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MIVETRASFGGVGTRVLAVPGSDPPVVLLHGYADSADTWTEVLRGFGAAGRRAVAVDLPGFGRAGARAPG PLLGQFDAFAGALLKDLGPVVLVGNSLGAATAVRAANRHPALVAGLVALDDPVNARHWLARLARLRPVPA PVWRGVGAIRLPAPAARALTEAAARKVLYGPDAVVNPDVVSRWSSLVTQPRALETLGRYAFQYAIETAGG HREVRVNCPTLIVHGGRDRIIPVHASRILHRQIPGSDLVVLPRSGHCPQLDDPAAVVRLTLRLLDGIPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2343 | - | - | 100% (279) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 1e-19 | 31.25% (256) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_4279 | - | 2e-14 | 29.25% (253) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 1e-20 | 30.60% (268) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_2367 | - | 4e-16 | 29.07% (258) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 1e-20 | 30.60% (268) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_02603 | - | 1e-09 | 27.10% (262) | hypothetical protein MLBr_02603 |
| M. abscessus ATCC 19977 | MAB_2946c | - | 3e-86 | 56.68% (277) | Alpha/beta hydrolase fold |
| M. marinum M | MMAR_5064 | bphD | 4e-19 | 30.60% (268) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. avium 104 | MAV_0592 | - | 5e-17 | 29.04% (272) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
| M. smegmatis MC2 155 | MSMEG_0220 | - | 3e-15 | 27.38% (263) | monoglyceride lipase |
| M. thermoresistible (build 8) | TH_3363 | - | 1e-13 | 26.06% (284) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4140 | bphD | 1e-19 | 30.60% (268) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2343|M.vanbaalenii_PYR-1 ----------MIVETRASFGGVGTRVLAVPGS----------DPPVVLLH
MAB_2946c|M.abscessus_ATCC_199 ----------MIAESRAEYGGVVTRVLSVPGG----------GPPIVLLH
Mb3600c|M.bovis_AF2122/97 ----MTATEELTFESTSRFAEVDVDGPLKLHYHEAGV---GNDQTVVLLH
Rv3569c|M.tuberculosis_H37Rv ----MTATEELTFESTSRFAEVDVDGPLKLHYHEAGV---GNDQTVVLLH
MAV_0592|M.avium_104 ----MTATEELTFESTSRFAEVDVDGPLKLHYHEAGLSFKGTGRTVVLLH
MMAR_5064|M.marinum_M MTVTQSKTAEHTFESTSRYAEVDVDGPLKLHYHEAGV---GNDQTVVLLH
MUL_4140|M.ulcerans_Agy99 MTVTQSKTAEHTFESTSRYAEVDVDGPLKLHYHEAGV---GNDQTVVLLH
TH_3363|M.thermoresistible__bu ---------MRTFDYQETLREVRTP-AGVLRYHEAGD-----GPPLLLLH
MLBr_02603|M.leprae_Br4923 ---------MTITRTERNFYGVGGVRIVYDVWMPDTR----PRAVIILAH
MSMEG_0220|M.smegmatis_MC2_155 --------MVSSTRSEHSFAGVGGVRIVYDVWTPDTD----PRGVVVLAH
Mflv_2367|M.gilvum_PYR-GCK -------------MTDLRYLDLHGDRCAYRDEGDGEE-------TLLLLH
: ::* *
Mvan_2343|M.vanbaalenii_PYR-1 GYADSADTWTEVLRGFGAAGR--RAVAVDLPGFGRAGA-----RAPGPLL
MAB_2946c|M.abscessus_ATCC_199 GYSDSALTWRPVLARLASAGR--AAIAVDLPGFGHAAP-----RPPGPLL
Mb3600c|M.bovis_AF2122/97 GGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDK-----RAEHGQF
Rv3569c|M.tuberculosis_H37Rv GGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDK-----RAEHGQF
MAV_0592|M.avium_104 GGGPGAASWTNFGRNIPVLARHFHVLAVDQPGYGLSDK-----RAEHGQF
MMAR_5064|M.marinum_M GGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDK-----RAEHGQF
MUL_4140|M.ulcerans_Agy99 GGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDK-----RAEHGQF
TH_3363|M.thermoresistible__bu GSGPGVTGWRNFRGNLGVFAEHFRCLVLEFPGFGVSDD-----FGGHPMI
MLBr_02603|M.leprae_Br4923 GFGEHARRYDHVAHYFAAAGL--ATYALDLRGHGRSAGKRVLVRDLSEYN
MSMEG_0220|M.smegmatis_MC2_155 GYAEHAGRYHHVAQRFGAAGL--LVYALDHRGHGRSGGKRVHLRDLSEFV
Mflv_2367|M.gilvum_PYR-GCK GMAGSSETWRAVIPHLAKRYR---VIAPDLLGHGSSAK------PRGDYS
* . : . : . : *.* :
Mvan_2343|M.vanbaalenii_PYR-1 GQFDAFAGALLKD---LGPVVLVGNSLGAATAVRAANRHPALVAGLVALD
MAB_2946c|M.abscessus_ATCC_199 AQFDVFADAVLAA---AGPAVLVGNSLGAATAVRAAARRENEVKALIALD
Mb3600c|M.bovis_AF2122/97 NRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFALDYPARAGRLVLMG
Rv3569c|M.tuberculosis_H37Rv NRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFALDYPARAGRLVLMG
MAV_0592|M.avium_104 NRYAARALNGLFEQLELGRVPLVGNSLGGGTAVRFALDYPDKAGRLVLMG
MMAR_5064|M.marinum_M NHYAARALKELFDQLGLGRVPLVGNSLGGGTAVRFALDYPDRAGRLVLMG
MUL_4140|M.ulcerans_Agy99 NHYAARALKELFDQLGLGRVLLVGNSLGGGTAVRFALDYPDRAGRLVLMG
TH_3363|M.thermoresistible__bu D--AQGAALAFADALGLDRVDIIGNSMGGGVGVSLAVRHPDRVNRLVTIG
MLBr_02603|M.leprae_Br4923 ADFDILVGIATRDHPGLKRIVAG-HSMGGAIVFAYGVERPDNYDLMVLSG
MSMEG_0220|M.smegmatis_MC2_155 EDFRTLVGIAANDHPTLPRIVLG-HSMGGGIVFAYGARYPGEYSAMVLSG
Mflv_2367|M.gilvum_PYR-GCK LGAFAAWLRDLLDELGIRSVTVVGQSLGGGVAMQFVYQHPDYCRRLVLIS
:*:*.. . :: .
Mvan_2343|M.vanbaalenii_PYR-1 DPVNARHWLARLARLRPVPAPVWRGVGAIRLPAPAARALTEAAARKVLYG
MAB_2946c|M.abscessus_ATCC_199 DPLNSRHLIARIVRRWSVPEVFWAWVSRMPVPAGTLRRAARYFVPKMLYG
Mb3600c|M.bovis_AF2122/97 PGGLSINLFA--------PDPTEGVKRLSKFSVAPTRENLEAFLRVMVYD
Rv3569c|M.tuberculosis_H37Rv PGGLSINLFA--------PDPTEGVKRLSKFSVAPTRENLEAFLRVMVYD
MAV_0592|M.avium_104 PGGLSINLFA--------PDPTEGVKRLGKFSAEPTRENLEAFLRVMVYD
MMAR_5064|M.marinum_M PGGLSINLFA--------PDPTEGVKRLGKFSVAPTRENLEAFLRVMVYD
MUL_4140|M.ulcerans_Agy99 PGGLSINLFA--------PDPTEGVKRLGKFSVAPTRENLEAFLRVMVYD
TH_3363|M.thermoresistible__bu --GIGTNIFS--------PGPSEGIRLLQEFTDDPTRDRLIAWLNSMVYD
MLBr_02603|M.leprae_Br4923 PAVAAQDMVS----------PLRAVVGKGLGLVAPGLPVHQLEVDAISRN
MSMEG_0220|M.smegmatis_MC2_155 PAVNAHDGVS----------PVLVAVAKVLGKLAPGIPVENLDADAVSRD
Mflv_2367|M.gilvum_PYR-GCK SGGLGQDVGWTLR-----LLSAPGSELLLPLIAPSPVVRAGDRVRAWFSA
. . .
Mvan_2343|M.vanbaalenii_PYR-1 PDAVVNPDVVSRWSSLVTQPRALETLGRYAFQYAIETAGGHRE-------
MAB_2946c|M.abscessus_ATCC_199 PGVAADPEVVAYWCELISGPSAVARLGRDACRYAHEALGSHSG-------
Mb3600c|M.bovis_AF2122/97 KNLIT-PELVDQRFALASTPESLTATRAMGKSFAGADFEAGMM-------
Rv3569c|M.tuberculosis_H37Rv KNLIT-PELVDQRFALASTPESLTATRAMGKSFAGADFEAGMM-------
MAV_0592|M.avium_104 QKLIT-DELIDERFALASTPESLAATRAMGMSFAGADFELGMM-------
MMAR_5064|M.marinum_M QKLIT-PELVDQRFELARTPESLAATRAMGKSFAAADFELGMM-------
MUL_4140|M.ulcerans_Agy99 QKLIT-PELVDQRFELARTPESLAATRAMGKSFAAADFELGMM-------
TH_3363|M.thermoresistible__bu PTLIT-EELIEERWAAATDPATLAAARRMYSKAAFAAMMAMMRDSDTPPP
MLBr_02603|M.leprae_Br4923 RAVVA---------AYKDDPLVYHGKVPAGVGRVMLQVGETMT-------
MSMEG_0220|M.smegmatis_MC2_155 PEVVA---------AYKADPMVHHGKLPAGIARALIGLGQSMP-------
Mflv_2367|M.gilvum_PYR-GCK RNIQS-PRGAEMWSAYASLSDAHTRHAFLRTLRSVVDYRGQAVSALN---
.
Mvan_2343|M.vanbaalenii_PYR-1 ----VRVNCPTLIVHGGRDRIIPVHASRILHRQIPGSDLVVLPRSGHCPQ
MAB_2946c|M.abscessus_ATCC_199 ----IEVSCPTLVVHGGRDRIIPIHSSGALQQQIPGSELVILPASGHCPQ
Mb3600c|M.bovis_AF2122/97 WREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQ
Rv3569c|M.tuberculosis_H37Rv WREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQ
MAV_0592|M.avium_104 WREVHRLRQPVLLIWGREDRVNPLDGALVALKTIARAQLHVFGQCGHWAQ
MMAR_5064|M.marinum_M WREVYKLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWAQ
MUL_4140|M.ulcerans_Agy99 WREVYKLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWAQ
TH_3363|M.thermoresistible__bu WATMHKVQAPTLLTWGRDDRVSPLDMALLPMRTIPGAELHVFPNCGHWVM
MLBr_02603|M.leprae_Br4923 -RRAPVLTTPLLVVHGSEDRLVLVDGSHRLVECVGSTDVELKVYPGLYHE
MSMEG_0220|M.smegmatis_MC2_155 -QRAAALTAPLLVVHGDKDRLIPVAGSRLLVDRVASEDVHLKVYPGLYHE
Mflv_2367|M.gilvum_PYR-GCK -KLHLTTELPLMVIWGDQDRIIPVDHGFALDQHRPGCRLEILDGVGHFPH
* :: * **: : . : : *
Mvan_2343|M.vanbaalenii_PYR-1 LDDPAAVVRLTLRLLDGIPR----------
MAB_2946c|M.abscessus_ATCC_199 LDNPDEVTRLIVDFCDRISEPRQPDAAHSG
Mb3600c|M.bovis_AF2122/97 VEKFDEFNKLTIEFLGG-GR----------
Rv3569c|M.tuberculosis_H37Rv VEKFDEFNKLTIEFLGG-GR----------
MAV_0592|M.avium_104 VEKFDEFNKLTIDFLGG-A-----------
MMAR_5064|M.marinum_M VEKFDEFNRLTIDFLGG-AR----------
MUL_4140|M.ulcerans_Agy99 VEKFDEFNRLTIDFLGG-AR----------
TH_3363|M.thermoresistible__bu IEAKSAFERTVLAFLTDPARG---------
MLBr_02603|M.leprae_Br4923 VFNEPERDQVLEDVVCWILKRL--------
MSMEG_0220|M.smegmatis_MC2_155 VFNEPEQKLVLDDVTSWIVSHL--------
Mflv_2367|M.gilvum_PYR-GCK VEKPDAVVDLLDDFIATTHASVRPADVPER
: .