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AGSPTTCAERTPGRIGCSRRPVALWPMSDRAEQHGISYASAGVDIEAGDRAVELFKPLAKKATRPEVRGG LGGFAGLFALRGDYREPLLASSTDGVGTKLAVAQAMDKHDTVGIDLVAMVVDDLVVCGAEPLFLQDYIAV GRTVPERVAELVSGIADGCVLAGCALLGGETAEHPGLMAPDHYDISATGIGVVEADDVLGPDRVRPGDVI IGMASTGLHSNGYSLARHVLLEIDHMNLAGHVEEFGRTLGEELLEPTRIYAKDCLALAAETQVRTFCHVT GGGLAGNLERVIPHGLVAELDRGTWTPAPVFGMIAQRGRIERAEMEKTFNMGVGMVAIVAPEDTDRALAV LTARHLNCWTLGTIEKGGKDGPRAVLVGQHPRF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5111 | - | - | 100% (384) | phosphoribosylaminoimidazole synthetase |
| M. vanbaalenii PYR-1 | Mvan_2362 | - | 1e-07 | 25.32% (233) | hydrogenase expression/formation protein HypE |
| M. vanbaalenii PYR-1 | Mvan_2404 | - | 5e-06 | 23.27% (275) | hydrogenase expression/formation protein HypE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0832 | purM | 1e-180 | 86.53% (349) | phosphoribosylaminoimidazole synthetase |
| M. gilvum PYR-GCK | Mflv_1636 | - | 0.0 | 97.17% (353) | phosphoribosylaminoimidazole synthetase |
| M. tuberculosis H37Rv | Rv0809 | purM | 1e-180 | 86.53% (349) | phosphoribosylaminoimidazole synthetase |
| M. leprae Br4923 | MLBr_02205 | purM | 1e-178 | 85.71% (350) | phosphoribosylaminoimidazole synthetase |
| M. abscessus ATCC 19977 | MAB_0728 | - | 1e-173 | 82.73% (359) | phosphoribosylaminoimidazole synthetase |
| M. marinum M | MMAR_4880 | purM | 0.0 | 88.83% (349) | 5'-phosphoribosyl-5-aminoimidazole synthetase, PurM |
| M. avium 104 | MAV_0748 | purM | 0.0 | 89.68% (349) | phosphoribosylaminoimidazole synthetase |
| M. smegmatis MC2 155 | MSMEG_5798 | purM | 0.0 | 90.42% (355) | phosphoribosylaminoimidazole synthetase |
| M. thermoresistible (build 8) | TH_0070 | purM | 0.0 | 88.52% (357) | PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM |
| M. ulcerans Agy99 | MUL_0418 | purM | 0.0 | 83.86% (378) | phosphoribosylaminoimidazole synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5111|M.vanbaalenii_PYR-1 -------------------MAGSPTTCAERTPGRIGCSRRPVALWPMSDR
Mflv_1636|M.gilvum_PYR-GCK --------------------MLSMTKGVEQ-----------------SGI
Mb0832|M.bovis_AF2122/97 --------------------MTDLAKGP-------------------GKD
Rv0809|M.tuberculosis_H37Rv --------------------MTDLAKGP-------------------GKD
MLBr_02205|M.leprae_Br4923 --------------------MMDPGKSP-------------------GGQ
MMAR_4880|M.marinum_M --------------------MTDPEKSPESS----------------GRG
MUL_0418|M.ulcerans_Agy99 MRGARVADTGGERRPVAFIAMTDPEKSPESS----------------GRG
MAV_0748|M.avium_104 --------------------MTDPGKSP-------------------GRH
MSMEG_5798|M.smegmatis_MC2_155 --------------------MTDREDSV----------------------
TH_0070|M.thermoresistible__bu --------------------MTER--------------------------
MAB_0728|M.abscessus_ATCC_1997 --------------------MPDMSER-----------------------
.
Mvan_5111|M.vanbaalenii_PYR-1 AEQHGISYASAGVDIEAGDRAVELFKPLAKKATRPEVRGGLGGFAGLFAL
Mflv_1636|M.gilvum_PYR-GCK ADQHGISYASAGVDIEAGDRAVELFKPLAKKATRPEVRGDLGGFAGLFAL
Mb0832|M.bovis_AF2122/97 PGSRGITYASAGVDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTL
Rv0809|M.tuberculosis_H37Rv PGSRGITYASAGVDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTL
MLBr_02205|M.leprae_Br4923 LGNHGITYASTGVDIEAGDRSVELFKPMAVKAIRTEVLGGLGGFAGLFAL
MMAR_4880|M.marinum_M PASQGVTYAAAGVDIEAGDRAVELFKPLATRATRPEVRGGLGGFAGLFAL
MUL_0418|M.ulcerans_Agy99 PASQGVTYAAAGVDIEAGDRAVELFKPLATRATRPEVRGGLGGFAGLFAL
MAV_0748|M.avium_104 SGSQGITYASAGVDIEAGDRAVELFKPLATKATRPEVRGGLGGFAGLFAL
MSMEG_5798|M.smegmatis_MC2_155 -SSDAISYASAGVDIEAGDRAVELFKPLAAKATRPEVRGGLGGFAGLFAL
TH_0070|M.thermoresistible__bu AEQHGISYASAGVDIEAGDRAVELIKPLASRASRPEVMGGLGGFAGLFKL
MAB_0728|M.abscessus_ATCC_1997 ADKPSNSYAAAGVDIEAGDRAVELFKKSVAKTHRPEVLGGIGGFAGLFAL
. . :**::*********:::*:* . :: *.** *.:******* *
Mvan_5111|M.vanbaalenii_PYR-1 RGDYREPLLASSTDGVGTKLAVAQAMDKHDTVGIDLVAMVVDDLVVCGAE
Mflv_1636|M.gilvum_PYR-GCK RGDYREPLLASSTDGVGTKLAVAQAMDKHDTVGIDLVAMVVDDLVVCGAE
Mb0832|M.bovis_AF2122/97 RGDYREPVLAASSDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAE
Rv0809|M.tuberculosis_H37Rv RGDYREPVLAASSDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAE
MLBr_02205|M.leprae_Br4923 RSGYREPVLAASTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAE
MMAR_4880|M.marinum_M RNDYREPVLAASTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAE
MUL_0418|M.ulcerans_Agy99 RNDYREPVLAASTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAE
MAV_0748|M.avium_104 RGEYREPLLAASTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAE
MSMEG_5798|M.smegmatis_MC2_155 KRDYREPVLASSTDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAE
TH_0070|M.thermoresistible__bu RGGYREPILASSTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAE
MAB_0728|M.abscessus_ATCC_1997 KGGYREPVLAASTDGVGTKIAVAQAMDKRDTVGLDLVAMVVDDLVVCGAE
: ****:**:*:******:*:******:****:****************
Mvan_5111|M.vanbaalenii_PYR-1 PLFLQDYIAVGRTVPERVAELVSGIADGCVLAGCALLGGETAEHPGLMAP
Mflv_1636|M.gilvum_PYR-GCK PLFLQDYIAIGRTVPERVAELVSGIADGCVQAGCALLGGETAEHPGLMAP
Mb0832|M.bovis_AF2122/97 PLFLLDYIAVGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEP
Rv0809|M.tuberculosis_H37Rv PLFLLDYIAVGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEP
MLBr_02205|M.leprae_Br4923 PLFLQDYIAVGRTVPERLSAIVDGIAEGCMLAGCALLGGETAEHPGLMEV
MMAR_4880|M.marinum_M PLFLQDYIAVGRTVPERVSAIVSGIAEGCVRAGCALLGGETAEHPGLMAP
MUL_0418|M.ulcerans_Agy99 PLFLQDYIAVGRTVPERVSAIVSGIAEGCVRAGCALLGGETAEHPGLMAP
MAV_0748|M.avium_104 PLFLQDYIAVGRTVPERLSAIVSGIAEGCVRAGCALLGGETAEHPGLMEP
MSMEG_5798|M.smegmatis_MC2_155 PLFLQDYIAVGRTVPERVSAIVAGIAEGCVRAGCALLGGETAEHPGLMEP
TH_0070|M.thermoresistible__bu PLFLQDYIAVGRTVPERISELVSGIAEGCVQAGCALLGGETAEHPGLMAP
MAB_0728|M.abscessus_ATCC_1997 PLFLQDYIAVGKVVPERVSELVAGIAEGCAIAGCALLGGETAEHPGLMAP
**** ****:*: ****:: :* ***:** ****************:
Mvan_5111|M.vanbaalenii_PYR-1 DHYDISATGIGVVEADDVLGPDRVRPGDVIIGMASTGLHSNGYSLARHVL
Mflv_1636|M.gilvum_PYR-GCK DHYDISATGIGVVEADDVLGPDRVRPGDVIIAMASTGLHSNGYSLARHVL
Mb0832|M.bovis_AF2122/97 DHYDISATGVGVVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRKVL
Rv0809|M.tuberculosis_H37Rv DHYDISATGVGVVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRKVL
MLBr_02205|M.leprae_Br4923 DHYDIAATGVGVVEADDTLGPDRVKPGDVIIALRSSGLHSNGYSLARSVL
MMAR_4880|M.marinum_M DHYDISATGVGVVEADDVLGPERVKPGDVIIAMGSSGLHSNGYSLARNVL
MUL_0418|M.ulcerans_Agy99 DHYDISATGVGVVEADNVLGPERVKPGDVIIAMGSSGLHSNGYSLARNVL
MAV_0748|M.avium_104 DHYDISATGVGVVEADDVLGPDRVKPGDVIIAMGSSGLHSNGYSLARTVL
MSMEG_5798|M.smegmatis_MC2_155 DHYDISATGVGIVEADDVLGPDRVRPGDVIIAMASSGLHSNGYSLARKVL
TH_0070|M.thermoresistible__bu DHYDLSAFGVGIVEADDLLGPERVRPGDVIIAMGSSGLHSNGYSLARKVL
MAB_0728|M.abscessus_ATCC_1997 DDFDLSATGVGIVEADRVLGPDRVRPGDVVIAMGSSGLHSNGYSLARHVL
*.:*::* *:*:**** ***:**:****:*.: *:*********.* **
Mvan_5111|M.vanbaalenii_PYR-1 LEIDHMNLAGHVEEFGRTLGEELLEPTRIYAKDCLALAAETQVRTFCHVT
Mflv_1636|M.gilvum_PYR-GCK LEIDHMNLAGHVEEFGRTLGEELLEPTRIYAKDCLALAAETQVRTFCHVT
Mb0832|M.bovis_AF2122/97 LEIDRMNLAGHVEEFGRTLGEELLEPTRIYAKDCLALAAETRVRTFCHVT
Rv0809|M.tuberculosis_H37Rv LEIDRMNLAGHVEEFGRTLGEELLEPTRIYAKDCLALAAETRVRTFCHVT
MLBr_02205|M.leprae_Br4923 LEIDRMNLAGYVEEFGRTLGEELLEPTRIYAKDCLALAAETHVRTFCHVT
MMAR_4880|M.marinum_M LEIDRMNLAGYVEEFGRTLGEELLEPTRIYAKDCLALTAETHVRTFCHVT
MUL_0418|M.ulcerans_Agy99 LEIDRMNLAGYVEEFGRTLGEELLEPTRIYAKDCLALTAETHVRTFCHVT
MAV_0748|M.avium_104 LEIDRMNLEGYVEEFGRTLGEELLEPTRIYAKDCLALAAETHVRTFCHVT
MSMEG_5798|M.smegmatis_MC2_155 LEIDRMNLAGHVEEFGRTLGEELLEPTLIYAKDCLALAAETQVRTFCHVT
TH_0070|M.thermoresistible__bu LEIDRMNLAGHVEEFGRTLGEELLEPTRIYARDCLALAAETNVRTFCHIT
MAB_0728|M.abscessus_ATCC_1997 LEIDRMDLFGQVEEFGRTLGEELLEPTRIYAKDCLALAAETEVRTFCHVT
****:*:* * **************** ***:*****:***.******:*
Mvan_5111|M.vanbaalenii_PYR-1 GGGLAGNLERVIPHGLVAELDRGTWTPAPVFGMIAQRGRIERAEMEKTFN
Mflv_1636|M.gilvum_PYR-GCK GGGLAGNLERVIPHGLVAQLDRGTWTPAPVFGMIAQRGRIERAEMEKTFN
Mb0832|M.bovis_AF2122/97 GGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFN
Rv0809|M.tuberculosis_H37Rv GGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFN
MLBr_02205|M.leprae_Br4923 GGGLAGNLQRVIPHGLVAEVDRGTWTPAPVFAMIAQRGRVAREEMEKTFN
MMAR_4880|M.marinum_M GGGLAGNLERVIPHGLVAEIDRGTWTPAPVFAMIAQRGRVVREEMEKTFN
MUL_0418|M.ulcerans_Agy99 GGGLAGNLERVIPHGLVAEIDRGTWTPAPVFAMIAQRGRVVREEMEKTFN
MAV_0748|M.avium_104 GGGLAGNLARVIPHGLVAELDRGTWTPAPVFAMIAQRGRVTREEMEKTFN
MSMEG_5798|M.smegmatis_MC2_155 GGGLAGNLERVIPHGLTAELDRGTWTPAPVFGMIAQRGRIERAEMEKTFN
TH_0070|M.thermoresistible__bu GGGLAGNLERVIPNGLSAELDRGTWTPAPVFAMIAQRGRIERAEMERTFN
MAB_0728|M.abscessus_ATCC_1997 GGGLAGNLARVIPDGLVAELDRGSWTPGPIFAMIAQRGRIERAEMEKTFN
******** ****.** *::***:***.*:* *******: * ***:***
Mvan_5111|M.vanbaalenii_PYR-1 MGVGMVAIVAPEDTDRALAVLTARHLNCWTLGTIEKGGKDG--PRAVLVG
Mflv_1636|M.gilvum_PYR-GCK MGVGMVAVVAPEDTDRALAVLTARHLDCWTLGTIEKGAKDG--SRAVLVG
Mb0832|M.bovis_AF2122/97 MGVGMIAVVAPEDTTRALAVLTARHLDCWVLGTVCKGGKQG--PRAKLVG
Rv0809|M.tuberculosis_H37Rv MGVGMIAVVAPEDTTRALAVLTARHLDCWVLGTVCKGGKQG--PRAKLVG
MLBr_02205|M.leprae_Br4923 MGVGMIAVVAPEDTDRALAILTARHLDCWVLGTVCKGSKVG--PRAKLVG
MMAR_4880|M.marinum_M MGVGMIAVVAPEDTDRALAILTARHLDCWVLGTVCKGGKEG--PRATLVG
MUL_0418|M.ulcerans_Agy99 MGVGMIAVVAPEDTDRALAILTARHLDCWVLGTVCKGGKEG--PRATLVG
MAV_0748|M.avium_104 MGVGMIAVVAPEDTDRALAILTARHLDCWVLGTVGKGGKAG--PRAKLVG
MSMEG_5798|M.smegmatis_MC2_155 MGVGMVAVVAPEDTDRALAILTARHLNCWTLGTVKKGGKDS--VRAQLVG
TH_0070|M.thermoresistible__bu MGVGMVAIVAPEDTDRALAILTARHLDCWVLGTVTKAGKDE--PRARLVG
MAB_0728|M.abscessus_ATCC_1997 MGVGMVAVVAPEDVDRALAVLTARHIDCWTLGTIKKSGKDSGSESALLVG
*****:*:*****. ****:*****::**.***: *..* * ***
Mvan_5111|M.vanbaalenii_PYR-1 QHPRF
Mflv_1636|M.gilvum_PYR-GCK QHPRF
Mb0832|M.bovis_AF2122/97 QHPRF
Rv0809|M.tuberculosis_H37Rv QHPRF
MLBr_02205|M.leprae_Br4923 QHPRF
MMAR_4880|M.marinum_M QHPRF
MUL_0418|M.ulcerans_Agy99 QHPRF
MAV_0748|M.avium_104 QHPRF
MSMEG_5798|M.smegmatis_MC2_155 QHPRF
TH_0070|M.thermoresistible__bu QHPRF
MAB_0728|M.abscessus_ATCC_1997 QHPRF
*****