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VSAVDRAAEPGIADTEPVLFDMHDSGVAVLTLNRPERMNSWGGGLAQAFYRCIDRAEADPHVRVIVLTGN GRAFCAGADMGDLDSISAAGDTGRGERSDGESGLADTDVSQLVGERHPHFLTQLRKPLIAAINGACAGIG LTHALMCDVRFAAAGAKFTTAFARRGLIAEYGISWILPRIVGWSAAQDLLLSGRTFYAEEANELGLVNQV VAPDELMAHTLAYAEDMARNCAPSSLAVIKRQIYRDALRNLSDASADAEKLMHESMQRPDFIEGITAFFE KRQPSFPPLKEETP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1993 | - | - | 100% (294) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_3400 | - | 1e-37 | 39.02% (264) | enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_3603 | - | 6e-30 | 33.96% (265) | enoyl-CoA hydratase/isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1099c | echA8 | 3e-29 | 31.94% (263) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4351 | - | 1e-136 | 82.49% (297) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1070c | echA8 | 3e-29 | 31.94% (263) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01241 | - | 2e-29 | 35.06% (271) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_0104 | - | 1e-32 | 35.63% (261) | enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_4015 | echA12_1 | 1e-91 | 60.22% (274) | enoyl-CoA hydratase, EchA12_1 |
| M. avium 104 | MAV_1590 | - | 1e-109 | 68.90% (283) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_2229 | - | 1e-103 | 65.61% (285) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_4111 | - | 1e-104 | 67.38% (279) | PUTATIVE enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_3879 | echA12_1 | 6e-91 | 59.85% (274) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1099c|M.bovis_AF2122/97 -----------------MTYETILVERDQRVGIITLNRPQALNALNSQVM
Rv1070c|M.tuberculosis_H37Rv -----------------MTYETILVERDQRVGIITLNRPQALNALNSQVM
MAB_0104|M.abscessus_ATCC_1997 -------------------MTELHEEIRDGVAVLTLHGPSTRNSFTVELG
Mvan_1993|M.vanbaalenii_PYR-1 ----MSAVDRAAEPGIADTEPVLFDMHDSGVAVLTLNRPERMNSWGGGLA
Mflv_4351|M.gilvum_PYR-GCK ----MSAVDRAVDR---RAEPVLFDLHDSGVAVLTLNRPDRMNSWGGGLA
MAV_1590|M.avium_104 ----MSAADHVVTD-----EAVLYQTTETGVAVVTFNRPERLNAWGPDIS
TH_4111|M.thermoresistible__bu ---------------------VRYEVRDPGVAVVTFDRPERLNTWARDIS
MSMEG_2229|M.smegmatis_MC2_155 ----MSVAETGTSD------AVRYEVNDAGVAVITLNRPERLNSWGADIS
MMAR_4015|M.marinum_M ----MSAAD--AQD------AVLYEATPGGVAIITFNRADRLNAWGPDLA
MUL_3879|M.ulcerans_Agy99 --MRMSAAD--AQD------AVLYEATPGGVAIITFNRADRLNAWGLDLA
MLBr_01241|M.leprae_Br4923 MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLM
*.::*:. . *: :
Mb1099c|M.bovis_AF2122/97 NEVTSAATELDDDPDIGAIIITGSAKAFAAGADIKEMADLTFADAFTAD-
Rv1070c|M.tuberculosis_H37Rv NEVTSAATELDDDPDIGAIIITGSAKAFAAGADIKEMADLTFADAFTAD-
MAB_0104|M.abscessus_ATCC_1997 RQLGAAYQRLDDDPAVRVIVLTGAPPAFCSGAQISAAAET-FAAPRNPD-
Mvan_1993|M.vanbaalenii_PYR-1 QAFYRCIDRAEADPHVRVIVLTGNGRAFCAGADMGDLD--SISAAGDTGR
Mflv_4351|M.gilvum_PYR-GCK RAFYECIDRAEADPDVRVIVLTGNGRAFCAGADMGDLD--SISGASDS--
MAV_1590|M.avium_104 SGFYACIDRAEADPAVRVIVLTGAGRGFCAGANLGGAG--SIDAKLGD--
TH_4111|M.thermoresistible__bu SGFYAAIDRADADPDVRVIVWTGNGRAFCAGADLGSASGESLGAGLQKT-
MSMEG_2229|M.smegmatis_MC2_155 AGVYASFDRAEADPAVRAIVLTGTGRGFCAGAYMGEMA--SLGESISG--
MMAR_4015|M.marinum_M AGFYAAIDRAEADPGIRVIVLTGRGRGFCAGAYLGSAD---AAAGYDKT-
MUL_3879|M.ulcerans_Agy99 AGFYTAIDRAEADPGIRVIVLTGRGRGFCAGAYLGSAD---AAAGYDKT-
MLBr_01241|M.leprae_Br4923 KSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFTAPVPQVEGLTQP-
. . * : .:: ** .*.:**
Mb1099c|M.bovis_AF2122/97 -----------------FFAT--WGKLAAVRTPTIAAVAGYALGGGCELA
Rv1070c|M.tuberculosis_H37Rv -----------------FFAT--WGKLAAVRTPTIAAVAGYALGGGCELA
MAB_0104|M.abscessus_ATCC_1997 -----------------FSASPVQPAAFELRTPVIAAVNGHAIGIGMTLA
Mvan_1993|M.vanbaalenii_PYR-1 GERSDGESGLADTDVSQLVGERHPHFLTQLRKPLIAAINGACAGIGLTHA
Mflv_4351|M.gilvum_PYR-GCK ----------SDTDVTQLVGERHPHFVTQLRTPIIAAINGACAGIGLTQA
MAV_1590|M.avium_104 ----------GDTDVTALVGDRHPHFLTALRKPIIAAINGACVGIGLTHA
TH_4111|M.thermoresistible__bu ----------DGTNVSRLVGERHPYFLTTVRKPIIAAINGACVGIGLTHA
MSMEG_2229|M.smegmatis_MC2_155 -----------DTDVSKIVGERHPHFLTTLRKPVIAAINGACVGIGLTHA
MMAR_4015|M.marinum_M ------MAKAKDANLADLVGERPPHFVTMLRKPVIAAINGPCVGIGLTQA
MUL_3879|M.ulcerans_Agy99 ------MAKAKDANLADLVGERPPHFVTMLRKPVIAAINGPCVGIGLTQA
MLBr_01241|M.leprae_Br4923 ----------VRALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLA
:: * ***: * . * * *
Mb1099c|M.bovis_AF2122/97 MMCDVLIAADTAKFGQPEIKLGVLP-GMGGSQRLTRAIGKAKAMDLILTG
Rv1070c|M.tuberculosis_H37Rv MMCDVLIAADTAKFGQPEIKLGVLP-GMGGSQRLTRAIGKAKAMDLILTG
MAB_0104|M.abscessus_ATCC_1997 LHADIRILAEEGRYAIPQVRFGVAP-DALAHWTLPRLVGTAVAAELLLTG
Mvan_1993|M.vanbaalenii_PYR-1 LMCDVRFAAAGAKFTTAFARRGLIA-EYGISWILPRIVGWSAAQDLLLSG
Mflv_4351|M.gilvum_PYR-GCK LMCDVRFAAAGAKFTTAFSRRGLIA-EYGISWILPRIVGWGAAQDLLLSG
MAV_1590|M.avium_104 LMCDVRFAAAGAKFATAFTRRGLIA-EYGITWILPRLAGWGAAMDLLLSG
TH_4111|M.thermoresistible__bu LMCDIRFAAAGAKFNTAFARRGLIA-EYGISWILPRLAGWGVATELLLSG
MSMEG_2229|M.smegmatis_MC2_155 LMCDIRFAAAGAKFATAFPRRGLIG-EYGITWILPRLAGWGAAADLLLSG
MMAR_4015|M.marinum_M LMCDVRFAAAGAKFAAVFARRGLIA-EFGISWILPRLTSWAVALDLLLSG
MUL_3879|M.ulcerans_Agy99 LMCDVRFAAAGAKFAAVFARRGLIA-EFGISWILPRLTSWAVALDLLLSG
MLBr_01241|M.leprae_Br4923 LAADVRVASTRAYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSG
: .*: . : . : . *: *.* . . * :::*:*
Mb1099c|M.bovis_AF2122/97 RTMDAAEAERSGLVSRVVPADDLLTEARATATTIS-QMSASAARMAKEAV
Rv1070c|M.tuberculosis_H37Rv RTMDAAEAERSGLVSRVVPADDLLTEARATATTIS-QMSASAARMAKEAV
MAB_0104|M.abscessus_ATCC_1997 ASFSAQRAVETGLANRCLPAGKVLGAALRMAHDIATNVAPESAALTKRLL
Mvan_1993|M.vanbaalenii_PYR-1 RTFYAEEANELGLVNQVVAPDELMAHTLAYAEDMARNCAPSSLAVIKRQI
Mflv_4351|M.gilvum_PYR-GCK RTFYAEEAKSLGLVNDVVAPDELMAHTLSYAEDMARNCAPSSMAVIKRQL
MAV_1590|M.avium_104 RTFFAEEAAKLGLVNEIVAPDELMARALTYADDIARNCSPASLAVIKRQA
TH_4111|M.thermoresistible__bu RTFRAEEAHRLGLVHDVVPAEELTEHTLAYAEDIARNCAPASLAVIKQQL
MSMEG_2229|M.smegmatis_MC2_155 RTFLAEEALQLGLVKEVVEPENLLTRALEYAEDLARNCSPASMAVIKRQL
MMAR_4015|M.marinum_M RTFLAEEAAQLGLVKEVVTPEQLMPRALEYAEDIARYCSPSSMAVIKRQV
MUL_3879|M.ulcerans_Agy99 RIFLAEEAAQLGLVKEVVTPEQLMPRALEYAEDIARYCSPSSMAVIKRQV
MLBr_01241|M.leprae_Br4923 RDVGAEEAEQIGLVSYRVSDDRLLDTCYSIAARMATFSRS-GTELTKRAL
. * .* **. : : * :: . . : *.
Mb1099c|M.bovis_AF2122/97 NRAFESSLSEGLLYERRLFHSA--FATEDQSEGMAAFIEKRAPQFTHR--
Rv1070c|M.tuberculosis_H37Rv NRAFESSLSEGLLYERRLFHSA--FATEDQSEGMAAFIEKRAPQFTHR--
MAB_0104|M.abscessus_ATCC_1997 WDAQMTGMSAAEVAARETADHLRLMGSQDAAEGPRAFIDGRPPRWAGQR-
Mvan_1993|M.vanbaalenii_PYR-1 YRDALRNLSDASADAEKLMHES--MQRPDFIEGITAFFEKRQPSFPPL--
Mflv_4351|M.gilvum_PYR-GCK HKDALRNLHDASAEAETLMHES--MLRPDFIEGITAFFEKRPPSFPPLST
MAV_1590|M.avium_104 YDDALRDVVDVSARAETLMHES--LQRPDVIEGITSFLEKRPPRFPPLAT
TH_4111|M.thermoresistible__bu YGDAMDGVVDVSARAEKLMHES--LRRPDVIEGITSFIEKRQPAFPPLAP
MSMEG_2229|M.smegmatis_MC2_155 YGDATDVVTDVSDRAVTLMHES--MVRPDLIEGITAFFEKRPPNFPPLAA
MMAR_4015|M.marinum_M YGDATRDVVEATSHAEVLLREA--MPRPDVIEGIVSFLEKRPPQFPSLTS
MUL_3879|M.ulcerans_Agy99 YGDATRDVVEATSHAEVLLREA--MPRPDVIEGIVSFLEKRPPQFPSLTS
MLBr_01241|M.leprae_Br4923 WGGLDAASLDKHMQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARG
: : *. . : * .
Mb1099c|M.bovis_AF2122/97 ------
Rv1070c|M.tuberculosis_H37Rv ------
MAB_0104|M.abscessus_ATCC_1997 ------
Mvan_1993|M.vanbaalenii_PYR-1 -KEETP
Mflv_4351|M.gilvum_PYR-GCK QKEETP
MAV_1590|M.avium_104 ------
TH_4111|M.thermoresistible__bu SDP---
MSMEG_2229|M.smegmatis_MC2_155 E-----
MMAR_4015|M.marinum_M SER---
MUL_3879|M.ulcerans_Agy99 SER---
MLBr_01241|M.leprae_Br4923 CATSPG