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MTKLAQTLGLTEFQAEIVSTVRQFVDKEVIPTAQELEHSDTYPQAIVDAMKEMGLFGLMIPEEYGGLGES LLTYALCVEELARGWMSVSGVINTHFIVAYMIRQHGTDAQKSRYLTRMATGETRGAFSMSEPELGSDVAA IRTRARDNGDGTYTIDGQKMWLTNGGSSTLVAALVRTDEGADKPHRNLTAFLIEKPTGFGEVAPGLTIPG KLDKLGYKGIDTTELIFDGYRAGATDILGEAPGQGFFQMMDGVEVGRVNVSARACGVGIRAFELAVRYAQ QRSTFGKPIAEHQAIAFQLAEMATKVEAAHLMMVNAARLKDSGERNDVAAGMAKYFASEVCAEVTQQSFR IHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRLLADYRV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1977 | - | - | 100% (397) | butyryl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0221 | - | e-102 | 48.83% (385) | butyryl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1476 | - | 2e-65 | 35.94% (384) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0221c | fadE3 | 1e-96 | 46.25% (387) | acyl-CoA dehydrogenase FADE3 |
| M. gilvum PYR-GCK | Mflv_4367 | - | 0.0 | 96.47% (397) | butyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv0215c | fadE3 | 2e-86 | 45.68% (359) | acyl-CoA dehydrogenase FADE3 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-59 | 34.90% (384) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3618c | - | 2e-62 | 35.42% (384) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4030 | - | 0.0 | 87.12% (396) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1575 | - | 0.0 | 88.41% (397) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2208 | - | 0.0 | 92.95% (397) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3384 | - | 0.0 | 90.93% (397) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_3895 | - | 0.0 | 86.36% (396) | acyl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0221c|M.bovis_AF2122/97 ----------MRNELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEA
Rv0215c|M.tuberculosis_H37Rv ----------MRNELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEA
Mvan_1977|M.vanbaalenii_PYR-1 -----MTKLAQTLGLTEFQAEIVSTVRQFVDKEVIPTAQELEHSDTYPQA
Mflv_4367|M.gilvum_PYR-GCK -----MSRLAQTLGLTEFQTEIVSTVRQFVDKEVIPTAQELEHADTYPQA
MSMEG_2208|M.smegmatis_MC2_155 -----MTKLAQTLGLTEFQTEIISTVRQLVDKEIIPAAQELEHSDTYPQA
TH_3384|M.thermoresistible__bu -----MTRLAQTLGLTEFQTEILRTVREFVDREIIPNAAEFERTDTYPQP
MAV_1575|M.avium_104 -----MTRLAQTLGLTEFQTEIIATVRQFVDKEVIPHAAELERADTYPQD
MMAR_4030|M.marinum_M -----MTKLAQTLGLTELQAEIVATVRQFVDKEVIPNASELERKDAYPHE
MUL_3895|M.ulcerans_Agy99 -----MTKLAQTLGLTELQAEIVATVRQFVDKEVIPNASELERKDAYPHE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
MAB_3618c|M.abscessus_ATCC_199 ---MAGNPSFDLFKLGEEHDELRAAIRGLAEKEIAPHAKDVDEKARFPQE
* : . : ::* : :::: * . :.:. :*.
Mb0221c|M.bovis_AF2122/97 WIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
Rv0215c|M.tuberculosis_H37Rv WIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
Mvan_1977|M.vanbaalenii_PYR-1 IVDAMKEMGLFGLMIPEEYGGLGESLLTYALCVEELARGWMSVSGVINTH
Mflv_4367|M.gilvum_PYR-GCK IVDAMREMGLFGLMIPEEYGGLGESLLTYALCVEELARGWMSVSGVINTH
MSMEG_2208|M.smegmatis_MC2_155 IVDQMKQMGLFGLMIPEEYGGLGESLLTYALCVEELARGWMSVSGVINTH
TH_3384|M.thermoresistible__bu IVDQMREMGLFGLMIPEEYGGLGESLLTYALCVEELARGWMSISGVINTH
MAV_1575|M.avium_104 IVDQMRDMGLFGLMIPQEYGGLGESLLTYALCVEELARGWMSVSGVLNTH
MMAR_4030|M.marinum_M IVEQMRSIGLFGLMIPEQYGGLGESLLTYALCVEELARGWMSVSGVLNTH
MUL_3895|M.ulcerans_Agy99 IVEQTRSIGLFGLMIPEQYGGLGESLLTYALCVEELARGWMSVSGVLNTH
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
MAB_3618c|M.abscessus_ATCC_199 ALDALVASGFNAVHVPEEYDGQGADSVAACIVIEEVARVCASSSLIPAVN
: *: .: : ::*.* . :*:** * : :
Mb0221c|M.bovis_AF2122/97 TVVAKLLTLFGTEEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTA
Rv0215c|M.tuberculosis_H37Rv TVVAKLLTLFGTEEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTA
Mvan_1977|M.vanbaalenii_PYR-1 FIVAYMIRQHGTDAQKSRYLTRMATGETRGAFSMSEPELGSDVAAIRTRA
Mflv_4367|M.gilvum_PYR-GCK FIVAYMIRQHGTDAQKSHYLPRMATGETRGAFSMSEPELGSDVAAIRTRA
MSMEG_2208|M.smegmatis_MC2_155 FIVAYMIRQHGTDEQKRKFLPRMATGETRGAFSMSEPELGSDVAAIRTRA
TH_3384|M.thermoresistible__bu FIVAYMIRQHGTEEQKQRFLPRMATGETRGAFSMSEPELGSDVAAIRTRA
MAV_1575|M.avium_104 FIVAYMLRQHGTDEQKQRFLPRMAVGETRGAFSMSEPELGSDVAAIRTRA
MMAR_4030|M.marinum_M FIVAYMLRQHGTEEQRQRFLPRMATGESRGAFSMSEPELGSDVAAIRTRA
MUL_3895|M.ulcerans_Agy99 FIVAYMLRQHGTEEQRQRFLPRMATGESRGAFSMSEPELGSDVAAIRTRA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
MAB_3618c|M.abscessus_ATCC_199 KLGTMGLILNGSDELKKQVLPAIASGEAMASYALSEREAGSDAASMRTRA
: : : *:: : *. :* .: :::* *** : * *
Mb0221c|M.bovis_AF2122/97 LADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNATPRHQGMSIVL
Rv0215c|M.tuberculosis_H37Rv LADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNATPRHQGMSIVL
Mvan_1977|M.vanbaalenii_PYR-1 RDNG---DGTYTIDGQKMWLTNGGSSTLVAALVRTDEGADKPHRNLTAFL
Mflv_4367|M.gilvum_PYR-GCK KNNG---DGTYTIDGQKMWLTNGGSSTLVATLVRTDEGADKPHRNLTAFL
MSMEG_2208|M.smegmatis_MC2_155 RNND---DGTYTIDGQKMWLTNGGSSTLVAALVRTDEGADKPHRNLTAFL
TH_3384|M.thermoresistible__bu TRNG---DGTYTIDGQKMWLTNGATSTLVAVLVRTDEGADKPHRNLTTFL
MAV_1575|M.avium_104 RRDP---DGGYTIDGQKMWLTNGATSTLIAVLVRTDEGSDKPHRNLTAFL
MMAR_4030|M.marinum_M TRGA---DGNYTIDGQKMWLTNGGSSTLVAVLVRTDEGAAQPHRNLTAFL
MUL_3895|M.ulcerans_Agy99 TRGA---DGNYTIDGQKMWLTNGGSSTLVAVLVRTDEGAAQPHRNLTAFL
MLBr_00737|M.leprae_Br4923 KADG----DDWILNGFKCWITNGGKSTWYTVMAVTDP--DKGANGISAFI
MAB_3618c|M.abscessus_ATCC_199 KADG----DDWIINGSKCWITNGGKSSWYTVMAVTDP--EKKANGISAFM
. ::* * *::*. * :.: ** ..:: .:
Mb0221c|M.bovis_AF2122/97 VEPG-------PGLTVSRDLPKLGYKGVESCELSFDNLRVPVSAILGGAM
Rv0215c|M.tuberculosis_H37Rv VEPG-------PGLTVSRDLPKLGYKGVESCELSFDNLRVPVSAILGGAM
Mvan_1977|M.vanbaalenii_PYR-1 IEKPTGFGEVAPGLTIPGKLDKLGYKGIDTTELIFDGYRAGATDILGEAP
Mflv_4367|M.gilvum_PYR-GCK IEKPTGFGEVAPGLTIPGKLDKLGYKGIDTTELIFDGYRADAGDILGEAP
MSMEG_2208|M.smegmatis_MC2_155 IEKPEGFGEVLPGLTIPGKLDKLGYKGIDTTELIFDGYRADAADILGGTP
TH_3384|M.thermoresistible__bu IEKPTGFGEVAPGLTIPGKIDKLGYKGIDTTELIFDGYRADAGDILGERP
MAV_1575|M.avium_104 VEKPVGFGEVVAGLRIPGKIDKLGYKGIETTELIFDGYRAAADDILGGTP
MMAR_4030|M.marinum_M VEKPTGFGEVLPGLTIPGKIDKLGYKGIDTTELIFDGYRATADDILGGTP
MUL_3895|M.ulcerans_Agy99 VEKPTGFGEVLPGLTIPGKIDKLGYKGIDTTEVIFDGYRATADDILGGTP
MLBr_00737|M.leprae_Br4923 VHKDD------EGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGE-P
MAB_3618c|M.abscessus_ATCC_199 VHKDD------EGFTVGPLEHKLGIKGSPTAELYFENCRIPGDRIIGE-P
:. *: : *** ** : *: *: * *:*
Mb0221c|M.bovis_AF2122/97 GQGFSQMMKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIWQH
Rv0215c|M.tuberculosis_H37Rv GQGFSQMMKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIWQH
Mvan_1977|M.vanbaalenii_PYR-1 GQGFFQMMDGVEVGRVNVSARACGVGIRAFELAVRYAQQRSTFGKPIAEH
Mflv_4367|M.gilvum_PYR-GCK GQGFFQMMDGVEVGRVNVSARACGVGIRAFELAVKYAQQRSTFGKPIAEH
MSMEG_2208|M.smegmatis_MC2_155 GQGFFQMMDGVEVGRVNVSARACGVGLRAFELAVRYAQQRETFGKPIAEH
TH_3384|M.thermoresistible__bu GQGFFQMMDGVEVGRVNVSARACGVGIRAFELAVRYAQQRHTFGKPIAEH
MAV_1575|M.avium_104 GQGFFQMMDGIEVGRVNVSARACGVAIRAFELAVRYAQQRETFGKPIAEH
MMAR_4030|M.marinum_M GQGFFQMMDGIEVGRVNVSARACGVGLRAFELAVRYAQQRHTFGKPIAEH
MUL_3895|M.ulcerans_Agy99 GQGFFPMMDGIEVGRVNVSARACGVGLRAFELAVRYAQQRHTFGKPIAEH
MLBr_00737|M.leprae_Br4923 GTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTF
MAB_3618c|M.abscessus_ATCC_199 GTGFKTALQTLDHTRPTIGAQALGIAQGALDQAIAYTKDRKQFGKSISDF
* ** : :: * :.*:* *:. *:: :: *:::* **..* .
Mb0221c|M.bovis_AF2122/97 QAVGNYLADMATKLTAARQLTRYAAERYDSGQRCD-MEAGMAKLFASEVA
Rv0215c|M.tuberculosis_H37Rv QAVGNYLADMATKLTAARQLTRYAAERYDSGQRCD-MEAGMAKLFASEVA
Mvan_1977|M.vanbaalenii_PYR-1 QAIAFQLAEMATKVEAAHLMMVNAARLKDSGERND-VAAGMAKYFASEVC
Mflv_4367|M.gilvum_PYR-GCK QAIAFQLAEMATKVEAAHLMMVNAARHKDSGERND-VAAGMAKYFASEVC
MSMEG_2208|M.smegmatis_MC2_155 QAVAFQLAEMATKVEAAHLMMVNAARLKDSGERND-VAAGMAKYLASEFC
TH_3384|M.thermoresistible__bu QAIAFQLAEMATKVEAAHLMMVNAARLKDSGERND-VAAGMAKYLASEFC
MAV_1575|M.avium_104 QAIAFQLAEMATKVEAAHLMMVNAARLKDSGERND-VAAGMAKYLASEYC
MMAR_4030|M.marinum_M QAISFQLAEMATKVEAAHLMMVHAARLKDSGERND-VAAGMAKYLASEYC
MUL_3895|M.ulcerans_Agy99 QAISFQLAEMATKVEAAHLMMVHAARLKDSGERND-VAAGMAKYLASEYC
MLBr_00737|M.leprae_Br4923 QSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIA
MAB_3618c|M.abscessus_ATCC_199 QGVQFMLADMAMKVEAARLMVYTAAARAERGEKNLGFISSASKCFASDVA
*.: **:** *: **: : ** : *: . :. :* :**: .
Mb0221c|M.bovis_AF2122/97 MEIALNAVRIHGGYGYSTEYDVERYFRDAPLMILGEGTNEIQRNVIAGQL
Rv0215c|M.tuberculosis_H37Rv MEIALNAVRIHGGYGYSTEYDVERR-------------------------
Mvan_1977|M.vanbaalenii_PYR-1 AEVTQQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRL
Mflv_4367|M.gilvum_PYR-GCK AEVTQQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRL
MSMEG_2208|M.smegmatis_MC2_155 SEVTQQAFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRL
TH_3384|M.thermoresistible__bu AEVTEQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRL
MAV_1575|M.avium_104 AEVTQQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKNIISKRL
MMAR_4030|M.marinum_M SEVTQQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKSIISKRL
MUL_3895|M.ulcerans_Agy99 SEVTQQSFRIHGGYGYSKEYEIERLMRDAPFLLIGEGTSEIQKSIISKRL
MLBr_00737|M.leprae_Br4923 MEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRAL
MAB_3618c|M.abscessus_ATCC_199 MEVTTDAVQLFGGAGYTTDFPVERMMRDAKITQIYEGTNQIQRVVMSRAL
*:: ::.::.** **:.:: :**
Mb0221c|M.bovis_AF2122/97 VARGGI
Rv0215c|M.tuberculosis_H37Rv ------
Mvan_1977|M.vanbaalenii_PYR-1 LADYRV
Mflv_4367|M.gilvum_PYR-GCK LADYRV
MSMEG_2208|M.smegmatis_MC2_155 LADYKV
TH_3384|M.thermoresistible__bu LADYRI
MAV_1575|M.avium_104 LAEYRV
MMAR_4030|M.marinum_M LHEYRE
MUL_3895|M.ulcerans_Agy99 LHEYRE
MLBr_00737|M.leprae_Br4923 LR----
MAB_3618c|M.abscessus_ATCC_199 LTS---