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GEKCLPDELRTLFLFEALTDEQLATLCENGHIATFEPGPIHVEGDPATCFYVLIDGELVMSKRSGGVDIE TNRTSQRGVYCGAWSAYIPGEEHVYQATVRVTRPSRFFVLDATAFAEFMQKEFPMAVHLLEGHMVGGLRQ RQILGQREKLLALGQLSAGLTHQLNNPAGATARAVADLREGVGKMRHKLAMLADGEFTPAALKVLVSIQD EVAEQVAKSKSQELSALEISDREDQIGDWLEDHGISAAWDYAPTFVEAGLDVDWLERVEASVADVDCSAT LPGAIGWLKYTIDNELLMNQIAEASKRISALLAGAKQYSQMDRAEYQSANVHELIYSTIKTIFGDKVGKD NPIKLVWEKDPSLPELQCYPGDLNQVWTNIIDNAIQAMDGHGTLTIRTRRQSGDAGVVVEICDDGPGIPE DVIDRIFTPFFTTKPFGEGTGLGLDLAWRIVVEKHHGHLTVESVPGNTRFIVSLPWQAPAPE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1369 | - | - | 100% (483) | cyclic nucleotide-binding protein |
| M. vanbaalenii PYR-1 | Mvan_1370 | - | e-131 | 51.27% (474) | cyclic nucleotide-binding protein |
| M. vanbaalenii PYR-1 | Mvan_5174 | - | 6e-15 | 30.93% (194) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3790c | - | 4e-13 | 32.46% (191) | putative two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_5004 | - | 0.0 | 85.89% (482) | cyclic nucleotide-binding protein |
| M. tuberculosis H37Rv | Rv3764c | - | 4e-13 | 32.46% (191) | two component sensor kinase |
| M. leprae Br4923 | MLBr_02440 | - | 8e-06 | 33.64% (107) | putative two-component system sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3340 | - | 1e-11 | 31.78% (129) | sensor histidine kinase |
| M. marinum M | MMAR_5316 | tcrY | 4e-13 | 32.47% (194) | two-component sensor kinase TcrY |
| M. avium 104 | MAV_0305 | - | 5e-12 | 31.28% (195) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_1515 | - | 0.0 | 77.82% (487) | two-component sensor histidine kinase |
| M. thermoresistible (build 8) | TH_0454 | - | 5e-06 | 34.69% (98) | sensor-type histidine kinase PrrB |
| M. ulcerans Agy99 | MUL_0464 | phoR | 1e-10 | 26.70% (191) | two component system response phosphate sensor kinase, PhoR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3790c|M.bovis_AF2122/97 -------------------------------MGITAATEMALRRHLVAQL
Rv3764c|M.tuberculosis_H37Rv -------------------------------MGITAATEMALRRHLVAQL
MAV_0305|M.avium_104 -----MADTRRVWSLRLRLLVGQIVVLALVCLGITAVTELALNHHLVKQL
MMAR_5316|M.marinum_M MSSNRLVRRPGAWSLRLRLLVGQILVLAVVCVGITAATELALHHHLVAQL
MUL_0464|M.ulcerans_Agy99 ----MAERLPRAVQLRVGLVAATLALVLCGLLASGVAVTSILRHSLVSRI
Mvan_1369|M.vanbaalenii_PYR-1 -----MGEKCLPDELRTLFLFEALTDEQLATLCENGHIATFEPGPIHVEG
Mflv_5004|M.gilvum_PYR-GCK -----MGEKCLPDELRSLFLFEKLTDDQLQDLCAHGHIATFEPGPICTEG
MSMEG_1515|M.smegmatis_MC2_155 -----MSELCVRDELRTLFLFEHLTDAQLDTLCEAGRIEKFPPGPICTEG
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0454|M.thermoresistible__bu ------------------MNLVTRLFRRTPSLRTRVAFATAIAAAIVVGI
MLBr_02440|M.leprae_Br4923 --------------------------------------------------
Mb3790c|M.bovis_AF2122/97 DNQLGGTSYRSVLMYPEKMPRPPWRRETHNYIRSGPGPRFLDAPGQPAGM
Rv3764c|M.tuberculosis_H37Rv DNQLGGTSYRSVLMYPEKMPRPPWRHETHNYIRSGPGPRFLDAPGQPAGM
MAV_0305|M.avium_104 DGQLAGTSFRSALMYPE--PNHP-RHEHSPYPRPGPGPRFLDAPGQPAGM
MMAR_5316|M.marinum_M DGQLGGTSHRSALMYPE--SSHRFWRHQHRYWRPGPGPRFLDAPGQPAGM
MUL_0464|M.ulcerans_Agy99 DSTLLEASRT--------WAQASWRHSMPSVEGPDP------ARPPSKFY
Mvan_1369|M.vanbaalenii_PYR-1 DPATCFYVLIDGELVMSKRSGGVDIETNRTSQRGVYCGAWSAYIPGEEHV
Mflv_5004|M.gilvum_PYR-GCK DPATCFYVMIDGELVMSKRSGGVDLETNRTSQRGVYCGAWSAYVPGEDKT
MSMEG_1515|M.smegmatis_MC2_155 EPATCFYVLIDGELVMSKRSGGVDIQTNRTSQRGVYFGAWSAYIPGEEHI
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0454|M.thermoresistible__bu VGVVVWVGITND------RKERLDRRLDEAAGFALPFVPRGLEQIPPSPN
MLBr_02440|M.leprae_Br4923 ---------------------------------------------MFSAL
Mb3790c|M.bovis_AF2122/97 VAAVVSDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGL
Rv3764c|M.tuberculosis_H37Rv VAAVVSDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGL
MAV_0305|M.avium_104 VAAVVSHGKTVDAGYLTSSGTRDALTSTAQTQLEQIAGSRAPVTVNLDGL
MMAR_5316|M.marinum_M VGAVVRDGKAIVAGYLTNSGDRAEISPTAQAQLAAVAGSQDPVTLNLDGL
MUL_0464|M.ulcerans_Agy99 VRSISPDGRAMTA--INDRNAEPALPADN------DVGSDPTTLPSVNGS
Mvan_1369|M.vanbaalenii_PYR-1 YQATVRVTRPSRFFVLDATAFAEFMQKEFPMAVHLLEGHMVGGLRQRQIL
Mflv_5004|M.gilvum_PYR-GCK YQASVRVTRPSRFFVLDAAAFATFMQREFPMAVHLLEGHMVGGVRQRQII
MSMEG_1515|M.smegmatis_MC2_155 YEASVRLTQPSRIFVLDADTFAVFMQSQFPMAVHLLEGHKVGGRRQSQII
MAB_3340|M.abscessus_ATCC_1997 -MTRPRYGIGLRLLVVNSLVVLAGIATTS-------------VVAAIVGP
TH_0454|M.thermoresistible__bu DQDVVITVRRGDEVRSNSEVVLPELDADY-------------ADTYIDGV
MLBr_02440|M.leprae_Br4923 LLAGVLSGLAFVVGIVAGIRLSPRLIERRQ--------RLANEWAGITVL
:
Mb3790c|M.bovis_AF2122/97 GRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATT
Rv3764c|M.tuberculosis_H37Rv GRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATT
MAV_0305|M.avium_104 GRYRVVAAPSRNGSDIIVTGLSMANIDATLIRMLVIFGIVTVIALAAATI
MMAR_5316|M.marinum_M GRYRVVSALSRRGDELIVTGLSMSDVDATMIRMLIIFGIVTIVALVAATT
MUL_0464|M.ulcerans_Agy99 NIEWRAVSVHGPQGGLTTVAIDLSDVQHTVRSLVWLQIGIGAGVLVVVGL
Mvan_1369|M.vanbaalenii_PYR-1 GQREKLLALGQLSAGLTHQLN--NPAGATARAVADLREGVGKMRHKLAML
Mflv_5004|M.gilvum_PYR-GCK DTREKLLALGQLSAGLTHQLN--NPAGATARAVADLREGVGKMRHKLAML
MSMEG_1515|M.smegmatis_MC2_155 GQREKLLALGTITAGLTHQLN--NPAAATARAVADLREGVGKMRHKLAML
MAB_3340|M.abscessus_ATCC_1997 PMFRRLMDQQVSPGAGNDHPYERAFRDATAMSIGFAVAVSALAALTLS--
TH_0454|M.thermoresistible__bu RYRVRTVQTPYPIRTTLAVGATYDDTIADTANLHRRVILICTLAIGAATI
MLBr_02440|M.leprae_Br4923 QMLQRIIALMPLGAAVVDTYRDVVYLNEQAKELGLVRDRQLDDQAWRAAQ
:
Mb3790c|M.bovis_AF2122/97 AGIVIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPDANPSTEV
Rv3764c|M.tuberculosis_H37Rv AGIVIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPDANPSTEV
MAV_0305|M.avium_104 AGVVIIRRALAPLRRVAQTAREVADLPLARGEVELPVRVRESDANPSTEV
MMAR_5316|M.marinum_M AGAIIIRRALAPLRRVAQTATEVVDLPLDRGEVELPVRVSETDANPDTEV
MUL_0464|M.ulcerans_Agy99 AGFAVVQRSLRPLSEVEQTAAAIASGQLDR---------RVPERDPRTEV
Mvan_1369|M.vanbaalenii_PYR-1 ADGEFTPAALKVLVSIQDEVAEQVAKSKSQELSALEISDREDQIGDWLED
Mflv_5004|M.gilvum_PYR-GCK ADGKFTPEALRVLVSIQDEVAEQVAKSKAQELTAIETSDREDQIGDWLEA
MSMEG_1515|M.smegmatis_MC2_155 ADGKFSAETLRVLVTIQDEVAEQVAKNKSVELTALEASDREDQIGDWLED
MAB_3340|M.abscessus_ATCC_1997 --WYLSHRVHRSATALSQAASAVADG---------NYDIRVPPPRLGKEF
TH_0454|M.thermoresistible__bu AGWLLAAFAVRPFKQLAAQARSIDAG----------DEVPDVEIRGATEA
MLBr_02440|M.leprae_Br4923 QALGGDDVEFDLLPGKRPAAGRSGLS------------VHGHARLLSEKD
. :
Mb3790c|M.bovis_AF2122/97 GQLGSALNRMLDHIAAALSAR-------QASETRVRQFVADAS--HELRT
Rv3764c|M.tuberculosis_H37Rv GQLGSALNRMLDHIAAALSAR-------QASETCVRQFVADAS--HELRT
MAV_0305|M.avium_104 GQLGAALNRMLDHIADALSAR-------QASETRVRQFVADAS--HELRT
MMAR_5316|M.marinum_M GQLGSALNRMLDHIAAALSTR-------QASETRVRQFVADAS--HELRT
MUL_0464|M.ulcerans_Agy99 GQLSLAMNGMLSQIQVALAASEDSAEKARSSEERMRRFITDAS--HELRT
Mvan_1369|M.vanbaalenii_PYR-1 HGISAAWDYAPTFVEAGLDVD---------WLERVEASVADVD----CSA
Mflv_5004|M.gilvum_PYR-GCK HGISAAWDYAPTFVDAGLDVD---------WLERVEASIDDVD----CSA
MSMEG_1515|M.smegmatis_MC2_155 HNIPMAWEYAPTFVEAGLDID---------WLERISASIEDVHDETCGAK
MAB_3340|M.abscessus_ATCC_1997 DAVAAAFNKMAQRLGAVDEAR--------------RQMLADLA--HEIRT
TH_0454|M.thermoresistible__bu VEIADAVKGMLQRIWKEQDRT-------KAALASARDFASAAA--HELRT
MLBr_02440|M.leprae_Br4923 RRFAVVFVHDQSDYVRMEAAR--------------RDFVANVS--HELKT
. .
Mb3790c|M.bovis_AF2122/97 PLAAIRGYTELTQRIGDDPEAVAHAMSRVASETERITRLVEDLLLLARLD
Rv3764c|M.tuberculosis_H37Rv PLAAIRGYTELTQRIGDDPEAVAHAMSRVASETERITRLVEDLLLLARLD
MAV_0305|M.avium_104 PLAAIRGYTELTQRMGDDREAVAQAMSRVASETERMTRLVEDLLLLARLD
MMAR_5316|M.marinum_M PLAAIRGYTELAQRMGDDRAAVAHAMSRVGSETERITSLVEDLLLLARLD
MUL_0464|M.ulcerans_Agy99 PLTTIRGFAELYRQG--AARDVAMLLSRIESEASRMGLLVDDLLTLARLD
Mvan_1369|M.vanbaalenii_PYR-1 TLPGAIGWLKYTIDN-------ELLMNQIAEASKRISALLAGAKQYSQMD
Mflv_5004|M.gilvum_PYR-GCK TLPGAIGWLKYTIDN-------ELLMNQIAEASKRISALLAGAKQYSQMD
MSMEG_1515|M.smegmatis_MC2_155 TLQSALGWLKYTIDT-------ELRMNEIGEASRRISALLAGAKQYSQMD
MAB_3340|M.abscessus_ATCC_1997 PVAVLEAYMEAVEDG--VQQLDQQTVATLRDQTRRLTRFSIDVNALSVAE
TH_0454|M.thermoresistible__bu PLTAMRTNLEVLSTLDMPEEQRKEVLADVIRTQSRIEATLSALERLAQGE
MLBr_02440|M.leprae_Br4923 PVGAMALLAEALLASADDAETVSRFAEKVLIEANRLGYMVAELIELSRLQ
.: : : *: : :
Mb3790c|M.bovis_AF2122/97 S-GRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEP--VVIPGDA
Rv3764c|M.tuberculosis_H37Rv S-GRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEP--VVIPGDA
MAV_0305|M.avium_104 S-GRPLEREPVDLSRLAVDAVNDAHVAGPDHQWELDLPEEP--VVITGDA
MMAR_5316|M.marinum_M S-GRPLEREPVDMSRLAVDAVSDAHVAGPDQQWELDLPAEP--VVVTGDA
MUL_0464|M.ulcerans_Agy99 V-QRPLERNRVDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDE
Mvan_1369|M.vanbaalenii_PYR-1 R-AEYQSANVHELIYSTIKTIFGDKVG-KDNPIKLVWEKDPSLPELQCYP
Mflv_5004|M.gilvum_PYR-GCK R-AEYQQVNVHELLFSTVKTIFGDKLG-KDK-INLVWDKDKTLPELLCYP
MSMEG_1515|M.smegmatis_MC2_155 R-GAYQSADVHELLRSTL-MMFGGKIG-KDKPITLVKEMDKTLPELQCYP
MAB_3340|M.abscessus_ATCC_1997 SRTTSIDARSVSPADLVTTAVAAFAPRYQTKGVILTSHADDGLPDVWADP
TH_0454|M.thermoresistible__bu L-STSDDHVPVDITELLDRAAHEAMRIYPDLEVSLVP---APTVIIVGLP
MLBr_02440|M.leprae_Br4923 GAERLPNVTDIDVDIIVSEAIARHKVAADTAAIEVRTDPPSG-LRVLGDQ
. . : :
Mb3790c|M.bovis_AF2122/97 ARLHQVVTNLLANARVHTGPGTIVTTRLSTGPTHV--VLQVIDNGPGIPA
Rv3764c|M.tuberculosis_H37Rv ARLHQVVTNLLANARVHTGPGTIVTTRLSTGPTHV--VLQVIDNGPGIPA
MAV_0305|M.avium_104 ARLHQVLTNLLANARVHTGAGTVVTTRLSTEPAHT--VLQVIDNGPGIPA
MMAR_5316|M.marinum_M ARLHQVVANLLANARIHTGPGAVVTTRLSSGPTHV--VLEVIDNGPGIPE
MUL_0464|M.ulcerans_Agy99 PRLRQVLSNLVGNALQHTPDSADVTVRVGTAGENA--VLEVADKGPGMPA
Mvan_1369|M.vanbaalenii_PYR-1 GDLNQVWTNIIDNAIQAMDGHGTLTIRTRRQSGDAGVVVEICDDGPGIPE
Mflv_5004|M.gilvum_PYR-GCK GDLNQVWTNIIDNAIQAMDGQGTLTIRTMRENEDL-IRVEICDDGPGIPD
MSMEG_1515|M.smegmatis_MC2_155 GDLNQVWTNIIDNAIQAMDGHGTLTIRTARENDEM-IRVEICDDGPGIPE
MAB_3340|M.abscessus_ATCC_1997 ERMGQVLSNLLDNALRHTGPGGQVTVTATATGTGA--TIAVADTGDGVPA
TH_0454|M.thermoresistible__bu AGLRLAVDNAIANAVKHGG---ATRVQLSAVSSREGVEIAIDDNGTGVPE
MLBr_02440|M.leprae_Br4923 TLLVTALANLVSNAIAYSPGGSLVSISRRRRGDNI--EIAVTDRGIGIAL
: . * : ** : : * * *:.
Mb3790c|M.bovis_AF2122/97 ALQSEVFERFARGDTSRSRQAGSTGLGLAIVS-AVVKAHNGTITVSSSPG
Rv3764c|M.tuberculosis_H37Rv ALQSEVFERFARGDTSRSRQAGSTGLGLAIVS-AVVKAHNGTITVSSSPG
MAV_0305|M.avium_104 ELQSEVFERFARGDSSRSRKGGSTGLGLAIVS-AVVKAHNGTISVNSSPG
MMAR_5316|M.marinum_M AMQSEIFERFARGDTSRSRKGGSTGLGLAIVA-AVVKAHNGTITVNSSPG
MUL_0464|M.ulcerans_Agy99 EDAARVFERFYRTDSSRARASGGTGLGLSIVH-SLVKAHGGDVTLTTAPG
Mvan_1369|M.vanbaalenii_PYR-1 DVIDRIFTPFFTTKP----FGEGTGLGLDLAWRIVVEKHHGHLTVESVPG
Mflv_5004|M.gilvum_PYR-GCK DIIDRIFTPFFTTKP----FGEGTGLGLDLAWRIVVEKHKGNLTVQSQPG
MSMEG_1515|M.smegmatis_MC2_155 DIINRIFTPFFTTKP----FGEGTGLGLDLAWRIVVEKHNGDLRVYSEPG
MAB_3340|M.abscessus_ATCC_1997 EHLDRLFDRFYRADAARDRQHGGAGIGLSIAK-ALVEAHEGRIEAHSAGH
TH_0454|M.thermoresistible__bu EERERVFDRFTRGSTAS---HSGSGLGLALVA-QQAEIHGGTASLEASPL
MLBr_02440|M.leprae_Br4923 EDQERVFERFFRGDKARSRATGGSGLGLAIVK-HVAANHNGSIGVWSKPG
.:* * . .:*:** :. . * * :
Mb3790c|M.bovis_AF2122/97 Y--TEFAVRLPLDGWQPLESSPR---------------------------
Rv3764c|M.tuberculosis_H37Rv Y--TEFAVRLPLDGWQPLESSPR---------------------------
MAV_0305|M.avium_104 H--TEFTVRLPPNGWQPHASA-----------------------------
MMAR_5316|M.marinum_M R--TEFVVRLPLDAWQRSGVPPG---------------------------
MUL_0464|M.ulcerans_Agy99 EG-CCFRVTLPRVSEAAVELTEPVS-------------------------
Mvan_1369|M.vanbaalenii_PYR-1 N--TRFIVSLPWQAPAPE--------------------------------
Mflv_5004|M.gilvum_PYR-GCK D--TRFVICLPLAAPAPTGPSNE---------------------------
MSMEG_1515|M.smegmatis_MC2_155 N--TRFVVLLPLQAPPPDGDSSN---------------------------
MAB_3340|M.abscessus_ATCC_1997 AAGTTFTVSLPRPSDHPEKAPGQRPG------------------------
TH_0454|M.thermoresistible__bu GG-ARLVLRLPGPR------------------------------------
MLBr_02440|M.leprae_Br4923 TG-STFTLSIPAAMPLYQDNDEQSGQPRGCDMWLNRPQREEEEFKSMTPA
: : :*
Mb3790c|M.bovis_AF2122/97 ---------------------------
Rv3764c|M.tuberculosis_H37Rv ---------------------------
MAV_0305|M.avium_104 ---------------------------
MMAR_5316|M.marinum_M ---------------------------
MUL_0464|M.ulcerans_Agy99 ---------------------------
Mvan_1369|M.vanbaalenii_PYR-1 ---------------------------
Mflv_5004|M.gilvum_PYR-GCK ---------------------------
MSMEG_1515|M.smegmatis_MC2_155 ---------------------------
MAB_3340|M.abscessus_ATCC_1997 ---------------------------
TH_0454|M.thermoresistible__bu ---------------------------
MLBr_02440|M.leprae_Br4923 QAMMQSEVTRGNVNDKCPDCGGRGIAG