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MGKCGIKAAVTAAATAGVALAGAAAIGVAPTLSVSPQLTASLHYVRGTNIGYLPTEQEFEHFIDVVIDGT EVTPPDSPYEQILYNAGFWPFSRGGFADPTFNKAVSQGVESLEAEQLAAGDMIFGFSHGAVVASRYKATH TGNTYILVGNPSRPNGGIMQRFKGITVPIVDFTFSGATPDNGDLTYDVVRQYDGWADFPTYLWNPIAVAN AVVGILLVHGNTQFELTAADLEAAKATGDPDYYQFDADSNTHYYVVKTYPVPLLMPVAWLPDPIIAALDA PLRWFIELAYDRSDYSEPTRAKFFAPLKPLGAVDVPADEAETVESDTVVPDSSADVADGDVQLSRADDVA VDDEVAVDEVEVGGAEPEDSEVADAEDSEVEDPQATEPAVAEEVSEELEVPDEPAGEDDVQASGEDTPAP DETTDSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1011 | - | - | 100% (427) | hypothetical protein Mvan_1011 |
| M. vanbaalenii PYR-1 | Mvan_4726 | - | 1e-30 | 29.25% (335) | hypothetical protein Mvan_4726 |
| M. vanbaalenii PYR-1 | Mvan_4815 | - | 3e-30 | 30.69% (378) | hypothetical protein Mvan_4815 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1465 | PE16 | 5e-28 | 34.60% (237) | PE family protein |
| M. gilvum PYR-GCK | Mflv_5244 | - | 1e-126 | 55.06% (425) | hypothetical protein Mflv_5244 |
| M. tuberculosis H37Rv | Rv0159c | PE3 | 3e-28 | 30.93% (333) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 3e-06 | 22.61% (230) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 4e-29 | 27.47% (364) | PE/PPE family protein |
| M. marinum M | MMAR_4321 | - | 1e-29 | 31.19% (327) | PE family protein |
| M. avium 104 | MAV_3172 | - | 3e-05 | 30.51% (118) | prolipoprotein diacylglyceryl transferase |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 2e-26 | 27.46% (426) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 1e-43 | 31.32% (447) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 7e-30 | 30.89% (327) | PE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1011|M.vanbaalenii_PYR-1 ------MGKC-------------GIKAAVTAAATAGVALAGAAAIGVAPT
Mflv_5244|M.gilvum_PYR-GCK ------MGKHRVTGRRRPRTERRGVKAAVSAAAVAAAAVGGAVVLGAAPT
Mb1465|M.bovis_AF2122/97 --MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVS
Rv0159c|M.tuberculosis_H37Rv --MSYVIAAPEMLATTAADVDGIGSAIRAASASAAGPTTGLLAAAADEVS
MMAR_4321|M.marinum_M --MIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAADEVS
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
TH_3724|M.thermoresistible__bu --------------------------VVAVGALTWGGXGVASPAGQPERA
MAB_4141|M.abscessus_ATCC_1997 ------------MAGQYSVPGKRHSLRRYVATITAVAATCTVLAPLAMES
MSMEG_6144|M.smegmatis_MC2_155 -------------------------MIAAVAAVVTAALVTTVPALGATAF
MLBr_01232|M.leprae_Br4923 ---MKRLLATTLAALTVGTVSGFGSTVASSEPGEPWLPPSPVPVRENSPA
MAV_3172|M.avium_104 ----------------------MTKLLAYFPSPPQGVWHLGPVPIRAYAL
Mvan_1011|M.vanbaalenii_PYR-1 LSVSPQLTASLHYVRGTNIGYLPTEQEFEHFID-----------------
Mflv_5244|M.gilvum_PYR-GCK LSISPQLAASLHYLRGTNIGGIPTDQQYEDFIT-----------------
Mb1465|M.bovis_AF2122/97 AAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALV
Rv0159c|M.tuberculosis_H37Rv SAAAALFSEYARECQEVLKQAAAFHGEFTRALAAAGAAYAQAEASNTAAM
MMAR_4321|M.marinum_M EAIATLFDNYAQGYQAVSRQAAAFHDAFAQTLFAASDSYVRAEAAAVKAL
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKAL
TH_3724|M.thermoresistible__bu AALRLTATADAIIMPGTKIGYIPSQDEFTAYAT-----------------
MAB_4141|M.abscessus_ATCC_1997 RTIASTLASYVIGIGGNNDGASAN--------------------------
MSMEG_6144|M.smegmatis_MC2_155 TISGTRILHDPPYPEQLVPG------------------------------
MLBr_01232|M.leprae_Br4923 KIVYALGGARPPTFDWDYYTIRAGDEFFPDVNR-----------------
MAV_3172|M.avium_104 FIIAGIVAALLIGDRRWEAR------------------------------
Mvan_1011|M.vanbaalenii_PYR-1 -----------------------------------------VVIDGTEVT
Mflv_5244|M.gilvum_PYR-GCK -----------------------------------------TVIDGSGVA
Mb1465|M.bovis_AF2122/97 D------------------TAATGASELGSGGR------TALILGSTGTP
Rv0159c|M.tuberculosis_H37Rv S------------------GTAGSSGALGSVGMLSGNPLTALMMGGTGEP
MMAR_4321|M.marinum_M AGLTEPVANLFAPVLSGPESVAASATALLSGAPLKP-VEAALILSESGVP
MUL_0967|M.ulcerans_Agy99 AGLTEPVANLFAPVLSGPESVAASATALLSGAPLKP-VEAALILSESGVP
TH_3724|M.thermoresistible__bu -----------------------------------------AVIGATAGA
MAB_4141|M.abscessus_ATCC_1997 -------------------------------------------IPRKLGG
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------EFAGYD
MLBr_01232|M.leprae_Br4923 -------------------------------------------KLIDYPA
MAV_3172|M.avium_104 --------------------------------------------GGERGV
Mvan_1011|M.vanbaalenii_PYR-1 PPDSPYEQILYNAGFWPFSR-----------------GGFADPTFNKAVS
Mflv_5244|M.gilvum_PYR-GCK ATEGAYQKVPYNAGFRPFSH-----------------GGFDDLSYDDSFE
Mb1465|M.bovis_AF2122/97 RPPFDYMQQVYDRYIAPHYL-GYAFSGLYTPAQFQPWTGIPSLTYDQSVA
Rv0159c|M.tuberculosis_H37Rv ILSDRVLAIIDSAYIRPIFG-PNNPVAQYTPEQWWPFIGN--LSLDQSIA
MMAR_4321|M.marinum_M TPSASYISDVYTKYVEPNFPSATAPQGVSTPNGLYPFTGIKDLTLDISLA
MUL_0967|M.ulcerans_Agy99 TPSASYISDVYTKYVEPNFPSATAPQGVSTPNGLYPFTGIKDLSLDISLA
TH_3724|M.thermoresistible__bu PGAVDYLGVPG---------------------EFWPATGLDSLTFDASVA
MAB_4141|M.abscessus_ATCC_1997 AYSVDYHPVSYPGAIWP-------------------VSGLTAPTFKTSVA
MSMEG_6144|M.smegmatis_MC2_155 VEHIKYPASVFG-------------------------MDRGIWEAAGAVA
MLBr_01232|M.leprae_Br4923 RAPFRYVPTFLVP------------------------GPRDEVTIGEAIA
MAV_3172|M.avium_104 IYDIALWTVPFGLVG----------------------GRLYHLATDWRTY
Mvan_1011|M.vanbaalenii_PYR-1 QGVESLEAEQL--------AAGDMIFGFSHGAVVASRYK-----------
Mflv_5244|M.gilvum_PYR-GCK QGLELLAAQEP--------APGDVIFGFSQGAVVASLYK-----------
Mb1465|M.bovis_AF2122/97 EGAGYLHTAIMQQVAA---GNDVVVLGFSQGASVATLEMRHLASLPAGVA
Rv0159c|M.tuberculosis_H37Rv QGVTLLNNGINAELQN---GHDVVVFGYSQSAAVATNEIRALMALPPGQA
MMAR_4321|M.marinum_M RGATILNDAILQQLAALPAGSSVAVLGYSQSAVLSSLVMPKLLAEG----
MUL_0967|M.ulcerans_Agy99 RGATILNDAILQQLAALPAGSSVAVLGYSQSAVLSSRVMPKLLAEG----
TH_3724|M.thermoresistible__bu XGQAMLTPMVDGAIES---DTPIVVFGHSQSAVIATKEKQRLLAEYPD-P
MAB_4141|M.abscessus_ATCC_1997 QGRTNLNDEIVTAG-----NQPITIVGYSLGAVVVSKSHSDLLQRYP---
MSMEG_6144|M.smegmatis_MC2_155 AGVDRFVGVDDEGNP---ITEKIIVAGFSQGAIVIAYEKKRLMKLDEDER
MLBr_01232|M.leprae_Br4923 VATKNLNQAIHRG------TEPAAVVGLSQGSLALDTEQEQLATDPT--A
MAV_3172|M.avium_104 WGPGGAGFGAAVRIWDGGLGIWGAVALGAVGAWIGCRRHGIPLPAFADAL
. : : .:
Mvan_1011|M.vanbaalenii_PYR-1 ATHTGNTYILVGNPSRPNGGIMQRFKGITVP---IVDFTFSGATPDN---
Mflv_5244|M.gilvum_PYR-GCK ATHTGNTYILVGNPSRPNGGVMQRFNGAKIP---LLDVTFGGATPNNGVD
Mb1465|M.bovis_AF2122/97 PSPDQLSFVLLGNPNNPNGGILARFPGLYLQ---SLGLTFNGATP-DTDY
Rv0159c|M.tuberculosis_H37Rv PDPSRLAFTLIGNINNPNGGVLERYVGLYLP---FLDMSFNGATPPDSPY
MMAR_4321|M.marinum_M VTSSQVNFVLLGNPMNPNGGVLARFPDLTLP---SLGFTFYGATP-DNAF
MUL_0967|M.ulcerans_Agy99 VTSSQVNFVLLGNPMNPNGGVLARFPDLTLP---SLGFTFYGATP-DNAF
TH_3724|M.thermoresistible__bu DTAPDVTFVMVANPNRPNGGLLARFPGLYIP---ILGVTFNGATPAPADG
MAB_4141|M.abscessus_ATCC_1997 GGNPNIQFVLMGSANTPNGGIFARFPWLKIP---LADIESNGAWEPDQFK
MSMEG_6144|M.smegmatis_MC2_155 PTVDQLKFVTIGDPTGPNG--ILRWIPFRIP---IIGLTP--VRPPDTPY
MLBr_01232|M.leprae_Br4923 PPPDQLTFNTFGDPSGYHGFGKSVLASIFRPGDYIPLIDYTMPQRMDSQY
MAV_3172|M.avium_104 APGIILAQAIGRLGNYFNQELYGRETTLPWGLEIFYRRDPSGYIDPHSLD
:
Mvan_1011|M.vanbaalenii_PYR-1 ---GDLTYDVVRQYDGWADFPTYLWNPIAVANAVVGILLVHGNTQFELTA
Mflv_5244|M.gilvum_PYR-GCK GAPGDLTIDVTRQYDGWADFPRYLWNPVAIANAIAGIALIHGATQFELTA
Mb1465|M.bovis_AF2122/97 A-----TTIYTTQYDGFADFPKYPLNILADVNALLGIYYSH-SLYYGLTP
Rv0159c|M.tuberculosis_H37Rv Q-----TYMYTGQYDGYAHNPQYPLNILSDLNAFMGIRWVH-NAYP-FTA
MMAR_4321|M.marinum_M P-----TVSYTLEYDGFADFPRYPINLLADINAVMGIPFVH-ADYQHLTQ
MUL_0967|M.ulcerans_Agy99 P-----TVSYTLEYDGFADFPRYPINLLADINAVMGIPFVH-ADYQDLTQ
TH_3724|M.thermoresistible__bu P---FDSYDVAREFDGWADFPRYPLNLVATANAILGIYYLHGGYYELLTE
MAB_4141|M.abscessus_ATCC_1997 T------KVINTEYDTYGDFPAY-FNPLALANSIAAIQYAHPDAYYDRID
MSMEG_6144|M.smegmatis_MC2_155 E-----TTIINGEYDGWADFPDRPWNLIATANALLGIIYVHGRYEDKVDG
MLBr_01232|M.leprae_Br4923 D-----SNRVVAAYDGLSEFPDRADNLLAQLNCFAGGAISHTPSGFFNPE
MAV_3172|M.avium_104 G--------VSTGQVALVVQPTFLYELLWNLLIFVALLYADRRLTLGHGR
* : : . . .
Mvan_1011|M.vanbaalenii_PYR-1 ADLEAAKATGDPDYYQFDA--DSNTHYYVVKTYPVPLLMPVA---WLPDP
Mflv_5244|M.gilvum_PYR-GCK EQLEEAKASGDSDYYQFDA--DSNTHYYVIRTYPIPLLMPLDP--FLSDS
Mb1465|M.bovis_AF2122/97 EQVASGIVLPVSSPDT-----NTTYILLPNEDLPLLQPLRGI----VPEP
Rv0159c|M.tuberculosis_H37Rv AEVANAVPLPTSPGYTG----NTHYYMFLTQDLPLLQPIRAIP--FVGTP
MMAR_4321|M.marinum_M AQLDSAVQLPTEGPTQ------STYYMIPTEHLPLLAPLRFIP--YVGDP
MUL_0967|M.ulcerans_Agy99 AQLDSAVQLPTEGPTQ------STYYMIPTEHLPLLAPLRFIP--YVGDP
TH_3724|M.thermoresistible__bu NPDILDDPERTIVQQYG----DTTYYLIRTEQLPLLRPLRDLG---VPEE
MAB_4141|M.abscessus_ATCC_1997 PAALDDPDNPNVVKTVQG---NTTYYLVRAEHLPLLQPLRDLTNPIGASF
MSMEG_6144|M.smegmatis_MC2_155 WDLSTVPEKNIVETVNKAG-GKTTTYLIPTEKLPLLQPLRDLG---FPES
MLBr_01232|M.leprae_Br4923 DVPPQNIRTTVNSRGAK-----TTTYLIPVNHLPLTLPLRYLG---WSDA
MAV_3172|M.avium_104 LFALYVAGYCVGRFCVELLRDDTATHIAGIRINSFTSTFVFIG------A
: . .. :
Mvan_1011|M.vanbaalenii_PYR-1 IIAALDAPLRWFIELAYDR-------SDYSEPTRAKFFAP-LKPLGAVDV
Mflv_5244|M.gilvum_PYR-GCK AMAALDAPLRKFIETAYDR-------ADYSEPARASLF----KPWGADRS
Mb1465|M.bovis_AF2122/97 LLDLIEPDLRAIIELGYDR------TGYADVPTPAALFPVHIDPIAVPPQ
Rv0159c|M.tuberculosis_H37Rv IAELIQPDLRVLVDLGYG-------YGYADVPTPASLFAP-INPIAVASA
MMAR_4321|M.marinum_M LAELLEPNLRVLVNLGYGDPAYGYDTGPANVPTPFGLFPP-VSPLTVAEH
MUL_0967|M.ulcerans_Agy99 LAELLEPNLRVLVNFGYGDPAYGYDTGPANVPTPFGLFPP-VSPLTVAEH
TH_3724|M.thermoresistible__bu FVDALEPYVRRIVDLGYDR------NTPYGEPAPVRVLPPLTPAPGPATQ
MAB_4141|M.abscessus_ATCC_1997 VLDAIEPTLRVFIDMAYDRDTGPGTTTQFSFFTPSKNIVDAFNKLPTAIA
MSMEG_6144|M.smegmatis_MC2_155 FVAALEAPLRKIIDAAYKRNDPGRVTVTTTEETVVEDESEITQTAVTEID
MLBr_01232|M.leprae_Br4923 LVDQIDAVLQPKIDAAYAYN-----DNPLNKPISVDPVNGMDPIAGID--
MAV_3172|M.avium_104 VVYLMAAPKGREDPESLRGNQYVEEEPAEPEPATVAATTEAATEGVAAPA
: . .
Mvan_1011|M.vanbaalenii_PYR-1 PADEAETVESDTVVPDSSADVAD---------------------------
Mflv_5244|M.gilvum_PYR-GCK SAQTVDVVETTEPVAVEAVEADE---------------------------
Mb1465|M.bovis_AF2122/97 IGAAIGGPLTALDGLLDTVINDQLNPVVTSG--------------IYQAG
Rv0159c|M.tuberculosis_H37Rv LATG-------------TVQ------------------------------
MMAR_4321|M.marinum_M LAAGTQQGIVNSG---AALQAQGPPSIPLSD--------------IAHTL
MUL_0967|M.ulcerans_Agy99 LAAGTQQGIVNSG---AALQAQGPPSIPLSD--------------IAHTL
TH_3724|M.thermoresistible__bu HNAGQGITVASATSTPDKRTPVVEAP------------------------
MAB_4141|M.abscessus_ATCC_1997 EGAHNVENGLAGATPKQSASPEKPASPPVPQPGPTNPGSATTQIPAPEAP
MSMEG_6144|M.smegmatis_MC2_155 ETPSTDGDIDETAVQSTTQRRTVAN----------------------TAA
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_3172|M.avium_104 DGAEAAGADATAQRPEESAEPDVEKP------------------------
Mvan_1011|M.vanbaalenii_PYR-1 --------GDVQLSRADDVAVDDEVAVDEVEVGGAEPEDSEVADAEDSEV
Mflv_5244|M.gilvum_PYR-GCK --------EDTARSAPRDSGKR-SVDTESEESEGAEVADEALS--PDPVE
Mb1465|M.bovis_AF2122/97 AELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAIQ
Rv0159c|M.tuberculosis_H37Rv ----------GPQAALVSIGLLPQSALPNTYP-----------YLPSANP
MMAR_4321|M.marinum_M TANPPWAGTPALPPSTSPASSIEDFILAVQAAN-SSISRGFVKTLSTAYA
MUL_0967|M.ulcerans_Agy99 TANPPWAGTPALPPSTSPASSIEDFILAVQAAN-SSISRGFVKTLSTAYA
TH_3724|M.thermoresistible__bu --------VEEPPVQTGRSTLKREKPVSARHLVRNSLRAVPGLRRGEPAA
MAB_4141|M.abscessus_ATCC_1997 TPSVVSLSTAEPPAPPASAKAADPTAISVSTAGASTARDQDFQPDTKPDP
MSMEG_6144|M.smegmatis_MC2_155 DRTAETAEVAEVTEDVDELAEQEEPVKEEATKDDEVTKVADEADKATPVK
MLBr_01232|M.leprae_Br4923 ---------AELRDSILNVFAQLRSILPPPPG------------------
MAV_3172|M.avium_104 --------ESEETEAEAAEEPESEETEAAEEPGEPEAEEPEEPEAEEPEE
Mvan_1011|M.vanbaalenii_PYR-1 EDPQATEPAVAEEVSEELEVPDEPAGEDDVQASGEDTPAPDETTDSA---
Mflv_5244|M.gilvum_PYR-GCK EQDTAADEDHAESPDTDTDSTSETAADSDSSDDGADTAA-----------
Mb1465|M.bovis_AF2122/97 DLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV---
Rv0159c|M.tuberculosis_H37Rv GLMFN----FGQ------SSVTELSVLSGALGSVARLIPPIA--------
MMAR_4321|M.marinum_M TLLPT--TDIASELVFTLPSYNLNLFLDGVIQAINGQPIEGLINAIGNPI
MUL_0967|M.ulcerans_Agy99 TLLPT--TDIASELVFTLPSYNLNLFLDGVIQAINGQPIGD---------
TH_3724|M.thermoresistible__bu TPTPDVTPDVTPDAPAGQPEPAEPNESAAPPAAAEADDASE---------
MAB_4141|M.abscessus_ATCC_1997 KSTPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSLKNH
MSMEG_6144|M.smegmatis_MC2_155 ESTSVEKTDQAVKPDDTDKTVTTAEKVEKADEAEKVEKTKPNVRKVKRPQ
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_3172|M.avium_104 PETEEPEADSDEEPEEESGEAPEQPVAEEPEPAPQQPETKRRWGARLRDR
Mvan_1011|M.vanbaalenii_PYR-1 ------------------------------------------------
Mflv_5244|M.gilvum_PYR-GCK ------------------------------------------------
Mb1465|M.bovis_AF2122/97 ------------------------------------------------
Rv0159c|M.tuberculosis_H37Rv ------------------------------------------------
MMAR_4321|M.marinum_M AASTGLITLAGGFQLIVISYALDTILFGTPHPLP--------------
MUL_0967|M.ulcerans_Agy99 ------------------------------------------------
TH_3724|M.thermoresistible__bu ------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 LKSVPGLSEKKNPAADASSKHSQPANAPAHTSDKTSDHASETGRGAA-
MSMEG_6144|M.smegmatis_MC2_155 FNVFKPKKTRVTVPKAEPSTKAKPATKPDNDNDDTSDTTDKTAEKDAA
MLBr_01232|M.leprae_Br4923 ------------------------------------------------
MAV_3172|M.avium_104 LSGR--------------------------------------------