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SAADAQDAVLYEATPGGVAIITFNRADRLNAWGPDLAAGFYAAIDRAEADPGIRVIVLTGRGRGFCAGAY LGSADAAAGYDKTMAKAKDANLADLVGERPPHFVTMLRKPVIAAINGPCVGIGLTQALMCDVRFAAAGAK FAAVFARRGLIAEFGISWILPRLTSWAVALDLLLSGRTFLAEEAAQLGLVKEVVTPEQLMPRALEYAEDI ARYCSPSSMAVIKRQVYGDATRDVVEATSHAEVLLREAMPRPDVIEGIVSFLEKRPPQFPSLTSSER*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4015 | echA12_1 | - | 100% (278) | enoyl-CoA hydratase, EchA12_1 |
| M. marinum M | MMAR_2974 | - | 1e-34 | 35.61% (264) | enoyl-CoA hydratase |
| M. marinum M | MMAR_2278 | echA12 | 8e-30 | 34.81% (270) | enoyl-CoA hydratase, EchA12 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1507 | echA12 | 3e-29 | 33.71% (267) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4351 | - | 1e-94 | 61.85% (270) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1472 | echA12 | 5e-29 | 33.71% (267) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01241 | - | 9e-30 | 34.59% (266) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_0834 | - | 9e-34 | 39.19% (222) | putative enoyl-CoA hydratase/isomerase |
| M. avium 104 | MAV_1590 | - | 1e-105 | 67.63% (278) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_2229 | - | 1e-99 | 66.79% (268) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_4111 | - | 6e-93 | 63.10% (271) | PUTATIVE enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_3879 | echA12_1 | 1e-154 | 98.92% (278) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_1993 | - | 9e-92 | 60.22% (274) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4015|M.marinum_M ----MSAAD--AQD------AVLYEATPGGVAIITFNRADRLNAWGPDLA
MUL_3879|M.ulcerans_Agy99 --MRMSAAD--AQD------AVLYEATPGGVAIITFNRADRLNAWGLDLA
Mflv_4351|M.gilvum_PYR-GCK ----MSAVDRAVDR---RAEPVLFDLHDSGVAVLTLNRPDRMNSWGGGLA
Mvan_1993|M.vanbaalenii_PYR-1 ----MSAVDRAAEPGIADTEPVLFDMHDSGVAVLTLNRPERMNSWGGGLA
MAV_1590|M.avium_104 ----MSAADHVVTD-----EAVLYQTTETGVAVVTFNRPERLNAWGPDIS
MSMEG_2229|M.smegmatis_MC2_155 ----MSVAETGTSD------AVRYEVNDAGVAVITLNRPERLNSWGADIS
TH_4111|M.thermoresistible__bu ---------------------VRYEVRDPGVAVVTFDRPERLNTWARDIS
Mb1507|M.bovis_AF2122/97 MPHRCAAQVVAG--YRSTVSLVLVEHPRPEIAQITLNRPERMNSMAFDVM
Rv1472|M.tuberculosis_H37Rv MPHRCAAQVVAG--YRSTVSLVLVEHPRPEIAQITLNRPERMNSMAFDVM
MLBr_01241|M.leprae_Br4923 MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLM
MAB_0834|M.abscessus_ATCC_1997 --------------------MIRVEPREHGILVVTIDRPERRNALDPQTV
: : : :*::*. * *:
MMAR_4015|M.marinum_M AGFYAAIDRAEADPGIRVIVLTGRGRGFCAGAYLGSAD---AAAGYDKT-
MUL_3879|M.ulcerans_Agy99 AGFYTAIDRAEADPGIRVIVLTGRGRGFCAGAYLGSAD---AAAGYDKT-
Mflv_4351|M.gilvum_PYR-GCK RAFYECIDRAEADPDVRVIVLTGNGRAFCAGADMGDLD--SISGASDS--
Mvan_1993|M.vanbaalenii_PYR-1 QAFYRCIDRAEADPHVRVIVLTGNGRAFCAGADMGDLD--SISAAGDTGR
MAV_1590|M.avium_104 SGFYACIDRAEADPAVRVIVLTGAGRGFCAGANLGGAG--SIDAKLGD--
MSMEG_2229|M.smegmatis_MC2_155 AGVYASFDRAEADPAVRAIVLTGTGRGFCAGAYMGEMA--SLGESISG--
TH_4111|M.thermoresistible__bu SGFYAAIDRADADPDVRVIVWTGNGRAFCAGADLGSASGESLGAGLQKT-
Mb1507|M.bovis_AF2122/97 VPLKEALAQVSYDNSVRVVVLTGAGRGFSSGADHK-------SAGVVPHV
Rv1472|M.tuberculosis_H37Rv VPLKEALAQVSYDNSVRVVVLTGAGRGFSPGADHK-------SAGVVPHV
MLBr_01241|M.leprae_Br4923 KSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQK-------FTAPVPQV
MAB_0834|M.abscessus_ATCC_1997 AELHAVIESIDGDPKVRVVVLTAVGASFCAGADLKSLPSDFTSAGVTSTA
. : * :*.:* *. * .*..**
MMAR_4015|M.marinum_M ------MAKAKDANLADLVGERPPHFVTMLRKPVIAAINGPCVGIGLTQA
MUL_3879|M.ulcerans_Agy99 ------MAKAKDANLADLVGERPPHFVTMLRKPVIAAINGPCVGIGLTQA
Mflv_4351|M.gilvum_PYR-GCK ----------SDTDVTQLVGERHPHFVTQLRTPIIAAINGACAGIGLTQA
Mvan_1993|M.vanbaalenii_PYR-1 GERSDGESGLADTDVSQLVGERHPHFLTQLRKPLIAAINGACAGIGLTHA
MAV_1590|M.avium_104 ----------GDTDVTALVGDRHPHFLTALRKPIIAAINGACVGIGLTHA
MSMEG_2229|M.smegmatis_MC2_155 -----------DTDVSKIVGERHPHFLTTLRKPVIAAINGACVGIGLTHA
TH_4111|M.thermoresistible__bu ----------DGTNVSRLVGERHPYFLTTVRKPIIAAINGACVGIGLTHA
Mb1507|M.bovis_AF2122/97 ENLTRP----TYALRSMELLDDVILMLRRLHQPVIAAVNGPAIGGGLCLA
Rv1472|M.tuberculosis_H37Rv ENLTRP----TYALRSMELLDDVILMLRRLHQPVIAAVNGPAIGGGLCLA
MLBr_01241|M.leprae_Br4923 EGLTQP----VRALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLA
MAB_0834|M.abscessus_ATCC_1997 ALLAATDSELVRTLAAQELMASLFERIHRMRQPVIAAVNGHAIGGGFALA
: : : : :: *:***:** . * *: *
MMAR_4015|M.marinum_M LMCDVRFAAAGAKFAAVFARRGLIA-EFGISWILPRLTSWAVALDLLLSG
MUL_3879|M.ulcerans_Agy99 LMCDVRFAAAGAKFAAVFARRGLIA-EFGISWILPRLTSWAVALDLLLSG
Mflv_4351|M.gilvum_PYR-GCK LMCDVRFAAAGAKFTTAFSRRGLIA-EYGISWILPRIVGWGAAQDLLLSG
Mvan_1993|M.vanbaalenii_PYR-1 LMCDVRFAAAGAKFTTAFARRGLIA-EYGISWILPRIVGWSAAQDLLLSG
MAV_1590|M.avium_104 LMCDVRFAAAGAKFATAFTRRGLIA-EYGITWILPRLAGWGAAMDLLLSG
MSMEG_2229|M.smegmatis_MC2_155 LMCDIRFAAAGAKFATAFPRRGLIG-EYGITWILPRLAGWGAAADLLLSG
TH_4111|M.thermoresistible__bu LMCDIRFAAAGAKFNTAFARRGLIA-EYGISWILPRLAGWGVATELLLSG
Mb1507|M.bovis_AF2122/97 LAADIRVASSSAYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTG
Rv1472|M.tuberculosis_H37Rv LAADIRVASSSAYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTG
MLBr_01241|M.leprae_Br4923 LAADVRVASTRAYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSG
MAB_0834|M.abscessus_ATCC_1997 LACDIRFASPAASFGAVFIRHGVSNCDMGTSYHLPRLVGAARAAELMLTG
* .*:*.*:. * * :. ..*: : * :: *** . . * :::*:*
MMAR_4015|M.marinum_M RTFLAEEAAQLGLVKEVVTPEQLMPRALEYAEDIARYCSPSSMAVIKRQV
MUL_3879|M.ulcerans_Agy99 RIFLAEEAAQLGLVKEVVTPEQLMPRALEYAEDIARYCSPSSMAVIKRQV
Mflv_4351|M.gilvum_PYR-GCK RTFYAEEAKSLGLVNDVVAPDELMAHTLSYAEDMARNCAPSSMAVIKRQL
Mvan_1993|M.vanbaalenii_PYR-1 RTFYAEEANELGLVNQVVAPDELMAHTLAYAEDMARNCAPSSLAVIKRQI
MAV_1590|M.avium_104 RTFFAEEAAKLGLVNEIVAPDELMARALTYADDIARNCSPASLAVIKRQA
MSMEG_2229|M.smegmatis_MC2_155 RTFLAEEALQLGLVKEVVEPENLLTRALEYAEDLARNCSPASMAVIKRQL
TH_4111|M.thermoresistible__bu RTFRAEEAHRLGLVHDVVPAEELTEHTLAYAEDIARNCAPASLAVIKQQL
Mb1507|M.bovis_AF2122/97 RDVSAEEAERIGLVSRQVPDEQLLDACYAIAARMAGFS-RPGIELTKRTL
Rv1472|M.tuberculosis_H37Rv RDVSAEEAERIGLVSRQVPDEQLLDACYAIAARMAGFS-RPGIELTKRTL
MLBr_01241|M.leprae_Br4923 RDVGAEEAEQIGLVSYRVSDDRLLDTCYSIAARMATFS-RSGTELTKRAL
MAB_0834|M.abscessus_ATCC_1997 RVFDAQEAYRMGLVFDVVPAEELLDAALSKAREIAVHS-PLAVWMTKETM
* . *:** :*** * :.* * :* . . : *.
MMAR_4015|M.marinum_M YG--DATRDVVEATSHAEVLLREAMPRPDVIEGIVSFLEKRPPQFPSLTS
MUL_3879|M.ulcerans_Agy99 YG--DATRDVVEATSHAEVLLREAMPRPDVIEGIVSFLEKRPPQFPSLTS
Mflv_4351|M.gilvum_PYR-GCK HK--DALRNLHDASAEAETLMHESMLRPDFIEGITAFFEKRPPSFPPLST
Mvan_1993|M.vanbaalenii_PYR-1 YR--DALRNLSDASADAEKLMHESMQRPDFIEGITAFFEKRQPSFPPL--
MAV_1590|M.avium_104 YD--DALRDVVDVSARAETLMHESLQRPDVIEGITSFLEKRPPRFPPLAT
MSMEG_2229|M.smegmatis_MC2_155 YG--DATDVVTDVSDRAVTLMHESMVRPDLIEGITAFFEKRPPNFPPLAA
TH_4111|M.thermoresistible__bu YG--DAMDGVVDVSARAEKLMHESLRRPDVIEGITSFIEKRQPAFPPLAP
Mb1507|M.bovis_AF2122/97 WSGLDAASLEAHMQAEGLGQLFVRLLTANFEEAVAARAEQRAPVFTDDT-
Rv1472|M.tuberculosis_H37Rv WSGLDAASLEAHMQAEGLGQLFVRLLTANFEEAVAARAEQRAPVFTDDT-
MLBr_01241|M.leprae_Br4923 WGGLDAASLDKHMQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARG
MAB_0834|M.abscessus_ATCC_1997 WQTVDAPSLRHALDLENRTQVMCT-ATGELRRSFDAFREGRG--------
** : :. .. . * *
MMAR_4015|M.marinum_M SER---
MUL_3879|M.ulcerans_Agy99 SER---
Mflv_4351|M.gilvum_PYR-GCK QKEETP
Mvan_1993|M.vanbaalenii_PYR-1 -KEETP
MAV_1590|M.avium_104 ------
MSMEG_2229|M.smegmatis_MC2_155 E-----
TH_4111|M.thermoresistible__bu SDP---
Mb1507|M.bovis_AF2122/97 ------
Rv1472|M.tuberculosis_H37Rv ------
MLBr_01241|M.leprae_Br4923 CATSPG
MAB_0834|M.abscessus_ATCC_1997 ------