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RNELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEAWIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQ VTQELARGWMSLAGAMGGHTVVAKLLTLFGTEEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTAL ADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNATPRHQGMSIVLVEPGPGLTVSRDLPKLGYKGV ESCELSFDNLRVPVSAILGGAMGQGFSQMMKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIW QHQAVGNYLADMATKLTAARQLTRYAAERYDSGQRCDMEAGMAKLFASEVAMEIALNAVRIHGGYGYSTE YDVERR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0215c | fadE3 | - | 100% (357) | PROBABLE ACYL-CoA DEHYDROGENASE FADE3 |
| M. tuberculosis H37Rv | Rv0752c | fadE9 | 8e-51 | 34.27% (356) | acyl-CoA dehydrogenase FADE9 |
| M. tuberculosis H37Rv | Rv2724c | fadE20 | 1e-47 | 36.15% (343) | acyl-CoA dehydrogenase FADE20 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0221c | fadE3 | 0.0 | 100.00% (356) | acyl-CoA dehydrogenase FADE3 |
| M. gilvum PYR-GCK | Mflv_0446 | - | 1e-166 | 82.15% (353) | butyryl-CoA dehydrogenase |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-46 | 32.39% (355) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2081 | - | 7e-53 | 38.25% (332) | acyl CoA dehydrogenase |
| M. marinum M | MMAR_0455 | fadE3_2 | 1e-178 | 86.44% (354) | acyl-CoA dehydrogenase FadE3_2 |
| M. avium 104 | MAV_4958 | - | 1e-178 | 86.93% (352) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1991 | - | 1e-144 | 71.88% (352) | isovaleryl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3837 | - | 1e-174 | 86.40% (353) | PUTATIVE Butyryl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4024 | fadE3 | 1e-178 | 86.16% (354) | acyl-CoA dehydrogenase FadE3 |
| M. vanbaalenii PYR-1 | Mvan_0221 | - | 1e-163 | 81.30% (353) | butyryl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0446|M.gilvum_PYR-GCK ----------MVDGLSSEEAMLVQTVRAFIDRDVKPTVRDVEHANTYPEA
Mvan_0221|M.vanbaalenii_PYR-1 ----------MVEGLSSEEAMLVETVRTFIDREVRPTVRDVEHANTYPEA
Rv0215c|M.tuberculosis_H37Rv -----MRN-----ELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEA
Mb0221c|M.bovis_AF2122/97 -----MRN-----ELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEA
MMAR_0455|M.marinum_M -----MDNQRADSQLDEDEAMLVATVRAFIDRDVKPSVREVEHANTYPQA
MUL_4024|M.ulcerans_Agy99 ----MMNNDSPDSQLDEDEAMLVATVRAFIDRDVRPSVREVEHANTYPQA
MAV_4958|M.avium_104 --------------MNDEEDMLVATVRAFIDREVKPTVREVEHADAYPEA
TH_3837|M.thermoresistible__bu ----------VNVVLNDEETMLVETVRAFIDRDVKPTVREVEHANEYPQA
MSMEG_1991|M.smegmatis_MC2_155 ------------MALTAEEETIVKTVHDFVEKQVKPVVRELEHANTYPEE
MAB_2081|M.abscessus_ATCC_1997 ------MSSPISPWMNAELLELRDLAAKFFSAELAPHANRFADQHHVDRE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
: : : : . :: * . . . .
Mflv_0446|M.gilvum_PYR-GCK WIDQMKQIGIYGLAVPESYGGTPVSTRCYVLVTQELARGWMSLAGAMGGH
Mvan_0221|M.vanbaalenii_PYR-1 WIEKMKQIGIFGLAIPESEGGAPVSTRCYVLVTQELARGWMSLAGAMGGH
Rv0215c|M.tuberculosis_H37Rv WIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
Mb0221c|M.bovis_AF2122/97 WIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
MMAR_0455|M.marinum_M WIEQMKRIGIYGLAIGEAYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
MUL_4024|M.ulcerans_Agy99 WIEQMKRIGIYGLAIGEAYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
MAV_4958|M.avium_104 WIEQMKRIGIYGLAVPEEYGGSPVSMPCYVRVTEQLARGWMSLAGAMGGH
TH_3837|M.thermoresistible__bu WIEQMKRIGIYGLAIPESYGGSPVSMPCYVEVTQELSRGWMSLAGAMGGH
MSMEG_1991|M.smegmatis_MC2_155 LIETMKEIGIFGLAIPEPYGFGAVSMPCYVQVAEELARGWMSLAGAMGGH
MAB_2081|M.abscessus_ATCC_1997 LWNRAGELGLLCMSIPEEYGGGGGTFAHEAVVLEEQARIGDSSWGAGLHS
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
*: : : * * * :: :* *
Mflv_0446|M.gilvum_PYR-GCK TVVAKLLTLFGTEEQKQRYLPAMATGEIRATMALTEPGGGSDLQAMGTVA
Mvan_0221|M.vanbaalenii_PYR-1 TVVAKLLSLFGTDEQKQRYLPPMATGELRATMALTEPGGGSDLQAMSTVA
Rv0215c|M.tuberculosis_H37Rv TVVAKLLTLFGTEEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTA
Mb0221c|M.bovis_AF2122/97 TVVAKLLTLFGTEEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTA
MMAR_0455|M.marinum_M TVVAKLLMLFGTDEQKSTYLPAMATGELRATMALTEPGGGSDLQNMSTTA
MUL_4024|M.ulcerans_Agy99 TVVAKLLMLFGTDEQKSTYLPAMATGELRATMALTEPGGGSDLQNMSTTA
MAV_4958|M.avium_104 TVVAKLLTLFGTEDQKRAYLPRMASGEIRATMALTEPGGGSDLQNMSTTA
TH_3837|M.thermoresistible__bu TVVAKLLTLFGTEEQKQRYLPAMATGEIRATMALTEPGGGSDLQNMTTTA
MSMEG_1991|M.smegmatis_MC2_155 TVVSKLLLLFGTEEQKQKYLPRMATGELRATMALTEPGGGSDLQAMRTVA
MAB_2081|M.abscessus_ATCC_1997 GIVAHYILQYATEELRAQWLPKMASGEMIGAIAMTEPGTGSDLQSVKTKA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
: : : .::: : ** :*: .: *::* *** : * *
Mflv_0446|M.gilvum_PYR-GCK RRD-GDD---LVLSGTKTWISNARRSGLIALLCKTDPDATPKHSGISVVL
Mvan_0221|M.vanbaalenii_PYR-1 RRD-GDE---LVISGAKTWISNARRSGLIALLCKTDPEATPRHSGISVVL
Rv0215c|M.tuberculosis_H37Rv LADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNATPRHQGMSIVL
Mb0221c|M.bovis_AF2122/97 LADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNATPRHQGMSIVL
MMAR_0455|M.marinum_M MADGPDQ---LLITGAKTWISNARRSGLIALLCKTDPHATPRHHGISIVL
MUL_4024|M.ulcerans_Agy99 MADGPDQ---LLITGAKTWISNARRSGLIALLCKTDPHATPRHHGISIVL
MAV_4958|M.avium_104 LPD-PDSD-GLVINGAKTWISNARRSGLIALLCKTDPKATPRHKGISILL
TH_3837|M.thermoresistible__bu LPGPGGG---LVINGAKTWISNARRSGLIALLCKTDPDATPRHRGISVVL
MSMEG_1991|M.smegmatis_MC2_155 RRD-GDD---YVINGSKTWISNARRSDLVALMCKTDPDAQPAHKGVSILL
MAB_2081|M.abscessus_ATCC_1997 LLDGDE----YVITGSKTFITNGQQADLIIVVAKTDPSQG--AAGISLIV
MLBr_00737|M.leprae_Br4923 KADGDD----WILNGFKCWITNGGKSTWYTVMAVTDPDKG--ANGISAFI
. ::.* * :*:*. :: ::. *** *:* .:
Mflv_0446|M.gilvum_PYR-GCK VDNPTPGLTVSRDLPKLGYKGVESCELAFDACRVPASAILGGTPGKGFSQ
Mvan_0221|M.vanbaalenii_PYR-1 VDNPTDGLTVSRDLPKLGYKGVESCELTFDGCRVPESAILGGAAGRGFAQ
Rv0215c|M.tuberculosis_H37Rv VEPGP-GLTVSRDLPKLGYKGVESCELSFDNLRVPVSAILGGAMGQGFSQ
Mb0221c|M.bovis_AF2122/97 VEPGP-GLTVSRDLPKLGYKGVESCELSFDNLRVPVSAILGGAMGQGFSQ
MMAR_0455|M.marinum_M VEPGP-GLNISADLPKLGYKGVEACELSFDNYRAPTSAILGGQPGQGFSQ
MUL_4024|M.ulcerans_Agy99 VEPGP-GLNISADLPKLGYKGVEACELSFDNYRAPTSAILGGQPGQGFSQ
MAV_4958|M.avium_104 VEHRP-GLTVSRDLPKLGYKGVESCELSFDNFRAPATAVLGGVAGQGFSQ
TH_3837|M.thermoresistible__bu VEQGTTGLSVSRDLPKLGYKGVESCELVFDDCRVPASAILGGEPGKGFTQ
MSMEG_1991|M.smegmatis_MC2_155 VEKVP-GFDVSRDLPKLGYKGVESCELNFTDARVPVSSLLGDDEGRGFAQ
MAB_2081|M.abscessus_ATCC_1997 VEADRAGFRRGKVLDKIGQRGQDTSELFFDEVRVPRSHLLGQAEGQGFIQ
MLBr_00737|M.leprae_Br4923 VHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIG-EPGTGFKT
*. *: . *:* :* : ** * * * ::* * **
Mflv_0446|M.gilvum_PYR-GCK MMKGLETGRIQVASRALGVASAALEDALAYAQDRESFGRPIWKHQAVGHY
Mvan_0221|M.vanbaalenii_PYR-1 MMKGLETGRIQVASRALGVASAALADALAYAQDRESFGQPIWKHQAVGHY
Rv0215c|M.tuberculosis_H37Rv MMKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIWQHQAVGNY
Mb0221c|M.bovis_AF2122/97 MMKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIWQHQAVGNY
MMAR_0455|M.marinum_M MMKGLETGRIQVAARALGVASAALDDALAYAQQRHSFGQPIWKHQAIGNY
MUL_4024|M.ulcerans_Agy99 MMKGLETGRIQVAARALGVASAALDDALAYAQQRHSFGQPIWKHQAIGNY
MAV_4958|M.avium_104 MMKGLETGRIQVAARALGVATAALEDALAYAQQRESFGQPIWQHQSVGNY
TH_3837|M.thermoresistible__bu MMKGLETGRIQVAARALGVATAALEDALAYAQQRESFGQPIWKHQAIGHY
MSMEG_1991|M.smegmatis_MC2_155 MMKGLEVGRLQVAARATGVARAAFEDALRYSQERESFGKPIWQHQSVGNM
MAB_2081|M.abscessus_ATCC_1997 LMTQLPQERLIVAVGAVAAMELALEQTLKYTREREAFGRPVFGFQNTKFT
MLBr_00737|M.leprae_Br4923 ALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFM
: * * :. * . *: :: *:::*. **..: .*
Mflv_0446|M.gilvum_PYR-GCK LADMATKLTAARQLTLYAADRYDSGER-ADMEAGMAKLFASEVAMEIALN
Mvan_0221|M.vanbaalenii_PYR-1 LADMATKLTAARQLTLYAADRYDSGAR-ADMEAGMAKLFASEVAMEIALN
Rv0215c|M.tuberculosis_H37Rv LADMATKLTAARQLTRYAAERYDSGQR-CDMEAGMAKLFASEVAMEIALN
Mb0221c|M.bovis_AF2122/97 LADMATKLTAARQLTRYAAERYDSGQR-CDMEAGMAKLFASEVAMEIALN
MMAR_0455|M.marinum_M LADMATKLTAARQLTHYAAQRYDSGQR-CDMEAGMAKLFASETAMEIALN
MUL_4024|M.ulcerans_Agy99 LADMATKLTAARQLTHYAAQRYDSGQR-CDMEAGMAKLFASETAMEIALN
MAV_4958|M.avium_104 LADMATKLTAARQLTRYAAERYDSGER-CDMEAGMAKLFASEVAMEIALN
TH_3837|M.thermoresistible__bu LADMATKLTAARQLTRYAAERYDSGQR-CDMEAGMAKLFASEVAMEIALN
MSMEG_1991|M.smegmatis_MC2_155 LADMGTKLYAARSLLLSAAEKFDAGQR-CDMEAGMAKLFASETAMQIALD
MAB_2081|M.abscessus_ATCC_1997 LAEAATETRIARVFLDYCIDLHLAGQL-DVQTVAMAKWWTTERAMKVLDD
MLBr_00737|M.leprae_Br4923 LADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTD
**: . : ** : . * . :* :::: **:: :
Mflv_0446|M.gilvum_PYR-GCK AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAGQLVARGGI
Mvan_0221|M.vanbaalenii_PYR-1 AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAGQLVARGGI
Rv0215c|M.tuberculosis_H37Rv AVRIHGGYGYSTEYDVERR-------------------------------
Mb0221c|M.bovis_AF2122/97 AVRIHGGYGYSTEYDVERYFRDAPLMILGEGTNEIQRNVIAGQLVARGGI
MMAR_0455|M.marinum_M AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIARQLIARGGI
MUL_4024|M.ulcerans_Agy99 AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIARQLIARGGI
MAV_4958|M.avium_104 AVRIHGGYGYSQEYDVERYFRDAPLMIVGEGTNEIQRNVIARQLVTRGGI
TH_3837|M.thermoresistible__bu AVRIHGGYGYSTEFDVERYFRDAPLMIVGEGTNEIQRNVIVSQLVARNTV
MSMEG_1991|M.smegmatis_MC2_155 AVRVHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAKQLVARGGL
MAB_2081|M.abscessus_ATCC_1997 CMQLHGGYGYMTEYPISRLWVDQRVQKIYAGTNEVMKEIISRSL------
MLBr_00737|M.leprae_Br4923 AVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----
.:::.** ** :: :.*
Mflv_0446|M.gilvum_PYR-GCK --
Mvan_0221|M.vanbaalenii_PYR-1 --
Rv0215c|M.tuberculosis_H37Rv --
Mb0221c|M.bovis_AF2122/97 --
MMAR_0455|M.marinum_M --
MUL_4024|M.ulcerans_Agy99 --
MAV_4958|M.avium_104 --
TH_3837|M.thermoresistible__bu --
MSMEG_1991|M.smegmatis_MC2_155 DI
MAB_2081|M.abscessus_ATCC_1997 --
MLBr_00737|M.leprae_Br4923 --