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MTASPVAATTVQFNPEARLFIDGRLRDSSTGKTVDNINPANEEVLGLATDASAEDMEEAIAAARRAFDST DWSTNHEFRQRCLMQLHDALQEEAEDIRAELIAEVGATVGMTHIAQMGWPLADAIRWPAQLISTFQWERM LDQDAKMGVPYNRVVVKEPMGVVGAITPWNFPFEIISNKVGQILATGNTMVLKPAMETPWSALRWGRIIA EKTDIPAGVVNIVPASDNDIAQVLATDPRIDMVSFTGSTAVGKLIQRLSADTMKRNMLELGGKSAYLILD DADMGMALPGCIGALMHSGQGCALATRMLVPRSHYDQAVEVASATFGSLAVGDPADPNTFCGPLVSAKQQ ARVLNYIEIAKRDGGRVTTGGGVPDGLDRGYFVAPTVVADVAPDHTIFQEEVFGPVLSITPYDGGDDGAV EMANNSTYGLAGGIMGSDERAMAVARRIRTGSLMINSGMYYGADAPFGGYKMSGIGRQNGIEGFEQHLQT KTIGYPL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2564 | - | - | 100% (497) | aldehyde dehydrogenase (NAD) family protein |
| M. avium 104 | MAV_1825 | - | 0.0 | 80.48% (497) | aldehyde dehydrogenase family protein |
| M. avium 104 | MAV_1275 | - | e-145 | 53.73% (482) | aldehyde dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 1e-136 | 50.52% (477) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_4340 | - | 1e-154 | 56.73% (483) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0768 | aldA | 1e-136 | 50.52% (477) | aldehyde dehydrogenase NAD dependent AldA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-51 | 30.32% (465) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1218 | - | 1e-135 | 50.10% (489) | aldehyde dehydrogenase AldA |
| M. marinum M | MMAR_4322 | aldA_2 | 1e-144 | 52.81% (498) | aldehyde dehydrogenase NAD dependent AldA_2 |
| M. smegmatis MC2 155 | MSMEG_2238 | - | 1e-152 | 56.70% (485) | aldehyde dehydrogenase (NAD) family protein |
| M. thermoresistible (build 8) | TH_3100 | - | 0.0 | 84.10% (497) | PUTATIVE aldehyde dehydrogenase (NAD) family protein |
| M. ulcerans Agy99 | MUL_0477 | aldA | 1e-137 | 51.99% (477) | NAD-dependent aldehyde dehydrogenase, AldA |
| M. vanbaalenii PYR-1 | Mvan_2005 | - | 1e-154 | 56.52% (483) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0791|M.bovis_AF2122/97 MALWGDGI-------------------SALLIDGKLSDGR-AGTFPTVNP
Rv0768|M.tuberculosis_H37Rv MALWGDGI-------------------SALLIDGKLSDGR-AGTFPTVNP
MUL_0477|M.ulcerans_Agy99 MALLADGV-------------------SSLFIDGKRCEGA-AGTFATVNP
MAB_1218|M.abscessus_ATCC_1997 MTVLSDGD-------------------SELFIDGKLLPGG-AGRFPTVNP
MAV_2564|M.avium_104 MTASPVAATT-----------VQFNPEARLFIDGRLRDSSTGKTVDNINP
TH_3100|M.thermoresistible__bu MTASPVATS------------VQFNPETRLYIDGELRESRTGKTVDNINP
Mflv_4340|M.gilvum_PYR-GCK MSATPTER---TETSLEWGRRAAQRAENRMLIDGELVGAASGEMFDNLSP
Mvan_2005|M.vanbaalenii_PYR-1 MSDAMTETVDGTQTSADWGRRAAQRAERRMLIDGELVEAESGAQFDNHSP
MSMEG_2238|M.smegmatis_MC2_155 MSDVVAAA-----DSVEIGRRAAARAEKRMLIDGELVAAA--VDFENISP
MMAR_4322|M.marinum_M MADTTEAV--------------EVRFESKMMIDGKLVDGQ-AGTFTNINP
MLBr_02573|M.leprae_Br4923 ------------------------------------------MSIATINP
. . .*
Mb0791|M.bovis_AF2122/97 ATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDA
Rv0768|M.tuberculosis_H37Rv ATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDA
MUL_0477|M.ulcerans_Agy99 ATEETLGVAADAVAGDMDRAIEAARRAFDDTDWSRNTELRVRCVRQLRDA
MAB_1218|M.abscessus_ATCC_1997 ATEEVLGTAADADSDDMSDAIEAARRAFDDSGWSRDVALRVHCIRQLRDG
MAV_2564|M.avium_104 ANEEVLGLATDASAEDMEEAIAAARRAFDSTDWSTNHEFRQRCLMQLHDA
TH_3100|M.thermoresistible__bu ATEEVLGTATDVGADDMEQAIAAARRAFDTTDWSTNHEFRRRCLLQLHDA
Mflv_4340|M.gilvum_PYR-GCK ATGAVLGATAAAGADDMDRAIAAARRAFDTTDWSTDKELRRRCLQQLQAA
Mvan_2005|M.vanbaalenii_PYR-1 ATGVVLGATTAAGERDMLRAIGAARTAFDTTDWATNRELRSRCLAQLQAA
MSMEG_2238|M.smegmatis_MC2_155 ATGSVLGTTSAASAGDMDAAMGAARRAFDETDWSTDRVRRQKVLLQLHDA
MMAR_4322|M.marinum_M ATEEPLGEVADASKTDMHRAIDAARRAFDETDWSTNRALRKRCLEQLQEA
MLBr_02573|M.leprae_Br4923 ATGETVKTFTPTTQDEVEDAIARAYARFDN-YRHTTFTQRAKWANATADL
*. : : . :: *: * ** * :
Mb0791|M.bovis_AF2122/97 MQQHVEELRELTISEVGAPRMLTASAQLEGPVGD-LSFAADTAESYPWKQ
Rv0768|M.tuberculosis_H37Rv MQQHVEELRELTISEVGAPRMLTASAQLEGPVGD-LSFAADTAESYPWKQ
MUL_0477|M.ulcerans_Agy99 MREHIEELRALTISEVGAPRMLTAAAQLEGPVND-LAFSADTAESYSWKQ
MAB_1218|M.abscessus_ATCC_1997 MKTHIEELRELTIAEVGAPRMLTAGAQLEGPVDD-LQFAADTAESFDWTS
MAV_2564|M.avium_104 LQEEAEDIRAELIAEVGATVGMTHIAQMGWPLADAIRWPAQLISTFQWER
TH_3100|M.thermoresistible__bu LQEEKEDIRAELIAEVGATVGMTFIAQLEWPLADAIRWPANYISEFAWER
Mflv_4340|M.gilvum_PYR-GCK IESEKEDLRTELVAEVGCPVMTTESAQLDWPLAEALRYPAGLIDDFEWER
Mvan_2005|M.vanbaalenii_PYR-1 IEAEKQDLRTELVAEVGCPVMTTESAQLDWPLAESLRYPAGLIDTFEWER
MSMEG_2238|M.smegmatis_MC2_155 LEAEKEDLREELIAEVGCPAMTTQNAQLDWPLAEALRYPARLIDEFEWER
MMAR_4322|M.marinum_M IEAEREELREELILEAGAPRAITFGPQLDAPLADALRYPVKLIDEYPWET
MLBr_02573|M.leprae_Br4923 LEAEANQSAALMTLEMGKTLQSAKDEAMKC--AKGFRYYAEKAETLLADE
:. . :: * * . : : . : : . .
Mb0791|M.bovis_AF2122/97 DLGEA--SPLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAG
Rv0768|M.tuberculosis_H37Rv DLGEA--SPLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAG
MUL_0477|M.ulcerans_Agy99 DLGAA--APMGIPTRRTVVREAVGVVGAITPWNFPHQINLAKLGPALAAG
MAB_1218|M.abscessus_ATCC_1997 DLGVA--SPMGIKTRRTLAREAVGVVGAVTPWNFPHQINLAKVGPALAAG
MAV_2564|M.avium_104 MLDQD--AKMGVPYNRVVVKEPMGVVGAITPWNFPFEIISNKVGQILATG
TH_3100|M.thermoresistible__bu PLPDA--ALMGAPYHRKVVKEPVGVVGAITQWNFPFEIISNKLGQALATG
Mflv_4340|M.gilvum_PYR-GCK VLDAG--GLFGERNIRMVVKEAVGVVAAVTPSNFPLEVILNKLGPALAAG
Mvan_2005|M.vanbaalenii_PYR-1 VLDGG--GLFGERNIRTVVKEPVGVVAAVTPSNFPIEVILNKLGPALAAG
MSMEG_2238|M.smegmatis_MC2_155 ELDGG--GLFGERNARTVVKEPVGVVAAITPSNFPIEVILNKLGPALAAG
MMAR_4322|M.marinum_M DLGDVLVSITGQMTTRKVWREPVGVVGAIVPWNFPFEVTINKLGQALGTG
MLBr_02573|M.leprae_Br4923 PAEAA----AVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAG
:.:*** *: *** . * :*
Mb0791|M.bovis_AF2122/97 NTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKD
Rv0768|M.tuberculosis_H37Rv NTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKD
MUL_0477|M.ulcerans_Agy99 NTVVLKPAPDTPWCAAVLGELIADCTDIPPGVVNIVTSSEHGLGALLAKD
MAB_1218|M.abscessus_ATCC_1997 NTLVLKPAPDTPWCAAVLGRIIAEHTDFPPGVVNIVTSSDHRIGAQLSTD
MAV_2564|M.avium_104 NTMVLKPAMETPWSALRWGRIIAEKTDIPAGVVNIVPASDNDIAQVLATD
TH_3100|M.thermoresistible__bu NSVVLKPAMETPWSALRWCRIIAEKTDIPPGVVNIVPTSDNSIAQVLATD
Mflv_4340|M.gilvum_PYR-GCK NTVVLKPDPHTPWNATRLGRLIAEKTDFPPGVVNVVTTPSNAVAGLLGTD
Mvan_2005|M.vanbaalenii_PYR-1 NTVVLKPDPHTPWNATRLGRLIAEHTDIPAGVVNVVPTPSNEVAGLLGAD
MSMEG_2238|M.smegmatis_MC2_155 NTVVLKPDPNTPWNATRLGRLIVERTDMPPGVVNVVPTPSNGVAALLGTD
MMAR_4322|M.marinum_M NTVVLKPAPDTPFNATRLGRLIAEKTDIPPGVVSVVTASDHLVGEELTLS
MLBr_02573|M.leprae_Br4923 NVGLLKHASNVPQCALYLADVIARG-GFPEDCFQTLLISANGVEAILR-D
* :** ..* * :*. .:* . .. : . : : * .
Mb0791|M.bovis_AF2122/97 PRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADL
Rv0768|M.tuberculosis_H37Rv PRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDD---ADL
MUL_0477|M.ulcerans_Agy99 PRVDMVSFTGSTATGRSVMADGAATIKRMFLELGGKSAFIVLDD---ADL
MAB_1218|M.abscessus_ATCC_1997 PRVDMVSFTGSTATGRAVMTDAAATVKKVFLELGGKSAFIVLDDLDEAAL
MAV_2564|M.avium_104 PRIDMVSFTGSTAVGKLIQRLSADTMKRNMLELGGKSAYLILDD---ADM
TH_3100|M.thermoresistible__bu PRVDMVSFTGSTAVGKLIQRLGADTMKRTMLELGGKSAYLVREG---ADL
Mflv_4340|M.gilvum_PYR-GCK ARVDLVSFTGSTAVGKLLMRQGADSMKRMFLELGGKSAAIVLDD---ANP
Mvan_2005|M.vanbaalenii_PYR-1 PRVDLVSFTGSTAVGKLLMRQGAETMKRMFLELGGKSAAIVLDD---ANP
MSMEG_2238|M.smegmatis_MC2_155 PRVDMVSFTGSTAVGKHLMRVGADTMKRTFLELGGKSAMIVLDD---AKP
MMAR_4322|M.marinum_M PKVDLISFTGSTGVGKRIMEKGAATMKRLFLELGGKSATIVLED---AEF
MLBr_02573|M.leprae_Br4923 PRVAAATLTGSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS---ADL
.:: ::*** .*: : .. :* .*****... :: . *
Mb0791|M.bovis_AF2122/97 AAASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGD
Rv0768|M.tuberculosis_H37Rv AAASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGD
MUL_0477|M.ulcerans_Agy99 AAASSVSAFTASMHAGQGCAITTRLVVPRARYDEAVAIAAGTMSSIKPGD
MAB_1218|M.abscessus_ATCC_1997 GSACSVAAFTAAMHAGQGCAITTRLVVPRERYDDAVAAAAATMGSLKPGD
MAV_2564|M.avium_104 GMALPG-CIGALMHSGQGCALATRMLVPRSHYDQAVEVASATFGSLAVGD
TH_3100|M.thermoresistible__bu EAALPG-CVGALMHSGQGCALATRMLVPRSIYDQAAEVASATFGSLAVGD
Mflv_4340|M.gilvum_PYR-GCK AVIVPT-AVGVCVHAGQACAATSRMLIHRSLYDQAVADITMAYQYVPVGD
Mvan_2005|M.vanbaalenii_PYR-1 AVIVPT-AMGVCVHAGQACAATSRMLIHRSLYDQAVTDITAAYAAMPVGD
MSMEG_2238|M.smegmatis_MC2_155 AHIIPG-AIGACVHAGQACAANTRMLVHRSLFDEAVANVAMAFAGIPVGD
MMAR_4322|M.marinum_M GLACAI-GIAPCMHAGQGCANPTRMLLPRSRYDEGVAILKSIYDNVMPGD
MLBr_02573|M.leprae_Br4923 DAAVATAVTGRVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGD
. : **.* .*:: ::: . : **
Mb0791|M.bovis_AF2122/97 PNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGGA----RPADREV
Rv0768|M.tuberculosis_H37Rv PNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGGA----RPADREV
MUL_0477|M.ulcerans_Agy99 PDDARTVCGPLISQRQRDRVEGYLDLAIAEGGTFACGGG----RPAGRQV
MAB_1218|M.abscessus_ATCC_1997 PAKPGTICGPVISARQRDRVQSYLDLAVAEGGSFACGGG----RPEGKDR
MAV_2564|M.avium_104 PADPNTFCGPLVSAKQQARVLNYIEIAKRDGGRVTTGGG----VPDGLDR
TH_3100|M.thermoresistible__bu PADPNTFCGPLVSARQRDRVLNYIEIAKREGGRITVGGG----VPEGLDR
Mflv_4340|M.gilvum_PYR-GCK PTDPGTLVGPVISAAQQERVLSAIEGARRDGAEITAGGGLVAGLPDHLAG
Mvan_2005|M.vanbaalenii_PYR-1 PVDPGTLVGPVISAAQKNRVLDAIDGARRDGAEITVGGGPVDGLPEHLAG
MSMEG_2238|M.smegmatis_MC2_155 PALPTTLVGPVISAAAKQRVLDACERARRDGAETVVGGGEAEGLPEHLAG
MMAR_4322|M.marinum_M PQDPATLCGPVISDKQRKRVLGYLNKGVEEGATCLVGGP---DAPTGFDR
MLBr_02573|M.leprae_Br4923 PTDPDTDVGPLATESGRAQVEQQVDAAAAAGAVIRCGGK----RPDR--P
* . * **: : : :* : . *. ** *
Mb0791|M.bovis_AF2122/97 GFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDG-DDDAVRIANDSPYG
Rv0768|M.tuberculosis_H37Rv GFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDG-DDDAVRIANDSPYG
MUL_0477|M.ulcerans_Agy99 GYFIEPTVIAGLTTDARPAREEIFGPVLTVLAHDG-DDDAVRIANDSPYG
MAB_1218|M.abscessus_ATCC_1997 GFFIEPTVVAGLTNAARVAREEIFGPVLVVIAHDG-DEDAVRIANDSPYG
MAV_2564|M.avium_104 GYFVAPTVVADVAPDHTIFQEEVFGPVLSITPYDGGDDGAVEMANNSTYG
TH_3100|M.thermoresistible__bu GYFVAPTVVADVEPHHTIFQEEIFGPVLSITPYNGGDDAAVELANNSTYG
Mflv_4340|M.gilvum_PYR-GCK GHFVAPTVITGVDNSAAIAQQEVFGPVLVLLPFDD-DDEAVRLANDSAFG
Mvan_2005|M.vanbaalenii_PYR-1 GHYVAPTVVVGVDNSAAIAQQEVFGPVLVLLPFDD-DDHAVRLANDSAFG
MSMEG_2238|M.smegmatis_MC2_155 GHYVAPTVIVGADPRSAIAQEEVFGPVLVMVPFDD-DDEAVRLANDTAFG
MMAR_4322|M.marinum_M GFYVRPTLFVDVDNSMTIAQEEIFGPVLSVIPFDT-EEDAIRIANDSVYG
MLBr_02573|M.leprae_Br4923 GWFYPPTVITDITKDMALYTDEVFGPVASVYCATN-IDDAIEIANATPFG
* : **:... :*:**** : : *:.:** : :*
Mb0791|M.bovis_AF2122/97 LSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGRE
Rv0768|M.tuberculosis_H37Rv LSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGRE
MUL_0477|M.ulcerans_Agy99 LSGTVYGGDPQRAADVAARLRVGAVNVNGGVWYCADAPFGGYKQSGIGRE
MAB_1218|M.abscessus_ATCC_1997 LSGTVFGDDDERSARVASRLRVGTVNVNGGVWYSADAPFGGYKQSGNGRE
MAV_2564|M.avium_104 LAGGIMG-SDERAMAVARRIRTGSLMINSGMYYGADAPFGGYKMSGIGRQ
TH_3100|M.thermoresistible__bu LAGAVMG-PDDRAMAVARRIRTGSLMINNSLYYGADAPFGGYKMSGIGRQ
Mflv_4340|M.gilvum_PYR-GCK LAGAVMSRSAERGMNIARRIRTGAFGVNGGMFYGADAPFGGYKSSGVGRQ
Mvan_2005|M.vanbaalenii_PYR-1 LAGAVMSRSAERGMRIARRVRTGSFGVNGGMFYGADAPFGGYKSSGVGRQ
MSMEG_2238|M.smegmatis_MC2_155 LAGAVLSASPERAMGIARRIRTGAIGVNGGMYYGADAPFGGYKNSGVGRQ
MMAR_4322|M.marinum_M LAGNVMSGSLEHSLAVARRLRAGFIGVNGGAPYGADTPFGGYKDSGVGRQ
MLBr_02573|M.leprae_Br4923 LGSNAWTQNESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRE
*.. .. . .: .* . :*. .: **** * ** **:
Mb0791|M.bovis_AF2122/97 MGLLGFEEYLEAKLIATAAN---
Rv0768|M.tuberculosis_H37Rv MGLLGFEEYLEAKLIATAAN---
MUL_0477|M.ulcerans_Agy99 MGLAGFEEYLETKLIATAAN---
MAB_1218|M.abscessus_ATCC_1997 MGVAGFEEYLETKVIATAVK---
MAV_2564|M.avium_104 NGIEGFEQHLQTKTIGYPL----
TH_3100|M.thermoresistible__bu NGHEGFEQYLETKTIAYPLEAGQ
Mflv_4340|M.gilvum_PYR-GCK CGIEGFSQYLETKTIARRERRKG
Mvan_2005|M.vanbaalenii_PYR-1 CGIEGFQQYLETKTIARRERRQS
MSMEG_2238|M.smegmatis_MC2_155 CGIEGFAQYTETKTIGWRRPRT-
MMAR_4322|M.marinum_M NGVAGFDQYTQIKSLGYPAG---
MLBr_02573|M.leprae_Br4923 LSTHGIREFCNIKTVWIA-----
. *: :. : * :