For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TVSMDVDIDGYRELLSEVFDEQVTAWTAEAVASERFPRKLIEHLGAAGVFRSKWGPAGGQHPDVAKLNEL AFRLGHLGSAGIGVGVSLHDSAIAVLRRFGRSDHLKAVCEQAIDGEAVLCIGASEESGGSDLQIVETEVR SAREGFEIRGIKKFVSLSPIADHIIVVARGVDHDPTSRHGNVLVVAVPTRQVEIQTPYRKVGAGPLDTAA VHIDTWVPADHLVARAGTGLAAISWGLAHERMSIAGQVASSCQRVLGVTHARMVQRRQFGATLFEHQALR IRMADLQARVDLLRHALTGIAAQGRLDLRAAAGVKVTAARLGEEVLSECMHIFGGAGYLVDETPLGRWWR DMKLARVGGGTDEVLWELVAAAMKPDFDSYAEMIGGTTASD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1944 | - | - | 100% (392) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4847 | - | 2e-27 | 27.37% (380) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1476 | - | 2e-25 | 26.72% (378) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1381 | fadE14 | 1e-174 | 79.11% (383) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1884 | - | 2e-29 | 27.91% (387) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1346 | fadE14 | 1e-174 | 79.11% (383) | acyl-CoA dehydrogenase |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-19 | 23.51% (370) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1073c | - | 2e-29 | 28.89% (360) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4532 | fadE13 | 2e-28 | 28.07% (367) | acyl-CoA dehydrogenase FadE13 |
| M. avium 104 | MAV_2876 | - | 1e-171 | 75.64% (390) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2130 | - | 0.0 | 83.33% (378) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4231 | - | 1e-178 | 79.27% (386) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4704 | fadE13 | 2e-27 | 28.65% (342) | acyl-CoA dehydrogenase FadE13 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1381|M.bovis_AF2122/97 -------------MTAG--------SDLDDFRGLLAKAFDERVVAWTAEA
Rv1346|M.tuberculosis_H37Rv -------------MTAG--------SDLDDFRGLLAKAFDERVVAWTAEA
MAV_2876|M.avium_104 ----------MTTLSAAT------TADIDHYRTVLAGAFDDQVLEWTREA
MSMEG_2130|M.smegmatis_MC2_155 -------------MTASAPALTPSTTTVEEYRELLDRVFDDQVTQWTAEA
TH_4231|M.thermoresistible__bu -------------MTAVS------ETSVDDYRDLLGRVFDERVTAWTAEA
Mvan_1944|M.vanbaalenii_PYR-1 -------------MTVSM------DVDIDGYRELLSEVFDEQVTAWTAEA
MMAR_4532|M.marinum_M ---------MSIWN---------TPERE-ELRKTVRSFAEREVLPHIDEW
MUL_4704|M.ulcerans_Agy99 ---------MSIWN---------TPERE-ELRKSVRSFAEREVLPHIDEW
Mflv_1884|M.gilvum_PYR-GCK ---------MSIWT---------TPERD-DLRRTVRAFAEREVLPFADEW
MAB_1073c|M.abscessus_ATCC_199 ------MTAVNSWN---------TPERK-ALRETVRDFAEREILPNVNEW
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFK---------LPEEHNELRATIRALAEKEIAPHAADV
* : : .: :
Mb1381|M.bovis_AF2122/97 EAQERFPRQLIEHLGVCGVFDAKWATD---ARPDVGKLVELAFALGQLAS
Rv1346|M.tuberculosis_H37Rv EAQERFPRQLIEHLGVCGVFDAKWATD---ARPDVGKLVELAFALGQLAS
MAV_2876|M.avium_104 EARQRFPRELIEHLGARGVFSEKWCGG---MLPDVGKLVELARALGRLSS
MSMEG_2130|M.smegmatis_MC2_155 EETERFPRQLIEHLGRNGVFTEKWGDA---QQPDVAKLIELAFSLGRLGS
TH_4231|M.thermoresistible__bu EETERFPRALIEYLGRSGVFAEKWQDH---QLPDVAKLIELALALGRLGS
Mvan_1944|M.vanbaalenii_PYR-1 VASERFPRKLIEHLGAAGVFRSKWGPAGG-QHPDVAKLNELAFRLGHLGS
MMAR_4532|M.marinum_M ERTGELPRDLHRRAGAAGLLGAGLPESAGGGGGDGADSVIICEQMHQSGA
MUL_4704|M.ulcerans_Agy99 ERTGELPLDLHRRAGAAGLLGAGLPESAGGGGGDGADSVIICEQMHQSGA
Mflv_1884|M.gilvum_PYR-GCK ERAREIPRDLHRAAAAAGLLGAGFPEEVGGDGGDGADAVVICEEMHESGC
MAB_1073c|M.abscessus_ATCC_199 EREGLLPRELHRKAGDLGLLGPGSPEAVGGGGGDAIDPVIVCEELHYAGV
MLBr_00737|M.leprae_Br4923 DQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDA
:* *. * : :
Mb1381|M.bovis_AF2122/97 AG-IGVGVSLHDSAIAILRRFGKSDYLRDICDQAIRGAAVLCIGASEESG
Rv1346|M.tuberculosis_H37Rv AG-IGVGVSLHDSAIAILRRFGKSDYLRDICDQAIRGAAVLCIGASEESG
MAV_2876|M.avium_104 AG-IGVGVSLHDSAIAVLRRFGKSDYLRDICERAIAGQAVLCIGASEESG
MSMEG_2130|M.smegmatis_MC2_155 AG-IGVGVSLHDSAICVLRRFGRSDYLRNICEQAIRGEAVLCIGASEESG
TH_4231|M.thermoresistible__bu AG-IGVGVSLHDSAIAILRRFGRSDHLREIAEQAIRGEAVLCIGASEESG
Mvan_1944|M.vanbaalenii_PYR-1 AG-IGVGVSLHDSAIAVLRRFGRSDHLKAVCEQAIDGEAVLCIGASEESG
MMAR_4532|M.marinum_M PGGVFASLFTCGIAVPHMIASGDERLIEEFVRPTLAGDKIGALAITEPGG
MUL_4704|M.ulcerans_Agy99 PGGVFASLFTCGIAVPHMIASGDERLIEEFVRPTLAGNKIGALAITEPGG
Mflv_1884|M.gilvum_PYR-GCK PGGVFASLFTSGIAVPHMIASQDERLIDTYVRPTLRGENIGSLAITEPGG
MAB_1073c|M.abscessus_ATCC_199 PGGVFASLFTCGISTPHMIASGDQRLIDNYVKPTLAGELIGSLAITEPGG
MLBr_00737|M.leprae_Br4923 SASLIPAVNKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSEREA
.. : .: . : . : . . :* .
Mb1381|M.bovis_AF2122/97 GSDLQIVETEIRSRDGGFEVRGVKKFVSLSPIADHIMVVARSVDHDPTSR
Rv1346|M.tuberculosis_H37Rv GSDLQIVETEIRSRDGGFEVRGVKKFVSLSPIADHIMVVARSVDHDPTSR
MAV_2876|M.avium_104 GSDLQIVRTEMSSRDGGFDVRGVKKFVSLSPIADHIMVVARSIDHDSASK
MSMEG_2130|M.smegmatis_MC2_155 GSDLQIVETEVRSARGGFEVKGIKKFVSLSPIADHIIVVARGVDHDPTSR
TH_4231|M.thermoresistible__bu GSDLQIVETEVRSEGDGFRVRGTKKFVSLSPIADHIVVVARSVDHDPSSR
Mvan_1944|M.vanbaalenii_PYR-1 GSDLQIVETEVRSAREGFEIRGIKKFVSLSPIADHIIVVARGVDHDPTSR
MMAR_4532|M.marinum_M GSDVGHLRTSAVRDGDHFIVNGAKTYITSGVR-ADFVVTAVRTGG-PGAG
MUL_4704|M.ulcerans_Agy99 GSDVGHLRTSAVREGDHFIVNGAKTYITSGVR-ADFVVTAVRTGG-PGAG
Mflv_1884|M.gilvum_PYR-GCK GSDVGHLTTRAVRDGDCFIVNGAKTYITSGVR-ADYVVTAARTGG-PGAA
MAB_1073c|M.abscessus_ATCC_199 GSDVGHLTTSAKRDGDHYIVNGAKTFITSGVR-ADYVVTAVRTGG-PGAA
MLBr_00737|M.leprae_Br4923 GSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPD-KGAN
*** : * : :.* * ::: . * * :
Mb1381|M.bovis_AF2122/97 HGNVAVVAVPAAQVSVQTPYRKVGAGPLDTAAVCID-TWVPADALVARAG
Rv1346|M.tuberculosis_H37Rv HGNVAVVAVPAAQVSVQTPYRKVGAGPLDTAAVCID-TWVPADALVARAG
MAV_2876|M.avium_104 HGNVALIAVPTSQVSVQRPYAKVGAGPLDTAAVHID-TWVPADALVARAG
MSMEG_2130|M.smegmatis_MC2_155 HGNVLVIAVPTSQCEVQTPYRKVGAGPLDTAAVHID-TWVPEQALVARAG
TH_4231|M.thermoresistible__bu HGNVMLIAVPTTQVEVQTPYRKVGAGPLDTAAVHID-TWVPGDALIARPG
Mvan_1944|M.vanbaalenii_PYR-1 HGNVLVVAVPTRQVEIQTPYRKVGAGPLDTAAVHID-TWVPADHLVARAG
MMAR_4532|M.marinum_M GVSLLVVEKGTPGFVVSRKLDKMGWRSSDTAELSYTDARVPAANLVGAEN
MUL_4704|M.ulcerans_Agy99 GVSLLVVEKGTPGFVVSRKLDKMGWRSSDTAELSYTDARIPAANLVGAEN
Mflv_1884|M.gilvum_PYR-GCK GISLIVVDKGTPGFAVSRKLDKMGWRSSDTAELSYTDVRVPAANVVGAEN
MAB_1073c|M.abscessus_ATCC_199 GVSLLLIDKDTPGFEVARKLDKMGWRSSDTAELSFTDVRVPAENLVGSEN
MLBr_00737|M.leprae_Br4923 GISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPG
. :: : *:* *: : :* ::. .
Mb1381|M.bovis_AF2122/97 TGLAAISWGLAHERMSIAGQIAASCQRAIGITLARMMSRRQFGQTLFEHQ
Rv1346|M.tuberculosis_H37Rv TGLAAISWGLAHERMSIAGQIAASCQRAIGITLARMMSRRQFGQTLFEHQ
MAV_2876|M.avium_104 TGLAAISWGLAHERMSIAGQIAASCQRAIGITLARMMTRRQFGRTLFEHQ
MSMEG_2130|M.smegmatis_MC2_155 TGLAAISWGLAHERMSIAGQVASGSQRILGITLARMMKRRQFGHTLYEHQ
TH_4231|M.thermoresistible__bu TGLAAISWGLAHERLSIAGQVAAGCQRVIGITLARMMKRRQFGSTLYEHQ
Mvan_1944|M.vanbaalenii_PYR-1 TGLAAISWGLAHERMSIAGQVASSCQRVLGVTHARMVQRRQFGATLFEHQ
MMAR_4532|M.marinum_M SGFAQIAQAFVSERIALAAQAYSSAQRCLDITVQWCRDRETFGRPLISRQ
MUL_4704|M.ulcerans_Agy99 SGFAQIAQAFVSERIALAAQAYSSAQRCLDITVQWCRDRETFGRPLISRQ
Mflv_1884|M.gilvum_PYR-GCK TGFLQIAAAFVSERVGLAAQAYSSAQRCLDLTVEWCRNRQTFGKPLIARQ
MAB_1073c|M.abscessus_ATCC_199 TGFAQIAGAFVSERIGLAAQAYASAQRCLDLTVEWCRNRETFGRPLISRQ
MLBr_00737|M.leprae_Br4923 TGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQ
:*: : * :..* . .* :. : *. ** .: *
Mb1381|M.bovis_AF2122/97 ALRLRMADLQARVDLLRYALHGIAE---QGRLELR-TAAAVKVTAARLGE
Rv1346|M.tuberculosis_H37Rv ALRLRMADLQARVDLLRYALHGIAE---QGRLELR-TAAAVKVTAARLGE
MAV_2876|M.avium_104 ALRLRMADLQARVDLLQHGLNGIAA---QGRLDLR-AAAGVKVTAARLGE
MSMEG_2130|M.smegmatis_MC2_155 ALRMRMADLQARVDMLRYGLAGIAA---GGKLDLR-AAAAFKVTAARLGE
TH_4231|M.thermoresistible__bu ALRMRMADLQARTDMLRFALTGIAT---QGRLDLR-TAAAIKVSAARLGE
Mvan_1944|M.vanbaalenii_PYR-1 ALRIRMADLQARVDLLRHALTGIAA---QGRLDLR-AAAGVKVTAARLGE
MMAR_4532|M.marinum_M SVQNTLAEMARRIDVARVYSRSVVERQLAGEHDLIPQVCFAKNTAVEAGE
MUL_4704|M.ulcerans_Agy99 SVQNTLAEMARRIDVARVYSRSVVERQLAGEHDLIPQVCFAKNTAVEAGE
Mflv_1884|M.gilvum_PYR-GCK TVQSTLAEMARRIDVARVYTRHVVERQLAGDADLITEVCFAKNTAVEAGE
MAB_1073c|M.abscessus_ATCC_199 SVQNTLAEMARRIDVARVYTHALVDRAIAGESNLIAEVCFAKNTAVEAGE
MLBr_00737|M.leprae_Br4923 SIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAM
::: :*:: : : : . * :* . * * .
Mb1381|M.bovis_AF2122/97 EVISECMHIFGGAGYLVDETTLGKWWRDMKLARVGGGTDEVLWELVAAGM
Rv1346|M.tuberculosis_H37Rv EVISECMHIFGGAGYLVDETTLGKWWRDMKLARVGGGTDEVLWELVAAGM
MAV_2876|M.avium_104 EVMSECMHIFGGAGYLVEETPLGRWWRDMKLARVGGGTDEVLWELVAAGM
MSMEG_2130|M.smegmatis_MC2_155 EVISECMHIFGGSGYLVDETPLGKWWRDMKLARVGGGTDEVLWELVAAAM
TH_4231|M.thermoresistible__bu EVLSECMHIFGGSGYLVDETPLGRWWRDMKLARVGGGTDEVLWELVAAAM
Mvan_1944|M.vanbaalenii_PYR-1 EVLSECMHIFGGAGYLVDETPLGRWWRDMKLARVGGGTDEVLWELVAAAM
MMAR_4532|M.marinum_M WVANQAVQLFGGMGYMAES-EIERQYRDMRILGIGGGTTEILTALAAKLL
MUL_4704|M.ulcerans_Agy99 WVANQAVQLFGGMGYMAES-EIERQYRDMRILGIGGGTTEILTALAAKLL
Mflv_1884|M.gilvum_PYR-GCK WVANQAVQLFGGMGYMTES-EVERQYRDMRILGIGGGTTEILTSLAAKTL
MAB_1073c|M.abscessus_ATCC_199 WVANQGVQLFGGMGYMAES-EIERQYRDMRIIGIGGGTTEILTSLAAKLL
MLBr_00737|M.leprae_Br4923 EVTTDAVQLFGGAGYTSDF-PVERFMRDAKITQIYEGTNQIQRVVMSRAL
* .: :::*** ** : : : ** :: : ** :: : : :
Mb1381|M.bovis_AF2122/97 TPDHDGYAAVVGASKA--
Rv1346|M.tuberculosis_H37Rv TPDHDGYAAVVGASKA--
MAV_2876|M.avium_104 AADHGGYRSVVGASSA--
MSMEG_2130|M.smegmatis_MC2_155 KPDYDGYAEFAGPDAV--
TH_4231|M.thermoresistible__bu KPDYDGYQEIYGADG---
Mvan_1944|M.vanbaalenii_PYR-1 KPDFDSYAEMIGGTTASD
MMAR_4532|M.marinum_M GYQS--------------
MUL_4704|M.ulcerans_Agy99 GYQS--------------
Mflv_1884|M.gilvum_PYR-GCK GYQT--------------
MAB_1073c|M.abscessus_ATCC_199 GFQS--------------
MLBr_00737|M.leprae_Br4923 LR----------------