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MSDAMTETVDGTQTSADWGRRAAQRAERRMLIDGELVEAESGAQFDNHSPATGVVLGATTAAGERDMLRA IGAARTAFDTTDWATNRELRSRCLAQLQAAIEAEKQDLRTELVAEVGCPVMTTESAQLDWPLAESLRYPA GLIDTFEWERVLDGGGLFGERNIRTVVKEPVGVVAAVTPSNFPIEVILNKLGPALAAGNTVVLKPDPHTP WNATRLGRLIAEHTDIPAGVVNVVPTPSNEVAGLLGADPRVDLVSFTGSTAVGKLLMRQGAETMKRMFLE LGGKSAAIVLDDANPAVIVPTAMGVCVHAGQACAATSRMLIHRSLYDQAVTDITAAYAAMPVGDPVDPGT LVGPVISAAQKNRVLDAIDGARRDGAEITVGGGPVDGLPEHLAGGHYVAPTVVVGVDNSAAIAQQEVFGP VLVLLPFDDDDHAVRLANDSAFGLAGAVMSRSAERGMRIARRVRTGSFGVNGGMFYGADAPFGGYKSSGV GRQCGIEGFQQYLETKTIARRERRQS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2005 | - | - | 100% (516) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5157 | - | e-130 | 49.79% (484) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0904 | - | e-126 | 49.27% (481) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 1e-129 | 49.27% (481) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_4340 | - | 0.0 | 87.70% (504) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0768 | aldA | 1e-129 | 49.27% (481) | aldehyde dehydrogenase NAD dependent AldA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 3e-45 | 28.63% (461) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1218 | - | 1e-124 | 47.84% (487) | aldehyde dehydrogenase AldA |
| M. marinum M | MMAR_4322 | aldA_2 | 1e-142 | 54.34% (495) | aldehyde dehydrogenase NAD dependent AldA_2 |
| M. avium 104 | MAV_2564 | - | 1e-154 | 56.52% (483) | aldehyde dehydrogenase (NAD) family protein |
| M. smegmatis MC2 155 | MSMEG_2238 | - | 0.0 | 76.20% (500) | aldehyde dehydrogenase (NAD) family protein |
| M. thermoresistible (build 8) | TH_3376 | - | 0.0 | 79.65% (403) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_0477 | aldA | 1e-122 | 49.06% (481) | NAD-dependent aldehyde dehydrogenase, AldA |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0791|M.bovis_AF2122/97 MALWGDGI-------------------SALLIDGKLSDGRAG-TFPTVNP
Rv0768|M.tuberculosis_H37Rv MALWGDGI-------------------SALLIDGKLSDGRAG-TFPTVNP
MUL_0477|M.ulcerans_Agy99 MALLADGV-------------------SSLFIDGKRCEGAAG-TFATVNP
MAB_1218|M.abscessus_ATCC_1997 MTVLSDGD-------------------SELFIDGKLLPGGAG-RFPTVNP
Mvan_2005|M.vanbaalenii_PYR-1 MSDAMTETVDGTQTSADWGRRAAQRAERRMLIDGELVEAESGAQFDNHSP
Mflv_4340|M.gilvum_PYR-GCK MSATPTER---TETSLEWGRRAAQRAENRMLIDGELVGAASGEMFDNLSP
MSMEG_2238|M.smegmatis_MC2_155 MSDVVAAA-----DSVEIGRRAAARAEKRMLIDGELVAAAV--DFENISP
TH_3376|M.thermoresistible__bu --------------------------------------------------
MAV_2564|M.avium_104 MTASPVAA-----TTVQFN------PEARLFIDGRLRDSSTGKTVDNINP
MMAR_4322|M.marinum_M MADTTEAV--------------EVRFESKMMIDGKLVDGQAG-TFTNINP
MLBr_02573|M.leprae_Br4923 ------------------------------------------MSIATINP
Mb0791|M.bovis_AF2122/97 ATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDA
Rv0768|M.tuberculosis_H37Rv ATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDA
MUL_0477|M.ulcerans_Agy99 ATEETLGVAADAVAGDMDRAIEAARRAFDDTDWSRNTELRVRCVRQLRDA
MAB_1218|M.abscessus_ATCC_1997 ATEEVLGTAADADSDDMSDAIEAARRAFDDSGWSRDVALRVHCIRQLRDG
Mvan_2005|M.vanbaalenii_PYR-1 ATGVVLGATTAAGERDMLRAIGAARTAFDTTDWATNRELRSRCLAQLQAA
Mflv_4340|M.gilvum_PYR-GCK ATGAVLGATAAAGADDMDRAIAAARRAFDTTDWSTDKELRRRCLQQLQAA
MSMEG_2238|M.smegmatis_MC2_155 ATGSVLGTTSAASAGDMDAAMGAARRAFDETDWSTDRVRRQKVLLQLHDA
TH_3376|M.thermoresistible__bu -------------------------------------VQKDDMILISX--
MAV_2564|M.avium_104 ANEEVLGLATDASAEDMEEAIAAARRAFDSTDWSTNHEFRQRCLMQLHDA
MMAR_4322|M.marinum_M ATEEPLGEVADASKTDMHRAIDAARRAFDETDWSTNRALRKRCLEQLQEA
MLBr_02573|M.leprae_Br4923 ATGETVKTFTPTTQDEVEDAIARAYARFDN-YRHTTFTQRAKWANATADL
:
Mb0791|M.bovis_AF2122/97 MQQHVEELRELTISEVGAPRMLTASAQLEGPVGD-LSFAADTAESYPWKQ
Rv0768|M.tuberculosis_H37Rv MQQHVEELRELTISEVGAPRMLTASAQLEGPVGD-LSFAADTAESYPWKQ
MUL_0477|M.ulcerans_Agy99 MREHIEELRALTISEVGAPRMLTAAAQLEGPVND-LAFSADTAESYSWKQ
MAB_1218|M.abscessus_ATCC_1997 MKTHIEELRELTIAEVGAPRMLTAGAQLEGPVDD-LQFAADTAESFDWTS
Mvan_2005|M.vanbaalenii_PYR-1 IEAEKQDLRTELVAEVGCPVMTTESAQLDWPLAESLRYPAGLIDTFEWER
Mflv_4340|M.gilvum_PYR-GCK IESEKEDLRTELVAEVGCPVMTTESAQLDWPLAEALRYPAGLIDDFEWER
MSMEG_2238|M.smegmatis_MC2_155 LEAEKEDLREELIAEVGCPAMTTQNAQLDWPLAEALRYPARLIDEFEWER
TH_3376|M.thermoresistible__bu ----------XXIAEVGCPAMTVGNAQLDWPVAESLRYPARLIDEFEWER
MAV_2564|M.avium_104 LQEEAEDIRAELIAEVGATVGMTHIAQMGWPLADAIRWPAQLISTFQWER
MMAR_4322|M.marinum_M IEAEREELREELILEAGAPRAITFGPQLDAPLADALRYPVKLIDEYPWET
MLBr_02573|M.leprae_Br4923 LEAEANQSAALMTLEMGKTLQSAKDEAMKC--AKGFRYYAEKAETLLADE
* * . . : . : : . .
Mb0791|M.bovis_AF2122/97 DLGEA--SPLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAG
Rv0768|M.tuberculosis_H37Rv DLGEA--SPLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAG
MUL_0477|M.ulcerans_Agy99 DLGAA--APMGIPTRRTVVREAVGVVGAITPWNFPHQINLAKLGPALAAG
MAB_1218|M.abscessus_ATCC_1997 DLGVA--SPMGIKTRRTLAREAVGVVGAVTPWNFPHQINLAKVGPALAAG
Mvan_2005|M.vanbaalenii_PYR-1 VLDGG--GLFGERNIRTVVKEPVGVVAAVTPSNFPIEVILNKLGPALAAG
Mflv_4340|M.gilvum_PYR-GCK VLDAG--GLFGERNIRMVVKEAVGVVAAVTPSNFPLEVILNKLGPALAAG
MSMEG_2238|M.smegmatis_MC2_155 ELDGG--GLFGERNARTVVKEPVGVVAAITPSNFPIEVILNKLGPALAAG
TH_3376|M.thermoresistible__bu TLAGG--GLFGERNVRVVVKEPVGVVAAITPSNFPIEVTLNKLGPALAAG
MAV_2564|M.avium_104 MLDQD--AKMGVPYNRVVVKEPMGVVGAITPWNFPFEIISNKVGQILATG
MMAR_4322|M.marinum_M DLGDVLVSITGQMTTRKVWREPVGVVGAIVPWNFPFEVTINKLGQALGTG
MLBr_02573|M.leprae_Br4923 PAEAA----AVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAG
:.:*** *: * *** . * :*
Mb0791|M.bovis_AF2122/97 NTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKD
Rv0768|M.tuberculosis_H37Rv NTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKD
MUL_0477|M.ulcerans_Agy99 NTVVLKPAPDTPWCAAVLGELIADCTDIPPGVVNIVTSSEHGLGALLAKD
MAB_1218|M.abscessus_ATCC_1997 NTLVLKPAPDTPWCAAVLGRIIAEHTDFPPGVVNIVTSSDHRIGAQLSTD
Mvan_2005|M.vanbaalenii_PYR-1 NTVVLKPDPHTPWNATRLGRLIAEHTDIPAGVVNVVPTPSNEVAGLLGAD
Mflv_4340|M.gilvum_PYR-GCK NTVVLKPDPHTPWNATRLGRLIAEKTDFPPGVVNVVTTPSNAVAGLLGTD
MSMEG_2238|M.smegmatis_MC2_155 NTVVLKPDPNTPWNATRLGRLIVERTDMPPGVVNVVPTPSNGVAALLGTD
TH_3376|M.thermoresistible__bu NTVVLKPDPNTPWNATRLGRLIAEHTDIPPGVVNVVPTPDNEVAELLATD
MAV_2564|M.avium_104 NTMVLKPAMETPWSALRWGRIIAEKTDIPAGVVNIVPASDNDIAQVLATD
MMAR_4322|M.marinum_M NTVVLKPAPDTPFNATRLGRLIAEKTDIPPGVVSVVTASDHLVGEELTLS
MLBr_02573|M.leprae_Br4923 NVGLLKHASNVPQCALYLADVIARG-GFPEDCFQTLLISANGVEAILR-D
*. :** ..* * . :*. .:* . .. : . : : * .
Mb0791|M.bovis_AF2122/97 PRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADL
Rv0768|M.tuberculosis_H37Rv PRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADL
MUL_0477|M.ulcerans_Agy99 PRVDMVSFTGSTATGRSVMADGAATIKRMFLELGGKSAFIVLDD---ADL
MAB_1218|M.abscessus_ATCC_1997 PRVDMVSFTGSTATGRAVMTDAAATVKKVFLELGGKSAFIVLDDLDEAAL
Mvan_2005|M.vanbaalenii_PYR-1 PRVDLVSFTGSTAVGKLLMRQGAETMKRMFLELGGKSAAIVLDD---ANP
Mflv_4340|M.gilvum_PYR-GCK ARVDLVSFTGSTAVGKLLMRQGADSMKRMFLELGGKSAAIVLDD---ANP
MSMEG_2238|M.smegmatis_MC2_155 PRVDMVSFTGSTAVGKHLMRVGADTMKRTFLELGGKSAMIVLDD---AKP
TH_3376|M.thermoresistible__bu PRVDMVSFTGSTEVGKHLLRQGAETMKRSFLELGGKSALIVLDD---ADP
MAV_2564|M.avium_104 PRIDMVSFTGSTAVGKLIQRLSADTMKRNMLELGGKSAYLILDD---ADM
MMAR_4322|M.marinum_M PKVDLISFTGSTGVGKRIMEKGAATMKRLFLELGGKSATIVLED---AEF
MLBr_02573|M.leprae_Br4923 PRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS---ADL
.:: ::*** .*: : .. :* .*****... ::: . *
Mb0791|M.bovis_AF2122/97 AAASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGD
Rv0768|M.tuberculosis_H37Rv AAASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGD
MUL_0477|M.ulcerans_Agy99 AAASSVSAFTASMHAGQGCAITTRLVVPRARYDEAVAIAAGTMSSIKPGD
MAB_1218|M.abscessus_ATCC_1997 GSACSVAAFTAAMHAGQGCAITTRLVVPRERYDDAVAAAAATMGSLKPGD
Mvan_2005|M.vanbaalenii_PYR-1 AVIVPT-AMGVCVHAGQACAATSRMLIHRSLYDQAVTDITAAYAAMPVGD
Mflv_4340|M.gilvum_PYR-GCK AVIVPT-AVGVCVHAGQACAATSRMLIHRSLYDQAVADITMAYQYVPVGD
MSMEG_2238|M.smegmatis_MC2_155 AHIIPG-AIGACVHAGQACAANTRMLVHRSLFDEAVANVAMAFAGIPVGD
TH_3376|M.thermoresistible__bu DRIIPA-AIGVCVHAGQACASTTRMLVHRSLYDDAVAAVTAAFAAVPVGD
MAV_2564|M.avium_104 GMALPG-CIGALMHSGQGCALATRMLVPRSHYDQAVEVASATFGSLAVGD
MMAR_4322|M.marinum_M GLACAI-GIAPCMHAGQGCANPTRMLLPRSRYDEGVAILKSIYDNVMPGD
MLBr_02573|M.leprae_Br4923 DAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGD
. : **.* .*:: ::: * : **
Mb0791|M.bovis_AF2122/97 PNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGGA----RPADREV
Rv0768|M.tuberculosis_H37Rv PNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGGA----RPADREV
MUL_0477|M.ulcerans_Agy99 PDDARTVCGPLISQRQRDRVEGYLDLAIAEGGTFACGGG----RPAGRQV
MAB_1218|M.abscessus_ATCC_1997 PAKPGTICGPVISARQRDRVQSYLDLAVAEGGSFACGGG----RPEGKDR
Mvan_2005|M.vanbaalenii_PYR-1 PVDPGTLVGPVISAAQKNRVLDAIDGARRDGAEITVGGGPVDGLPEHLAG
Mflv_4340|M.gilvum_PYR-GCK PTDPGTLVGPVISAAQQERVLSAIEGARRDGAEITAGGGLVAGLPDHLAG
MSMEG_2238|M.smegmatis_MC2_155 PALPTTLVGPVISAAAKQRVLDACERARRDGAETVVGGGEAEGLPEHLAG
TH_3376|M.thermoresistible__bu PALPGTVVGPVISAAQQQRILDACDEACAEGAEITTGGGVVTDLPDHLTG
MAV_2564|M.avium_104 PADPNTFCGPLVSAKQQARVLNYIEIAKRDGGRVTTGGG----VPDGLDR
MMAR_4322|M.marinum_M PQDPATLCGPVISDKQRKRVLGYLNKGVEEGATCLVGGP---DAPTGFDR
MLBr_02573|M.leprae_Br4923 PTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGK----RPDR--P
* . * **: : : :: : . *. ** *
Mb0791|M.bovis_AF2122/97 GFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDG-DDDAVRIANDSPYG
Rv0768|M.tuberculosis_H37Rv GFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDG-DDDAVRIANDSPYG
MUL_0477|M.ulcerans_Agy99 GYFIEPTVIAGLTTDARPAREEIFGPVLTVLAHDG-DDDAVRIANDSPYG
MAB_1218|M.abscessus_ATCC_1997 GFFIEPTVVAGLTNAARVAREEIFGPVLVVIAHDG-DEDAVRIANDSPYG
Mvan_2005|M.vanbaalenii_PYR-1 GHYVAPTVVVGVDNSAAIAQQEVFGPVLVLLPFDD-DDHAVRLANDSAFG
Mflv_4340|M.gilvum_PYR-GCK GHFVAPTVITGVDNSAAIAQQEVFGPVLVLLPFDD-DDEAVRLANDSAFG
MSMEG_2238|M.smegmatis_MC2_155 GHYVAPTVIVGADPRSAIAQEEVFGPVLVMVPFDD-DDEAVRLANDTAFG
TH_3376|M.thermoresistible__bu GHYVQPTVVVGVDNSAPIAQREIFGPVLVILPFAD-DDEAVRIANDSVFG
MAV_2564|M.avium_104 GYFVAPTVVADVAPDHTIFQEEVFGPVLSITPYDGGDDGAVEMANNSTYG
MMAR_4322|M.marinum_M GFYVRPTLFVDVDNSMTIAQEEIFGPVLSVIPFDT-EEDAIRIANDSVYG
MLBr_02573|M.leprae_Br4923 GWFYPPTVITDITKDMALYTDEVFGPVASVYCATN-IDDAIEIANATPFG
* : **:... *:**** : : *:.:** : :*
Mb0791|M.bovis_AF2122/97 LSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGRE
Rv0768|M.tuberculosis_H37Rv LSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGRE
MUL_0477|M.ulcerans_Agy99 LSGTVYGGDPQRAADVAARLRVGAVNVNGGVWYCADAPFGGYKQSGIGRE
MAB_1218|M.abscessus_ATCC_1997 LSGTVFGDDDERSARVASRLRVGTVNVNGGVWYSADAPFGGYKQSGNGRE
Mvan_2005|M.vanbaalenii_PYR-1 LAGAVMSRSAERGMRIARRVRTGSFGVNGGMFYGADAPFGGYKSSGVGRQ
Mflv_4340|M.gilvum_PYR-GCK LAGAVMSRSAERGMNIARRIRTGAFGVNGGMFYGADAPFGGYKSSGVGRQ
MSMEG_2238|M.smegmatis_MC2_155 LAGAVLSASPERAMGIARRIRTGAIGVNGGMYYGADAPFGGYKNSGVGRQ
TH_3376|M.thermoresistible__bu LAGAVLSGSAERGMAVARRVRTGAIGVNGGMFYGADAPFGGFKQSGLGRQ
MAV_2564|M.avium_104 LAGGIMG-SDERAMAVARRIRTGSLMINSGMYYGADAPFGGYKMSGIGRQ
MMAR_4322|M.marinum_M LAGNVMSGSLEHSLAVARRLRAGFIGVNGGAPYGADTPFGGYKDSGVGRQ
MLBr_02573|M.leprae_Br4923 LGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRE
*.. . .. . .: .* . :*. .: **** * ** **:
Mb0791|M.bovis_AF2122/97 MGLLGFEEYLEAKLIATAAN---
Rv0768|M.tuberculosis_H37Rv MGLLGFEEYLEAKLIATAAN---
MUL_0477|M.ulcerans_Agy99 MGLAGFEEYLETKLIATAAN---
MAB_1218|M.abscessus_ATCC_1997 MGVAGFEEYLETKVIATAVK---
Mvan_2005|M.vanbaalenii_PYR-1 CGIEGFQQYLETKTIARRERRQS
Mflv_4340|M.gilvum_PYR-GCK CGIEGFSQYLETKTIARRERRKG
MSMEG_2238|M.smegmatis_MC2_155 CGIEGFAQYTETKTIGWRRPRT-
TH_3376|M.thermoresistible__bu CGLEGFQQYLETRTIAHRVPRRQ
MAV_2564|M.avium_104 NGIEGFEQHLQTKTIGYPL----
MMAR_4322|M.marinum_M NGVAGFDQYTQIKSLGYPAG---
MLBr_02573|M.leprae_Br4923 LSTHGIREFCNIKTVWIA-----
. *: :. : : :