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VLSSGRWDEPIRWVHVGDVPDMSALLLGGELVLTTGTALNTAPEVYLRGLADAGALGVVVELGTAMHEVP QSVTDLARSLGLALVALRRQIKFVDVTEAVHRQIVAAQFDEVAFDRKVHETFTELSVRRASVSSIVDAAA RILDQPVVLEDLAHQALAVSARGEPAAELLKNWERRSRRNPTEGGGAEPWVITSVGLRGEEWGRLLIPSP PAEPGRARMVLERAATALALHRMIEQNRTGLHQQAQSGLIDDVLQGRIADEREIAARAHALGLRKVPRYL PMVVRVDGLAGGVDPVAAQRLNVNLLETVVHTVNASGHTGLFSVRGPGEIGGLVALNPGRASADKALSEI GQQLRRDIGRSTGGKRSVCAVAQPGVEIADSIRGLAEAAHIAEVALAMGDAEARDFHRAADVRLRGLISL LRDDPRVQQFAETELKAMLAEDPAAHHGLTDLQVLRAYLQLGGNKVALAKRLHVSRPALYKRLAAISDKL GVPLDDAESMTSLHVAMMVQDARRRRESPAPSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1825 | - | - | 100% (523) | purine catabolism PurC domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1854 | - | 1e-16 | 22.75% (523) | purine catabolism PurC domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0861 | - | 1e-15 | 23.14% (523) | transcriptional regulator, CdaR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1226c | - | 0.0001 | 32.61% (138) | hypothetical protein Mb1226c |
| M. gilvum PYR-GCK | Mflv_0356 | - | 1e-166 | 60.43% (513) | purine catabolism PurC domain-containing protein |
| M. tuberculosis H37Rv | Rv1194c | - | 0.0001 | 32.61% (138) | hypothetical protein Rv1194c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4347 | - | 1e-124 | 49.13% (517) | putative regulatory protein |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2447 | - | 1e-159 | 57.41% (526) | regulatory protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1825|M.vanbaalenii_PYR-1 --------------------MLSSGRWDEPIRWVHVGDVPDMSALLLGGE
Mflv_0356|M.gilvum_PYR-GCK MPLTLADVIALPVVQRGRPEVLSSRRWDDTIRWVHVSDLADLSTLLQGGE
MSMEG_2447|M.smegmatis_MC2_155 MIPTVRDVIGLPVVQAGDPEVVSAENLDCPVRWVHVSDMPDLAGLLHGGE
MAB_4347|M.abscessus_ATCC_1997 --MTVAEILALPVVLAGDPQVVGGGSLDRPVRWVHVSDVADLSGLLQGGE
Mb1226c|M.bovis_AF2122/97 ------------------------------MAWQQPS--PRIRELIREGA
Rv1194c|M.tuberculosis_H37Rv ------------------------------MAWQQPS--PRIRELIREGA
: * : . . : *: *
Mvan_1825|M.vanbaalenii_PYR-1 LVLTTGTALNT--APEVYLRGLADAGALGVVVELGTAMHEVPQSVTDLAR
Mflv_0356|M.gilvum_PYR-GCK LVLTTGAAMAR--SPRTYLRGLAEAGAVGVVVEVGAVVPEVPPGVGGIAE
MSMEG_2447|M.smegmatis_MC2_155 LVLTTGAGLAE--APDDYLERMTRAGAVGLVVELGTRVSRLPRGVSDVAR
MAB_4347|M.abscessus_ATCC_1997 LVLTTGGPLADPDACTRYLGGLFAAGAAGVVVELGTSLQAIPSGVAREAD
Mb1226c|M.bovis_AF2122/97 RIALN---PSPEWIEELDRATIAANPAIANDPVLAKVVQTANRANLVYWA
Rv1194c|M.tuberculosis_H37Rv RIALN---PSPEWIEELDRATIAANPAIANDPVLAKVVQTANRANLVYWA
: . : * . :. : .
Mvan_1825|M.vanbaalenii_PYR-1 SLGLALVALRRQIKFVDVTEAVHRQIVAAQFDEVAFDRKVHETFTELSVR
Mflv_0356|M.gilvum_PYR-GCK QLDLALVVLHRTVRFVEVTEAVHRMIVAEQYDVVEFDRRVHETFTDLSMK
MSMEG_2447|M.smegmatis_MC2_155 SLGLPLVLLHRQTRFVEITEAVHRLIVADQYEELAFAHRTHETFTDLSMR
MAB_4347|M.abscessus_ATCC_1997 KLQLPVIALHRKIRFVDVTEQVHRSIVAEQYDEVAFARHVHEVFTELTMR
Mb1226c|M.bovis_AF2122/97 AANLRDPGARVPANLGTEPLRMARDLVRRGLDTVAFNIYRTGEHIGWRFW
Rv1194c|M.tuberculosis_H37Rv AANLRDPGARVPANLGTEPLRMARDLVRRGLDTVAFNIYRTGEHIGWRFW
* : .: . : * :* : : * . .
Mvan_1825|M.vanbaalenii_PYR-1 RASVSSIVDAAARILDQPVVLEDLAHQALAVSARGEPAAELLKNWERRSR
Mflv_0356|M.gilvum_PYR-GCK RASLSGIVDAAAKLLGEHVVLEDLSHQALVASTG--IPADLLTDWARRSR
MSMEG_2447|M.smegmatis_MC2_155 RASLADIVRAAADMINESVVLEDLSHQVLAISPRGEAATAVLAEWQRRSR
MAB_4347|M.abscessus_ATCC_1997 RATLGEIVDACGQIAESAIVLEDLNRQVVAFTTHGDSPTGVIHDWERRSR
Mb1226c|M.bovis_AF2122/97 MGIAFELTSDPQELRELLDVSARSVNDFIEATLTG-IAAQVQSEHDELTR
Rv1194c|M.tuberculosis_H37Rv MGIAFELTSDPQELRELLDVSARSVNDFIEATLTG-IAAQVQSEHDELTR
. :. : * .: : : .: : : . :*
Mvan_1825|M.vanbaalenii_PYR-1 RN----PTEGGGAEPWVITSVGLRGEEWGRLLIPSPPAEPGRARMVLERA
Mflv_0356|M.gilvum_PYR-GCK RS----PGGGAGAEPWSATDVGPRFEQWGRLVVPYAPADATRAATVLERA
MSMEG_2447|M.smegmatis_MC2_155 ----------AMAEPWITTSVGPRTEEWGRLIIPHTPAAPARAKTVLERA
MAB_4347|M.abscessus_ATCC_1997 LTPVLPETGETGPESWLTTPVGPGRQEWGRLIAPSG-GSSLRGRMALERA
Mb1226c|M.bovis_AF2122/97 ------------------STHAERLEVVG-LILDGAPISPERAEAKLG--
Rv1194c|M.tuberculosis_H37Rv ------------------STHAERLEVVG-LILDGAPISPERAEAKLG--
: . : * *: . *. *
Mvan_1825|M.vanbaalenii_PYR-1 ATALALHRMIEQNRTGLHQQAQSGLIDDVLQGRIADEREIAARAHALGLR
Mflv_0356|M.gilvum_PYR-GCK AAALAMHRMVEQNRTGLQHQAQSGLIDDVLRGRVVDDRDAAARAQALGLR
MSMEG_2447|M.smegmatis_MC2_155 AQALALHRMAERGRSGLEHQAQSGLIEDVLGGRIADDREAAARAEALGLR
MAB_4347|M.abscessus_ATCC_1997 AQALALHRMIEQHQTTLEQQAQSGLVEELRRGRIKDEAEASARARALGVK
Mb1226c|M.bovis_AF2122/97 -----------------YPLSRAHTAAIIWSDELDGDHSYLDRAADLFCH
Rv1194c|M.tuberculosis_H37Rv -----------------YPLSRAHTAAIIWSDELDGDHSYLDRAADLFCH
::: : ..: .: . ** * :
Mvan_1825|M.vanbaalenii_PYR-1 KVPRYLPMVVRVDGLAGGVDPVAAQRLNVNLLETVVHTVNASGHTGLFSV
Mflv_0356|M.gilvum_PYR-GCK SNAQYLPVVVRVARPAEIDDPVAGHRRNVAVLDAVAHTVNACGHTGLFSL
MSMEG_2447|M.smegmatis_MC2_155 AGGPYLPVTVRTEAPAERLDPVGVQRRNIRILDAVTHSVRSQGHTAICSI
MAB_4347|M.abscessus_ATCC_1997 PALSYIPLTVRVRE-EPCADQVLLQRRQIRLLDAVRHAVRTARLSALTAN
Mb1226c|M.bovis_AF2122/97 AVGSTRPLTVVAGAASRWAWVTDADGLDIDTVQAAVDNAPG---------
Rv1194c|M.tuberculosis_H37Rv AVGSTRPLTVVAGAASRWAWVTDADGLDIDTVQAAVDNAPG---------
*:.* . . . :: :::. . .
Mvan_1825|M.vanbaalenii_PYR-1 RGPGEIGGLVALNPGR-ASADKALSEIGQQLRRDIGRSTGGKRSVCAVAQ
Mflv_0356|M.gilvum_PYR-GCK RGDGEVGAVLSLKDSRTRSVDQALGALARRIHTEIRRVDGSDRVVVTLGP
MSMEG_2447|M.smegmatis_MC2_155 RRDGEIGFVLALTPRRNLTADAALARLAEGLRESVTRSGVTTKVVVAVAN
MAB_4347|M.abscessus_ATCC_1997 PRPGQIDVLLSQTHAS--SAEEILTNVSSVIRASLQRLDDISRCVVGVGP
Mb1226c|M.bovis_AF2122/97 -------------------------------------------ARIAIGT
Rv1194c|M.tuberculosis_H37Rv -------------------------------------------ARIAIGT
:.
Mvan_1825|M.vanbaalenii_PYR-1 PGVEIADSIRGLAEAAHIAEVALAMGD---AEARDFHRAADVRLRGLISL
Mflv_0356|M.gilvum_PYR-GCK SARNVTDAIAGLAEAIDTAEVALSLR----GDVRDFYRTSDIRLRGLISL
MSMEG_2447|M.smegmatis_MC2_155 NATAFADAVHGLREAAHIAEVALPMAGTARLSGRAFVRASDVRLRGLITL
MAB_4347|M.abscessus_ATCC_1997 ASTRLIDAAVSLDDSAHVAEVALSLPD----DAKAFHRASDTRLRGLLAL
Mb1226c|M.bovis_AF2122/97 TANGVEGFRRSHLEALITQRTLSRLRS-----TQRVAFFADVKMVALISQ
Rv1194c|M.tuberculosis_H37Rv TANGVEGFRRSHLEALITQRTLSRLRS-----TQRVAFFADVKMVALISQ
. . . . :: .. : : . :* :: .*::
Mvan_1825|M.vanbaalenii_PYR-1 LRDDPRVQQFAETELKAMLAEDPAAHHGLTDLQVLRAYLQLGGNKVALAK
Mflv_0356|M.gilvum_PYR-GCK LRDDPRIRRFAETELRALLAHDAGAEP--SNISVLREYLRLAGNKSALAE
MSMEG_2447|M.smegmatis_MC2_155 MSDDPRVQTFAETELRSLLIHDADHGE--DDMAVLRGYLELAGNKSALAK
MAB_4347|M.abscessus_ATCC_1997 IRSDPRVQAFAEVELRGVLENRARHGD--DLFQLLREFLNTGGNKTELAK
Mb1226c|M.bovis_AF2122/97 NPD--AASEFITSTLGDLESASPDLQT------ALLTFINEQCNASRAAK
Rv1194c|M.tuberculosis_H37Rv NPD--AASEFITSTLGDLESASPDLQT------ALLTFINEQCNASRAAK
. * * : . * ::. * *:
Mvan_1825|M.vanbaalenii_PYR-1 RLHVSRPALYKRLAAISDKLGVPLDDAESMTSLHVAMMVQDARRRRESPA
Mflv_0356|M.gilvum_PYR-GCK RLHMSRPALYKRLRGIEDALGVDLDDGESMTSLHVAVMVLDSLTG-----
MSMEG_2447|M.smegmatis_MC2_155 RLHMSRPALYSRLAAIQRRLGVDLDDGESMTSLHVALLILDTHRSANPEP
MAB_4347|M.abscessus_ATCC_1997 RLHLSRPTLYTKLAIVQRLLGVDLDDAESRTSLHTAMLVLDHVNP-----
Mb1226c|M.bovis_AF2122/97 RLHTHRNTFLRRLESAQRLLPRPLDHTSVHVAVALEALQWRGNKAHALSS
Rv1194c|M.tuberculosis_H37Rv RLHTHRNTFLRRLESAQRLLPRPLDHTSVHVAVALEALQWRGNKAHALSS
*** * :: :* . * **. . .:: :
Mvan_1825|M.vanbaalenii_PYR-1 PSG-------
Mflv_0356|M.gilvum_PYR-GCK -SG-------
MSMEG_2447|M.smegmatis_MC2_155 AR--------
MAB_4347|M.abscessus_ATCC_1997 ----------
Mb1226c|M.bovis_AF2122/97 PGRRSNSVPA
Rv1194c|M.tuberculosis_H37Rv PGRRSNSVPA