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MKFIQYYLDCLSHASYLIADETTGRAVVVDPQRDVAEYLADATEFGYTIELVIETHFHADFLSGHLELAK ATGAKIVYSSVAETEFESMGVADGQIYSLGEVTLKFLHTPGHTPESLSIVVYEHAGDEVPYGVLTGDALF IGDVGRPDLLASIGFTREELADKLYDSLHTKLMTLPDATRVYPAHGAGSACGKNLSTDLWSTMGEQKATN YALRAPDKATFMELVTEGQPPAPSYFVYDAILNRKDRELLDETKMPEAMSYEQVRDAVKAGAVLVDGRNP EEFALGHLRGAVNIGLEGRYAEFAGSVVPTDVDIVLFTEPGQELEGKTRLARIGFDRVIGYLERPFEAML DHQDEVQVASRLTAKAFDARAAELADLQIVDVRNPGEVAAGMIPDAVSIPVGQLPARLGELDPAKPTVVY CAGGYRSSVAASLLRAHGFADVSDILGGYGAWDEAHQNA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1830 | - | - | 100% (459) | beta-lactamase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4023 | - | 0.0 | 100.00% (459) | beta-lactamase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5835 | - | 1e-61 | 35.93% (437) | beta-lactamase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0651c | - | 5e-12 | 26.61% (218) | glyoxalase II |
| M. gilvum PYR-GCK | Mflv_0985 | - | 0.0 | 89.98% (459) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv0634c | - | 6e-12 | 26.61% (218) | glyoxalase II |
| M. leprae Br4923 | MLBr_01391 | - | 4e-12 | 26.94% (193) | hypothetical protein MLBr_01391 |
| M. abscessus ATCC 19977 | MAB_0121 | - | 2e-12 | 45.88% (85) | rhodanese-like protein |
| M. marinum M | MMAR_2442 | - | 9e-14 | 28.22% (202) | hypothetical protein MMAR_2442 |
| M. avium 104 | MAV_4532 | - | 1e-12 | 27.60% (221) | metallo-beta-lactamase family protein |
| M. smegmatis MC2 155 | MSMEG_5385 | - | 0.0 | 85.56% (457) | metallo-beta-lactamase family protein |
| M. thermoresistible (build 8) | TH_1234 | - | 0.0 | 84.53% (459) | metallo-beta-lactamase family protein |
| M. ulcerans Agy99 | MUL_1621 | - | 1e-13 | 28.79% (198) | hypothetical protein MUL_1621 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0651c|M.bovis_AF2122/97 --------------------------------------------------
Rv0634c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4532|M.avium_104 --------------------------------------------------
Mvan_1830|M.vanbaalenii_PYR-1 MKFIQYYLDCLSHASYLIADETTGRAVVVDPQRDVAEYLADATEFGYTIE
Mflv_0985|M.gilvum_PYR-GCK MKFIQYYLDCLSHASYLIADETTGRAVVVDPQRDVAEYLSDAEEFGYTIE
MSMEG_5385|M.smegmatis_MC2_155 MKFTQYYLDCLSHASYLIADETTGRAVVVDPQRDVAGYLADAEEFGYTIE
TH_1234|M.thermoresistible__bu MKFIQYYLDCLSHASYLIADDKTGRAVVVDPQRDVAEYLSDAEKYGYTIE
MAB_0121|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2442|M.marinum_M ----------------------------------------------MTVV
MUL_1621|M.ulcerans_Agy99 ----------------------------------------------MTVV
MLBr_01391|M.leprae_Br4923 ----------------------------------------------MTAS
Mb0651c|M.bovis_AF2122/97 MSKDRLYFRQLLS---------GRDFAVGDMFATQMRNFAYLIGDRTTGD
Rv0634c|M.tuberculosis_H37Rv MSKDRLYFRQLLS---------GRDFAVGDMFATQMRNFAYLIGDRTTGD
MAV_4532|M.avium_104 MSDDRLYFRQLLS---------GRDFAAGDMFATQMRNFAYLIGDRQTGD
Mvan_1830|M.vanbaalenii_PYR-1 LVIETHFHADFLSGHLELAKATGAKIVYSSVAETEFESMGVADGQIYSLG
Mflv_0985|M.gilvum_PYR-GCK LVIETHFHADFLSGHLELAEATGAKIVYSSVAETEFESMGVADGERYSLG
MSMEG_5385|M.smegmatis_MC2_155 LVIETHFHADFLSGHLELAKATGAKIVYSSVAETEFESMGVADGERYSLG
TH_1234|M.thermoresistible__bu LVIETHFHADFLSGHLELAEATGAKIVYSSVAETEFESMGVADGERYSLG
MAB_0121|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2442|M.marinum_M DD---NYTGHVDPGTVARRTLPGATILKASVGP--MDNNAYLVTCSATGQ
MUL_1621|M.ulcerans_Agy99 DD---NYTGHVDPGTVARRTLPGATILKASVGP--VDNNAYLVTCSATGQ
MLBr_01391|M.leprae_Br4923 IDPVNDYTGHVDPGTAARRALPGATILKVSVGP--MDNNAYLVTCSATGE
Mb0651c|M.bovis_AF2122/97 CVVVDPAYAAGDLLDALESDDMQLSG------------------------
Rv0634c|M.tuberculosis_H37Rv CVVVDPAYAAGDLLDALESDDMQLSG------------------------
MAV_4532|M.avium_104 CVVVDPAYAASDLLDTLEADGMHLSG------------------------
Mvan_1830|M.vanbaalenii_PYR-1 EVTLKFLHTPGHTPESLSIVVYEHAGDEVPYGVLTGDALFIGDVGRPDLL
Mflv_0985|M.gilvum_PYR-GCK DVTLEFRHTPGHTPESMSIVVYEHADDQVPYGVLTGDALFIGDVGRPDLL
MSMEG_5385|M.smegmatis_MC2_155 EVTLEFRHTPGHTPESMSVVVYEHSNDDVPYGVLTGDALFIGDVGRPDLL
TH_1234|M.thermoresistible__bu DVTLEFLHTPGHTPESLSIVVYEHADDEIPYGVLTGDTLFIGDVGRPDLL
MAB_0121|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2442|M.marinum_M TLLIDAANDAEVLIDLIRRYAPKIAL------------------------
MUL_1621|M.ulcerans_Agy99 TLLIDAANDAEVLIDLIRRYAPKIAL------------------------
MLBr_01391|M.leprae_Br4923 TLLIDAANDAEVLIDLVQRYAPKLSL------------------------
Mb0651c|M.bovis_AF2122/97 -------------------------VLVTHHHPDHVGGSMMGFQLPG---
Rv0634c|M.tuberculosis_H37Rv -------------------------VLVTHHHPDHVGGSMMGFQLPG---
MAV_4532|M.avium_104 -------------------------VLVTHHHPDHVGGSMMGFTLAG---
Mvan_1830|M.vanbaalenii_PYR-1 ASIGFTREELADKLYDSLHTKLMTLPDATRVYPAHGAGSACGKNLSTDLW
Mflv_0985|M.gilvum_PYR-GCK ASIGFTREELAEKLYDSLHNKLMTLPDATRVYPAHGAGSACGKNLSTDLW
MSMEG_5385|M.smegmatis_MC2_155 ASIGFTREELAEKLYDSLRNKLMTLPDATRVYPAHGAGSACGKNLSTERW
TH_1234|M.thermoresistible__bu ASIGYTREELADKLYDSLHHKLMTLPDATRVYPAHGAGSACGKNLSTELW
MAB_0121|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2442|M.marinum_M -------------------------IVTSHQHFDHWQ-------------
MUL_1621|M.ulcerans_Agy99 -------------------------IVTSHQHFDHWQ-------------
MLBr_01391|M.leprae_Br4923 -------------------------IVTSHQHFDHWQ-------------
Mb0651c|M.bovis_AF2122/97 ---------------------------------------------LAELL
Rv0634c|M.tuberculosis_H37Rv ---------------------------------------------LAELL
MAV_4532|M.avium_104 ---------------------------------------------LAELV
Mvan_1830|M.vanbaalenii_PYR-1 STMGEQKATNYALRAPDKATFMELVTEGQPPAPSYFVYDAILNRKDRELL
Mflv_0985|M.gilvum_PYR-GCK STMGEQKETNYALRAPDKATFMALVTEGQPPAPSYFVYDAILNRKDRELL
MSMEG_5385|M.smegmatis_MC2_155 STIGEQKQTNYALRAPDLATFMALVTAGQPAAPSYFVYDAILNRKDRDLL
TH_1234|M.thermoresistible__bu STIGEQRETNYALRAPDKATFIELVTEGQPPAPGYFVYDAILNRKNRGLL
MAB_0121|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2442|M.marinum_M --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01391|M.leprae_Br4923 --------------------------------------------------
Mb0651c|M.bovis_AF2122/97 ERASVPVHVNTHEALWVSRVTGIPVGDLITHEHGDK--------------
Rv0634c|M.tuberculosis_H37Rv ERASVPVHVNTHEALWVSRVTGIPVGDLITHEHGDK--------------
MAV_4532|M.avium_104 ERAPVPVHVNSHEALWVSRVTGISASDLTAHENHDK--------------
Mvan_1830|M.vanbaalenii_PYR-1 DETKMPEAMSYEQVRDAVKAGAVLVDGRNPEEFALGHLRGAVNIGLEGRY
Mflv_0985|M.gilvum_PYR-GCK DQTKMPAAMTYEQVRDAMAAGAILVDGRGPEEFATGHLRGAVNIGLAGRY
MSMEG_5385|M.smegmatis_MC2_155 DETEIPAAMRYEQVNQALRDGAILVDGRSPEEFATGHLRQAINIGLQGRY
TH_1234|M.thermoresistible__bu DETALPPVLSYDEMLAAVERGAVLVDGRSPEEFAQGHLRGAINIGLDGRY
MAB_0121|M.abscessus_ATCC_1997 ------------------------------MSFPTG--------------
MMAR_2442|M.marinum_M ALQAVAEATGAPTAAHEIDAEPLPVKPDRLLANGDR--------------
MUL_1621|M.ulcerans_Agy99 ALQAVAEATGAPTAAHEIDAEPLPVKPDRLLANGDR--------------
MLBr_01391|M.leprae_Br4923 ALEAVVAATGAPTAVHELDAEPLPVRPDRLLTNGDC--------------
Mb0651c|M.bovis_AF2122/97 ---------------------------VSVGDIDIELLHTPGHTPG----
Rv0634c|M.tuberculosis_H37Rv ---------------------------VSVGDIDIELLHTPGHTPG----
MAV_4532|M.avium_104 ---------------------------VSIGDIEIELLHTPGHTPG----
Mvan_1830|M.vanbaalenii_PYR-1 AEFAGSVVPTDVDIVLFTEPGQELEGKTRLARIGFDRVIGYLERPFEAML
Mflv_0985|M.gilvum_PYR-GCK AEFAGSVVPTDVDIVLFTEPGQELEGKNRLARIGFDRVVGYLDRPFEVMF
MSMEG_5385|M.smegmatis_MC2_155 AEFAGSVVPADVDIVLFTEPGEELEAKNRLARIGFDRVIGHLDRPFEVML
TH_1234|M.thermoresistible__bu AEFAGSVLPADVDIVLFTEPGDELEAKNRLARIGFDRVIGHLDRPFEVMM
MAB_0121|M.abscessus_ATCC_1997 ---------------------------DDVPQVGIDEIS-----------
MMAR_2442|M.marinum_M ---------------------------VQIGELSFDVIHLRGHTPG----
MUL_1621|M.ulcerans_Agy99 ---------------------------VQIGELSFDVIHLRGHTPG----
MLBr_01391|M.leprae_Br4923 ---------------------------VQIGELTFDVIHLRGHTPG----
: : :: :
Mb0651c|M.bovis_AF2122/97 -----------------SQCFLLDGRLVAGDTLFLEGCGRTDFPGGDSDE
Rv0634c|M.tuberculosis_H37Rv -----------------SQCFLLDGRLVAGDTLFLEGCGRTDFPGGDSDE
MAV_4532|M.avium_104 -----------------SQCFLLDGRLVAGDTLFLEGCGRTDFPGGDSDE
Mvan_1830|M.vanbaalenii_PYR-1 DHQDEVQVASRLTAKAFDARAAELADLQIVDVRNPGEVAAGMIPDAVSIP
Mflv_0985|M.gilvum_PYR-GCK THPGDVQMASRLTAKAFDQRAAEVADLQIVDVRNPGEVAAGTIPNAITIP
MSMEG_5385|M.smegmatis_MC2_155 AHPDDVQMASRLTATAFDQRTAEVADLQIVDVRNPGEVADGAIPHAITIP
TH_1234|M.thermoresistible__bu AHPDRVQVASRLTVKAFDQRAAELPDLQIVDVRNPGEVALGAIPGAIAIP
MAB_0121|M.abscessus_ATCC_1997 --------------------AALSLGVKLLDVREDDEWAAGHIEGAQHIP
MMAR_2442|M.marinum_M -----------------SIALALDGAATG----GVTQLFTGDCLFPGGVG
MUL_1621|M.ulcerans_Agy99 -----------------SIALALDGAATG----GVTQLFTGDCLFPGGVG
MLBr_01391|M.leprae_Br4923 -----------------SIALALDGATSGPKTGRVTQLFTGDCLFPGGVG
Mb0651c|M.bovis_AF2122/97 MYRSLRQLAELPGDPTVFPGHWYSAEPSASLSEVKRSNYVYRPASLDQWR
Rv0634c|M.tuberculosis_H37Rv MYRSLRQLAELPGDPTVFPGHWYSAEPSASLSEVKRSNYVYRPASLDQWR
MAV_4532|M.avium_104 MYRSLQRLAKLPGDPTVFPGHWYSAEPSASLSEVKRSNYVYRASDLDQWR
Mvan_1830|M.vanbaalenii_PYR-1 VGQLPARLGELDPAKPTVVYCAGGYRSSVAASLLRAHGFADVSDILGGYG
Mflv_0985|M.gilvum_PYR-GCK VGQLPARLGELDPAKPTVVYCAGGYRSSVAASLLRGNGFTDVSDILGGFG
MSMEG_5385|M.smegmatis_MC2_155 VGQLPARLGELDPAKPTVVYCAGGYRSSVAASVLRRNGFADVSDILGGYG
TH_1234|M.thermoresistible__bu VGQLPDRLTELDPTRPTVVYCAGGYRSSVAASLLRRSGFTDVSDILGGYG
MAB_0121|M.abscessus_ATCC_1997 LGDVPSRMDELDPDAPLWVICHAGGRSQRAAAYLNRNGF-DVSNVSGGML
MMAR_2442|M.marinum_M KTWQPGDFTQLVEDVSSRVFDVYPDSTVVYPGHGDDTVLGVERPHLDEWR
MUL_1621|M.ulcerans_Agy99 KTWQPGDFTQLVEDVSSRVFNVYPDSTVVYPGHGDDTALGFERPHLDEWR
MLBr_01391|M.leprae_Br4923 KTWQRSDFTQLLDDVTTRVFDVYADTTAIYPGHGDDTVLGAERPSLAEWR
: :* . . .
Mb0651c|M.bovis_AF2122/97 MLMGG------
Rv0634c|M.tuberculosis_H37Rv MLMGG------
MAV_4532|M.avium_104 MLMGG------
Mvan_1830|M.vanbaalenii_PYR-1 AWDEAHQNA--
Mflv_0985|M.gilvum_PYR-GCK AWEETHQNA--
MSMEG_5385|M.smegmatis_MC2_155 AWRDARQGV--
TH_1234|M.thermoresistible__bu AWVDARQVA--
MAB_0121|M.abscessus_ATCC_1997 AWVQAGKPTIS
MMAR_2442|M.marinum_M ERGW-------
MUL_1621|M.ulcerans_Agy99 ERGW-------
MLBr_01391|M.leprae_Br4923 ERGW-------