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VSIWTTPERDDLRKTVRAFVEREVLPHAGEWERIGELPRELHRKAAEVGLLGAGFPESVGGGGGDGADAV VICEEMHRAGAPGGVFASLFTSGIAVPHMIASGDEHLIDTYVRPTLRGEKIGALAITEPGGGSDVGHLTT RAVKDGDCYILNGAKTFITSGVRADYVVTAVRTGGPGAGGISLIVVDKDGPGCSPGLQVTRKLDKMGWRS SDTAELSYTDARVPAGNLVGAENTGFLQIAAAFVSERVGLAAQAYSSAQRCLDLTVEWCRSRETFGKPLI TRQSVQNTLAEMARRIDVARVYTHHVVERELAGETNLIAEVCFAKNTAVDAGEWVAHQAVQLFGGMGYMA ESEVERQYRDMRILGIGGGTSEILTALAAKTLGYQS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4847 | - | - | 100% (386) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2439 | - | 8e-66 | 37.57% (378) | long-chain-acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0906 | - | 3e-60 | 37.11% (380) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1000c | fadE13 | 1e-172 | 83.29% (353) | acyl-CoA dehydrogenase FADE13 |
| M. gilvum PYR-GCK | Mflv_1884 | - | 0.0 | 85.49% (386) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0975c | fadE13 | 0.0 | 84.46% (386) | acyl-CoA dehydrogenase FADE13 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-52 | 34.65% (381) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1073c | - | 1e-179 | 78.76% (386) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_4532 | fadE13 | 0.0 | 81.35% (386) | acyl-CoA dehydrogenase FadE13 |
| M. avium 104 | MAV_1091 | - | 0.0 | 83.42% (386) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5491 | - | 0.0 | 84.97% (386) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2845 | - | 6e-65 | 39.95% (388) | PUTATIVE acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4704 | fadE13 | 0.0 | 80.31% (386) | acyl-CoA dehydrogenase FadE13 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1000c|M.bovis_AF2122/97 ---------MNIWTTPERQ-QLRKTVRAFAEREILPHVDEWERIGELPRG
Rv0975c|M.tuberculosis_H37Rv ---------MNIWTTPERQ-QLRKTVRAFAEREILPHVDEWERIGELPRG
MMAR_4532|M.marinum_M ---------MSIWNTPERE-ELRKTVRSFAEREVLPHIDEWERTGELPRD
MUL_4704|M.ulcerans_Agy99 ---------MSIWNTPERE-ELRKSVRSFAEREVLPHIDEWERTGELPLD
MAV_1091|M.avium_104 ---------MNLWTTPERE-QLRKTVRSFAEREILPHVDEWERSGELPRE
Mvan_4847|M.vanbaalenii_PYR-1 ---------MSIWTTPERD-DLRKTVRAFVEREVLPHAGEWERIGELPRE
Mflv_1884|M.gilvum_PYR-GCK ---------MSIWTTPERD-DLRRTVRAFAEREVLPFADEWERAREIPRD
MSMEG_5491|M.smegmatis_MC2_155 ---------MSIWTTAERE-ALRKTVRAFAEREVLPHAHEWERAGEIPRE
MAB_1073c|M.abscessus_ATCC_199 ------MTAVNSWNTPERK-ALRETVRDFAEREILPNVNEWEREGLLPRE
TH_2845|M.thermoresistible__bu --------MRRSLYTADHD-AYRETVREFLAREVVPFQEEWDRNRWIDRD
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
.:.. * ::* : :*: * : :: :
Mb1000c|M.bovis_AF2122/97 LHRLAGAAGLLGAGFPEAVGGGGG-DGADPVIICEEMHQAGAPGGVYASL
Rv0975c|M.tuberculosis_H37Rv LHRLAGAAGLLGAGFPEAVGGGGG-DGADPVIICEEMHQAGAPGGVYASL
MMAR_4532|M.marinum_M LHRRAGAAGLLGAGLPESAGGGGG-DGADSVIICEQMHQSGAPGGVFASL
MUL_4704|M.ulcerans_Agy99 LHRRAGAAGLLGAGLPESAGGGGG-DGADSVIICEQMHQSGAPGGVFASL
MAV_1091|M.avium_104 LHRSAGAAGLLGAGFPESVGGGGG-DGADAVIICEEMHQAGAPGGVFASL
Mvan_4847|M.vanbaalenii_PYR-1 LHRKAAEVGLLGAGFPESVGGGGG-DGADAVVICEEMHRAGAPGGVFASL
Mflv_1884|M.gilvum_PYR-GCK LHRAAAAAGLLGAGFPEEVGGDGG-DGADAVVICEEMHESGCPGGVFASL
MSMEG_5491|M.smegmatis_MC2_155 LHRKAAELGLLGAGFPEDAGGSGG-DGADPVVICEEMHYAGSPGGVYASL
MAB_1073c|M.abscessus_ATCC_199 LHRKAGDLGLLGPGSPEAVGGGGG-DAIDPVIVCEELHYAGVPGGVFASL
TH_2845|M.thermoresistible__bu VFARAAKAGIYALQIDEKYGGAGEPDYRYRMVVCEEIARITALSFGLTVS
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGA-DSVAACIVIEEVARVDASASLIPAV
*: . * ** * * :: *:: . .
Mb1000c|M.bovis_AF2122/97 FTCGIAVPHMVASGDERLIATYVRPTLAGEKIGALAITEPGGGSDVGHLR
Rv0975c|M.tuberculosis_H37Rv FTCGIAVPHMVASGDERLIATYVRPTLAGEKIGALAITEPGGGSDVGHLR
MMAR_4532|M.marinum_M FTCGIAVPHMIASGDERLIEEFVRPTLAGDKIGALAITEPGGGSDVGHLR
MUL_4704|M.ulcerans_Agy99 FTCGIAVPHMIASGDERLIEEFVRPTLAGNKIGALAITEPGGGSDVGHLR
MAV_1091|M.avium_104 FTCGIAVPHMIASGDQRLIEEFVRPTLAGEKIGSLAITEPGGGSDVGHLR
Mvan_4847|M.vanbaalenii_PYR-1 FTSGIAVPHMIASGDEHLIDTYVRPTLRGEKIGALAITEPGGGSDVGHLT
Mflv_1884|M.gilvum_PYR-GCK FTSGIAVPHMIASQDERLIDTYVRPTLRGENIGSLAITEPGGGSDVGHLT
MSMEG_5491|M.smegmatis_MC2_155 FTCGIAVPHMIASGDQRLIDTYVRPTLRGEKIGALAITEPGGGSDVGHLR
MAB_1073c|M.abscessus_ATCC_199 FTCGISTPHMIASGDQRLIDNYVKPTLAGELIGSLAITEPGGGSDVGHLT
TH_2845|M.thermoresistible__bu LQDDLVLHYLLDLTTEEQKQRWLPGFASGELIGALAMTEPDAGSDLRGIR
MLBr_00737|M.leprae_Br4923 NKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
. :: :. : :.: *::* .*** :
Mb1000c|M.bovis_AF2122/97 TSAVRDGDHYVINGAKTYITSG-VRADYVVTAVRTGGPGAAGVSLLVVEK
Rv0975c|M.tuberculosis_H37Rv TSAVRDGDHYVINGAKTYITSG-VRADYVVTAVRTGGPGAAGVSLLVVEK
MMAR_4532|M.marinum_M TSAVRDGDHFIVNGAKTYITSG-VRADFVVTAVRTGGPGAGGVSLLVVEK
MUL_4704|M.ulcerans_Agy99 TSAVREGDHFIVNGAKTYITSG-VRADFVVTAVRTGGPGAGGVSLLVVEK
MAV_1091|M.avium_104 TSAVRDGDHYIVNGAKTYITSG-VRADYVVTAVRTGGPGAAGVSLLVVEK
Mvan_4847|M.vanbaalenii_PYR-1 TRAVKDGDCYILNGAKTFITSG-VRADYVVTAVRTGGPGAGGISLIVVDK
Mflv_1884|M.gilvum_PYR-GCK TRAVRDGDCFIVNGAKTYITSG-VRADYVVTAARTGGPGAAGISLIVVDK
MSMEG_5491|M.smegmatis_MC2_155 TRADLDGDHYVINGAKTYITSG-VRADYVVTAARTGGPGAGGVSLIVVDK
MAB_1073c|M.abscessus_ATCC_199 TSAKRDGDHYIVNGAKTFITSG-VRADYVVTAVRTGGPGAAGVSLLLIDK
TH_2845|M.thermoresistible__bu TTAHRDGDRWILNGQKTFISSG-IMADVVVVAARTG----ERHSLFVVER
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHK
* * :** :::** * :*:.* : .* *. * :::.:
Mb1000c|M.bovis_AF2122/97 D----TPGFEVTRKLDKMGWRSSDTAELCYTDVAVPATNLVGAENSGFTQ
Rv0975c|M.tuberculosis_H37Rv D----TPGFEVTRKLDKMGWRSSDTAELCYTDVAVPATNLVGAENSGFTQ
MMAR_4532|M.marinum_M G----TPGFVVSRKLDKMGWRSSDTAELSYTDARVPAANLVGAENSGFAQ
MUL_4704|M.ulcerans_Agy99 G----TPGFVVSRKLDKMGWRSSDTAELSYTDARIPAANLVGAENSGFAQ
MAV_1091|M.avium_104 G----TPGFEVTRKLDKMGWRSSDTAELSYTDVRVPVSNLVGAENTGFAQ
Mvan_4847|M.vanbaalenii_PYR-1 DGPGCSPGLQVTRKLDKMGWRSSDTAELSYTDARVPAGNLVGAENTGFLQ
Mflv_1884|M.gilvum_PYR-GCK G----TPGFAVSRKLDKMGWRSSDTAELSYTDVRVPAANVVGAENTGFLQ
MSMEG_5491|M.smegmatis_MC2_155 G----TPGFEVTRKLDKMGWRSSDTAELSYTDVRVPVANLVGSENTGFAQ
MAB_1073c|M.abscessus_ATCC_199 D----TPGFEVARKLDKMGWRSSDTAELSFTDVRVPAENLVGSENTGFAQ
TH_2845|M.thermoresistible__bu D----TPGFERGRKLDKIGLPAQDTAELFFRDAVVPAENLLGEEGRGLAY
MLBr_00737|M.leprae_Br4923 D----DEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKT
. *: * .*:* .. *:** : . :* .::* . *:
Mb1000c|M.bovis_AF2122/97 IARAFVSERIGLAAQAYSSAQRCLDLTAQWCRDRETFGRPLISRQSVQNT
Rv0975c|M.tuberculosis_H37Rv IARAFVSERIGLAAQAYSSAQRCLDLTAQWCRDRETFGRPLISRQSVQNT
MMAR_4532|M.marinum_M IAQAFVSERIALAAQAYSSAQRCLDITVQWCRDRETFGRPLISRQSVQNT
MUL_4704|M.ulcerans_Agy99 IAQAFVSERIALAAQAYSSAQRCLDITVQWCRDRETFGRPLISRQSVQNT
MAV_1091|M.avium_104 IAQAFVSERIGLAAQAYSSAQRCLDLTVQWCRDRETFGRPLISRQSVQNT
Mvan_4847|M.vanbaalenii_PYR-1 IAAAFVSERVGLAAQAYSSAQRCLDLTVEWCRSRETFGKPLITRQSVQNT
Mflv_1884|M.gilvum_PYR-GCK IAAAFVSERVGLAAQAYSSAQRCLDLTVEWCRNRQTFGKPLIARQTVQST
MSMEG_5491|M.smegmatis_MC2_155 IAAAFVAERVGLATQAYAGAQRCLDLTVEWCRNRDTFGRPLISRQAVQNT
MAB_1073c|M.abscessus_ATCC_199 IAGAFVSERIGLAAQAYASAQRCLDLTVEWCRNRETFGRPLISRQSVQNT
TH_2845|M.thermoresistible__bu LMSHLPRERLGVTAKAMATTRAIFDMTVEYCRQRKAFGAPLIDKQHVRFE
MLBr_00737|M.leprae_Br4923 ALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFM
: * : ::* . :: :* : : :.*. ** .: * ::
Mb1000c|M.bovis_AF2122/97 LAEMARRIDVARVYAHHVVERQLAGETDLIAQVCFAKNTAVQAGEWVANQ
Rv0975c|M.tuberculosis_H37Rv LAEMARRIDVARVYAHHVVERQLAGETDLIAQVCFAKNTAVQAGEWVANQ
MMAR_4532|M.marinum_M LAEMARRIDVARVYSRSVVERQLAGEHDLIPQVCFAKNTAVEAGEWVANQ
MUL_4704|M.ulcerans_Agy99 LAEMARRIDVARVYSRSVVERQLAGEHDLIPQVCFAKNTAVEAGEWVANQ
MAV_1091|M.avium_104 LAEMARRIDVARVYSRNVVERQLAGETNLIPQVCFAKNTAVEAGEWVANQ
Mvan_4847|M.vanbaalenii_PYR-1 LAEMARRIDVARVYTHHVVERELAGETNLIAEVCFAKNTAVDAGEWVAHQ
Mflv_1884|M.gilvum_PYR-GCK LAEMARRIDVARVYTRHVVERQLAGDADLITEVCFAKNTAVEAGEWVANQ
MSMEG_5491|M.smegmatis_MC2_155 LAGMARRIDVARVYTRHVVERQLAGETNLIAEVCFAKNTAVEAGEWVANQ
MAB_1073c|M.abscessus_ATCC_199 LAEMARRIDVARVYTHALVDRAIAGESNLIAEVCFAKNTAVEAGEWVANQ
TH_2845|M.thermoresistible__bu LADMATEIDVAQAYTDQSVLAYNAGELTPV-DAAKGKWFVSELQKRVIDR
MLBr_00737|M.leprae_Br4923 LADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTD
** ** .::.*: . *: . .* . : *
Mb1000c|M.bovis_AF2122/97 AVQLFGGMGYMAESEAN----------ANTGTCESSVSEAAPPK-Y--
Rv0975c|M.tuberculosis_H37Rv AVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTALAAKTLGYQS
MMAR_4532|M.marinum_M AVQLFGGMGYMAESEIERQYRDMRILGIGGGTTEILTALAAKLLGYQS
MUL_4704|M.ulcerans_Agy99 AVQLFGGMGYMAESEIERQYRDMRILGIGGGTTEILTALAAKLLGYQS
MAV_1091|M.avium_104 AVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTALSAKLLGFQS
Mvan_4847|M.vanbaalenii_PYR-1 AVQLFGGMGYMAESEVERQYRDMRILGIGGGTSEILTALAAKTLGYQS
Mflv_1884|M.gilvum_PYR-GCK AVQLFGGMGYMTESEVERQYRDMRILGIGGGTTEILTSLAAKTLGYQT
MSMEG_5491|M.smegmatis_MC2_155 AVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTSLAAKTLGFQS
MAB_1073c|M.abscessus_ATCC_199 GVQLFGGMGYMAESEIERQYRDMRIIGIGGGTTEILTSLAAKLLGFQS
TH_2845|M.thermoresistible__bu CLQLHGGYGYMTEYPVARAYLDTRVQTIYGGTTEIMKEIIGRELAAGR
MLBr_00737|M.leprae_Br4923 AVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR--
:**.** ** :: ** : .