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TNDTEIAVLTAPPTLFTGGTIWTGRGDTDAVLVDGGVVVALGDEARRRGGAHHVDLDGGFLMPSFADGHA HPLYGGLEAVGPPVRRCGSVDEIVRAVQRYAADHPDEDWIVGASYDSSLAPEGLFDARWLDAAVPDRPVV LRAWDYHTVWCNSAALQRAGITAETPEPVLGEIPRRADGSPLGTLREWGATDLVMNAMPPRDEAVRVGAL GTAADYYLSRGVTWVQDAWVEPADVATYVAAAGQGALRMRFNLALYADPRHFDAQVTQFAEQRALVEAAR SPLLTAQTVKFFADGVVENETGALLAPYCTGLHDHAGQHNWEGESLAEAARRVDELGLQIHIHAIGDAAV RQALDAIEYVAAQNGPRDRRAVIAHCQLVDRDDLDRFAALSVIPNMQPLWAQLDALMTVLTIPRLGADRA DSQYPIRTLDASGAPLAFGSDWPVSSGAPLDGVAVAASRTTSDGDPPGGWTPHEILPVERALTAYTAAVA HQAFAENTWGIIEPGFSADMVWLDRDPRLTPPLELPSTSVVGTYLRGTLASPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1184 | - | - | 100% (544) | amidohydrolase 3 |
| M. vanbaalenii PYR-1 | Mvan_3625 | - | 5e-29 | 29.53% (552) | amidohydrolase 3 |
| M. vanbaalenii PYR-1 | Mvan_3420 | - | 6e-19 | 25.56% (450) | amidohydrolase 3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0567 | - | 3e-33 | 28.32% (558) | hypothetical protein Mb0567 |
| M. gilvum PYR-GCK | Mflv_2930 | - | 2e-52 | 29.95% (551) | amidohydrolase 3 |
| M. tuberculosis H37Rv | Rv0552 | - | 3e-33 | 28.32% (558) | hypothetical protein Rv0552 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2546 | - | 2e-56 | 32.23% (546) | amidohydrolase |
| M. marinum M | MMAR_1131 | - | 1e-37 | 28.55% (550) | metal-dependent hydrolase |
| M. avium 104 | MAV_4591 | - | 6e-34 | 27.64% (550) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_0445 | - | 0.0 | 76.81% (526) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_0643 | - | 2e-05 | 26.87% (201) | amidohydrolase 3 |
| M. ulcerans Agy99 | MUL_0894 | - | 6e-37 | 28.36% (550) | metal-dependent hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1184|M.vanbaalenii_PYR-1 ------------------------------------------------MT
MSMEG_0445|M.smegmatis_MC2_155 ------------------------------------------------MS
Mflv_2930|M.gilvum_PYR-GCK MCTACEWAPHFAAYGRRNPVTRRTALRAAAVTALAVTAAACATGPDSDTS
MAB_2546|M.abscessus_ATCC_1997 MCTACEWAPHFAALSAKS--TRRTALRAAVALTLAAGAAACSAGTVPAPT
MMAR_1131|M.marinum_M --------------------------------------------------
MUL_0894|M.ulcerans_Agy99 --------------------------------------------------
Mb0567|M.bovis_AF2122/97 --------------------------------------------------
Rv0552|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4591|M.avium_104 --------------------------------------------------
TH_0643|M.thermoresistible__bu --------------------------------------------------
Mvan_1184|M.vanbaalenii_PYR-1 NDTEIAVLTAPPTLFTGGTIWTGRGD---TDAVLVDGGVVVALGDEARR-
MSMEG_0445|M.smegmatis_MC2_155 --QRIVPTVNSSTVFRNGVIWSPDGNT-TTDALLISGGVVQAVGDAAKA-
Mflv_2930|M.gilvum_PYR-GCK VTSAASGAEAPDFVFHNGRVYTVTESAPWAEAVVVTGNSITFVGDNAAAR
MAB_2546|M.abscessus_ATCC_1997 TGSAGPQNTHADFVFRNGRVYTVAGPTEWAQAVAVQGNAITHVGDEAGAM
MMAR_1131|M.marinum_M ------MTGDADAIYTNGDIVTVDDEQPIAEAVAVKDGRIVAVGAHDDVV
MUL_0894|M.ulcerans_Agy99 ------MTGDADAIYTNGDIVTVDDEQPIAEAVAVKDGRIVAVGAHDDVV
Mb0567|M.bovis_AF2122/97 --------MADADLVMTGTVLTVDDARPTAEAIAVADGRVIAVGDRSEVA
Rv0552|M.tuberculosis_H37Rv --------MADADLVMTGTVLTVDDARPTAEAIAVADGRVIAVGDRSEVA
MAV_4591|M.avium_104 ------MHMGQADLVLTGTVLTVDEARPTAEALAVADGRIVAVGTRAEIA
TH_0643|M.thermoresistible__bu --------------------------------------------------
Mvan_1184|M.vanbaalenii_PYR-1 ----RGGAHHVDLDGGFLMPSFADGHAHPLYGGLEA-----VGPPVRRCG
MSMEG_0445|M.smegmatis_MC2_155 ----GSADVEVDLEGGFLMPSFGDGHAHPLYGGLES-----AGPAVRKGK
Mflv_2930|M.gilvum_PYR-GCK -ALAGPDTEVIDLAGKLLMPGFVEGHIHPFLGSFLS-----TGVDLQVP-
MAB_2546|M.abscessus_ATCC_1997 -ALVGPNTRVVDLAGRLLMPGFVEGHIHPFFGAFLS-----GGVNLQVS-
MMAR_1131|M.marinum_M REHLGPHTRRVDLAGNTLLPGFIDPHSHYINALTVANQVNVFAPPAGPAA
MUL_0894|M.ulcerans_Agy99 RENLGPHTRRVDLAGNTLLPGFIDPHSHYINALTVANQVNVFAPPAGPAA
Mb0567|M.bovis_AF2122/97 -GLVGANTRVIDLGAGCVMPGFVEAHGHPLLEAVVLS----DRFVDIRPV
Rv0552|M.tuberculosis_H37Rv -GLVGANTRVIDLGAGCVMPGFVEAHGHPLLEAVVLS----DRFVDIRPV
MAV_4591|M.avium_104 -AHVGPHTQTVDIGDGCVMPGFVEAHGHPLMEAVALS----DRIVDIRPV
TH_0643|M.thermoresistible__bu --------------------------------------------------
Mvan_1184|M.vanbaalenii_PYR-1 SVDEIVRAVQRY--AADHPDEDWIVGASYDSSLAPEG-LFDARWLDAAVP
MSMEG_0445|M.smegmatis_MC2_155 SVDEIVAAVKEY--ADAHPEQEWIVGASYDGSLASDG-LFDARWLDAVVP
Mflv_2930|M.gilvum_PYR-GCK TRQDALNAIAAY--ATDKADG-PVRGFGWRVDMFGPQ-GPTRTELDSVLP
MAB_2546|M.abscessus_ATCC_1997 TKEAALAAIAKY--AEENPVG-PVRGFGWRVDMFGPE-GPTRQELDSVLP
MMAR_1131|M.marinum_M DVEAIVAELKKFRDARDIADGEIIMAYGYDETVMPDGRTLHREDLDADFP
MUL_0894|M.ulcerans_Agy99 DVEAIVAELKKFRDARDIADGEIIMAYGYDETVMPDGRTLHREDLDADFP
Mb0567|M.bovis_AF2122/97 TMRDADDVVAAIRGEVARRGPAGAYLVGWDPLLQSGLGEPTLTWLDSLAP
Rv0552|M.tuberculosis_H37Rv TMRDADDVVAAIRGEVARRGPAGAYLVGWDPLLQSGLGEPTLTWLDSLAP
MAV_4591|M.avium_104 TLANADDVVAAVKSEVGKRGEAGAYLNGWDPLLQQGLPQPTLAWLDDIAP
TH_0643|M.thermoresistible__bu --------------------------------------------------
Mvan_1184|M.vanbaalenii_PYR-1 DRPVVLRAWDYHTVWCNSAALQRAGITAETPEPVLGEIPRRAD--GSPLG
MSMEG_0445|M.smegmatis_MC2_155 DRPVVLRAWDYHTFWVNSAALQRAGIAADTPDPVMGEIPRRAD--GSPLG
Mflv_2930|M.gilvum_PYR-GCK DRPGFFFAIDGHSMWANSKALEMAGISRDSEDPIPGFSYYVRDENGEPTG
MAB_2546|M.abscessus_ATCC_1997 DRPGFFFAVDAHSMWANSKSLEVAGINRETPDPVPGFSYYAKDSHGEPTG
MMAR_1131|M.marinum_M NNPVLVGHVSLHGAVLNSAAMQKFGISADTETPPGGVIVRKEGS-TEPDG
MUL_0894|M.ulcerans_Agy99 NNPVLVGHVSLHGAVLNSAAMQKFGISADTETPPGGVIVRKEGS-TEPDG
Mb0567|M.bovis_AF2122/97 NGPLVIIHNSGHKAYFNSHAAWLNGLTRDTADPKG--AKYGRDGNGELDG
Rv0552|M.tuberculosis_H37Rv NGPLVIIHNSGHKAYFNSHAAWLNGLTRDTADPKG--AKYGRDGNGELDG
MAV_4591|M.avium_104 DGPLVIIHNSGHKAFFNSRAAQRHGLNRDTPDPKG--ARYGRDADGELDG
TH_0643|M.thermoresistible__bu -VPVRVQHRSGVLWTLNSAGLARIGMPDHPD--------------GRLRS
* . . ** . *: .. .
Mvan_1184|M.vanbaalenii_PYR-1 TLREWGATDLVMNAMPPRDEAVRVGALGTAADYYLSRGVTWVQDAWV---
MSMEG_0445|M.smegmatis_MC2_155 TLREWGATDLVSAVMPARDESVRVGALSTAADYYLARGVTWVQDAWV---
Mflv_2930|M.gilvum_PYR-GCK YVLEVDAVLGLVNAIEPISTDSMEQLLRAWLPKASEAGITSVFDAGVPPI
MAB_2546|M.abscessus_ATCC_1997 FILEISAILDLVNAIEPVTAQSLQRALEDWLPNAAAAGITSVFDAGVPAV
MMAR_1131|M.marinum_M LIMETAFLPIFASLPKPTPEQEVQWSIAGQLLYAAVG-ITTAHEGLT---
MUL_0894|M.ulcerans_Agy99 LIMETAFLPIFASLPKPTPEQEVQWSIAGQLLYAAVG-ITTAHEGLT---
Mb0567|M.bovis_AF2122/97 TAEEIGAILPLLAGVADPSN--FGAMLRAECARLNRAGLTTCSEMAF---
Rv0552|M.tuberculosis_H37Rv TAEEIGAILPLLAGVADPSN--FGAMLRAECARLNRAGLTTCSEMAF---
MAV_4591|M.avium_104 TAEETGAVFPLLDGAIDTAG--YPRMLHAECARLNRAGLTTCSEMAF---
TH_0643|M.thermoresistible__bu ADPDWSNSLQRRETR--------IADLSAELTRYGVTGVTDATPGLD---
: : :*
Mvan_1184|M.vanbaalenii_PYR-1 ---EPADVATYVAAAGQGALRMRFNLALYADPRHFDAQVTQFAEQRALVE
MSMEG_0445|M.smegmatis_MC2_155 ---EPADVDTYVAAAQQGALRMRFNLAFYADPRHFDEQVTQYAAARDRVR
Mflv_2930|M.gilvum_PYR-GCK GGDQGALIELYTNVESRGELPFRVVASYSVKSPPVDDAVAELTGIRDRIS
MAB_2546|M.abscessus_ATCC_1997 AS-QAALIGLYGDIERRGRLPFRVVASYTVKAPPFGDVVAKFAETRDQVS
MMAR_1131|M.marinum_M ---HAADVALLRRAAAGG-----ADLIDVIAYPFILELDEVLPENPADTF
MUL_0894|M.ulcerans_Agy99 ---HAADIALLRRAAAGG-----VDIIDVIAYPFILELDEVLPENPADTF
Mb0567|M.bovis_AF2122/97 ---------------DPGYRPMVEAVRAELTVRLCTYEISNARMCTDATP
Rv0552|M.tuberculosis_H37Rv ---------------DPGYRPMVEAVRAELTVRLCTYEISNARMCTDATP
MAV_4591|M.avium_104 ---------------DPRFRPMVEQLRGQLTVRLRSYEISNPQLRTDATP
TH_0643|M.thermoresistible__bu ----------------------------------VGDVVRLTGMNRRGNL
Mvan_1184|M.vanbaalenii_PYR-1 AARSPLLTAQTVKFFADGVVENETGALLAPYCT--------GLHDHAGQH
MSMEG_0445|M.smegmatis_MC2_155 AAGSDLLTAQTVKFFADGVVENETGALLAPYCS--------GLHSHG-MQ
Mflv_2930|M.gilvum_PYR-GCK ---SDLVQVNVVKIIGDGTQEGYTAWLLEPYAD--------KPDSIG-GS
MAB_2546|M.abscessus_ATCC_1997 ---TDLVRVGAVKIMGDGTQGGYTAWLIDPYAD--------KPDSIG-TS
MMAR_1131|M.marinum_M GTYHNRLKLGGVKITLDGSPQGRTAFFTAPYLADGPG----GEKNWSGEL
MUL_0894|M.ulcerans_Agy99 GTYHNRLKLGGVKITLDGSPQGRTAFFTTPYLADGPG----GEKNWSGEL
Mb0567|M.bovis_AF2122/97 GQGDDMLRQVGIKIWVDGSPWVGNIDLTFPYLDTPATRAIGVPPGSRGCA
Rv0552|M.tuberculosis_H37Rv GQGDDMLRQVGIKIWVDGSPWVGNIDLTFPYLDTPATRAIGVPPGSRGCA
MAV_4591|M.avium_104 GEGDDMLRQVGIKIWVDGSPWIGNIALSFPYLDTEATRTIGVTPGSCGCA
TH_0643|M.thermoresistible__bu SQRVNCLAPGKRILHDDR--------------------------------
: : *
Mvan_1184|M.vanbaalenii_PYR-1 NWEGESLAEAARRVDELGLQIHIHAIGDAAVRQALDAIEYVAAQNGPRDR
MSMEG_0445|M.smegmatis_MC2_155 VWEGDSLAQAARRVDDLGLQIHIHAIGDAAVRQALDAIEYVVRQNGPRDR
Mflv_2930|M.gilvum_PYR-GCK PFTDDQWRQLVREVDAAGFDVHIHACGERTARTALDSIEAAAKVNPARER
MAB_2546|M.abscessus_ATCC_1997 PFTEQEWGELVGRIDSAGIDMHVHACGERTARVALDAFEAAIANNPARDR
MMAR_1131|M.marinum_M PFSQETVNGWFKRVYDLGLPLNIHANGDGAIDVLLAAHEYAAADDPTKDR
MUL_0894|M.ulcerans_Agy99 PFSQETVNGWFKRVYDLGLPLNIHANGDGAIDVLLAAHEYAAADDPTKDR
Mb0567|M.bovis_AF2122/97 NYTREQLAEIVGAYFPRGWQIACHVHGDGGVDTILDVYEEALRRNPRDDH
Rv0552|M.tuberculosis_H37Rv NYTREQLAEIVGAYFPRGWQIACHVHGDGGVDTILDVYEEALRRNPRDDH
MAV_4591|M.avium_104 NYTTEQLREIVGAYFPLGWQLACHVQGDAGVDTILDVYEEALKRHPRDDH
TH_0643|M.thermoresistible__bu -LDLTELTEWIATRHAAGGAVAIHCVTAAQLVVTLTALRAVGTHPQDR--
* : * * . .
Mvan_1184|M.vanbaalenii_PYR-1 RAVIAHCQLVDRDDLDRFAALSVIPNMQPLWAQLDALMTVLTIPRLGADR
MSMEG_0445|M.smegmatis_MC2_155 RPVIAHAQLVDDADLGRFAELGVIPNMQPLWAQMDALMTVLTIPRLGVER
Mflv_2930|M.gilvum_PYR-GCK RHTVAHLVYLEEPDSRRFGDLGVIAEFSANWFSADPDTVINLAARYGAPR
MAB_2546|M.abscessus_ATCC_1997 RHTVAHLIYVDDADSARFAKLGVVAQFSANWFSADPDTVVNMAARYGAPR
MMAR_1131|M.marinum_M HTTVIHSQFVRRDQLAKYVEYNLIPSLFTEHAFYFGDTHVRLR---GKEQ
MUL_0894|M.ulcerans_Agy99 HTTVIHSQFVRRDQLAKYVEYNLIPSLFTEHAFYFGDTHVRLR---GKEQ
Mb0567|M.bovis_AF2122/97 RLRLEHVGAIRPDQLRRAAELGVTCSIFVDQIHYWGDVIVDDL--FGAQR
Rv0552|M.tuberculosis_H37Rv RLRLEHVGAIRPDQLRRAAELGVTCSIFVDQIHYWGDVIVDDL--FGAQR
MAV_4591|M.avium_104 RLRLEHVGAIRPDQLQRAADLGVTCSIFVDQIHYWGDVLVDGL--FGEER
TH_0643|M.thermoresistible__bu ---IEHAAVVPDDSLEEIAALGLTVVTQPNFIAERGDQYRTDVP---ADE
: * : . . .: .
Mvan_1184|M.vanbaalenii_PYR-1 ADSQYPIRTLDASGAPLAFGSDWPVS----SGAPLDGVAVAASRTTSDGD
MSMEG_0445|M.smegmatis_MC2_155 AQKQYRIRSLENSGAALAFGSDWPVS----SGAPLDGIAVAVSRRTADGE
Mflv_2930|M.gilvum_PYR-GCK KDNLYRIQDVLSSGGRVSLGTDWPAAGYFSTYKPLDSIQIGVTRQLIGDP
MAB_2546|M.abscessus_ATCC_1997 KDNFYRIQDILRTGAHVALGTDWPAAGYFSTYKPLESIQIGVTRQLIGDP
MMAR_1131|M.marinum_M AHFLSPMRAAIDMGLRPTNHTDFNVT-------PLDQMFVLWTAVNRVSR
MUL_0894|M.ulcerans_Agy99 AHFLSPMRAAIDMGLRPTNHTDFNVT-------PLDQMFVLWTAVNRVSR
Mb0567|M.bovis_AF2122/97 GSRWMPAGSAVAAGMRISLHNDPPVT-------PEEPLRNISVAATRVAP
Rv0552|M.tuberculosis_H37Rv GSRWMPAGSAVAAGMRISLHNDPPVT-------PEEPLRNISVAATRVAP
MAV_4591|M.avium_104 GSRWMPAGSAVATGMRISLHNDPPVT-------PEEPLRNISVAATRKAP
TH_0643|M.thermoresistible__bu HHELWRLKSLLDAGIPTALSTDAPFG-------DADPWAAMRAAVHRTTG
* : .* :
Mvan_1184|M.vanbaalenii_PYR-1 PPGGWTP-HEILPVERALTAYTAAVAHQAFAENTWGIIEPGFSADMVWLD
MSMEG_0445|M.smegmatis_MC2_155 PEGGWTP-HEILPPEAALASYTGAVAYQAFAEKTWGRIVPGASADLVWLD
Mflv_2930|M.gilvum_PYR-GCK AAEVLSPADQKLTVEQAVHANTLGAAYQLRLDGLVGSVETGKRADLIVVD
MAB_2546|M.abscessus_ATCC_1997 GAQVLRPHDQKLSVAEAVRANTLGAAYQIRMDNKVGSVEVGKLADLIVLD
MMAR_1131|M.marinum_M SGEVIGA-DQRVTALEALKAITINAAYQYSEEQSKGSITVGKLADLVIVD
MUL_0894|M.ulcerans_Agy99 SGEVIGA-DQRVTAVEALKAITINAAYQYSEEQSKGSITVGKLADLVIVD
Mb0567|M.bovis_AF2122/97 SGRVLAP-EERLTVEQAIRAQTIDAAWQLFAEDAIGSLQVGKYADMVVLS
Rv0552|M.tuberculosis_H37Rv SGRVLAP-EERLTVEQAIRAQTIDAAWQLFAEDAIGSLQVGKYADMVVLS
MAV_4591|M.avium_104 SGRVLAP-EERLTVEQAIRAQTLDAAWQLFADDVIGSLEVGKYADLVVLS
TH_0643|M.thermoresistible__bu SGAVLGA-DERIDAGTALRMFFGTADRPTRPR----TVEPGQPADLCVLS
. .: : *: . : * **: :.
Mvan_1184|M.vanbaalenii_PYR-1 RDPRLTPPLELPSTSVVGTYLRGTLASPS------
MSMEG_0445|M.smegmatis_MC2_155 RDPRTVPPLELPAVGVRATYLQGRPAHTAAD----
Mflv_2930|M.gilvum_PYR-GCK RNIFEIDPHDIHSAAVTLTMMDGEIRHRV------
MAB_2546|M.abscessus_ATCC_1997 RNILECDPQDIHTATVLMTMMNGQVRHELQGLKS-
MMAR_1131|M.marinum_M NNPLTVDPMKLKDIAVLETIKEGRTIYREPATQSS
MUL_0894|M.ulcerans_Agy99 NNPLTVDPMKLKDIAVLETIKEGRTVYREPATQSS
Mb0567|M.bovis_AF2122/97 ADPRTVPPEQIADLAVRATFLAGRQVYRR------
Rv0552|M.tuberculosis_H37Rv ADPRTVPPEQIADLAVRATFLAGRQVYRR------
MAV_4591|M.avium_104 ADPRAVPPERIADLQVRATYLAGRRVYPQ------
TH_0643|M.thermoresistible__bu APPDRVLR-ELSAELVSATIVGGKPVYQKPV----
: * * *