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MRNQARALVLVVLSLVTAVVLGIASVFVSALALGATALIVPGTGTPDSDVVAGYRENAWNRYIDGIVCTD PGECADPDLVGIPYPASFWPLSFLPGWCVPGRCEKWDVSVGEGTENLLAALSPFLAAESAEEVFVFGYSQ GGAVVANALTQLTDLSEDVKSRLNVVTIGGIENPDGGMWQRLAWLRYLLGEPVPILDLSFDPAMPTDTGI PTTTIGFEYDPVVYAPLYWGNPFAIVNMIAAFDTVHGYYLAPNQNNDNPMPYGYTDATLAPQLDCGLSPA NCRTDSFGNSYIMIPATSLPLTDLVRSLADSLGIGWLAEPFIDLAEPVLREFVDLGFDWSGDPGISRALS ILPFKIFQNWLKVGVDLAVAAVKGVEAFIKNFIPEETASLDRSRPAESAGEETTAPETDVEAGDTAAAVA TDDTTDGEGTATVEEDGVAPEDVAGDEEQAVAEDVSGADGAEDATEEATDVVTEETTDVVTEDEVTVDDE DADSETTDDTDTGAAEVDDTSVDTAAAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1238 | - | - | 100% (518) | hypothetical protein Mvan_1238 |
| M. vanbaalenii PYR-1 | Mvan_1011 | - | 3e-20 | 27.22% (496) | hypothetical protein Mvan_1011 |
| M. vanbaalenii PYR-1 | Mvan_4726 | - | 7e-17 | 23.88% (578) | hypothetical protein Mvan_4726 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1465 | PE16 | 7e-22 | 29.45% (326) | PE family protein |
| M. gilvum PYR-GCK | Mflv_1918 | - | 2e-15 | 24.33% (522) | hypothetical protein Mflv_1918 |
| M. tuberculosis H37Rv | Rv1430 | PE16 | 7e-22 | 29.45% (326) | PE family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4141 | - | 1e-23 | 24.55% (440) | PE/PPE family protein |
| M. marinum M | MMAR_0383 | - | 3e-22 | 32.67% (303) | PE family protein |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2737 | - | 7e-47 | 32.46% (499) | PPE family protein |
| M. thermoresistible (build 8) | TH_4159 | - | 1e-113 | 42.41% (540) | PUTATIVE PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 4e-21 | 28.70% (338) | PE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1238|M.vanbaalenii_PYR-1 ----------MRNQARALVLVVLSLVTAVVLGIASVFVSALALGAT-ALI
TH_4159|M.thermoresistible__bu ----------MRQAARSILIAVVALLGVAAVAVSGTVTAAVMLAAK-AIV
Mb1465|M.bovis_AF2122/97 ----------MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPT-TQV
Rv1430|M.tuberculosis_H37Rv ----------MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPT-TQV
MMAR_0383|M.marinum_M ----------MSYVITAPEMLTTAATDLDGIGSAIKAASAAVAGPT-TGV
MUL_1034|M.ulcerans_Agy99 ----------MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALT-SGL
MSMEG_2737|M.smegmatis_MC2_155 ------MGTHARSVSRTLLITLVVVIGTVALAFASTISSAARLVATYALI
MAB_4141|M.abscessus_ATCC_1997 ----------MAGQYSVPGKRHSLRRYVATITAVAATCTVLAPLAMESRT
Mflv_1918|M.gilvum_PYR-GCK MGKGDFGLKASEFTGRSSTRFADSVRRRPGGATYGLYRHDGLGVGTWAWV
:
Mvan_1238|M.vanbaalenii_PYR-1 VPGTGTPDSDVVAGYR-------------ENAWNRYIDGIVCTDPGECAD
TH_4159|M.thermoresistible__bu VPGTGTPDANVVPNYL-------------ENFVDYYMGDTFCDESEACTG
Mb1465|M.bovis_AF2122/97 LAAAADEVSAAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVD
Rv1430|M.tuberculosis_H37Rv LAAAADEVSAAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVD
MMAR_0383|M.marinum_M AAAAADEVSGAIAKLFGMFGQEYQSVVAQASAFQTEFTRLLATAGDSYAI
MUL_1034|M.ulcerans_Agy99 LAAAQDEVSAAIAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAGAAYAQ
MSMEG_2737|M.smegmatis_MC2_155 VPGTGTPNPAVVQNYM-------------ENAVNHYLVPGGDCVGG-CEP
MAB_4141|M.abscessus_ATCC_1997 IASTLASYVIGIGGNN--------------DGASANIPRKLGGAYSVDYH
Mflv_1918|M.gilvum_PYR-GCK FARSSRSFPRSRRCWRYPRGVPTPVAVLVANTTALVMGGTFHPLTGPRDS
. : . :
Mvan_1238|M.vanbaalenii_PYR-1 PDLVG---------------------------------------------
TH_4159|M.thermoresistible__bu DDLVG---------------------------------------------
Mb1465|M.bovis_AF2122/97 AEAAN-------------------AALVDTAATG-------------ASE
Rv1430|M.tuberculosis_H37Rv AEAAN-------------------AALVDTAATG-------------ASE
MMAR_0383|M.marinum_M TEASN----------ALGALNTQAQTLLG-GAFGTAAG------TSATGP
MUL_1034|M.ulcerans_Agy99 AEAANASLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTAVSST
MSMEG_2737|M.smegmatis_MC2_155 PIAVP---------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 PVS-----------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK PEFVT---------------------------------------------
Mvan_1238|M.vanbaalenii_PYR-1 ---------------IPYP-------------ASFWPLSFLPGWCVPGRC
TH_4159|M.thermoresistible__bu ---------------VNYP-------------ASFWPLFIFPGWCEPDRC
Mb1465|M.bovis_AF2122/97 LGSGGRTALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQF
Rv1430|M.tuberculosis_H37Rv LGSGGRTALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQF
MMAR_0383|M.marinum_M LAAGTHVAFVMGGTAIPWPDATYVTAVQDLFIDPHFPGFTTQVLFTPEQL
MUL_1034|M.ulcerans_Agy99 LMADPVVALIMGGTSVPLPGPGYVSDINNNYIQPLFSGAIPQALFTPEQF
MSMEG_2737|M.smegmatis_MC2_155 ------------------------------YIAQFWP-IPLPGWG-GLEG
MAB_4141|M.abscessus_ATCC_1997 -----------------------------------YPGAIWPVSGLTAPT
Mflv_1918|M.gilvum_PYR-GCK -------------------AYLDNAVDNQISAAYGYAVTNAVAVYTPEEF
:
Mvan_1238|M.vanbaalenii_PYR-1 EKWD---------VSVGEGTENLL--------------AALSPFLAA---
TH_4159|M.thermoresistible__bu EKWN---------VSVGDGVAGLN--------------AELINTWQE---
Mb1465|M.bovis_AF2122/97 QPWT-GIPSLTYDQSVAEGAGYLH--------------TAIMQQVA----
Rv1430|M.tuberculosis_H37Rv QPWT-GIPSLTYDQSVAEGAGYLH--------------TAIMQQVA----
MMAR_0383|M.marinum_M WPFTSNLGSLTFGQSVAQGVAILR--------------DALSAQLSD---
MUL_1034|M.ulcerans_Agy99 WPVTPGLGNLTFNQSVAQGVTLLN--------------DAINTQLA----
MSMEG_2737|M.smegmatis_MC2_155 AKWN---------VSVGSGVTSLT--------------TRYNNVLVNPDF
MAB_4141|M.abscessus_ATCC_1997 FKTS-----------VAQGRTNLN--------------DEIVTAGNQ---
Mflv_1918|M.gilvum_PYR-GCK FPLG----GLTFDDSVAEGLANLGRCLRAEPGCVFNADPAVAARVGTVAP
*..* *
Mvan_1238|M.vanbaalenii_PYR-1 ESAEEVFVFGYSQGGAVVANALTQLTDLSED---VKSRLNVVTIGGIENP
TH_4159|M.thermoresistible__bu EPDAEIVIAGYSQGGAVVSNELRNLAKLTPE---QKERLEVVMIGNIANP
Mb1465|M.bovis_AF2122/97 -AGNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNP
Rv1430|M.tuberculosis_H37Rv -AGNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNP
MMAR_0383|M.marinum_M -PANTAVVFGYSQSATIATNQIRAFMSQLN--PPSPSQLSFVLTGNPNNP
MUL_1034|M.ulcerans_Agy99 -LGNKVVAFGYSQSATIVNNEILALMAMGTG-APDPGDLSFIMVGAPNNP
MSMEG_2737|M.smegmatis_MC2_155 TDTDDISIFGYSQGATVASIVKGNLDNPDN-----ADHLNFFFIGNPQRP
MAB_4141|M.abscessus_ATCC_1997 ----PITIVGYSLGAVVVSKSHSDLLQRYPG---GNPNIQFVLMGSANTP
Mflv_1918|M.gilvum_PYR-GCK RHDDTFVVFGYSQSAAVASLLKRQLIDAPGP---EPAATTFMLAANPMRP
*:* .. :. : .. . *
Mvan_1238|M.vanbaalenii_PYR-1 DGGMWQRLAWLRYLLGEPVPILDLSFDPAMPTDTGIP------TTTIGFE
TH_4159|M.thermoresistible__bu DGGLWQRLSPLN-LVGE--LLLDATLGPPMITDSGIR------VTNIGYE
Mb1465|M.bovis_AF2122/97 NGGILARFPGLY------LQSLGLTFNGATP-DTDYA------TTIYTTQ
Rv1430|M.tuberculosis_H37Rv NGGILARFPGLY------LQSLGLTFNGATP-DTDYA------TTIYTTQ
MMAR_0383|M.marinum_M DGGVLERFNGLY------LPIVDVLFNGATPPDSPYP------TAIYTAQ
MUL_1034|M.ulcerans_Agy99 DGGLLARFPGFY------IPFLDVSFNGATPAANPYP------TSIFTAQ
MSMEG_2737|M.smegmatis_MC2_155 NGGFFERLAFLG-----TVPVLDATFGNPTPTDTCEHSDGTHCATDFALM
MAB_4141|M.abscessus_ATCC_1997 NGGIFARFPWLK------IPLADIESNGAWEPDQFKT-------KVINTE
Mflv_1918|M.gilvum_PYR-GCK NGGVLGRFPALT------IPILGITFHGATPTAGVDG---AYRTVDVVRQ
:**. *: : . .
Mvan_1238|M.vanbaalenii_PYR-1 YDPVV-YAPLYWGNPFAIVNMIAAFDTVHGYYLA-PNQNNDNPMPYGYTD
TH_4159|M.thermoresistible__bu YDPVV-YAPRYWGNPFAILNALVAFDTVHGQYLAGPNRPEAGELPYGYQP
Mb1465|M.bovis_AF2122/97 YDGFA-DFPKYPLNILADVNALLGIYYSHSLYYGLTPEQ--------VAS
Rv1430|M.tuberculosis_H37Rv YDGFA-DFPKYPLNILADVNALLGIYYSHSLYYGLTPEQ--------VAS
MMAR_0383|M.marinum_M YDGIA-NFPRYPLNVVSDVNAIMGFLYDEHYYAGLTSDPNAIGSGPTVAN
MUL_1034|M.ulcerans_Agy99 YDGIA-HAPQYRLNILSDINAIMGYFYVHGNYPDLMSG-----------Q
MSMEG_2737|M.smegmatis_MC2_155 YDGVV-DFPAYPLNLLATANALAGFWYVHGTYLAPDDDEPPTATPYGYTP
MAB_4141|M.abscessus_ATCC_1997 YDTYG-DFPAY-FNPLALANSIAAIQYAHPDAYYDRIDPAALDDP--DNP
Mflv_1918|M.gilvum_PYR-GCK YDGLGGDFPVRPLNLLATVNALLGYGIMHGETVDVPFAQ-------ARFQ
** * * .: * : . .
Mvan_1238|M.vanbaalenii_PYR-1 ATLAPQLD-----CGLSPANCRTDSFGNSYIMIPATSLPLTDLVRSLADS
TH_4159|M.thermoresistible__bu DEVEGLLEYARENCGEPGSNCRLDANGNKYIMIPAKSLPLADAVLSLGAS
Mb1465|M.bovis_AF2122/97 GIVLPVSS--------------PDT-NTTYILLPNEDLPLLQPLRGI---
Rv1430|M.tuberculosis_H37Rv GIVLPVSS--------------PDT-NTTYILLPNEDLPLLQPLRGI---
MMAR_0383|M.marinum_M AVQLPTSP--------------GYTGNTEYYMVLGQHLPLTDPLRQIPY-
MUL_1034|M.ulcerans_Agy99 AIQLPTSP--------------GYTGNTDYYMYLTQDLPLVQPIRDIPY-
MSMEG_2737|M.smegmatis_MC2_155 DEVKTAIEAANAPDGCTAANHCQRHGDTIYVTLPAKTLPIMQPLLDLGAA
MAB_4141|M.abscessus_ATCC_1997 NVVKTVQG------------------NTTYYLVRAEHLPLLQPLRDLTNP
Mflv_1918|M.gilvum_PYR-GCK GREG----------------------DTDYYLIGTDLLPLLQPLLLFVP-
.. * **: : : :
Mvan_1238|M.vanbaalenii_PYR-1 LGIGWLAEPFIDLAEPVLREFVDLGFDWSG----DPGISRALSILPFKIF
TH_4159|M.thermoresistible__bu VGLTPVVKPLVDLFAPVVKVLVDLGYDWSG----DPGVPRTLSLLPFNPF
Mb1465|M.bovis_AF2122/97 -----VPEPLLDLIEPDLRAIIELGYDRTG----YADVPTPAALFPVHI-
Rv1430|M.tuberculosis_H37Rv -----VPEPLLDLIEPDLRAIIELGYDRTG----YADVPTPAALFPVHI-
MMAR_0383|M.marinum_M -----VGTPIADLIQPSLRVIVDLGYSDYGPGQNYADIPTPASLFSLP--
MUL_1034|M.ulcerans_Agy99 -----AGPPLADLIQPQLRVLVDLGYSDYGPGLSYADVPTPAGLLSVP--
MSMEG_2737|M.smegmatis_MC2_155 TGTSALIIPIVDLISPLTQTLIETGYDRTN-----YGRPTPAGLIPRIN-
MAB_4141|M.abscessus_ATCC_1997 IG----ASFVLDAIEPTLRVFIDMAYDRDTG----PGTTTQFSFFTPSK-
Mflv_1918|M.gilvum_PYR-GCK -------RPILSALDAPLRVLVEDAYDRDAG----PGDPTTARWWPVKD-
. . . : ::: .:. . . .
Mvan_1238|M.vanbaalenii_PYR-1 QNWLKVGVDLAVAAVKGVEAFIKNF--------------IPEETAS---L
TH_4159|M.thermoresistible__bu NNWFEVGLKLIEATGEGVEAFLENFGITSGAPVVTNHTPAPAPTADSTQA
Mb1465|M.bovis_AF2122/97 -DPIAVPPQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSV
Rv1430|M.tuberculosis_H37Rv -DPIAVPPQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSV
MMAR_0383|M.marinum_M -NPLAVSYYLGKGA-----------------------VQG----VQAFMV
MUL_1034|M.ulcerans_Agy99 -NPFAVSYYLLKGS-----------------------LQAPYGAAVEIGV
MSMEG_2737|M.smegmatis_MC2_155 --LVKLVSDLINDIPEGINAALTPG-------------LTPLPGSTGPTV
MAB_4141|M.abscessus_ATCC_1997 -NIVDAFNKLPTAIAEGAHNVENGLAG-----------ATPKQSASPEKP
Mflv_1918|M.gilvum_PYR-GCK --FAGTAAKLIASVPVAVDNLTEGFG-----------LGRVLGTPVPGVF
:
Mvan_1238|M.vanbaalenii_PYR-1 DRSR---PAESAGEETTAPETDVEAGDTAAAVATDDTTDGEGTATVEEDG
TH_4159|M.thermoresistible__bu DLMR---AASVGADPMRAVKPAPEAAERVPVAESEPDEQGESPSGNAERT
Mb1465|M.bovis_AF2122/97 AAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAIQDLAAG
Rv1430|M.tuberculosis_H37Rv AAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAIQDLAAG
MMAR_0383|M.marinum_M DEG------------WLPQSYLP------------DTYPYVASLS-----
MUL_1034|M.ulcerans_Agy99 EAG------------LLGPESFP------------DTYPWVPSLN-----
MSMEG_2737|M.smegmatis_MC2_155 TATVQAPAPKTGDTENRIQAVTDVVGKDTNKVDVKTTDTGTEPVQPTDQP
MAB_4141|M.abscessus_ATCC_1997 ASPPVPQPGPTNPGSATTQIPAPEAPTPSVVSLSTAEPPAPPASAKAADP
Mflv_1918|M.gilvum_PYR-GCK GVGGPDLPDVDEGGAVTSDIDEDAVAQRDSASSTERSAPAEESRSAVGGA
.
Mvan_1238|M.vanbaalenii_PYR-1 VAPEDVAGDEEQAVAEDVSGADGAEDATEEATDVVTEETTDVVTEDEVTV
TH_4159|M.thermoresistible__bu TAPRLRLVTERDTATAPTTGTGPATQTEPETPDTPAEPTPEPVADTGTTP
Mb1465|M.bovis_AF2122/97 DLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV--------
Rv1430|M.tuberculosis_H37Rv DLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV--------
MMAR_0383|M.marinum_M --PGLNVYLGQPSVTGLSLLTGALGT---AARDLGWIPSWD---------
MUL_1034|M.ulcerans_Agy99 --PGLNFYLGQPSVTLLSLLSGGLG----DIFHLIPPPVFP---------
MSMEG_2737|M.smegmatis_MC2_155 --TDQGTVTGDVTAAAAPEVTAPADTDAVETPKANGKPLIRISPIAKPNE
MAB_4141|M.abscessus_ATCC_1997 TAISVSTAGASTARDQDFQPDTKPDPKSTPPPTKDSVGEADKSKNTLKPT
Mflv_1918|M.gilvum_PYR-GCK DSDGRDDVVDPEPAAPEAETSEAETVTETEADDADDADDGADADDEDIDA
.
Mvan_1238|M.vanbaalenii_PYR-1 D--------DEDADSETTDDTDTGAAEVDDTSVDTAAAA-----------
TH_4159|M.thermoresistible__bu DRLIGVGAQDPGTGPATKDAPATKDAPATKNAPATKDAKPALKAPVTKKP
Mb1465|M.bovis_AF2122/97 --------------------------------------------------
Rv1430|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0383|M.marinum_M --------------------------------------------------
MUL_1034|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2737|M.smegmatis_MC2_155 GMTAGTGTSGKAQPPSLRKALGIKGHPVRDLVKSVSKALGIDRPAKGGSN
MAB_4141|M.abscessus_ATCC_1997 LRLPKLPVAQPGTAPKSPKFPSLKNHLKSVPGLSEKKNPAADASSKHSQP
Mflv_1918|M.gilvum_PYR-GCK DGADADGEDTAGNTAEAA--------------------------------
Mvan_1238|M.vanbaalenii_PYR-1 -------------------------
TH_4159|M.thermoresistible__bu VMKDRTPADRKGQSTRAGKGLDRAA
Mb1465|M.bovis_AF2122/97 -------------------------
Rv1430|M.tuberculosis_H37Rv -------------------------
MMAR_0383|M.marinum_M -------------------------
MUL_1034|M.ulcerans_Agy99 -------------------------
MSMEG_2737|M.smegmatis_MC2_155 PKKATTDAKDTKAASDAKDAA----
MAB_4141|M.abscessus_ATCC_1997 ANAPAHTSDKTSDHASETGRGAA--
Mflv_1918|M.gilvum_PYR-GCK -------------------------