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SAVDRAVDRRAEPVLFDLHDSGVAVLTLNRPDRMNSWGGGLARAFYECIDRAEADPDVRVIVLTGNGRAF CAGADMGDLDSISGASDSSDTDVTQLVGERHPHFVTQLRTPIIAAINGACAGIGLTQALMCDVRFAAAGA KFTTAFSRRGLIAEYGISWILPRIVGWGAAQDLLLSGRTFYAEEAKSLGLVNDVVAPDELMAHTLSYAED MARNCAPSSMAVIKRQLHKDALRNLHDASAEAETLMHESMLRPDFIEGITAFFEKRPPSFPPLSTQKEET P*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4351 | - | - | 100% (282) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_3132 | - | 3e-40 | 40.45% (267) | enoyl-CoA hydratase/isomerase |
| M. gilvum PYR-GCK | Mflv_2902 | - | 8e-31 | 35.52% (259) | enoyl-CoA hydratase/isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1099c | echA8 | 8e-31 | 33.07% (251) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1070c | echA8 | 8e-31 | 33.07% (251) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 2e-31 | 32.66% (248) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_0104 | - | 3e-34 | 36.98% (265) | enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_4015 | echA12_1 | 1e-94 | 61.85% (270) | enoyl-CoA hydratase, EchA12_1 |
| M. avium 104 | MAV_1590 | - | 1e-110 | 69.93% (276) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_2229 | - | 1e-104 | 68.05% (266) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_4111 | - | 1e-100 | 66.67% (264) | PUTATIVE enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_3879 | echA12_1 | 7e-94 | 61.48% (270) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_1993 | - | 1e-136 | 82.49% (297) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4351|M.gilvum_PYR-GCK --MSAVDRAVDR---RAEPVLFDLHDSGVAVLTLNRPDRMNSWGGGLARA
Mvan_1993|M.vanbaalenii_PYR-1 --MSAVDRAAEPGIADTEPVLFDMHDSGVAVLTLNRPERMNSWGGGLAQA
MAV_1590|M.avium_104 --MSAADHVVTD-----EAVLYQTTETGVAVVTFNRPERLNAWGPDISSG
TH_4111|M.thermoresistible__bu -------------------VRYEVRDPGVAVVTFDRPERLNTWARDISSG
MSMEG_2229|M.smegmatis_MC2_155 --MSVAETGTSD------AVRYEVNDAGVAVITLNRPERLNSWGADISAG
MMAR_4015|M.marinum_M --MSAAD--AQD------AVLYEATPGGVAIITFNRADRLNAWGPDLAAG
MUL_3879|M.ulcerans_Agy99 MRMSAAD--AQD------AVLYEATPGGVAIITFNRADRLNAWGLDLAAG
MAB_0104|M.abscessus_ATCC_1997 -----------------MTELHEEIRDGVAVLTLHGPSTRNSFTVELGRQ
Mb1099c|M.bovis_AF2122/97 ---------------MTYETILVERDQRVGIITLNRPQALNALNSQVMNE
Rv1070c|M.tuberculosis_H37Rv ---------------MTYETILVERDQRVGIITLNRPQALNALNSQVMNE
MLBr_02402|M.leprae_Br4923 ---------------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNE
*.::*:. .. *: :
Mflv_4351|M.gilvum_PYR-GCK FYECIDRAEADPDVRVIVLTGNGRAFCAGADMGDLD--SISGASDS----
Mvan_1993|M.vanbaalenii_PYR-1 FYRCIDRAEADPHVRVIVLTGNGRAFCAGADMGDLD--SISAAGDTGRGE
MAV_1590|M.avium_104 FYACIDRAEADPAVRVIVLTGAGRGFCAGANLGGAG--SIDAKLGD----
TH_4111|M.thermoresistible__bu FYAAIDRADADPDVRVIVWTGNGRAFCAGADLGSASGESLGAGLQKT---
MSMEG_2229|M.smegmatis_MC2_155 VYASFDRAEADPAVRAIVLTGTGRGFCAGAYMGEMA--SLGESISG----
MMAR_4015|M.marinum_M FYAAIDRAEADPGIRVIVLTGRGRGFCAGAYLGSAD---AAAGYDKT---
MUL_3879|M.ulcerans_Agy99 FYTAIDRAEADPGIRVIVLTGRGRGFCAGAYLGSAD---AAAGYDKT---
MAB_0104|M.abscessus_ATCC_1997 LGAAYQRLDDDPAVRVIVLTGAPPAFCSGAQISAAA-----ETFAAP---
Mb1099c|M.bovis_AF2122/97 VTSAATELDDDPDIGAIIITGSAKAFAAGADIKEMADLTFADAFTAD---
Rv1070c|M.tuberculosis_H37Rv VTSAATELDDDPDIGAIIITGSAKAFAAGADIKEMADLTFADAFTAD---
MLBr_02402|M.leprae_Br4923 ITNAAKELDIDPDVGAILITGSPKVFAAGADIKEMASLTFTDAFDAD---
. . . : ** : .*: ** *.:** :
Mflv_4351|M.gilvum_PYR-GCK --------SDTDVTQLVGERHPHFVTQLRTPIIAAINGACAGIGLTQALM
Mvan_1993|M.vanbaalenii_PYR-1 RSDGESGLADTDVSQLVGERHPHFLTQLRKPLIAAINGACAGIGLTHALM
MAV_1590|M.avium_104 --------GDTDVTALVGDRHPHFLTALRKPIIAAINGACVGIGLTHALM
TH_4111|M.thermoresistible__bu --------DGTNVSRLVGERHPYFLTTVRKPIIAAINGACVGIGLTHALM
MSMEG_2229|M.smegmatis_MC2_155 ---------DTDVSKIVGERHPHFLTTLRKPVIAAINGACVGIGLTHALM
MMAR_4015|M.marinum_M ----MAKAKDANLADLVGERPPHFVTMLRKPVIAAINGPCVGIGLTQALM
MUL_3879|M.ulcerans_Agy99 ----MAKAKDANLADLVGERPPHFVTMLRKPVIAAINGPCVGIGLTQALM
MAB_0104|M.abscessus_ATCC_1997 -----------RNPDFSASPVQPAAFELRTPVIAAVNGHAIGIGMTLALH
Mb1099c|M.bovis_AF2122/97 ---------------FFATWG--KLAAVRTPTIAAVAGYALGGGCELAMM
Rv1070c|M.tuberculosis_H37Rv ---------------FFATWG--KLAAVRTPTIAAVAGYALGGGCELAMM
MLBr_02402|M.leprae_Br4923 ---------------FFSAWG--KLAAVRTPMIAAVAGYALGGGCELAMM
: . :*.* ***: * . * * *:
Mflv_4351|M.gilvum_PYR-GCK CDVRFAAAGAKFTTAFSRRGLIAEYGISWILPRIVGWGAAQDLLLSGRTF
Mvan_1993|M.vanbaalenii_PYR-1 CDVRFAAAGAKFTTAFARRGLIAEYGISWILPRIVGWSAAQDLLLSGRTF
MAV_1590|M.avium_104 CDVRFAAAGAKFATAFTRRGLIAEYGITWILPRLAGWGAAMDLLLSGRTF
TH_4111|M.thermoresistible__bu CDIRFAAAGAKFNTAFARRGLIAEYGISWILPRLAGWGVATELLLSGRTF
MSMEG_2229|M.smegmatis_MC2_155 CDIRFAAAGAKFATAFPRRGLIGEYGITWILPRLAGWGAAADLLLSGRTF
MMAR_4015|M.marinum_M CDVRFAAAGAKFAAVFARRGLIAEFGISWILPRLTSWAVALDLLLSGRTF
MUL_3879|M.ulcerans_Agy99 CDVRFAAAGAKFAAVFARRGLIAEFGISWILPRLTSWAVALDLLLSGRIF
MAB_0104|M.abscessus_ATCC_1997 ADIRILAEEGRYAIPQVRFGVAPDALAHWTLPRLVGTAVAAELLLTGASF
Mb1099c|M.bovis_AF2122/97 CDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTM
Rv1070c|M.tuberculosis_H37Rv CDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTM
MLBr_02402|M.leprae_Br4923 CDLLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTI
.*: : * .:: : *: *.* . . * :*:*:* :
Mflv_4351|M.gilvum_PYR-GCK YAEEAKSLGLVNDVVAPDELMAHTLSYAEDMARNCAPSSMAVIKRQLHKD
Mvan_1993|M.vanbaalenii_PYR-1 YAEEANELGLVNQVVAPDELMAHTLAYAEDMARNCAPSSLAVIKRQIYRD
MAV_1590|M.avium_104 FAEEAAKLGLVNEIVAPDELMARALTYADDIARNCSPASLAVIKRQAYDD
TH_4111|M.thermoresistible__bu RAEEAHRLGLVHDVVPAEELTEHTLAYAEDIARNCAPASLAVIKQQLYGD
MSMEG_2229|M.smegmatis_MC2_155 LAEEALQLGLVKEVVEPENLLTRALEYAEDLARNCSPASMAVIKRQLYGD
MMAR_4015|M.marinum_M LAEEAAQLGLVKEVVTPEQLMPRALEYAEDIARYCSPSSMAVIKRQVYGD
MUL_3879|M.ulcerans_Agy99 LAEEAAQLGLVKEVVTPEQLMPRALEYAEDIARYCSPSSMAVIKRQVYGD
MAB_0104|M.abscessus_ATCC_1997 SAQRAVETGLANRCLPAGKVLGAALRMAHDIATNVAPESAALTKRLLWDA
Mb1099c|M.bovis_AF2122/97 DAAEAERSGLVSRVVPADDLLTEARATATTIS-QMSASAARMAKEAVNRA
Rv1070c|M.tuberculosis_H37Rv DAAEAERSGLVSRVVPADDLLTEARATATTIS-QMSASAARMAKEAVNRA
MLBr_02402|M.leprae_Br4923 DAAEAERSGLVSRVVLADDLLPEAKAVATTIS-QMSRSATRMAKEAVNRS
* .* **. : . .: : * :: : : : *.
Mflv_4351|M.gilvum_PYR-GCK ALR--NLHDASAEAETLMHESMLRPDFIEGITAFFEKRPPSFPPLSTQKE
Mvan_1993|M.vanbaalenii_PYR-1 ALR--NLSDASADAEKLMHESMQRPDFIEGITAFFEKRQPSFPPL---KE
MAV_1590|M.avium_104 ALR--DVVDVSARAETLMHESLQRPDVIEGITSFLEKRPPRFPPLAT---
TH_4111|M.thermoresistible__bu AMD--GVVDVSARAEKLMHESLRRPDVIEGITSFIEKRQPAFPPLAPSDP
MSMEG_2229|M.smegmatis_MC2_155 ATD--VVTDVSDRAVTLMHESMVRPDLIEGITAFFEKRPPNFPPLAAE--
MMAR_4015|M.marinum_M ATR--DVVEATSHAEVLLREAMPRPDVIEGIVSFLEKRPPQFPSLTSSER
MUL_3879|M.ulcerans_Agy99 ATR--DVVEATSHAEVLLREAMPRPDVIEGIVSFLEKRPPQFPSLTSSER
MAB_0104|M.abscessus_ATCC_1997 QMTGMSAAEVAARETADHLRLMGSQDAAEGPRAFIDGRPPRWAGQR----
Mb1099c|M.bovis_AF2122/97 FES--SLSEGLLYERRLFHSAFATEDQSEGMAAFIEKRAPQFTHR-----
Rv1070c|M.tuberculosis_H37Rv FES--SLSEGLLYERRLFHSAFATEDQSEGMAAFIEKRAPQFTHR-----
MLBr_02402|M.leprae_Br4923 FES--TLAEGLLHERRLFHSTFVTDDQSEGMAAFIEKRAPQFTHR-----
: : * ** :*:: * * :.
Mflv_4351|M.gilvum_PYR-GCK ETP
Mvan_1993|M.vanbaalenii_PYR-1 ETP
MAV_1590|M.avium_104 ---
TH_4111|M.thermoresistible__bu ---
MSMEG_2229|M.smegmatis_MC2_155 ---
MMAR_4015|M.marinum_M ---
MUL_3879|M.ulcerans_Agy99 ---
MAB_0104|M.abscessus_ATCC_1997 ---
Mb1099c|M.bovis_AF2122/97 ---
Rv1070c|M.tuberculosis_H37Rv ---
MLBr_02402|M.leprae_Br4923 ---