For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SPLVDHLRSHGDRPAVLTADQPLNYRELAEMVESFAHTLGRRRRLVLLETRNDVATVVRHLGALAGRHVV LPVPAGRDHTNLITTYRPDVVIDAAGVHVRSEAAHELHDDLALLMSTSGSTGSPKLVRLSRTNLTANAGS IAEYLQIRETDRAATTLPMSYCYGLSVVHSHLLVGAALIMTEQSVADDDFWELFTRHRGTTFAGVPYTFE LLDRIGFASMRLPHLRYVTQAGGRMPPERVREYAALADRWGWQLFVMYGATEATARMAYLPPDLALTRSN AIGRPVPGGSFSLEPLDEWPEVGTGELVYRGANVMMGYADEPADLARGATLDALRTGDIARRDEHGLYEI IGRRSRFVKMYGLRIDLQQLENTLSEAGVRALCTDNGDRLAVVAGAGHDPDDVRRTAAGAAGVPAGAVDV ACVHELPTLPSGKPDYPTARVLAAGAPRRTQHDGDLRRMFADVLHLNPAEITEDASFVDLGGNSLTYVTL SVRLERALGRLPADWPRLPLRELQNLPAPSRRWWQFWGSTLETSVALRAVAIVLIVGSHAELFELWGGAH ILLGVAGYNFGRFCLTPLPRPVRIRHLRTTIAWIAIPSALWVAFALVVTDDYHASNLLLANKFLGPHDSM TAGRLWFVEVLVWTLIALAVLFCIPAVDRLERRHPFALAIGFLAFGMALRYGVVGVDEGRDAWFSMLAFW FFAAGWAASKASTVWQRAAVTAVLVVGLHGYFDDTLRQLLVLTGLALLIWLPAVRCPAGIAVVAGVVAEA SLYIYLTHYQVYPLFGSHELVGVVAAVVVGITVSAAVTLARQWWGDRSSAGRMRRGLPLGDEPLLDQGGG EDAVGPDQARGHDAAAPRRGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2199 | - | - | 100% (862) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_4263 | - | 2e-18 | 29.41% (357) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_5386 | - | 3e-18 | 27.40% (562) | non-ribosomal peptide synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2404c | mbtB | 1e-18 | 25.68% (553) | phenyloxazoline synthase MBTB (phenyloxazoline synthetase) |
| M. gilvum PYR-GCK | Mflv_4142 | - | 0.0 | 76.60% (859) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2383c | mbtB | 1e-18 | 25.68% (553) | phenyloxazoline synthase MBTB (phenyloxazoline synthetase) |
| M. leprae Br4923 | MLBr_01051 | xclC | 3e-14 | 25.81% (341) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4098c | - | 6e-24 | 28.04% (542) | peptide synthetase NRP |
| M. marinum M | MMAR_1606 | - | 1e-25 | 29.46% (353) | fatty-acid-CoA ligase |
| M. avium 104 | MAV_3243 | - | 7e-24 | 28.18% (543) | linear gramicidin synthetase subunit B |
| M. smegmatis MC2 155 | MSMEG_2469 | - | 0.0 | 66.13% (865) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_3328 | - | 0.0 | 63.97% (866) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3431 | - | 3e-23 | 31.27% (259) | fatty-acid-CoA ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 MSADPTRTLLSMDLLDDDDHDRLDEWGNRAVLTEPAAEPVSIPVVFAVQV
MAV_3243|M.avium_104 MTVGAGRRLLSIDLLDGGEHDRLDEWGNRAILTKPVKAPASIPGMFAAQV
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 ERAPETVALVCRDRSWTYRELDQITNRIAHLLAGNGAGPGEVVGLLVPRS
MAV_3243|M.avium_104 ARSAEAVALSFEGRSMTYRELDEASNRLAHLLAEQGAAPGECVALLFSRS
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 GEAIIGLLAILKTGAAYLPIDPAHPDERIKFMVSDAGPVAVLTTADLGSR
MAV_3243|M.avium_104 DEAIVSILAVLKTGAAYLPIDPALPAARMEFMLGDATPIAAVTTAGLRDR
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 FEGLDVSVIEIDDPLID---GQPSSALPTPEPDDLAYMTYTSGTTGVPKA
MAV_3243|M.avium_104 LEGFDLPVIDVDEAAAEIERTQPSSALPGPSPDDIAYMIYTSGTTGTPKG
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 VAVTHHNVTQLVDAVRADLPARPGEVWSQWHSLVFDVSVWEIWGALLHGG
MAV_3243|M.avium_104 VAVTHRNVTEFLKTLHPKLPSGPGQVWSQWHSLVFDVSVWETWGALLHGG
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 RLVVVPESVASSPDDLHELLISEKVSVLCQTPSAAGMLSPERLESTTLIV
MAV_3243|M.avium_104 RLVVVPESVAGSPDDLHDLLVAEGVTVLSQTPSAVGMLSPEGLDSTALVV
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 AGEACPPELVDRWATSGRTMINAYGPTEATIYAAMSGPLTPGSGVAPIGS
MAV_3243|M.avium_104 AGEACPAEVVDRWAP-GRVMINAYGPTEATVYAAMSAPLTAESGAPPIGS
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 PVPGAALFVLDKWLRPAPEGVVGELYVAGNGVAPGYAHRSGLTASRFLAC
MAV_3243|M.avium_104 PVPGAALFVLDKWLRPAPEGVVGELYIAGRGVATGYARRAGLTASRFVAC
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 PFGGPGSRMYRTGDLVQWGEDGQLQYLGRADEQVKIRGYRIELGEIQAAL
MAV_3243|M.avium_104 PFGGPGARMYRTGDLVRWGADGQLQYLGRADEQVKIRGYRIELGEIQSAL
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 SRLDGVEQAVVIAREDRPGDKRLVGYIMGTADPVEARNALAERLPAYMVP
MAV_3243|M.avium_104 AALDGVDQAAVIAREDRPGDKRLVGYITGTADPAELRTQLGKRLPAYMVP
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 AAVVVLDALPLTVNGKLDKRALPAPEYRSVGTDYRAPSGPVEKVLADIYA
MAV_3243|M.avium_104 AAVVVLESLPLTVNGKLDKRALPAPEYHKRAGQYRAPSNHTEEILADIYA
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 QVLGVDRVGVDESFFDLGGDSILSMQVVSRARAAGVHCRPRDIFVEQTVS
MAV_3243|M.avium_104 QVLGVERVGVDDSFFDLGGDSILSMQVVARARAAGVICRPRDVFVEQTVA
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 GVAAVASLSDGRAGIVDDGIGPVLATPIIHWLQGVPGPVDQFNQTIVLQA
MAV_3243|M.avium_104 RLARVASDGADEEQVVDEGIGPVQATPIMRWLQTVQGPIDDFNQTMVLAA
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 PVGVTEDDVVVILQALLDRHATLRLRAESGDASGGWSLLVPDTGTVDARA
MAV_3243|M.avium_104 PSGVTADDVAVVLQALLDRHPMLRLRVED-DGAGGWNLQAPEPGSVRAAD
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 CLRVAESLSDAELVAARSRLNPAAGAQLSAVWVPDSRQLALMIHHLAVDG
MAV_3243|M.avium_104 CLQSVDTLSDAVLVAARSRLNPGAGVMVSAVWASETSQLALIIHHVAVDG
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 VSWRILLEDLNIAWAQHHGGQPVQLPAGGTSFARWAALLDEHARSQDVVA
MAV_3243|M.avium_104 VSWRTLIEDLNIAWAQHHSGQPVALPAGGTSFARWSSLLAEHALTPAVVE
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 TADAWREVTAVPAALPAVMPGLDTYATAKTLSVSLDADTTRELLSEVPAA
MAV_3243|M.avium_104 QADAWREVVATPAVLPAVQPEVDTYQSAEQLSVSLDVDTTRLLLGEVPAA
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 FHAGVQDILLIAFGLAWNEFLDSNTTSIGIGVEGHGRQEELGRVAGLDID
MAV_3243|M.avium_104 FHAGVQDILLIAFAMAWTQVVGAG-TPIGIDVEGHGRHEELG----PHVD
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 LSRTVGWFTTKYPVSLSVGGLSWKEIADGSPDLGPIIKSAKEQLRALPDP
MAV_3243|M.avium_104 LSRTVGWFTTKYPVALAIDGLDWASVVAGDDALGAAVKAAKEQLRALPDG
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 -----------------------MVHATACSEIIRAEVAELLGVRADALH
Rv2383c|M.tuberculosis_H37Rv -----------------------MVHATACSEIIRAEVAELLGVRADALH
MAB_4098c|M.abscessus_ATCC_199 LTYGLLRYLNPDVDLSGPEPAIGFNYLGRLGAGAADLTDDLWRINEDSLS
MAV_3243|M.avium_104 LTYGLLRYLNPDVDLGGSDPVIGFNYLGRLGA-AADLPGELWRLSPDSLS
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 PGANLVGQGLDSIRMMSLVG-------------------RWRRKGIAVDF
Rv2383c|M.tuberculosis_H37Rv PGANLVGQGLDSIRMMSLVG-------------------RWRRKGIAVDF
MAB_4098c|M.abscessus_ATCC_199 SAGVASSVSMPLMYTVDLNAGIVEGGLGEEAGPHLRAGWTWAPSSVTEPQ
MAV_3243|M.avium_104 LSGAAAAVAMPLMHTVDLNAGTMD----TEDGPHLHANWTWAPSAVDRDQ
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 ATLAATPTIEAWS----QLVSAGTGVAPTAVAAPGDAG--------LSQE
Rv2383c|M.tuberculosis_H37Rv ATLAATPTIEAWS----QLVSAGTGVAPTAVAAPGDAG--------LSQE
MAB_4098c|M.abscessus_ATCC_199 VQRLSQLWFEALAGICAYVRGGGGGLTPSDIAPAQLSQQQIDELHEQHKI
MAV_3243|M.avium_104 ISRLSQLWFEALAGICAHVRAGGGGLTPSDILPARLNQRQIDELSKQHQI
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 GEPFPLAPMQHAMWVGRHDHQQLG---------GVAGHLYVEFDGARVDP
Rv2383c|M.tuberculosis_H37Rv GEPFPLAPMQHAMWVGRHDHQQLG---------GVAGHLYVEFDGARVDP
MAB_4098c|M.abscessus_ATCC_199 VDVLPLTPIQEGLLFHTTFARAAGALEGDEAGIDFYAVQLDITVTGLVDQ
MAV_3243|M.avium_104 ADILPLTPLQQGLLFHASFAQDP--------GDDVYAVQLGITVTGALDS
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 DRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVADLR--HV
Rv2383c|M.tuberculosis_H37Rv DRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVADLR--HV
MAB_4098c|M.abscessus_ATCC_199 LRLRDAVHTVVRRHPNLAARFCTQFGDPVQVILADPVIAWRYLDLRGDDL
MAV_3243|M.avium_104 HRLHDAVHTVVNRHPNLAARFCPQYGEPVQVVPADPVMAWRYIQLGPEDV
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 APDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAAD
Rv2383c|M.tuberculosis_H37Rv APDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAAD
MAB_4098c|M.abscessus_ATCC_199 TPDEEIQHLCAAERAAVCDLADRPTLRAALIRTEGNQHRFVLTFHHVVID
MAV_3243|M.avium_104 DPEQKVEELCAAERAAVSDLANRPAFRAALIRTADNRHRFVLTNHHIVMD
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 AMSYRILLADLAALYDGREPPALGYTYQEYRQAIEAEETLPQPVRDADRD
Rv2383c|M.tuberculosis_H37Rv AMSYRILLADLAALYDGREPPALGYTYREYRQAIEAEETLPQPVRDADRD
MAB_4098c|M.abscessus_ATCC_199 GWSLPILLQEIFASYFGHRLPAP-SSYRSFVSWLADQD------LDAART
MAV_3243|M.avium_104 GWSLPILLREILAIYYGDQLPAP-ATYRSYLTWLAGQD------RSAAQA
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 WWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWLDPQTRDALFARARAR
Rv2383c|M.tuberculosis_H37Rv WWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWLDPQTRDALFARARAR
MAB_4098c|M.abscessus_ATCC_199 AWGKVLEGFDTPTLVAPP--APPGARGVES--YRVSAETTQALGDLARSQ
MAV_3243|M.avium_104 AWRQVLDGFDTPTLVGPAGRMRLGRRAVES--YRLSADTTRALGELARAC
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 GITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTS
Rv2383c|M.tuberculosis_H37Rv GITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTS
MAB_4098c|M.abscessus_ATCC_199 HTTVSTVLQAAWAQLLMVLTGQDDVAFGTAVSGRPAELAGSDSIVG----
MAV_3243|M.avium_104 HTTVNTVLQAGWAQLLMRLTGQHDVAFGTAVSGRPADLAGAESMVG----
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 SLLLDVDLTGARTAAARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQ
Rv2383c|M.tuberculosis_H37Rv SLLLDVDLTGARTAAARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQ
MAB_4098c|M.abscessus_ATCC_199 LLINTVPVRARATASTTIAELLGQLQSAHNDTIEHEHLALNEIHHVAGHE
MAV_3243|M.avium_104 LLINTVPVRANTHAETTVADLLDQLQQHHNDTLEHEHLALSEIHRVTGHD
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 VLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVTEFDGG
Rv2383c|M.tuberculosis_H37Rv VLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVTEFDGG
MAB_4098c|M.abscessus_ATCC_199 QLFDTLFLYESYPIDTSAFMGVQELAITEFVTREYNHYPLSVMALPGHE-
MAV_3243|M.avium_104 ALFDTLFLYENYPIDTSVPLGFHELAITDVTNREYNHYPLSVMALPGRE-
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 VLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQ
Rv2383c|M.tuberculosis_H37Rv VLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQ
MAB_4098c|M.abscessus_ATCC_199 LGIRVEYDTDKFGLDDIQAVFERFERVLVSMVSDADQRLSSLDVLQTDEH
MAV_3243|M.avium_104 LGLRVEFDTDVFDAAGIEKLTERFQRVLSEMTADPTRRLTSLEVMDEAEH
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M ------------------MTSLAGNLIEGARRHPNRIALRLDEIEIPYGA
MUL_3431|M.ulcerans_Agy99 ------------------MTSLAGNLIEGARRHPNRIALRLDEIEIPYGA
Mb2404c|M.bovis_AF2122/97 RAVRAALNG---RTAAPSTEALHDGFFRQAQQQPDAPAVFASSGDLSYAQ
Rv2383c|M.tuberculosis_H37Rv RAVRAALNG---RTAAPSTEALHDGFFRQAQQQPDAPAVFASSGDLSYAQ
MAB_4098c|M.abscessus_ATCC_199 KQLDGWGNRKVLVRGPEPVLSIPEAFAEQVDRAPEAVALTFEGRSTTYGE
MAV_3243|M.avium_104 ELLDAWGNRPVLS-QPATGTSIPALFAAQVARTPDAAALTFQGRSMSYRE
Mvan_2199|M.vanbaalenii_PYR-1 ----------------------MSPLVDHLRSHGDRPAVLTADQPLNYRE
Mflv_4142|M.gilvum_PYR-GCK ----------------------MTRLADHLRKHGDRIAVMTASAQVSYSE
MSMEG_2469|M.smegmatis_MC2_155 ------------------MHAASSALLDALRAHGDRTALITAERHVTYRE
TH_3328|M.thermoresistible__bu ----------------------VNALLRLLYAHGERPAVRTADTGLGYRE
MLBr_01051|M.leprae_Br4923 -------------------MLLASLNPSVVTATDIADAVCVDGVVLSRSG
*:
MMAR_1606|M.marinum_M LDAASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYYGVLRAGGVVVPM
MUL_3431|M.ulcerans_Agy99 LDTASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYYGVLRAGGVVVPM
Mb2404c|M.bovis_AF2122/97 LRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPI
Rv2383c|M.tuberculosis_H37Rv LRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPI
MAB_4098c|M.abscessus_ATCC_199 LDEAANRLANLLSVYGAAPGESVALLMPRSDEAIIAILAILKTGASYLPI
MAV_3243|M.avium_104 LDEASNRLAHLLIEEGAGPGECVALLFSRSAEAIVSILAVLKTGAAYLPI
Mvan_2199|M.vanbaalenii_PYR-1 LAEMVESFAHTLGRR----RRLVLLETRNDVATVVRHLGALAGRHVVLPV
Mflv_4142|M.gilvum_PYR-GCK LADRVDRFAGGLGTR----RQLVLIETRNDLSTLVGYLGVLAGGHVAIPV
MSMEG_2469|M.smegmatis_MC2_155 LADQVADASARLGTG----RRLVLLETSNDIATVVHYLAALAGGHVALPV
TH_3328|M.thermoresistible__bu LADRVATVAGELGSH----CGLVLLRTRNDVSTLVHYLGALAAGHVVLPV
MLBr_01051|M.leprae_Br4923 LVGAATSVAERVGGAR-----LVAVLATPTASTVLAITGCLIAGVPVVPV
* : : * : . * :*:
MMAR_1606|M.marinum_M NVLLKERETSFYLTDSEAKAIIAWHEFAPAAQAGADEAGAECILVKPGEF
MUL_3431|M.ulcerans_Agy99 NVLLKERETSFYLTDSEAKAIIAWHEFVPAAQAGADEAGAECILVKPGEF
Mb2404c|M.bovis_AF2122/97 GVDQPRDRAERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEF
Rv2383c|M.tuberculosis_H37Rv GVDQPRDRAERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEF
MAB_4098c|M.abscessus_ATCC_199 DPSVPDTRLEFMLSDAVPIAAVTTAELRARFDGSGVSVVQFDDAEDDPTG
MAV_3243|M.avium_104 DPALPAARIEFLLGDAEPVAVVTTAALRSRLDGCKPSVVDVDDPALDGQ-
Mvan_2199|M.vanbaalenii_PYR-1 PA---GRDHTNLITTYRPDVVIDAAGVHVRSE------------------
Mflv_4142|M.gilvum_PYR-GCK PA---AGDHSHILATYRPDVVVDGSGVHVRSE------------------
MSMEG_2469|M.smegmatis_MC2_155 AP---GGDHTAITQTYSPDTVIDADGIRHRHDR-----------------
TH_3328|M.thermoresistible__bu ND---GGDHTAMVRTYRPDMIIDGDGIHRLRTD-----------------
MLBr_01051|M.leprae_Br4923 PADIGVVERRHMLTDSGAQAWLGPGPSADSAPDGLPHIPVQLDARSWNR-
:
MMAR_1606|M.marinum_M EELIQAAEPLEEAAVREDDDTAVILYTSGTTGKPKGAELTHANLRRNVEV
MUL_3431|M.ulcerans_Agy99 EELIQAAEPLEEAAVREDDDTAVILYTSGTTGKPKGAELTHANLRRNVEV
Mb2404c|M.bovis_AF2122/97 VP-----------GPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVET
Rv2383c|M.tuberculosis_H37Rv VP-----------GPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVET
MAB_4098c|M.abscessus_ATCC_199 AIY-----GHTPLLTPAPDDIAYTIYTSGTTGVPKGVAIAHSNVTQALKF
MAV_3243|M.avium_104 --------PSAALPVPSSDNIAYLIYTSGTTGVPKGVAVSHDNVAQLVES
Mvan_2199|M.vanbaalenii_PYR-1 ------------AAHELHDDLALLMSTSGSTGSPKLVRLSRTNLTANAGS
Mflv_4142|M.gilvum_PYR-GCK ------------GAHALHDDLALLLSTSGSTGSPKLVRLSRANLIANATS
MSMEG_2469|M.smegmatis_MC2_155 ------------PAHRLHDELALLMSTSGSTGSPKLVRLSHTNLRSNAAA
TH_3328|M.thermoresistible__bu ------------SAHRLHPDLALLMSTSGSTGSPKLVRLSYSNLISNARA
MLBr_01051|M.leprae_Br4923 ------------YPEPSPDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDA
* : ***:** ** . ::
MMAR_1606|M.marinum_M IVQMLQVGPDDVILGALPLFHAFGQTAGLNAAVAAGACLTLIPRFS---P
MUL_3431|M.ulcerans_Agy99 IVQMLQVGPDDVILGALPLFHAFGQTAGLNAAVAAGACLTLIPRFS---P
Mb2404c|M.bovis_AF2122/97 FIRHFELGAADRWL-ALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDP
Rv2383c|M.tuberculosis_H37Rv FIRHFELGAADRWL-ALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDP
MAB_4098c|M.abscessus_ATCC_199 PLTHMPTGPG-EVWTQAGSLVFDITVWEIFGALLHGGRLVIIPDSVVRSP
MAV_3243|M.avium_104 LHADLPEG---GVWAQWHSLVFDVSVHEIWGALLHGGRLVVVPESVAASP
Mvan_2199|M.vanbaalenii_PYR-1 IAEYLQIRETDRAATTLPMSYCYG-LSVVHSHLLVGAALIMTEQSVAD--
Mflv_4142|M.gilvum_PYR-GCK IAGYLGIDETDRAATTLPMSYCYG-LSVVHSHLLVGAALILTERSVAD--
MSMEG_2469|M.smegmatis_MC2_155 IAEYLGIRETDRAATTLPLSYCYG-LSVLNSHLLRGAALILTEDSVLD--
TH_3328|M.thermoresistible__bu IAEYLEITDSDRAATTLPMSYCYG-LSVIHSHLLRGATLILTEHSVLD--
MLBr_01051|M.leprae_Br4923 LAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPT--
: . : * :
MMAR_1606|M.marinum_M EKALQIIERDRVTVFEGVPTMFAAMLHSTERPD-TGSLRLCVSGGAAMPV
MUL_3431|M.ulcerans_Agy99 EKALQIIERDRVTVFEGVPTMFAAMLHSTERPD-TGSLRLCVSGGAAMPV
Mb2404c|M.bovis_AF2122/97 DAWARLIDTYEVTALNFMPGWLDMLLEVGGG-R-LSSLRAVAVGGDWVRP
Rv2383c|M.tuberculosis_H37Rv DAWARLIDTYEVTALNFMPGWLDMLLEVGGG-R-LSSLRAVAVGGDWVRP
MAB_4098c|M.abscessus_ATCC_199 DDFRDLLIREKVTVLFQTPSAVGMLSPEGLN------NLTLVVAGEACPT
MAV_3243|M.avium_104 DELHDLLVAEGVTVLSQTPSAVGMLSPEGLD------STALVVAGEACPV
Mvan_2199|M.vanbaalenii_PYR-1 DDFWELFTRHRGTTFAGVPYTFELLDRIGFASMRLPHLRYVTQAGGRMPP
Mflv_4142|M.gilvum_PYR-GCK PEFWELFARHRGTSFAGVPYTFELLDRIGFTSMDLPHLRYVTQAGGKMSP
MSMEG_2469|M.smegmatis_MC2_155 DAFWELFTEHRGTSFAGVPHTFELLDRIGFDDMSLPHLRYITQAGGRMAP
TH_3328|M.thermoresistible__bu PGFWALFRRHRGTTFAGVPHTFDLLDRIGFDAMDLPHLRYLTQAGGRLDP
MLBr_01051|M.leprae_Br4923 -AYAQACSEAGGSLYFGVPTVWSRLVADEAVARALRPARLLVSGSASLPV
: * : . ..
MMAR_1606|M.marinum_M EVMRGFEQAFGTMVLEGYG--LSETSPTASFNHPDRERKPGSIGTPIAGV
MUL_3431|M.ulcerans_Agy99 EVMRGFEQAFGTMVLEGYG--LSETSPTASFNHPDRERKPGSIGTPIAGV
Mb2404c|M.bovis_AF2122/97 DLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGV
Rv2383c|M.tuberculosis_H37Rv DLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGV
MAB_4098c|M.abscessus_ATCC_199 EVVDRWAPGR--VMINGYG-----PTETTIYATFG-ELIAG-SGVVPIGV
MAV_3243|M.avium_104 EIVDRWAPGR--VMINAYG-----PTEATVYAAMSTPLQPG-TGSAPIGS
Mvan_2199|M.vanbaalenii_PYR-1 ERVREYAALA---DRWGWQLFVMYGATEATARMAYLPPDLALTRSNAIGR
Mflv_4142|M.gilvum_PYR-GCK ERVRRYATAA---RDRGWQLFVMYGATEATARMAYLPPDLARERPTAIGV
MSMEG_2469|M.smegmatis_MC2_155 ERVRRFAELG---QRQGWQLVVMYGATEATARMAYLPAELALTRPEAIGT
TH_3328|M.thermoresistible__bu ATVRRFARLG---RERGWQFFVMYGATEATARMAYLPPDLAEHRPEAIGR
MLBr_01051|M.leprae_Br4923 PVFDRLAHLTGHRPIERYG---STESLITLSTLADGERRAGWVGLPLAGV
: *
MMAR_1606|M.marinum_M QMKLLEVDTHG----------IGEIAIRGHNVMKGYWNRPDATAAAIDAE
MUL_3431|M.ulcerans_Agy99 QMKLLEVDTHG----------IGEIAIRGHNVMKGYWNRPDATAAVIDAE
Mb2404c|M.bovis_AF2122/97 PFPNNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEH
Rv2383c|M.tuberculosis_H37Rv PFPNNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEH
MAB_4098c|M.abscessus_ATCC_199 PVPDAALFVLDRWMRPVPPGVVGELYVAGLGVGIGYVKRQALTAARFVAC
MAV_3243|M.avium_104 PVPRAALFVLDRWLRPAPPGVVGELYIAGHGVATGYARRSGLTASRFVAC
Mvan_2199|M.vanbaalenii_PYR-1 PVPGGSFSLEP--LDEWPEVGTGELVYRGANVMMGYADEPADLARGATLD
Mflv_4142|M.gilvum_PYR-GCK PIPGGEFSIEP--VEDWPDTSSGELVYRGANVMMGYAHGPGDLVLDAGPD
MSMEG_2469|M.smegmatis_MC2_155 PIPGGRFDIEQ--LDGWPEG-TGELVYRGPNVMLGYAHGPDDLALGATLD
TH_3328|M.thermoresistible__bu AIPGGAFGIEP--VDGFTDA--GELVYRGPNVMMGYAHRPEDLALGSEVD
MLBr_01051|M.leprae_Br4923 QTRLVDESGGP---VPYDGETVGRLQVRSPTMFGGYLNRPEATAEAFDED
*.: . : ** .
MMAR_1606|M.marinum_M G-------WFRTGDLARIDED----GYYFIVDR-SKDMIIRGGYNVYPRE
MUL_3431|M.ulcerans_Agy99 G-------WFRTGDLARIDED----GYYFIVDR-SKDMII----------
Mb2404c|M.bovis_AF2122/97 DG----RTWYRTGDLARYWHD----GTLEFVGR-ADHRVKISGYRVELGE
Rv2383c|M.tuberculosis_H37Rv DG----RTWYRTGDLARYWHD----GTLEFVGR-ADHRVKISGYRVELGE
MAB_4098c|M.abscessus_ATCC_199 PFGEPGTRMYRTGDLVRWGVSESSVGQLEYLGR-ADEQVKIRGFRIELGE
MAV_3243|M.avium_104 PFGGPGARMYRTGDLVRWNQD----GQLEYLGR-ADEQVKLRGYRIELGE
Mvan_2199|M.vanbaalenii_PYR-1 AL--------RTGDIARRDEH----GLYEIIGR-RSRFVKMYGLRIDLQQ
Mflv_4142|M.gilvum_PYR-GCK VL--------RTGDIARRGAD----GLYEVVGR-RSRFVKIYGLRIDLQR
MSMEG_2469|M.smegmatis_MC2_155 AL--------RTGDIARRGAD----GLFEIVGR-SSRFVKLFGLRIDLQR
TH_3328|M.thermoresistible__bu VL--------RTGDIARRGAD----GLYEVIGR-RSRFVKLYGLRIDLQR
MLBr_01051|M.leprae_Br4923 G-------WYRTGDVAVVDSG----GMHRIVGRESVDLIKLGGYRIGAGE
****:. * :.* :
MMAR_1606|M.marinum_M IEEVLYEHPEVREAAVVAVPDDMLGEEVGAAIALIPGATSDAAALSDFVK
MUL_3431|M.ulcerans_Agy99 --------------------------------------------LSDFVK
Mb2404c|M.bovis_AF2122/97 IEAALQRLPGVHAAAATVLPG---GSDVLAAAVCVDDAGVTAESIRQQLA
Rv2383c|M.tuberculosis_H37Rv IEAALQRLPGVHAAAATVLPG---GSDVLAAAVCVDDAGVTAESIRQQLA
MAB_4098c|M.abscessus_ATCC_199 IQAALADVDGVEQAAVIARED----RPGDKRLVGYFIGTGEPAELRAALA
MAV_3243|M.avium_104 VQAALAGLDGVEQAAVIARED----RPGDKRLVGYITGTADPVGIRIQLA
Mvan_2199|M.vanbaalenii_PYR-1 LENTLSEAGVRALCTD-----------NGDRLAVVAGAGHDPDDVRRTAA
Mflv_4142|M.gilvum_PYR-GCK LETSLRDAGIPALCTD-----------SGDRLAVVATAEHEPGEVRRTAA
MSMEG_2469|M.smegmatis_MC2_155 LESGLAEQNITALCTG-----------DDDGVAVAALAPASAAEVTRLVA
TH_3328|M.thermoresistible__bu LETALRDRGVTALCTG-----------DDEHLAVAATGNHDAGEVRRKTA
MLBr_01051|M.leprae_Br4923 IEMALLGHPDVREVAVVGLPDE--DLGQRIVAFVVGAEALDADELINYVA
:
MMAR_1606|M.marinum_M ERVAAYKYPRRIWFVDELPKGPTGKILKRDITVPQASPAQQ---------
MUL_3431|M.ulcerans_Agy99 ERVAAYKYPRRIWFVDELPKGPTGKILKRDITVPQASPAQQ---------
Mb2404c|M.bovis_AF2122/97 DLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYA
Rv2383c|M.tuberculosis_H37Rv DLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYA
MAB_4098c|M.abscessus_ATCC_199 KRLPPYMVPAALVRLEALPLTVNGKLDKRALPAPEYDDAAR-------YR
MAV_3243|M.avium_104 ERLPAYMVPAAVVVLDALPLTVNGKLDKRALPAPEYRKRGGE------YI
Mvan_2199|M.vanbaalenii_PYR-1 GAAGVPAGAVDVACVHELPTLPSGKPDYPTARVLAAGAPRR---------
Mflv_4142|M.gilvum_PYR-GCK GAGGLPPAVVDVACVAELPKLPSGKPDYPAARTLAAAASAP---------
MSMEG_2469|M.smegmatis_MC2_155 AAARIPASGVRTTVVDELPRLHSGKPDYPAVRALASDRTTT---------
TH_3328|M.thermoresistible__bu ELAGVPVGVVNAAVVADLPMLPSGKPDYPAVRRLTRPTEPN---------
MLBr_01051|M.leprae_Br4923 QQLSIHKRPREVRFVDALPRNAMGKVLKKQLLFEG---------------
: :* **
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 APRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRR
Rv2383c|M.tuberculosis_H37Rv APRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRR
MAB_4098c|M.abscessus_ATCC_199 APANAVEEAVAGIYAQVLG--VERVGTDDSFFDLGGDSISAMRVVAAINT
MAV_3243|M.avium_104 APTNPTEETVAGIFARVLG--MERVSIDDSFFELGGDSLSAMRVIAEINT
Mvan_2199|M.vanbaalenii_PYR-1 TQHDG---DLRRMFADVLHLNPAEITEDASFVDLGGNSLTYVTLSVRLER
Mflv_4142|M.gilvum_PYR-GCK APHDG---DLRGVFADVLHLDRAEVTEDSSFVDLGGNSLTYVMMSLRLER
MSMEG_2469|M.smegmatis_MC2_155 EVPAGEVTDLRTLFGEVLQLDPASIDPDASFIDLGGNSLSYVAMSVRLER
TH_3328|M.thermoresistible__bu TTAPADDGDLRAVFADVLQLDADTIDPAASFIDLGGTSLTYVTMSVRLQR
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 WLDSPSLMVADMFAARTIAALAQLLTG---------------REANADRL
Rv2383c|M.tuberculosis_H37Rv WLDSPSLMVADMFAARTIAALAQLLTG---------------REANADRL
MAB_4098c|M.abscessus_ATCC_199 SFDA-QLAVRTLFEAPSVRSLSGYLDGAAGAP-ANGPTYASVHGPGATEV
MAV_3243|M.avium_104 AVDG-ALSVRTLFDSQSVRALSQRITSGADAENAAGPGFAAVHGADAKEV
Mvan_2199|M.vanbaalenii_PYR-1 ALGR----LPADWPRLPLRELQNLPAPSRRWWQFWGSTLETSVALRAVAI
Mflv_4142|M.gilvum_PYR-GCK ALGR----LPADWQRMSLRELQNLPAPKPRRWKSWGATLETSVALRAVAI
MSMEG_2469|M.smegmatis_MC2_155 ALGQ----LPAEWHRLPLSELERRAAPRRR----WGATVETSVALRAVAI
TH_3328|M.thermoresistible__bu VLGR----LPVDWQRIPIRDLQRSPAPRRR---WWSATLETSVALRAAAI
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 ELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTG--------
Rv2383c|M.tuberculosis_H37Rv ELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTG--------
MAB_4098c|M.abscessus_ATCC_199 RASDLTLDKFIDEATLQKAPTLPRAEATARTVLLTGATGFLGRYLVLQWL
MAV_3243|M.avium_104 YARDLTLDKFLDATTLSTAPTLPGPSPEVRTVLLTGATGFLGRYLVLEWL
Mvan_2199|M.vanbaalenii_PYR-1 VLIVGSHAELFELWGGAHILLGVAGYNFGRFCLTPLPR------------
Mflv_4142|M.gilvum_PYR-GCK VLIVGSHVELFELWGGAHILLGVAGYNFGRFCLTPLPR------------
MSMEG_2469|M.smegmatis_MC2_155 VLIVGSHAELFELWGGAHVLLAVAGYNFGRFCLTPLPR------------
TH_3328|M.thermoresistible__bu VLIVGSHAELFEIWGGAHILLGVVGYNSARFCLTPVSR------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 ---TDKPGAVLVFPHAGGAAAAYRWLAKSLVANDVDTFVVQYPQRADRRS
Rv2383c|M.tuberculosis_H37Rv ---TDKPGAVLVFPHAGGAAAAYRWLAKSLVANDVDTFVVQYPQRADRRS
MAB_4098c|M.abscessus_ATCC_199 RELEQVDGTLICLVRAKSDEEARRRLDKTFDSGDPELIRVYEALAADRLQ
MAV_3243|M.avium_104 EQLEQVDGKLICLVRARSDEEAWGRLEKTFNTGDPELLRHFQELAEEHLQ
Mvan_2199|M.vanbaalenii_PYR-1 ------PVRIRHLRTTIAWIAIPSALWVAFALVVTDDYHASNLLLANKFL
Mflv_4142|M.gilvum_PYR-GCK ------PTRIRHLRTTITWIAVPSVLWIAFASLITDDYHASNLLLANKIL
MSMEG_2469|M.smegmatis_MC2_155 ------EQRSRHLRRTIAGVAVPSIVWVAIALLITDHYHVTNLFLANKFL
TH_3328|M.thermoresistible__bu ------ADRIRRLRSTVTWVAIPSMCWIALTLLFTDDYHLTNLLLVQKFV
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 HPAADSIEALA-------------LELFEAGDWHLTAPLTLFGHCMGAIV
Rv2383c|M.tuberculosis_H37Rv HPAADSIEALA-------------LELFEAGDWHLTAPLTLFGHCMGAIV
MAB_4098c|M.abscessus_ATCC_199 VIAGDKAEPSLGLDQDTWQRLADTVDLIVDSAALVNSVLPYSELFGPNVV
MAV_3243|M.avium_104 VVAGDKGQANLGLDEQTWQQLADTVDLIVDSAAVVNGVLPYSELFTPNVG
Mvan_2199|M.vanbaalenii_PYR-1 GPHDSMTAGRLWFVEVLVWTLIALAVLFCIPAVDRLERRHPFALAIGFLA
Mflv_4142|M.gilvum_PYR-GCK GPHDSMTAGRLWFVEVLVWTLIALAALFCIPAMDRLERRPPFTLAMCFLG
MSMEG_2469|M.smegmatis_MC2_155 GPPDSMTAGRLWFVEVLVWILVALAAVCWLPAADRLERRQPFAFAAAFLA
TH_3328|M.thermoresistible__bu GPHDSMTAGRLWFIEVLVWTLLGLALLCRIRALDRLERRRPFEFALAFVA
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 AFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLG
Rv2383c|M.tuberculosis_H37Rv AFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLG
MAB_4098c|M.abscessus_ATCC_199 GTAELIRFALTTKLKPYTYISTADVGREIEKSVFREDADIRVISATRPSD
MAV_3243|M.avium_104 GTAELIRLALTTRKKPFAYVSTSDVGRQIEPSAFTEDADIRVISATRVID
Mvan_2199|M.vanbaalenii_PYR-1 FGMALRYGVVGVDEGRDAWFSMLAFWFFAAGWAASKASTVWQRAAVTAVL
Mflv_4142|M.gilvum_PYR-GCK VGLALRYDALGITMGDDAMFSLLAFWFFAAGWAASKATSAWQRAAVTAVL
MSMEG_2469|M.smegmatis_MC2_155 AGLALRYNLISFDLHDQACFTVLAFWFFAAGWAAAKATQTWQRVAVTAVL
TH_3328|M.thermoresistible__bu VGMLLRYNVFDLQMSPDAWSTVLTFWFFAAGWAAARATTVGRRLLVTAVL
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 GTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHAVGGNRD
Rv2383c|M.tuberculosis_H37Rv GTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHAVGGNRD
MAB_4098c|M.abscessus_ATCC_199 GSYANGYGNSKWAGEVLLREAHEQVGLPVKVFRSGMIMVDTSYAGQVNAS
MAV_3243|M.avium_104 GSYANGYGNSKWAGEVLLREAHDLCGLPVSVFRSDMILADTSYAGQLNVT
Mvan_2199|M.vanbaalenii_PYR-1 VVGLHGYFDDTLRQLLVLTGLALLIWLPAVRCPAGIAVVAGVVAEASLYI
Mflv_4142|M.gilvum_PYR-GCK VVGLVGYFDEPSRHLMVLTGLALLIWVPAIRCPAGVAVVAGVIAEASLYI
MSMEG_2469|M.smegmatis_MC2_155 AIGVYGYFGDSQRELMVLAGFALLIWVPALRCPAPVAAVLGVLAEASLYT
TH_3328|M.thermoresistible__bu AVGLIGYFDDPHRGMLVFAGLALLIWLPVLRCPAPLITAVGVVADASLYT
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 HRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR---
Rv2383c|M.tuberculosis_H37Rv HRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR---
MAB_4098c|M.abscessus_ATCC_199 DTVARMVLSVVATGVAP-YSVYQLDADGNRQRAHFDGLPVEFVAEAITAL
MAV_3243|M.avium_104 DIFTRMILSIVATGTAP-KSFYRLDADGNRQRSHFDALPVEFVAEAIAKL
Mvan_2199|M.vanbaalenii_PYR-1 YLTHYQVYPLFGSHELVGVVAAVVVGITVSAAVTLARQWWGDRSSAGRMR
Mflv_4142|M.gilvum_PYR-GCK YLTHYQVYPLFGSHELVGVVAAIVVGVSVSAAVTLARQRLGRLGSGG--R
MSMEG_2469|M.smegmatis_MC2_155 YLTHYQIYPLFGDHRILGVLASLVVGVAVTYAVTAARTRWSRRSVRR---
TH_3328|M.thermoresistible__bu YLTHFQVYPLFGEHRTAGVLASLAVGIALSALVTRVRGSARRLPPVR---
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 GGGAAGSFDGSADFETYHVMNPHDDGIGIDEYVDWLIEAGHPIERIDDFG
MAV_3243|M.avium_104 G---AQVMDG---FETYHVMNPHDDGIGLDEYVDWLIEAGYPIERVDDFG
Mvan_2199|M.vanbaalenii_PYR-1 RGLPLGDEPLLDQGGGEDAVGPDQARGHDAAAPRRGR-------------
Mflv_4142|M.gilvum_PYR-GCK GGLPVGDEPLLDQGRSEDAVTPDQVRGDDAATARRRR-------------
MSMEG_2469|M.smegmatis_MC2_155 ---PLGHQTLLHERGDDAAVELHETRGDDAAATGRGR-------------
TH_3328|M.thermoresistible__bu ------DEALLRQGRGDDTVGADQAGVHHCTAPARGR-------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4098c|M.abscessus_ATCC_199 EWVRQFEARLHALPDHQRQGSVLQMLKILQDHGWDGQPPEPVRGPMAPAD
MAV_3243|M.avium_104 EWLQRFETGLRGLPERQRQNSVLQMLLLLLRDPKNLQLAEPARGAFAPTD
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------------------
MMAR_1606|M.marinum_M --------------------------------------
MUL_3431|M.ulcerans_Agy99 --------------------------------------
Mb2404c|M.bovis_AF2122/97 --------------------------------------
Rv2383c|M.tuberculosis_H37Rv --------------------------------------
MAB_4098c|M.abscessus_ATCC_199 RFHAAVRKAKIGSDHDIPQVSAPIIAKYASDLQLHGLL
MAV_3243|M.avium_104 RFRAAVQEAKVGSDNDIPHISAPVIVKYVTDLQLLGLL
Mvan_2199|M.vanbaalenii_PYR-1 --------------------------------------
Mflv_4142|M.gilvum_PYR-GCK --------------------------------------
MSMEG_2469|M.smegmatis_MC2_155 --------------------------------------
TH_3328|M.thermoresistible__bu --------------------------------------
MLBr_01051|M.leprae_Br4923 --------------------------------------