVPAPPYGQGPAAARAGATAMTDVSDG-LLADLAHIAELSAVHIDLSSPS
: . * : :.. :
Mflv_3982|M.gilvum_PYR-GCK LP---IPQEVRDACSMLGLDPLYVANEGKLVAFVPAADADEVLAAMHAHP
Mvan_2404|M.vanbaalenii_PYR-1 LP---IPSEVRDACSMLGLDPLYVANEGKLVAFVPAADAGKVLAAMRAHP
MSMEG_2276|M.smegmatis_MC2_155 IP---VPESVSSACSFLGLDPLQVANEGKIVAFVDPAHSEAILETMRARP
MMAR_1859|M.marinum_M LP---VAPMVNGACELLGIDPLYVANEGKFIAVVAPEEAEAGLAALQSHP
TH_0225|M.thermoresistible__bu LV---VRPEVAAACEMLGIDLLYVANEGKFLAVVAAEEVDAALAALRAHP
MAV_0748|M.avium_104 VIPHGLVAELDRGTWTPAPVFAMIAQRGRVTREEMEKTFNMGVGMIAVVA
MUL_0418|M.ulcerans_Agy99 VIPHGLVAEIDRGTWTPAPVFAMIAQRGRVVREEMEKTFNMGVGMIAVVA
Mb0832|M.bovis_AF2122/97 VIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFNMGVGMIAVVA
Rv0809|M.tuberculosis_H37Rv VIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFNMGVGMIAVVA
MLBr_02205|M.leprae_Br4923 VIPHGLVAEVDRGTWTPAPVFAMIAQRGRVAREEMEKTFNMGVGMIAVVA
MAB_3284c|M.abscessus_ATCC_199 LEP--YLQPVAGAAGLLGADPWEWVLTG---------GEDHALVGMFPGV
: : . . . * : :
Mflv_3982|M.gilvum_PYR-GCK LGAQSAVIGTCVPDHPGMVVAKTALGGNR-VVDLPIGEQLPRIC
Mvan_2404|M.vanbaalenii_PYR-1 LGAHAVIIGACVADHPGMVVAKTALGGTR-VVDLPIGEQLPRIC
MSMEG_2276|M.smegmatis_MC2_155 EGANAAIIGRVVEGHPGMAVGKTPFGTTR-VIERELGEQLPRIC
MMAR_1859|M.marinum_M LGADAAEVGEIIAEPAETVILRTGFGGTR-IVDMLVGDPLPRIC
TH_0225|M.thermoresistible__bu LGADAAEIGEITTEPAGTVVLRTAFGGSR-IVDMLVGDPLPRIC
MAV_0748|M.avium_104 PEDTDRALAILTARHLDCWVLGTVGKGGKAGPRAKLVGQHPRF-
MUL_0418|M.ulcerans_Agy99 PEDTDRALAILTARHLDCWVLGTVCKGGKEGPRATLVGQHPRF-
Mb0832|M.bovis_AF2122/97 PEDTTRALAVLTARHLDCWVLGTVCKGGKQGPRAKLVGQHPRF-
Rv0809|M.tuberculosis_H37Rv PEDTTRALAVLTARHLDCWVLGTVCKGGKQGPRAKLVGQHPRF-
MLBr_02205|M.leprae_Br4923 PEDTDRALAILTARHLDCWVLGTVCKGSKVGPRAKLVGQHPRF-
MAB_3284c|M.abscessus_ATCC_199 VPTGWVPIGRVTVGEPGVTVDGAAWTRATGWDSFRLS-------
:. : : :