For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MGEKCLPDELRSLFLFEKLTDDQLQDLCAHGHIATFEPGPICTEGDPATCFYVMIDGELVMSKRSGGVDL ETNRTSQRGVYCGAWSAYVPGEDKTYQASVRVTRPSRFFVLDAAAFATFMQREFPMAVHLLEGHMVGGVR QRQIIDTREKLLALGQLSAGLTHQLNNPAGATARAVADLREGVGKMRHKLAMLADGKFTPEALRVLVSIQ DEVAEQVAKSKAQELTAIETSDREDQIGDWLEAHGISAAWDYAPTFVDAGLDVDWLERVEASIDDVDCSA TLPGAIGWLKYTIDNELLMNQIAEASKRISALLAGAKQYSQMDRAEYQQVNVHELLFSTVKTIFGDKLGK DKINLVWDKDKTLPELLCYPGDLNQVWTNIIDNAIQAMDGQGTLTIRTMRENEDLIRVEICDDGPGIPDD IIDRIFTPFFTTKPFGEGTGLGLDLAWRIVVEKHKGNLTVQSQPGDTRFVICLPLAAPAPTGPSNE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5004 | - | - | 100% (486) | cyclic nucleotide-binding protein |
| M. gilvum PYR-GCK | Mflv_1582 | - | 4e-12 | 30.53% (190) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_2267 | - | 3e-09 | 36.72% (128) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3790c | - | 1e-11 | 31.02% (187) | putative two component sensor kinase |
| M. tuberculosis H37Rv | Rv3764c | - | 1e-11 | 31.02% (187) | two component sensor kinase |
| M. leprae Br4923 | MLBr_02440 | - | 2e-06 | 33.02% (106) | putative two-component system sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3340 | - | 1e-09 | 26.49% (151) | sensor histidine kinase |
| M. marinum M | MMAR_5316 | tcrY | 2e-11 | 30.53% (190) | two-component sensor kinase TcrY |
| M. avium 104 | MAV_0305 | - | 5e-10 | 28.88% (187) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_1515 | - | 0.0 | 76.73% (490) | two-component sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2428 | - | 1e-05 | 30.28% (109) | PUTATIVE integral membrane sensor signal transduction histidine |
| M. ulcerans Agy99 | MUL_0464 | phoR | 3e-10 | 25.91% (193) | two component system response phosphate sensor kinase, PhoR |
| M. vanbaalenii PYR-1 | Mvan_1369 | - | 0.0 | 85.89% (482) | cyclic nucleotide-binding protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3790c|M.bovis_AF2122/97 -------------------------------MGITAATEMALRRHLVAQL
Rv3764c|M.tuberculosis_H37Rv -------------------------------MGITAATEMALRRHLVAQL
MAV_0305|M.avium_104 -----MADTRRVWSLRLRLLVGQIVVLALVCLGITAVTELALNHHLVKQL
MMAR_5316|M.marinum_M MSSNRLVRRPGAWSLRLRLLVGQILVLAVVCVGITAATELALHHHLVAQL
MUL_0464|M.ulcerans_Agy99 ----MAERLPRAVQLRVGLVAATLALVLCGLLASGVAVTSILRHSLVSRI
Mflv_5004|M.gilvum_PYR-GCK -----MGEKCLPDELRSLFLFEKLTDDQLQDLCAHGHIATFEPGPICTEG
Mvan_1369|M.vanbaalenii_PYR-1 -----MGEKCLPDELRTLFLFEALTDEQLATLCENGHIATFEPGPIHVEG
MSMEG_1515|M.smegmatis_MC2_155 -----MSELCVRDELRTLFLFEHLTDAQLDTLCEAGRIEKFPPGPICTEG
TH_2428|M.thermoresistible__bu ----------------MTFAQPYPPSPPQRQATSQPASSLSLRWRVMLLA
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
Mb3790c|M.bovis_AF2122/97 DNQLGGTSYRSVLMYPEKMPRPPWRRETHNYIRSGPGPRFLDAPGQPAGM
Rv3764c|M.tuberculosis_H37Rv DNQLGGTSYRSVLMYPEKMPRPPWRHETHNYIRSGPGPRFLDAPGQPAGM
MAV_0305|M.avium_104 DGQLAGTSFRSALMYPE--PNHP-RHEHSPYPRPGPGPRFLDAPGQPAGM
MMAR_5316|M.marinum_M DGQLGGTSHRSALMYPE--SSHRFWRHQHRYWRPGPGPRFLDAPGQPAGM
MUL_0464|M.ulcerans_Agy99 DSTLLEASRT--------WAQASWRHSMPSVEGPDP------ARPPSKFY
Mflv_5004|M.gilvum_PYR-GCK DPATCFYVMIDGELVMSKRSGGVDLETNRTSQRGVYCGAWSAYVPGEDKT
Mvan_1369|M.vanbaalenii_PYR-1 DPATCFYVLIDGELVMSKRSGGVDIETNRTSQRGVYCGAWSAYIPGEEHV
MSMEG_1515|M.smegmatis_MC2_155 EPATCFYVLIDGELVMSKRSGGVDIQTNRTSQRGVYFGAWSAYIPGEEHI
TH_2428|M.thermoresistible__bu MSMVAMVVVLMSIALYAVVSRALYNDIDNQLHSRARLLIESGSLAADPGR
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02440|M.leprae_Br4923 -------------------------------------------------M
Mb3790c|M.bovis_AF2122/97 VAAVVSDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTP--LTLDLD
Rv3764c|M.tuberculosis_H37Rv VAAVVSDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTP--LTLDLD
MAV_0305|M.avium_104 VAAVVSHGKTVDAGYLTSSGTRDALTSTAQTQLEQIAGSRAP--VTVNLD
MMAR_5316|M.marinum_M VGAVVRDGKAIVAGYLTNSGDRAEISPTAQAQLAAVAGSQDP--VTLNLD
MUL_0464|M.ulcerans_Agy99 VRSISPDGRAMTA--INDRNAEPALPADN-----DVGSDPTT--LPSVNG
Mflv_5004|M.gilvum_PYR-GCK YQASVRVTRPSRFFVLDAAAFATFMQREFPMAVHLLEGHMVG--GVRQRQ
Mvan_1369|M.vanbaalenii_PYR-1 YQATVRVTRPSRFFVLDATAFAEFMQKEFPMAVHLLEGHMVG--GLRQRQ
MSMEG_1515|M.smegmatis_MC2_155 YEASVRLTQPSRIFVLDADTFAVFMQSQFPMAVHLLEGHKVG--GRRQSQ
TH_2428|M.thermoresistible__bu AIEGTAYSDVNAMLVNPGRSIYTANQQGEALPLGEPERQVLSGELVMSLR
MAB_3340|M.abscessus_ATCC_1997 -MTRPRYGIGLRLLVVNSLVVLAGIATTS---------------VVAAIV
MLBr_02440|M.leprae_Br4923 FSALLLAGVLSGLAFVVGIVAGIRLSPRLIERRQRLANEWAG------IT
Mb3790c|M.bovis_AF2122/97 GLGRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAA
Rv3764c|M.tuberculosis_H37Rv GLGRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAA
MAV_0305|M.avium_104 GLGRYRVVAAPSRNGSDIIVTGLSMANIDATLIRMLVIFGIVTVIALAAA
MMAR_5316|M.marinum_M GLGRYRVVSALSRRGDELIVTGLSMSDVDATMIRMLIIFGIVTIVALVAA
MUL_0464|M.ulcerans_Agy99 SNIEWRAVSVHGPQG-GLTTVAIDLSDVQHTVRSLVWLQIGIGAGVLVVV
Mflv_5004|M.gilvum_PYR-GCK IIDTREKLLALGQLSAGLTHQLN--NPAGATARAVADLREGVGKMRHKLA
Mvan_1369|M.vanbaalenii_PYR-1 ILGQREKLLALGQLSAGLTHQLN--NPAGATARAVADLREGVGKMRHKLA
MSMEG_1515|M.smegmatis_MC2_155 IIGQREKLLALGTITAGLTHQLN--NPAAATARAVADLREGVGKMRHKLA
TH_2428|M.thermoresistible__bu TADQQRVLAIHLSNGSSLLISKS-LAPTMEVLRRLGTVLLIVGGIGVAVA
MAB_3340|M.abscessus_ATCC_1997 GPPMFRRLMDQQVSPGAGNDHPYERAFRDATAMSIGFAVAVSALAALTLS
MLBr_02440|M.leprae_Br4923 VLQMLQRIIALMPLGAAVVDTYRDVVYLNEQAKELGLVRDRQLDDQAWRA
. : :
Mb3790c|M.bovis_AF2122/97 TTAGIVIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPDANPST
Rv3764c|M.tuberculosis_H37Rv TTAGIVIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPDANPST
MAV_0305|M.avium_104 TIAGVVIIRRALAPLRRVAQTAREVADLPLARGEVELPVRVRESDANPST
MMAR_5316|M.marinum_M TTAGAIIIRRALAPLRRVAQTATEVVDLPLDRGEVELPVRVSETDANPDT
MUL_0464|M.ulcerans_Agy99 GLAGFAVVQRSLRPLSEVEQTAAAIASGQLDR---------RVPERDPRT
Mflv_5004|M.gilvum_PYR-GCK MLADGKFTPEALRVLVSIQDEVAEQVAKSKAQELTAIETSDREDQIGDWL
Mvan_1369|M.vanbaalenii_PYR-1 MLADGEFTPAALKVLVSIQDEVAEQVAKSKSQELSALEISDREDQIGDWL
MSMEG_1515|M.smegmatis_MC2_155 MLADGKFSAETLRVLVTIQDEVAEQVAKNKSVELTALEASDREDQIGDWL
TH_2428|M.thermoresistible__bu AIAGGMVARAGLRPVSRLTEAAERVAR----------TDDLRPIPVVGSD
MAB_3340|M.abscessus_ATCC_1997 ----WYLSHRVHRSATALSQAASAVADGN---------YDIRVPPPRLGK
MLBr_02440|M.leprae_Br4923 AQQALGGDDVEFDLLPGKRPAAGRSGLS------------VHGHARLLSE
.
Mb3790c|M.bovis_AF2122/97 EVGQLGSALNRMLDHIAAALSAR-------QASETRVRQFVADAS--HEL
Rv3764c|M.tuberculosis_H37Rv EVGQLGSALNRMLDHIAAALSAR-------QASETCVRQFVADAS--HEL
MAV_0305|M.avium_104 EVGQLGAALNRMLDHIADALSAR-------QASETRVRQFVADAS--HEL
MMAR_5316|M.marinum_M EVGQLGSALNRMLDHIAAALSTR-------QASETRVRQFVADAS--HEL
MUL_0464|M.ulcerans_Agy99 EVGQLSLAMNGMLSQIQVALAASEDSAEKARSSEERMRRFITDAS--HEL
Mflv_5004|M.gilvum_PYR-GCK EAHGISAAWDYAPTFVDAGLDVD---------WLERVEASIDDVD----C
Mvan_1369|M.vanbaalenii_PYR-1 EDHGISAAWDYAPTFVEAGLDVD---------WLERVEASVADVD----C
MSMEG_1515|M.smegmatis_MC2_155 EDHNIPMAWEYAPTFVEAGLDID---------WLERISASIEDVHDETCG
TH_2428|M.thermoresistible__bu ELARLTEAFNMMLRALAE--------------SRERQARLVADAG--HEL
MAB_3340|M.abscessus_ATCC_1997 EFDAVAAAFNKMAQRLGAVDEAR--------------RQMLADLA--HEI
MLBr_02440|M.leprae_Br4923 KDRRFAVVFVHDQSDYVRMEAAR--------------RDFVANVS--HEL
: . . : :
Mb3790c|M.bovis_AF2122/97 RTPLAAIRGYTELTQRIGD------DPEAVAHAMSRVASETERITRLVED
Rv3764c|M.tuberculosis_H37Rv RTPLAAIRGYTELTQRIGD------DPEAVAHAMSRVASETERITRLVED
MAV_0305|M.avium_104 RTPLAAIRGYTELTQRMGD------DREAVAQAMSRVASETERMTRLVED
MMAR_5316|M.marinum_M RTPLAAIRGYTELAQRMGD------DRAAVAHAMSRVGSETERITSLVED
MUL_0464|M.ulcerans_Agy99 RTPLTTIRGFAELYRQG--------AARDVAMLLSRIESEASRMGLLVDD
Mflv_5004|M.gilvum_PYR-GCK SATLPGAIGWLKYTIDN-------------ELLMNQIAEASKRISALLAG
Mvan_1369|M.vanbaalenii_PYR-1 SATLPGAIGWLKYTIDN-------------ELLMNQIAEASKRISALLAG
MSMEG_1515|M.smegmatis_MC2_155 AKTLQSALGWLKYTIDT-------------ELRMNEIGEASRRISALLAG
TH_2428|M.thermoresistible__bu RTPLTSLRTNVELLMASQQPGAPGLPEEEMAGLRADVIAQIEELSTLVGD
MAB_3340|M.abscessus_ATCC_1997 RTPVAVLEAYMEAVEDG--------VQQLDQQTVATLRDQTRRLTRFSID
MLBr_02440|M.leprae_Br4923 KTPVGAMALLAEALLASAD------DAETVSRFAEKVLIEANRLGYMVAE
.: : : .: :
Mb3790c|M.bovis_AF2122/97 LLLLARLD-SGRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEP-
Rv3764c|M.tuberculosis_H37Rv LLLLARLD-SGRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEP-
MAV_0305|M.avium_104 LLLLARLD-SGRPLEREPVDLSRLAVDAVNDAHVAGPDHQWELDLPEEP-
MMAR_5316|M.marinum_M LLLLARLD-SGRPLEREPVDMSRLAVDAVSDAHVAGPDQQWELDLPAEP-
MUL_0464|M.ulcerans_Agy99 LLTLARLD-VQRPLERNRVDLLVLAADAVHDARAIDRKRAITVEVLEGPG
Mflv_5004|M.gilvum_PYR-GCK AKQYSQMD-RAEYQQVNVHELLFSTVKTIFGDKLG-KDK-INLVWDKDKT
Mvan_1369|M.vanbaalenii_PYR-1 AKQYSQMD-RAEYQSANVHELIYSTIKTIFGDKVG-KDNPIKLVWEKDPS
MSMEG_1515|M.smegmatis_MC2_155 AKQYSQMD-RGAYQSADVHELLRSTL-MMFGGKIG-KDKPITLVKEMDKT
TH_2428|M.thermoresistible__bu LVDLTRDD-AGG-VIHEPVDIADVVDRSLERVRRRRNDIDFDIEVVPWQ-
MAB_3340|M.abscessus_ATCC_1997 VNALSVAESRTTSIDARSVSPADLVTTAVAAFAPRYQTKGVILTSHADDG
MLBr_02440|M.leprae_Br4923 LIELSRLQGAERLPNVTDIDVDIIVSEAIARHKVAADTAAIEVRTDPPSG
: : . . : :
Mb3790c|M.bovis_AF2122/97 -VVIPGDAARLHQVVTNLLANARVHTGPGTIVTTRLSTGPTHV--VLQVI
Rv3764c|M.tuberculosis_H37Rv -VVIPGDAARLHQVVTNLLANARVHTGPGTIVTTRLSTGPTHV--VLQVI
MAV_0305|M.avium_104 -VVITGDAARLHQVLTNLLANARVHTGAGTVVTTRLSTEPAHT--VLQVI
MMAR_5316|M.marinum_M -VVVTGDAARLHQVVANLLANARIHTGPGAVVTTRLSSGPTHV--VLEVI
MUL_0464|M.ulcerans_Agy99 TPEVLGDEPRLRQVLSNLVGNALQHTPDSADVTVRVGTAGENA--VLEVA
Mflv_5004|M.gilvum_PYR-GCK LPELLCYPGDLNQVWTNIIDNAIQAMDGQGTLTIRTMRENEDL-IRVEIC
Mvan_1369|M.vanbaalenii_PYR-1 LPELQCYPGDLNQVWTNIIDNAIQAMDGHGTLTIRTRRQSGDAGVVVEIC
MSMEG_1515|M.smegmatis_MC2_155 LPELQCYPGDLNQVWTNIIDNAIQAMDGHGTLTIRTARENDEM-IRVEIC
TH_2428|M.thermoresistible__bu ---VYGDAAGLSRAVMNLLDNAAKWSPSGGRVGVRLTQVDPVH-AELVVS
MAB_3340|M.abscessus_ATCC_1997 LPDVWADPERMGQVLSNLLDNALRHTGPGGQVTVTATATGTGA--TIAVA
MLBr_02440|M.leprae_Br4923 -LRVLGDQTLLVTALANLVSNAIAYSPGGSLVSISRRRRGDNI--EIAVT
: : . *:: ** : : :
Mb3790c|M.bovis_AF2122/97 DNGPGIPAALQSEVFERFARGDTSRSRQAGSTGLGLAIVS-AVVKAHNGT
Rv3764c|M.tuberculosis_H37Rv DNGPGIPAALQSEVFERFARGDTSRSRQAGSTGLGLAIVS-AVVKAHNGT
MAV_0305|M.avium_104 DNGPGIPAELQSEVFERFARGDSSRSRKGGSTGLGLAIVS-AVVKAHNGT
MMAR_5316|M.marinum_M DNGPGIPEAMQSEIFERFARGDTSRSRKGGSTGLGLAIVA-AVVKAHNGT
MUL_0464|M.ulcerans_Agy99 DKGPGMPAEDAARVFERFYRTDSSRARASGGTGLGLSIVH-SLVKAHGGD
Mflv_5004|M.gilvum_PYR-GCK DDGPGIPDDIIDRIFTPFFTTKP----FGEGTGLGLDLAWRIVVEKHKGN
Mvan_1369|M.vanbaalenii_PYR-1 DDGPGIPEDVIDRIFTPFFTTKP----FGEGTGLGLDLAWRIVVEKHHGH
MSMEG_1515|M.smegmatis_MC2_155 DDGPGIPEDIINRIFTPFFTTKP----FGEGTGLGLDLAWRIVVEKHNGD
TH_2428|M.thermoresistible__bu DHGPGIPPQERRLVFERFYRSTTAR--SMPGSGLGLAIVKQVVLKHGGTL
MAB_3340|M.abscessus_ATCC_1997 DTGDGVPAEHLDRLFDRFYRADAARDRQHGGAGIGLSIAK-ALVEAHEGR
MLBr_02440|M.leprae_Br4923 DRGIGIALEDQERVFERFFRGDKARSRATGGSGLGLAIVK-HVAANHNGS
* * *:. :* * .:*:** :. :
Mb3790c|M.bovis_AF2122/97 ITVSSSPGY----TEFAVRLP---LDGWQPLESSPR--------------
Rv3764c|M.tuberculosis_H37Rv ITVSSSPGY----TEFAVRLP---LDGWQPLESSPR--------------
MAV_0305|M.avium_104 ISVNSSPGH----TEFTVRLP---PNGWQPHASA----------------
MMAR_5316|M.marinum_M ITVNSSPGR----TEFVVRLP---LDAWQRSGVPPG--------------
MUL_0464|M.ulcerans_Agy99 VTLTTAPGEG---CCFRVTLP---RVSEAAVELTEPVS------------
Mflv_5004|M.gilvum_PYR-GCK LTVQSQPGD----TRFVICLP---LAAPAPTGPSNE--------------
Mvan_1369|M.vanbaalenii_PYR-1 LTVESVPGN----TRFIVSLP---WQAPAPE-------------------
MSMEG_1515|M.smegmatis_MC2_155 LRVYSEPGN----TRFVVLLP---LQAPPPDGDSSN--------------
TH_2428|M.thermoresistible__bu RVEDTVPGGQPPGTSIHVVLPGRPLSGVPPASQEPQPPQHAPGADPHAPT
MAB_3340|M.abscessus_ATCC_1997 IEAHSAGHAAG--TTFTVSLP---RPSDHPEKAPGQRPG-----------
MLBr_02440|M.leprae_Br4923 IGVWSKPGTG---STFTLSIPAAMPLYQDNDEQSGQPRGCDMWLNRPQRE
: : : :*
Mb3790c|M.bovis_AF2122/97 -------------------------------------
Rv3764c|M.tuberculosis_H37Rv -------------------------------------
MAV_0305|M.avium_104 -------------------------------------
MMAR_5316|M.marinum_M -------------------------------------
MUL_0464|M.ulcerans_Agy99 -------------------------------------
Mflv_5004|M.gilvum_PYR-GCK -------------------------------------
Mvan_1369|M.vanbaalenii_PYR-1 -------------------------------------
MSMEG_1515|M.smegmatis_MC2_155 -------------------------------------
TH_2428|M.thermoresistible__bu QTGNDAVQSVFTAENK---------------------
MAB_3340|M.abscessus_ATCC_1997 -------------------------------------
MLBr_02440|M.leprae_Br4923 EEEFKSMTPAQAMMQSEVTRGNVNDKCPDCGGRGIAG