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TEQGERSACVIDELRGLFLFDGLTDAQLTALCADGWVQTFPAGQLCREGDPARYFYVLLDGEIALSKRSG DRDVDIWRAAEPGVYCGAWSAFLRDPDLTYENSATVTRPSRLLVLDAMTLGDFLVTEFPMASHLLVGHSH GRFHAHRILGPHDRLVALGQLTAGLTHELNNPAAAAVRAAHGLRTQIAAMRHRRAELPENALPPEAMSSL VELQDRVAEAAGKPKDLTSVEKSDLEEALGRWLEARGVDDAWEHAATFAEAGLDIDWMERISASRCCDGP TSLSAVIRWLAGTAETELLLTEITDATKRISTLVDQAKRYSQLDRAPFDVADVHELLDSTLTMFSHRLGD AVTVVRDYDLGLPDLPCYAAELNQVWTHLIANALDALAGQPAGVLTIRTRHEQHMARVEVCDTGGGIPDD LLTRVFDPFFTTKPFGEGTGLGLDIAARIVDRHRGSLWAESTPGDTRFITSLPLTVEPARP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1370 | - | - | 100% (482) | cyclic nucleotide-binding protein |
| M. vanbaalenii PYR-1 | Mvan_1369 | - | e-131 | 51.27% (474) | cyclic nucleotide-binding protein |
| M. vanbaalenii PYR-1 | Mvan_5174 | - | 6e-12 | 30.05% (193) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3790c | - | 2e-11 | 30.89% (191) | putative two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_5004 | - | 1e-137 | 53.07% (473) | cyclic nucleotide-binding protein |
| M. tuberculosis H37Rv | Rv3764c | - | 2e-11 | 30.89% (191) | two component sensor kinase |
| M. leprae Br4923 | MLBr_00774 | mtrB | 7e-07 | 24.17% (211) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_3340 | - | 3e-11 | 28.65% (185) | sensor histidine kinase |
| M. marinum M | MMAR_5316 | tcrY | 3e-13 | 28.21% (319) | two-component sensor kinase TcrY |
| M. avium 104 | MAV_0305 | - | 4e-13 | 28.88% (322) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_1515 | - | 1e-134 | 51.66% (482) | two-component sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2175 | - | 7e-08 | 27.08% (192) | two-component sensor protein |
| M. ulcerans Agy99 | MUL_1502 | - | 3e-11 | 31.18% (186) | two component regulator - sensor kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3790c|M.bovis_AF2122/97 -------------------------------------------MGITAAT
Rv3764c|M.tuberculosis_H37Rv -------------------------------------------MGITAAT
MAV_0305|M.avium_104 -----------------MADTRRVWSLRLRLLVGQIVVLALVCLGITAVT
MMAR_5316|M.marinum_M ------------MSSNRLVRRPGAWSLRLRLLVGQILVLAVVCVGITAAT
Mflv_5004|M.gilvum_PYR-GCK --------------------MGEK-----CLPDELRSLFLFEKLTDDQLQ
MSMEG_1515|M.smegmatis_MC2_155 --------------------MSEL-----CVRDELRTLFLFEHLTDAQLD
Mvan_1370|M.vanbaalenii_PYR-1 --------------------MTEQGERSACVIDELRGLFLFDGLTDAQLT
MUL_1502|M.ulcerans_Agy99 ---------MAEELESPGDPETPTPSLQRRVILLVVALLAVLLVVLGVTI
MLBr_00774|M.leprae_Br4923 -MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGL
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2175|M.thermoresistible__bu VTPAATGERRGSRLTVQGWQNLVLSGMGVIVLAGAITGWLLLHRTDDMTR
Mb3790c|M.bovis_AF2122/97 EMALRRHLVAQLDNQLGG---TSYRSVLMYPEKMPRPPWRRETHNYIRSG
Rv3764c|M.tuberculosis_H37Rv EMALRRHLVAQLDNQLGG---TSYRSVLMYPEKMPRPPWRHETHNYIRSG
MAV_0305|M.avium_104 ELALNHHLVKQLDGQLAG---TSFRSALMYPE--PNHP-RHEHSPYPRPG
MMAR_5316|M.marinum_M ELALHHHLVAQLDGQLGG---TSHRSALMYPE--SSHRFWRHQHRYWRPG
Mflv_5004|M.gilvum_PYR-GCK DLCAHGHIATFEPGPICT---EGDPATCFYVMIDGELVMSKRSGGV---D
MSMEG_1515|M.smegmatis_MC2_155 TLCEAGRIEKFPPGPICT---EGEPATCFYVLIDGELVMSKRSGGV---D
Mvan_1370|M.vanbaalenii_PYR-1 ALCADGWVQTFPAGQLCR---EGDPARYFYVLLDGEIALSKRSGDR---D
MUL_1502|M.ulcerans_Agy99 DVSLGLQARRNLHDLLLA---ATSRADALASVGTSPELIAAEINGG---S
MLBr_00774|M.leprae_Br4923 SLAVILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETRS
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2175|M.thermoresistible__bu ELKNDIQPARVAAYQLQSALRDQETAVRSYALTGDEGFLTLYETAQRDER
Mb3790c|M.bovis_AF2122/97 PGPRFLDAPGQPAGMVAAVVSD---GTTVAAGYLTGSGSRAALTSTGRSQ
Rv3764c|M.tuberculosis_H37Rv PGPRFLDAPGQPAGMVAAVVSD---GTTVAAGYLTGSGSRAALTSTGRSQ
MAV_0305|M.avium_104 PGPRFLDAPGQPAGMVAAVVSH---GKTVDAGYLTSSGTRDALTSTAQTQ
MMAR_5316|M.marinum_M PGPRFLDAPGQPAGMVGAVVRD---GKAIVAGYLTNSGDRAEISPTAQAQ
Mflv_5004|M.gilvum_PYR-GCK LETNRTSQRGVYCGAWSAYVPG---EDKTYQASVRVTRP-SRFFVLDAAA
MSMEG_1515|M.smegmatis_MC2_155 IQTNRTSQRGVYFGAWSAYIPG---EEHIYEASVRLTQP-SRIFVLDADT
Mvan_1370|M.vanbaalenii_PYR-1 VDIWRAAEPGVYCGAWSAFLRD---PDLTYENSATVTRP-SRLLVLDAMT
MUL_1502|M.ulcerans_Agy99 VRALLVTADGATYGDPNISPDT---TAGPAVPALPGPPPLIPPGGHQGPH
MLBr_00774|M.leprae_Br4923 LDSSLQLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVDQ
MAB_3340|M.abscessus_ATCC_1997 -----MTRPRYGIGLRLLVVNS------LVVLAGIATTSVVAAIVGPPMF
TH_2175|M.thermoresistible__bu AAADYLRALVGDRPEQMSDLAD-IERNAATWRTDYVAPLLSAVRPTAQPE
Mb3790c|M.bovis_AF2122/97 LERIAGSRTPLTLDLDGLGRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQ
Rv3764c|M.tuberculosis_H37Rv LERIAGSRTPLTLDLDGLGRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQ
MAV_0305|M.avium_104 LEQIAGSRAPVTVNLDGLGRYRVVAAPSRNGSDIIVTGLSMANIDATLIR
MMAR_5316|M.marinum_M LAAVAGSQDPVTLNLDGLGRYRVVSALSRRGDELIVTGLSMSDVDATMIR
Mflv_5004|M.gilvum_PYR-GCK FATFMQREFPMAVHL--LEGHMVGGVRQRQIIDTREKLLALGQLSAGLTH
MSMEG_1515|M.smegmatis_MC2_155 FAVFMQSQFPMAVHL--LEGHKVGGRRQSQIIGQREKLLALGTITAGLTH
Mvan_1370|M.vanbaalenii_PYR-1 LGDFLVTEFPMASHL--LVGHSHGRFHAHRILGPHDRLVALGQLTAGLTH
MUL_1502|M.ulcerans_Agy99 GPPPPPPPPPGGPPPGPPPDATATAAVHTLPDGSRLILVADTTQTTQVTR
MLBr_00774|M.leprae_Br4923 VPNSLRGFIKAGQAAYQYATVHTEGFSGPALIIGTPTSSQVTNLELYLIF
MAB_3340|M.abscessus_ATCC_1997 RRLMDQQVSPGAGNDHPYERAFRDATAMSIGFAVAVSALAALTLSWYLSH
TH_2175|M.thermoresistible__bu LTALVEGERVEFDRMRALFDVQNSHLTETRQAAVDELERTRGWRNAVLIA
:
Mb3790c|M.bovis_AF2122/97 MLIIFGIVT-VIALVAATTAGIVIIKRALAPLRRVAQTASEVVDLPLDRG
Rv3764c|M.tuberculosis_H37Rv MLIIFGIVT-VIALVAATTAGIVIIKRALAPLRRVAQTASEVVDLPLDRG
MAV_0305|M.avium_104 MLVIFGIVT-VIALAAATIAGVVIIRRALAPLRRVAQTAREVADLPLARG
MMAR_5316|M.marinum_M MLIIFGIVT-IVALVAATTAGAIIIRRALAPLRRVAQTATEVVDLPLDRG
Mflv_5004|M.gilvum_PYR-GCK QLNNPAGAT-ARAVADLREG-VGKMRHKLAMLADGKFTPEALRVLVSIQD
MSMEG_1515|M.smegmatis_MC2_155 QLNNPAAAT-ARAVADLREG-VGKMRHKLAMLADGKFSAETLRVLVTIQD
Mvan_1370|M.vanbaalenii_PYR-1 ELNNPAAAA-VRAAHGLRTQ-IAAMRHRRAELPENALPPEAMSSLVELQD
MUL_1502|M.ulcerans_Agy99 QLRQLMIGAGLVTLVVAALLLVLVSRAALAPLDRLAALAKDITTG--DRG
MLBr_00774|M.leprae_Br4923 PLKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVPVRSASRIAE
MAB_3340|M.abscessus_ATCC_1997 RVHRSATALSQAASAVADGN------------------------------
TH_2175|M.thermoresistible__bu MVTAFFVTAALLAVLVRATITRPLEELAAACRRITEGDFGERISLRGPRD
:
Mb3790c|M.bovis_AF2122/97 EVKLPVRVPEPDANPSTEV---GQLGSALNRMLDHIAAALSARQASETRV
Rv3764c|M.tuberculosis_H37Rv EVKLPVRVPEPDANPSTEV---GQLGSALNRMLDHIAAALSARQASETCV
MAV_0305|M.avium_104 EVELPVRVRESDANPSTEV---GQLGAALNRMLDHIADALSARQASETRV
MMAR_5316|M.marinum_M EVELPVRVSETDANPDTEV---GQLGSALNRMLDHIAAALSTRQASETRV
Mflv_5004|M.gilvum_PYR-GCK EVAEQVAKSKAQELTAIET---SDREDQIGDWLEAHGISAAWDYAPTFVD
MSMEG_1515|M.smegmatis_MC2_155 EVAEQVAKNKSVELTALEA---SDREDQIGDWLEDHNIPMAWEYAPTFVE
Mvan_1370|M.vanbaalenii_PYR-1 RVAEAAGKPK--DLTSVEK---SDLEEALGRWLEARGVDDAWEHAATFAE
MUL_1502|M.ulcerans_Agy99 RRLRPSRGDTELGRAASAF---DGMLDALEDSELRAQQAATAAQRAENAT
MLBr_00774|M.leprae_Br4923 RFAEGHLSERMPVRGEDDM---ARLAVSFNDMAESLSRQITQLEEFGNLQ
MAB_3340|M.abscessus_ATCC_1997 -----YDIRVPPPRLGKEF---DAVAAAFNKMAQRLG-------AVDEAR
TH_2175|M.thermoresistible__bu LRSIATDVDDMRQRIVDELRTSHRAHAKLSEQTEALDEQAAELRRSNAEL
:
Mb3790c|M.bovis_AF2122/97 RQFVADASHELRTPLAAIR----GYTELTQRIG--DDPEAVAHAMSRVAS
Rv3764c|M.tuberculosis_H37Rv RQFVADASHELRTPLAAIR----GYTELTQRIG--DDPEAVAHAMSRVAS
MAV_0305|M.avium_104 RQFVADASHELRTPLAAIR----GYTELTQRMG--DDREAVAQAMSRVAS
MMAR_5316|M.marinum_M RQFVADASHELRTPLAAIR----GYTELAQRMG--DDRAAVAHAMSRVGS
Mflv_5004|M.gilvum_PYR-GCK AGLDVDWLERVEASIDDVD----CSATLPGAIGWLKYTIDNELLMNQIAE
MSMEG_1515|M.smegmatis_MC2_155 AGLDIDWLERISASIEDVHDETCGAKTLQSALGWLKYTIDTELRMNEIGE
Mvan_1370|M.vanbaalenii_PYR-1 AGLDIDWMERISASRCCDG-----PTSLSAVIRWLAGTAETELLLTEITD
MUL_1502|M.ulcerans_Agy99 RQFLVDAAHELRTPIAGMQVAAEQLASSAGQQQEDPAARGQYRRASLLLS
MLBr_00774|M.leprae_Br4923 RRFTSDVSHELRTPLTTVR-----MAADLIYDHSSDLDPTLRRSTELMVS
MAB_3340|M.abscessus_ATCC_1997 RQMLADLAHEIRTPVAVLE--------AYMEAVEDGVQQLDQQTVATLRD
TH_2175|M.thermoresistible__bu EQFAYVASHDLQEPLRKVAS----FCQLLEKRYGDQLDERGVEYIRFAVD
: . : . .
Mb3790c|M.bovis_AF2122/97 ETERITRLVEDLLLLARLDSGR-PLERGPVDMSRLAVDAVSDA-HVAGPD
Rv3764c|M.tuberculosis_H37Rv ETERITRLVEDLLLLARLDSGR-PLERGPVDMSRLAVDAVSDA-HVAGPD
MAV_0305|M.avium_104 ETERMTRLVEDLLLLARLDSGR-PLEREPVDLSRLAVDAVNDA-HVAGPD
MMAR_5316|M.marinum_M ETERITSLVEDLLLLARLDSGR-PLEREPVDMSRLAVDAVSDA-HVAGPD
Mflv_5004|M.gilvum_PYR-GCK ASKRISALLAGAKQYSQMDRAE-YQQVNVHELLFSTVKTIFGD-KLGKDK
MSMEG_1515|M.smegmatis_MC2_155 ASRRISALLAGAKQYSQMDRGA-YQSADVHELLRSTL-MMFGG-KIGKDK
Mvan_1370|M.vanbaalenii_PYR-1 ATKRISTLVDQAKRYSQLDRAP-FDVADVHELLDSTL-TMFSH-RLG--D
MUL_1502|M.ulcerans_Agy99 DARRAGRLVADMLDLSRIDAGL-PLDRHDTDLAEIVDAESQRT-TMLAPQ
MLBr_00774|M.leprae_Br4923 ELDRFETLLNDLLEISRHDAGVAELSVEAVDLRVMVNNALGNVGHLAEEA
MAB_3340|M.abscessus_ATCC_1997 QTRRLTRFSIDVNALSVAESRTTSIDARSVSPADLVTTAVAAFAPRYQTK
TH_2175|M.thermoresistible__bu GAKRMQVLINDLLTFSRVGRLN--ATEAAVSLDAALNTALDNLSTAIEES
* : : .
Mb3790c|M.bovis_AF2122/97 -HQWALDLPPEPVVIPGDAARLHQVVTNLLANARVHTGPG---TIVTTRL
Rv3764c|M.tuberculosis_H37Rv -HQWALDLPPEPVVIPGDAARLHQVVTNLLANARVHTGPG---TIVTTRL
MAV_0305|M.avium_104 -HQWELDLPEEPVVITGDAARLHQVLTNLLANARVHTGAG---TVVTTRL
MMAR_5316|M.marinum_M -QQWELDLPAEPVVVTGDAARLHQVVANLLANARIHTGPG---AVVTTRL
Mflv_5004|M.gilvum_PYR-GCK -INLVWDKDKTLPELLCYPGDLNQVWTNIIDNAIQAMDGQ--GTLTIRTM
MSMEG_1515|M.smegmatis_MC2_155 PITLVKEMDKTLPELQCYPGDLNQVWTNIIDNAIQAMDGH--GTLTIRTA
Mvan_1370|M.vanbaalenii_PYR-1 AVTVVRDYDLGLPDLPCYAAELNQVWTHLIANALDALAGQPAGVLTIRTR
MUL_1502|M.ulcerans_Agy99 ITVTRSGLG--TLTVAADPTRVAQILSNLLDNARRYTPAG---GAIAIDL
MLBr_00774|M.leprae_Br4923 GIELLVDMPVDEVIAEVDARRVERILRNLIANAIDHSEHK----PVRIRM
MAB_3340|M.abscessus_ATCC_1997 GVILTSHADDGLPDVWADPERMGQVLSNLLDNALRHTGPG---GQVTVTA
TH_2175|M.thermoresistible__bu GTEIVRPAG--LPTVVGDPTLMAMLWQNLIGNAVKFTRPRQRPRIVIDCR
. : : ::: **
Mb3790c|M.bovis_AF2122/97 S------------TGPTHVVLQVIDNGPGIPAALQSEVFERFARGDTSRS
Rv3764c|M.tuberculosis_H37Rv S------------TGPTHVVLQVIDNGPGIPAALQSEVFERFARGDTSRS
MAV_0305|M.avium_104 S------------TEPAHTVLQVIDNGPGIPAELQSEVFERFARGDSSRS
MMAR_5316|M.marinum_M S------------SGPTHVVLEVIDNGPGIPEAMQSEIFERFARGDTSRS
Mflv_5004|M.gilvum_PYR-GCK R------------ENEDLIRVEICDDGPGIPDDIIDRIFTPFFTTKP---
MSMEG_1515|M.smegmatis_MC2_155 R------------ENDEMIRVEICDDGPGIPEDIINRIFTPFFTTKP---
Mvan_1370|M.vanbaalenii_PYR-1 H------------EQH-MARVEVCDTGGGIPDDLLTRVFDPFFTTKP---
MUL_1502|M.ulcerans_Agy99 R------------AGQGVATVTVTDTGPGIPDDERNRIFERLVRLDAART
MLBr_00774|M.leprae_Br4923 A------------ADEDTVAVTVRDYGIGLRPGEEKLVFSRFWRSDPSRV
MAB_3340|M.abscessus_ATCC_1997 T------------ATGTGATIAVADTGDGVPAEHLDRLFDRFYRADAARD
TH_2175|M.thermoresistible__bu RRGAGEQGDDANHGDGDEWLISVSDNGIGIADEFVDKVFVIFQRLHGRD-
: : * * *: :* : .
Mb3790c|M.bovis_AF2122/97 RQAGSTGLGLAIVSA-VVKAHNGTITVS-SSPG-YTEFAVRLPLDGWQPL
Rv3764c|M.tuberculosis_H37Rv RQAGSTGLGLAIVSA-VVKAHNGTITVS-SSPG-YTEFAVRLPLDGWQPL
MAV_0305|M.avium_104 RKGGSTGLGLAIVSA-VVKAHNGTISVN-SSPG-HTEFTVRLPPNGWQPH
MMAR_5316|M.marinum_M RKGGSTGLGLAIVAA-VVKAHNGTITVN-SSPG-RTEFVVRLPLDAWQRS
Mflv_5004|M.gilvum_PYR-GCK -FGEGTGLGLDLAWRIVVEKHKGNLTVQ-SQPG-DTRFVICLPLAAPAPT
MSMEG_1515|M.smegmatis_MC2_155 -FGEGTGLGLDLAWRIVVEKHNGDLRVY-SEPG-NTRFVVLLPLQAPPPD
Mvan_1370|M.vanbaalenii_PYR-1 -FGEGTGLGLDIAAR-IVDRHRGSLWAE-STPG-DTRFITSLPLTVEPAR
MUL_1502|M.ulcerans_Agy99 RDHGGAGLGLPIARA-LARAHGGELVCL-PHQG-GARFRLTLPLAVAGGV
MLBr_00774|M.leprae_Br4923 RRSGGTGLGLAISIE-DARLHQGRLEAW-GEPGQGACFRLTLPLVRGHKV
MAB_3340|M.abscessus_ATCC_1997 RQHGGAGIGLSIAKA-LVEAHEGRIEAHSAGHAAGTTFTVSLPRPSDHPE
TH_2175|M.thermoresistible__bu -SYTGTGIGLALCKK-IVEHHGGTIWID-TGYADGARFCFTLPVTSTETA
.:*:** : . * * : . : * **
Mb3790c|M.bovis_AF2122/97 ESSPR----------------------------------
Rv3764c|M.tuberculosis_H37Rv ESSPR----------------------------------
MAV_0305|M.avium_104 ASA------------------------------------
MMAR_5316|M.marinum_M GVPPG----------------------------------
Mflv_5004|M.gilvum_PYR-GCK GPSNE----------------------------------
MSMEG_1515|M.smegmatis_MC2_155 GDSSN----------------------------------
Mvan_1370|M.vanbaalenii_PYR-1 P--------------------------------------
MUL_1502|M.ulcerans_Agy99 E--------------------------------------
MLBr_00774|M.leprae_Br4923 TTSPLPMKPILQPSPQASTAGQQHGTQRQRLREHAERSR
MAB_3340|M.abscessus_ATCC_1997 KAPGQRPG-------------------------------
TH_2175|M.thermoresistible__bu SAVLEGDQE------------------------------