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SELCVRDELRTLFLFEHLTDAQLDTLCEAGRIEKFPPGPICTEGEPATCFYVLIDGELVMSKRSGGVDIQ TNRTSQRGVYFGAWSAYIPGEEHIYEASVRLTQPSRIFVLDADTFAVFMQSQFPMAVHLLEGHKVGGRRQ SQIIGQREKLLALGTITAGLTHQLNNPAAATARAVADLREGVGKMRHKLAMLADGKFSAETLRVLVTIQD EVAEQVAKNKSVELTALEASDREDQIGDWLEDHNIPMAWEYAPTFVEAGLDIDWLERISASIEDVHDETC GAKTLQSALGWLKYTIDTELRMNEIGEASRRISALLAGAKQYSQMDRGAYQSADVHELLRSTLMMFGGKI GKDKPITLVKEMDKTLPELQCYPGDLNQVWTNIIDNAIQAMDGHGTLTIRTARENDEMIRVEICDDGPGI PEDIINRIFTPFFTTKPFGEGTGLGLDLAWRIVVEKHNGDLRVYSEPGNTRFVVLLPLQAPPPDGDSSN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1515 | - | - | 100% (490) | two-component sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 6e-10 | 28.21% (195) | sensor histidine kinase PhoR |
| M. smegmatis MC2 155 | MSMEG_4989 | - | 1e-09 | 35.85% (106) | sensor histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3790c | - | 3e-11 | 37.10% (124) | putative two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_5004 | - | 0.0 | 76.73% (490) | cyclic nucleotide-binding protein |
| M. tuberculosis H37Rv | Rv3764c | - | 3e-11 | 37.10% (124) | two component sensor kinase |
| M. leprae Br4923 | MLBr_00175 | - | 1e-06 | 29.82% (114) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_3340 | - | 3e-11 | 25.70% (179) | sensor histidine kinase |
| M. marinum M | MMAR_5316 | tcrY | 3e-11 | 30.16% (189) | two-component sensor kinase TcrY |
| M. avium 104 | MAV_0305 | - | 4e-10 | 38.32% (107) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2428 | - | 3e-07 | 32.20% (118) | PUTATIVE integral membrane sensor signal transduction histidine |
| M. ulcerans Agy99 | MUL_0464 | phoR | 6e-09 | 30.08% (133) | two component system response phosphate sensor kinase, PhoR |
| M. vanbaalenii PYR-1 | Mvan_1369 | - | 0.0 | 77.82% (487) | cyclic nucleotide-binding protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3790c|M.bovis_AF2122/97 -------------------------------------------MGITAAT
Rv3764c|M.tuberculosis_H37Rv -------------------------------------------MGITAAT
MAV_0305|M.avium_104 -----------------MADTRRVWSLRLRLLVGQIVVLALVCLGITAVT
MMAR_5316|M.marinum_M ------------MSSNRLVRRPGAWSLRLRLLVGQILVLAVVCVGITAAT
MUL_0464|M.ulcerans_Agy99 ----------------MAERLPRAVQLRVGLVAATLALVLCGLLASGVAV
MLBr_00175|M.leprae_Br4923 MVRFAW-------RRRASLRATSSLSLRWRVMLLAMSMVAMVVVLMAFAV
TH_2428|M.thermoresistible__bu -MTFAQPYPPSPPQRQATSQPASSLSLRWRVMLLAMSMVAMVVVLMSIAL
Mflv_5004|M.gilvum_PYR-GCK -----------------MGEKCLPDELRSLFLFEKLTDDQLQDLCAHGHI
Mvan_1369|M.vanbaalenii_PYR-1 -----------------MGEKCLPDELRTLFLFEALTDEQLATLCENGHI
MSMEG_1515|M.smegmatis_MC2_155 -----------------MSELCVRDELRTLFLFEHLTDAQLDTLCEAGRI
MAB_3340|M.abscessus_ATCC_1997 -----------------MTRPRYGIGLRLLVVN---SLVVLAGIATTSVV
:
Mb3790c|M.bovis_AF2122/97 EMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRRETHNYIRSGPGP
Rv3764c|M.tuberculosis_H37Rv EMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRHETHNYIRSGPGP
MAV_0305|M.avium_104 ELALNHHLVKQLDGQLAGTSFRSALMYPE--PNHP-RHEHSPYPRPGPGP
MMAR_5316|M.marinum_M ELALHHHLVAQLDGQLGGTSHRSALMYPE--SSHRFWRHQHRYWRPGPGP
MUL_0464|M.ulcerans_Agy99 TSILRHSLVSRIDSTLLEASRT--------WAQASWRHSMPSVEGPDP--
MLBr_00175|M.leprae_Br4923 YVVISAALYSDIDNQLQS--------------------RAQLLIASGS--
TH_2428|M.thermoresistible__bu YAVVSRALYNDIDNQLHS--------------------RARLLIESGS--
Mflv_5004|M.gilvum_PYR-GCK ATFEPGPICTEGDPATCFYVMIDG--------------ELVMSKRSGGVD
Mvan_1369|M.vanbaalenii_PYR-1 ATFEPGPIHVEGDPATCFYVLIDG--------------ELVMSKRSGGVD
MSMEG_1515|M.smegmatis_MC2_155 EKFPPGPICTEGEPATCFYVLIDG--------------ELVMSKRSGGVD
MAB_3340|M.abscessus_ATCC_1997 AAIVGPPMFRR---------------------------------------
:
Mb3790c|M.bovis_AF2122/97 RFLDAPGQPAGMVAAVVSDGTTVAAGYLTGSGSRAALTSTGRSQLERIAG
Rv3764c|M.tuberculosis_H37Rv RFLDAPGQPAGMVAAVVSDGTTVAAGYLTGSGSRAALTSTGRSQLERIAG
MAV_0305|M.avium_104 RFLDAPGQPAGMVAAVVSHGKTVDAGYLTSSGTRDALTSTAQTQLEQIAG
MMAR_5316|M.marinum_M RFLDAPGQPAGMVGAVVRDGKAIVAGYLTNSGDRAEISPTAQAQLAAVAG
MUL_0464|M.ulcerans_Agy99 ----ARPPSKFYVRSISPDGRAMTA--INDRNAEPALPADN-----DVGS
MLBr_00175|M.leprae_Br4923 ---LAADPGKAIEGTAYSDVNAMLVNPGHSIYTANQPGQTLPVGTAEKAV
TH_2428|M.thermoresistible__bu ---LAADPGRAIEGTAYSDVNAMLVNPGRSIYTANQQGEALPLGEPERQV
Mflv_5004|M.gilvum_PYR-GCK LETNRTSQRGVYCGAWSAYVPGEDKTYQASVRVTRPSRFFVLDAAAFATF
Mvan_1369|M.vanbaalenii_PYR-1 IETNRTSQRGVYCGAWSAYIPGEEHVYQATVRVTRPSRFFVLDATAFAEF
MSMEG_1515|M.smegmatis_MC2_155 IQTNRTSQRGVYFGAWSAYIPGEEHIYEASVRLTQPSRIFVLDADTFAVF
MAB_3340|M.abscessus_ATCC_1997 -----------LMDQQVSPGAGNDHPYERAFRDATAMSIGFAVAVSALAA
Mb3790c|M.bovis_AF2122/97 SRTPLTLDLDGLGRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQMLIIFG
Rv3764c|M.tuberculosis_H37Rv SRTPLTLDLDGLGRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQMLIIFG
MAV_0305|M.avium_104 SRAPVTVNLDGLGRYRVVAAPSRNGSDIIVTGLSMANIDATLIRMLVIFG
MMAR_5316|M.marinum_M SQDPVTLNLDGLGRYRVVSALSRRGDELIVTGLSMSDVDATMIRMLIIFG
MUL_0464|M.ulcerans_Agy99 DPTTLPSVNGSNIEWRAVSVHGPQG-GLTTVAIDLSDVQHTVRSLVWLQI
MLBr_00175|M.leprae_Br4923 IRGELFMSQRTASDQRILAIHLPNDSSLLIS-KSLRPTEAVMTKLRWVLL
TH_2428|M.thermoresistible__bu LSGELVMSLRTADQQRVLAIHLSNGSSLLIS-KSLAPTMEVLRRLGTVLL
Mflv_5004|M.gilvum_PYR-GCK MQREFPMAVHLLEGHMVGGVRQRQIIDTREKLLALGQLSAGLTHQLNNPA
Mvan_1369|M.vanbaalenii_PYR-1 MQKEFPMAVHLLEGHMVGGLRQRQILGQREKLLALGQLSAGLTHQLNNPA
MSMEG_1515|M.smegmatis_MC2_155 MQSQFPMAVHLLEGHKVGGRRQSQIIGQREKLLALGTITAGLTHQLNNPA
MAB_3340|M.abscessus_ATCC_1997 LTLSWYLSHRVHRSATALS-------------------------------
.
Mb3790c|M.bovis_AF2122/97 IVTVIALVAATTAGIVIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVR
Rv3764c|M.tuberculosis_H37Rv IVTVIALVAATTAGIVIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVR
MAV_0305|M.avium_104 IVTVIALAAATIAGVVIIRRALAPLRRVAQTAREVADLPLARGEVELPVR
MMAR_5316|M.marinum_M IVTIVALVAATTAGAIIIRRALAPLRRVAQTATEVVDLPLDRGEVELPVR
MUL_0464|M.ulcerans_Agy99 GIGAGVLVVVGLAGFAVVQRSLRPLSEVEQTAAAIASGQLDR--------
MLBr_00175|M.leprae_Br4923 IVGSLGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLR--------
TH_2428|M.thermoresistible__bu IVGGIGVAVAAIAGGMVARAGLRPVSRLTEAAERVARTDDLR--------
Mflv_5004|M.gilvum_PYR-GCK GATARAVADLR-EGVGKMRHKLAMLADGKFTPEALRVLVSIQDEVAEQVA
Mvan_1369|M.vanbaalenii_PYR-1 GATARAVADLR-EGVGKMRHKLAMLADGEFTPAALKVLVSIQDEVAEQVA
MSMEG_1515|M.smegmatis_MC2_155 AATARAVADLR-EGVGKMRHKLAMLADGKFSAETLRVLVTIQDEVAEQVA
MAB_3340|M.abscessus_ATCC_1997 -----QAASAVADGNYDIRVPPPRLG------------------------
. * : :
Mb3790c|M.bovis_AF2122/97 VPEPDANPSTEVGQLGSALNRMLDHIAAALSAR-------QASETRVRQF
Rv3764c|M.tuberculosis_H37Rv VPEPDANPSTEVGQLGSALNRMLDHIAAALSAR-------QASETCVRQF
MAV_0305|M.avium_104 VRESDANPSTEVGQLGAALNRMLDHIADALSAR-------QASETRVRQF
MMAR_5316|M.marinum_M VSETDANPDTEVGQLGSALNRMLDHIAAALSTR-------QASETRVRQF
MUL_0464|M.ulcerans_Agy99 -RVPERDPRTEVGQLSLAMNGMLSQIQVALAASEDSAEKARSSEERMRRF
MLBr_00175|M.leprae_Br4923 --PIPVFGSDELARLTEAFNLMLRALAESRERQ--------------ARL
TH_2428|M.thermoresistible__bu --PIPVVGSDELARLTEAFNMMLRALAESRERQ--------------ARL
Mflv_5004|M.gilvum_PYR-GCK KSKAQELTAIETSDREDQIGDWLEAHGISAAWD-------YAPTFVDAGL
Mvan_1369|M.vanbaalenii_PYR-1 KSKSQELSALEISDREDQIGDWLEDHGISAAWD-------YAPTFVEAGL
MSMEG_1515|M.smegmatis_MC2_155 KNKSVELTALEASDREDQIGDWLEDHNIPMAWE-------YAPTFVEAGL
MAB_3340|M.abscessus_ATCC_1997 ---------KEFDAVAAAFNKMAQRLGAVDEAR--------------RQM
* :. :
Mb3790c|M.bovis_AF2122/97 VADASHELRTPLAAIRGYTELTQRIGD------DPEAVAHAMSRVASETE
Rv3764c|M.tuberculosis_H37Rv VADASHELRTPLAAIRGYTELTQRIGD------DPEAVAHAMSRVASETE
MAV_0305|M.avium_104 VADASHELRTPLAAIRGYTELTQRMGD------DREAVAQAMSRVASETE
MMAR_5316|M.marinum_M VADASHELRTPLAAIRGYTELAQRMGD------DRAAVAHAMSRVGSETE
MUL_0464|M.ulcerans_Agy99 ITDASHELRTPLTTIRGFAELYRQG--------AARDVAMLLSRIESEAS
MLBr_00175|M.leprae_Br4923 VTDAGHELRTPLTSLRTNVELLIASMAPEAPRLPDQEMADLRADVLAQIE
TH_2428|M.thermoresistible__bu VADAGHELRTPLTSLRTNVELLMASQQPGAPGLPEEEMAGLRADVIAQIE
Mflv_5004|M.gilvum_PYR-GCK DVDWLERVEASIDDVD----CSATLPGAIGWLKYTIDNELLMNQIAEASK
Mvan_1369|M.vanbaalenii_PYR-1 DVDWLERVEASVADVD----CSATLPGAIGWLKYTIDNELLMNQIAEASK
MSMEG_1515|M.smegmatis_MC2_155 DIDWLERISASIEDVHDETCGAKTLQSALGWLKYTIDTELRMNEIGEASR
MAB_3340|M.abscessus_ATCC_1997 LADLAHEIRTPVAVLEAYMEAVEDG--------VQQLDQQTVATLRDQTR
* ..: :.: : :
Mb3790c|M.bovis_AF2122/97 RITRLVEDLLLLARLDSGRPLERG-PVDMSRLAVDAVSDAHVAGPDHQWA
Rv3764c|M.tuberculosis_H37Rv RITRLVEDLLLLARLDSGRPLERG-PVDMSRLAVDAVSDAHVAGPDHQWA
MAV_0305|M.avium_104 RMTRLVEDLLLLARLDSGRPLERE-PVDLSRLAVDAVNDAHVAGPDHQWE
MMAR_5316|M.marinum_M RITSLVEDLLLLARLDSGRPLERE-PVDMSRLAVDAVSDAHVAGPDQQWE
MUL_0464|M.ulcerans_Agy99 RMGLLVDDLLTLARLDVQRPLERN-RVDLLVLAADAVHDARAIDRKRAIT
MLBr_00175|M.leprae_Br4923 ELSTLVGDLVDLTRDDAG-QVVHE-PIDMSEVLYRSLERVRRRRNDIHFD
TH_2428|M.thermoresistible__bu ELSTLVGDLVDLTRDDAG-GVIHE-PVDIADVVDRSLERVRRRRNDIDFD
Mflv_5004|M.gilvum_PYR-GCK RISALLAGAKQYSQMDRAEYQQVN-VHELLFSTVKTIFGDKLG-KDK-IN
Mvan_1369|M.vanbaalenii_PYR-1 RISALLAGAKQYSQMDRAEYQSAN-VHELIYSTIKTIFGDKVG-KDNPIK
MSMEG_1515|M.smegmatis_MC2_155 RISALLAGAKQYSQMDRGAYQSAD-VHELLRSTL-MMFGGKIG-KDKPIT
MAB_3340|M.abscessus_ATCC_1997 RLTRFSIDVNALSVAESRTTSIDARSVSPADLVTTAVAAFAPRYQTKGVI
.: : . : : . :
Mb3790c|M.bovis_AF2122/97 LDLPPEP--VVIPGDAARLHQVVTNLLANARVHTGPGTIVTTRLS--TGP
Rv3764c|M.tuberculosis_H37Rv LDLPPEP--VVIPGDAARLHQVVTNLLANARVHTGPGTIVTTRLS--TGP
MAV_0305|M.avium_104 LDLPEEP--VVITGDAARLHQVLTNLLANARVHTGAGTVVTTRLS--TEP
MMAR_5316|M.marinum_M LDLPAEP--VVVTGDAARLHQVVANLLANARIHTGPGAVVTTRLS--SGP
MUL_0464|M.ulcerans_Agy99 VEVLEGPGTPEVLGDEPRLRQVLSNLVGNALQHTPDSADVTVRVG--TAG
MLBr_00175|M.leprae_Br4923 VQAIGWQ----IYGDAAGLSRAVLNLMDNAAKWSPSGGRVVVTMRQ-FDP
TH_2428|M.thermoresistible__bu IEVVPWQ----VYGDAAGLSRAVMNLLDNAAKWSPSGGRVGVRLTQ-VDP
Mflv_5004|M.gilvum_PYR-GCK LVWDKDKTLPELLCYPGDLNQVWTNIIDNAIQAMDGQGTLTIRTMRENED
Mvan_1369|M.vanbaalenii_PYR-1 LVWEKDPSLPELQCYPGDLNQVWTNIIDNAIQAMDGHGTLTIRTRRQSGD
MSMEG_1515|M.smegmatis_MC2_155 LVKEMDKTLPELQCYPGDLNQVWTNIIDNAIQAMDGHGTLTIRTARENDE
MAB_3340|M.abscessus_ATCC_1997 LTSHADDGLPDVWADPERMGQVLSNLLDNALRHTGPGGQVTVTAT--ATG
: : : :. *:: ** :
Mb3790c|M.bovis_AF2122/97 THVVLQVIDNGPGIPAALQSEVFERFARGDTSRSRQAGSTGLGLAIVS-A
Rv3764c|M.tuberculosis_H37Rv THVVLQVIDNGPGIPAALQSEVFERFARGDTSRSRQAGSTGLGLAIVS-A
MAV_0305|M.avium_104 AHTVLQVIDNGPGIPAELQSEVFERFARGDSSRSRKGGSTGLGLAIVS-A
MMAR_5316|M.marinum_M THVVLEVIDNGPGIPEAMQSEIFERFARGDTSRSRKGGSTGLGLAIVA-A
MUL_0464|M.ulcerans_Agy99 ENAVLEVADKGPGMPAEDAARVFERFYRTDSSRARASGGTGLGLSIVH-S
MLBr_00175|M.leprae_Br4923 SHVELVVSDYGPGIPPQERRLVFERFYRSTTARSLP--GSGLGLAIVK-Q
TH_2428|M.thermoresistible__bu VHAELVVSDHGPGIPPQERRLVFERFYRSTTARSMP--GSGLGLAIVK-Q
Mflv_5004|M.gilvum_PYR-GCK L-IRVEICDDGPGIPDDIIDRIFTPFFTTKP----FGEGTGLGLDLAWRI
Mvan_1369|M.vanbaalenii_PYR-1 AGVVVEICDDGPGIPEDVIDRIFTPFFTTKP----FGEGTGLGLDLAWRI
MSMEG_1515|M.smegmatis_MC2_155 M-IRVEICDDGPGIPEDIINRIFTPFFTTKP----FGEGTGLGLDLAWRI
MAB_3340|M.abscessus_ATCC_1997 TGATIAVADTGDGVPAEHLDRLFDRFYRADAARDRQHGGAGIGLSIAK-A
: : * * *:* :* * . .:*:** :.
Mb3790c|M.bovis_AF2122/97 VVKAHNGTITVS-SSPGY----TEFAVRLPLDGWQPLESSPR--------
Rv3764c|M.tuberculosis_H37Rv VVKAHNGTITVS-SSPGY----TEFAVRLPLDGWQPLESSPR--------
MAV_0305|M.avium_104 VVKAHNGTISVN-SSPGH----TEFTVRLPPNGWQPHASA----------
MMAR_5316|M.marinum_M VVKAHNGTITVN-SSPGR----TEFVVRLPLDAWQRSGVPPG--------
MUL_0464|M.ulcerans_Agy99 LVKAHGGDVTLT-TAPGEG---CCFRVTLPRVSEAAVELTEPVS------
MLBr_00175|M.leprae_Br4923 VVINHGGLLRVEDTAPGVQPPGTSIYVLLPGRPMPVSAYSTLADQDMGEA
TH_2428|M.thermoresistible__bu VVLKHGGTLRVEDTVPGGQPPGTSIHVVLPGRPLSGVPPASQEPQPP---
Mflv_5004|M.gilvum_PYR-GCK VVEKHKGNLTVQ-SQPGD----TRFVICLPLAAPAPTGPSNE--------
Mvan_1369|M.vanbaalenii_PYR-1 VVEKHHGHLTVE-SVPGN----TRFIVSLPWQAPAPE-------------
MSMEG_1515|M.smegmatis_MC2_155 VVEKHNGDLRVY-SEPGN----TRFVVLLPLQAPPPDGDSSN--------
MAB_3340|M.abscessus_ATCC_1997 LVEAHEGRIEAHSAGHAAG---TTFTVSLPRPSDHPEKAPGQRPG-----
:* * * : : . : : **
Mb3790c|M.bovis_AF2122/97 ------------------------------------
Rv3764c|M.tuberculosis_H37Rv ------------------------------------
MAV_0305|M.avium_104 ------------------------------------
MMAR_5316|M.marinum_M ------------------------------------
MUL_0464|M.ulcerans_Agy99 ------------------------------------
MLBr_00175|M.leprae_Br4923 NFQDKIGPAVQVSGKSANFRDSAHVISVDYQSARAR
TH_2428|M.thermoresistible__bu --QHAPGADPHAPTQTGN-DAVQSVFTAENK-----
Mflv_5004|M.gilvum_PYR-GCK ------------------------------------
Mvan_1369|M.vanbaalenii_PYR-1 ------------------------------------
MSMEG_1515|M.smegmatis_MC2_155 ------------------------------------
MAB_3340|M.abscessus_ATCC_1997 ------------------------------------