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VEGLSSEEAMLVETVRTFIDREVRPTVRDVEHANTYPEAWIEKMKQIGIFGLAIPESEGGAPVSTRCYVL VTQELARGWMSLAGAMGGHTVVAKLLSLFGTDEQKQRYLPPMATGELRATMALTEPGGGSDLQAMSTVAR RDGDELVISGAKTWISNARRSGLIALLCKTDPEATPRHSGISVVLVDNPTDGLTVSRDLPKLGYKGVESC ELTFDGCRVPESAILGGAAGRGFAQMMKGLETGRIQVASRALGVASAALADALAYAQDRESFGQPIWKHQ AVGHYLADMATKLTAARQLTLYAADRYDSGARADMEAGMAKLFASEVAMEIALNAVRIHGGYGYSTEYDV ERYFRDAPLMIVGEGTNEIQRNVIAGQLVARGGI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0221 | - | - | 100% (385) | butyryl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1977 | - | e-102 | 48.83% (385) | butyryl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1719 | - | 1e-59 | 35.54% (377) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0221c | fadE3 | 0.0 | 82.60% (385) | acyl-CoA dehydrogenase FADE3 |
| M. gilvum PYR-GCK | Mflv_0446 | - | 0.0 | 91.43% (385) | butyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv0215c | fadE3 | 1e-163 | 81.30% (353) | acyl-CoA dehydrogenase FADE3 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-57 | 34.22% (377) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3618c | - | 3e-61 | 36.34% (377) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4161 | fadE3 | 1e-180 | 83.25% (382) | acyl-CoA dehydrogenase FadE3 |
| M. avium 104 | MAV_5068 | - | 0.0 | 84.90% (384) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1991 | - | 1e-162 | 74.02% (381) | isovaleryl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3837 | - | 0.0 | 84.03% (382) | PUTATIVE Butyryl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4024 | fadE3 | 1e-180 | 83.25% (382) | acyl-CoA dehydrogenase FadE3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0221c|M.bovis_AF2122/97 -----MRN-----ELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEA
Rv0215c|M.tuberculosis_H37Rv -----MRN-----ELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEA
MMAR_4161|M.marinum_M ----MMNNDSPDSQLDEDEAMLVATVRAFIDRDVRPSVREVEHANTYPQA
MUL_4024|M.ulcerans_Agy99 ----MMNNDSPDSQLDEDEAMLVATVRAFIDRDVRPSVREVEHANTYPQA
TH_3837|M.thermoresistible__bu -----VN-----VVLNDEETMLVETVRAFIDRDVKPTVREVEHANEYPQA
Mvan_0221|M.vanbaalenii_PYR-1 -----MVE-----GLSSEEAMLVETVRTFIDREVRPTVRDVEHANTYPEA
Mflv_0446|M.gilvum_PYR-GCK -----MVD-----GLSSEEAMLVQTVRAFIDRDVKPTVRDVEHANTYPEA
MAV_5068|M.avium_104 -----MPT-----HLSDEEALLVETVRAFIDRDVRPSVREAEHANAYPEA
MSMEG_1991|M.smegmatis_MC2_155 ------------MALTAEEETIVKTVHDFVEKQVKPVVRELEHANTYPEE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
MAB_3618c|M.abscessus_ATCC_199 ---MAGNPSFDLFKLGEEHDELRAAIRGLAEKEIAPHAKDVDEKARFPQE
* :. : ::: : :::: * . : :. :*:
Mb0221c|M.bovis_AF2122/97 WIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
Rv0215c|M.tuberculosis_H37Rv WIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
MMAR_4161|M.marinum_M WIEQMKRIGIYGLAIGEAYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
MUL_4024|M.ulcerans_Agy99 WIEQMKRIGIYGLAIGEAYGGSPVSMPCYVQVTQELARGWMSLAGAMGGH
TH_3837|M.thermoresistible__bu WIEQMKRIGIYGLAIPESYGGSPVSMPCYVEVTQELSRGWMSLAGAMGGH
Mvan_0221|M.vanbaalenii_PYR-1 WIEKMKQIGIFGLAIPESEGGAPVSTRCYVLVTQELARGWMSLAGAMGGH
Mflv_0446|M.gilvum_PYR-GCK WIDQMKQIGIYGLAVPESYGGTPVSTRCYVLVTQELARGWMSLAGAMGGH
MAV_5068|M.avium_104 WIEQMKHIGIYGLAVPEEYGGSPVGTRCYVLVTQELARGWMSLAGAMGGH
MSMEG_1991|M.smegmatis_MC2_155 LIETMKEIGIFGLAIPEPYGFGAVSMPCYVQVAEELARGWMSLAGAMGGH
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
MAB_3618c|M.abscessus_ATCC_199 ALDALVASGFNAVHVPEEYDGQGADSVAACIVIEEVARVCASSSLIPAVN
: : *: .: : * . .. . * :*::* * : . :
Mb0221c|M.bovis_AF2122/97 TVVAKLLTLFGTEEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTA
Rv0215c|M.tuberculosis_H37Rv TVVAKLLTLFGTEEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTA
MMAR_4161|M.marinum_M TVVAKLLMLFGTDEQKSTYLPAMATGELRATMALTEPGGGSDLQNMSTTA
MUL_4024|M.ulcerans_Agy99 TVVAKLLMLFGTDEQKSTYLPAMATGELRATMALTEPGGGSDLQNMSTTA
TH_3837|M.thermoresistible__bu TVVAKLLTLFGTEEQKQRYLPAMATGEIRATMALTEPGGGSDLQNMTTTA
Mvan_0221|M.vanbaalenii_PYR-1 TVVAKLLSLFGTDEQKQRYLPPMATGELRATMALTEPGGGSDLQAMSTVA
Mflv_0446|M.gilvum_PYR-GCK TVVAKLLTLFGTEEQKQRYLPAMATGEIRATMALTEPGGGSDLQAMGTVA
MAV_5068|M.avium_104 TVVAKLLSMFGTEEQKQKYLPAMATGELRATMALTEPGGGSDLQNMITTA
MSMEG_1991|M.smegmatis_MC2_155 TVVSKLLLLFGTEEQKQKYLPRMATGELRATMALTEPGGGSDLQAMRTVA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
MAB_3618c|M.abscessus_ATCC_199 KLGTMGLILNGSDELKKQVLPAIASGEAMASYALSEREAGSDAASMRTRA
.: : * : *::* : ** :*: *: **:* .*** * * *
Mb0221c|M.bovis_AF2122/97 LADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNATPRHQGMSIVL
Rv0215c|M.tuberculosis_H37Rv LADGPEGSAGLLINGCKTWISNARRSGLFAVLCKTDPNATPRHQGMSIVL
MMAR_4161|M.marinum_M MADGPDQ---LLITGAKTWISNARRSGLIALLCKTDPHATPRHHGISIVL
MUL_4024|M.ulcerans_Agy99 MADGPDQ---LLITGAKTWISNARRSGLIALLCKTDPHATPRHHGISIVL
TH_3837|M.thermoresistible__bu LP-GPGG--GLVINGAKTWISNARRSGLIALLCKTDPDATPRHRGISVVL
Mvan_0221|M.vanbaalenii_PYR-1 RRDGD----ELVISGAKTWISNARRSGLIALLCKTDPEATPRHSGISVVL
Mflv_0446|M.gilvum_PYR-GCK RRDGD----DLVLSGTKTWISNARRSGLIALLCKTDPDATPKHSGISVVL
MAV_5068|M.avium_104 LPAGNGES-ELVINGAKTWISNARRSGLIALLCKTDPKARPQHSGISILL
MSMEG_1991|M.smegmatis_MC2_155 RRDGDD----YVINGSKTWISNARRSDLVALMCKTDPDAQPAHKGVSILL
MLBr_00737|M.leprae_Br4923 KADGDD----WILNGFKCWITNGGKSTWYTVMAVTDPDKG--ANGISAFI
MAB_3618c|M.abscessus_ATCC_199 KADGDD----WIINGSKCWITNGGKSSWYTVMAVTDPEKK--ANGISAFM
* ::.* * **:*. :* :::. ***. *:* .:
Mb0221c|M.bovis_AF2122/97 VEPGP-GLTVSRDLPKLGYKGVESCELSFDNLRVPVSAILGGAMGQGFSQ
Rv0215c|M.tuberculosis_H37Rv VEPGP-GLTVSRDLPKLGYKGVESCELSFDNLRVPVSAILGGAMGQGFSQ
MMAR_4161|M.marinum_M VEPGP-GLNISADLPKLGYKGVEACELSFDNYRAPTSAILGGQPGQGFSQ
MUL_4024|M.ulcerans_Agy99 VEPGP-GLNISADLPKLGYKGVEACELSFDNYRAPTSAILGGQPGQGFSQ
TH_3837|M.thermoresistible__bu VEQGTTGLSVSRDLPKLGYKGVESCELVFDDCRVPASAILGGEPGKGFTQ
Mvan_0221|M.vanbaalenii_PYR-1 VDNPTDGLTVSRDLPKLGYKGVESCELTFDGCRVPESAILGGAAGRGFAQ
Mflv_0446|M.gilvum_PYR-GCK VDNPTPGLTVSRDLPKLGYKGVESCELAFDACRVPASAILGGTPGKGFSQ
MAV_5068|M.avium_104 VEHG-PGLTVSRDLPKLGYKGVESCELSFDGCRVPASAVLGGEPGRGFAQ
MSMEG_1991|M.smegmatis_MC2_155 VEKVP-GFDVSRDLPKLGYKGVESCELNFTDARVPVSSLLGDDEGRGFAQ
MLBr_00737|M.leprae_Br4923 VHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIG-EPGTGFKT
MAB_3618c|M.abscessus_ATCC_199 VHKDDEGFTVGPLEHKLGIKGSPTAELYFENCRIPGDRIIG-EPGTGFKT
*. *: :. *** ** : ** * * * . ::* * **
Mb0221c|M.bovis_AF2122/97 MMKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIWQHQAVGNY
Rv0215c|M.tuberculosis_H37Rv MMKGLETGRIQVAARALGVATAALEDSLAYAQQRESFGRPIWQHQAVGNY
MMAR_4161|M.marinum_M MMKGLETGRIQVAARALGVASAALDDALAYAQQRHSFGQPIWKHQAIGNY
MUL_4024|M.ulcerans_Agy99 MMKGLETGRIQVAARALGVASAALDDALAYAQQRHSFGQPIWKHQAIGNY
TH_3837|M.thermoresistible__bu MMKGLETGRIQVAARALGVATAALEDALAYAQQRESFGQPIWKHQAIGHY
Mvan_0221|M.vanbaalenii_PYR-1 MMKGLETGRIQVASRALGVASAALADALAYAQDRESFGQPIWKHQAVGHY
Mflv_0446|M.gilvum_PYR-GCK MMKGLETGRIQVASRALGVASAALEDALAYAQDRESFGRPIWKHQAVGHY
MAV_5068|M.avium_104 MMKGLETGRIQVASRALGVATAALEDALAYAQQRESFGKPIWKHQSISNY
MSMEG_1991|M.smegmatis_MC2_155 MMKGLEVGRLQVAARATGVARAAFEDALRYSQERESFGKPIWQHQSVGNM
MLBr_00737|M.leprae_Br4923 ALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFM
MAB_3618c|M.abscessus_ATCC_199 ALQTLDHTRPTIGAQALGIAQGALDQAIAYTKDRKQFGKSISDFQGVQFM
: *: * :.::* *:* .*: :: *:::*..**..* .*.:
Mb0221c|M.bovis_AF2122/97 LADMATKLTAARQLTRYAAERYDSGQR-CDMEAGMAKLFASEVAMEIALN
Rv0215c|M.tuberculosis_H37Rv LADMATKLTAARQLTRYAAERYDSGQR-CDMEAGMAKLFASEVAMEIALN
MMAR_4161|M.marinum_M LADMATKLTAARQLTHYAAQRYDSGQR-CDMEAGMAKLFASETAMEIALN
MUL_4024|M.ulcerans_Agy99 LADMATKLTAARQLTHYAAQRYDSGQR-CDMEAGMAKLFASETAMEIALN
TH_3837|M.thermoresistible__bu LADMATKLTAARQLTRYAAERYDSGQR-CDMEAGMAKLFASEVAMEIALN
Mvan_0221|M.vanbaalenii_PYR-1 LADMATKLTAARQLTLYAADRYDSGAR-ADMEAGMAKLFASEVAMEIALN
Mflv_0446|M.gilvum_PYR-GCK LADMATKLTAARQLTLYAADRYDSGER-ADMEAGMAKLFASEVAMEIALN
MAV_5068|M.avium_104 LADMATKLTAARQLTLHAADRYDAGER-ADMEAGMAKLFASEVAMEIALN
MSMEG_1991|M.smegmatis_MC2_155 LADMGTKLYAARSLLLSAAEKFDAGQR-CDMEAGMAKLFASETAMQIALD
MLBr_00737|M.leprae_Br4923 LADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTD
MAB_3618c|M.abscessus_ATCC_199 LADMAMKVEAARLMVYTAAARAERGEKNLGFISSASKCFASDVAMEVTTD
****. *: *** : ** : : * .: :. :* ***: **::: :
Mb0221c|M.bovis_AF2122/97 AVRIHGGYGYSTEYDVERYFRDAPLMILGEGTNEIQRNVIAGQLVARGGI
Rv0215c|M.tuberculosis_H37Rv AVRIHGGYGYSTEYDVERR-------------------------------
MMAR_4161|M.marinum_M AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIARQLIARGGI
MUL_4024|M.ulcerans_Agy99 AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIARQLIARGGI
TH_3837|M.thermoresistible__bu AVRIHGGYGYSTEFDVERYFRDAPLMIVGEGTNEIQRNVIVSQLVARNTV
Mvan_0221|M.vanbaalenii_PYR-1 AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAGQLVARGGI
Mflv_0446|M.gilvum_PYR-GCK AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAGQLVARGGI
MAV_5068|M.avium_104 AVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVITGQLVARGGI
MSMEG_1991|M.smegmatis_MC2_155 AVRVHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAKQLVARGGL
MLBr_00737|M.leprae_Br4923 AVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----
MAB_3618c|M.abscessus_ATCC_199 AVQLFGGAGYTTDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLTS---
**::.** **:::: ***
Mb0221c|M.bovis_AF2122/97 --
Rv0215c|M.tuberculosis_H37Rv --
MMAR_4161|M.marinum_M --
MUL_4024|M.ulcerans_Agy99 --
TH_3837|M.thermoresistible__bu --
Mvan_0221|M.vanbaalenii_PYR-1 --
Mflv_0446|M.gilvum_PYR-GCK --
MAV_5068|M.avium_104 --
MSMEG_1991|M.smegmatis_MC2_155 DI
MLBr_00737|M.leprae_Br4923 --
MAB_3618c|M.abscessus_ATCC_199 --