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MADGAPRAQAVAVSGEKIVAVGSVDDCRAALPDAEVVDTGAAALAPGFIEPHGHPLISGVATQAPARSIA PWDCPTWADVQTVFTDALATTDPDTPLWFAGYDALLHGHPAPDAEELDGIFGDRVALLTDNSGHGIYFNS ALIRSYGWDSEPPADPVASHYGRNADGSLTGQGFELPVVTAVTGPLMAKMGNPLVSAAHYFALMARGGYT STSDMTYDPKFAAGYEALAAAPSCPLRVSMWEMSITDTYSDPATFAAGEAWLTKAGVKLWTDGSPWVGNI AISFPYLDTEATRTAGIDPATAGGTQSMNYSREQLDAILDRAAPAGWQMAFHANGDLALDLALDAYEDAL TRHGLLGSDHRWRLEHCGAGTRAQFDRAARLGVHVSLAPFQYYYWGDLLDGAMFDPEHGARWAAFGDAVA SGACVSLHNDGSVSPPTPVINIATAVTRRTRDGGVHRPDQAITLDQAWRAQTIDAARTLHRDHLVGSVEV GKLADFVELSADPWAVDPDALIDTVTVTGTWLGGRRIDLDEFLAAVGGADNAAHAHLAERNAKSCC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3625 | - | - | 100% (556) | amidohydrolase 3 |
| M. vanbaalenii PYR-1 | Mvan_1184 | - | 5e-29 | 29.53% (552) | amidohydrolase 3 |
| M. vanbaalenii PYR-1 | Mvan_3420 | - | 3e-14 | 24.57% (521) | amidohydrolase 3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0567 | - | 1e-92 | 39.25% (530) | hypothetical protein Mb0567 |
| M. gilvum PYR-GCK | Mflv_2885 | - | 0.0 | 84.39% (551) | amidohydrolase 3 |
| M. tuberculosis H37Rv | Rv0552 | - | 1e-92 | 39.25% (530) | hypothetical protein Rv0552 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1868c | - | 5e-97 | 41.78% (529) | hypothetical protein MAB_1868c |
| M. marinum M | MMAR_0898 | - | 9e-93 | 39.77% (533) | hypothetical protein MMAR_0898 |
| M. avium 104 | MAV_4591 | - | 1e-101 | 41.56% (527) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_1102 | - | 1e-100 | 42.75% (524) | twin-arginine translocation pathway signal |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0651 | - | 1e-90 | 39.02% (533) | hypothetical protein MUL_0651 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0567|M.bovis_AF2122/97 -----------------------------------MADADLVMTG-TVLT
Rv0552|M.tuberculosis_H37Rv -----------------------------------MADADLVMTG-TVLT
MMAR_0898|M.marinum_M -----------------------------------MADADVVITG-TVLT
MUL_0651|M.ulcerans_Agy99 -----------------------------------MADADVVITG-TVLT
MAV_4591|M.avium_104 ---------------------------------MHMGQADLVLTG-TVLT
MSMEG_1102|M.smegmatis_MC2_155 -----------------------------------MPAADLVFYG-TVMT
MAB_1868c|M.abscessus_ATCC_199 MSINRRQFVVGGAAATAATTGLAALAGCGHDTTDPDTGADLIFVGGPVVT
Mvan_3625|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2885|M.gilvum_PYR-GCK -------------------------------------MADVILTAKTIIT
Mb0567|M.bovis_AF2122/97 VDDARPTAEAIAVADGRVIAVGDRSEVAGLVGANTRVIDLGAGCVMPGFV
Rv0552|M.tuberculosis_H37Rv VDDARPTAEAIAVADGRVIAVGDRSEVAGLVGANTRVIDLGAGCVMPGFV
MMAR_0898|M.marinum_M VDDTRPTAEAIAVTDGRIVAVGDRSEVAGLIGEGTRTIDLGSGCLMPGFV
MUL_0651|M.ulcerans_Agy99 VDDTRPTAEAIAVTDGRVVAVGDRSEVAGLIGEGTRTIDLGSGCLMPGFV
MAV_4591|M.avium_104 VDEARPTAEALAVADGRIVAVGTRAEIAAHVGPHTQTVDIGDGCVMPGFV
MSMEG_1102|M.smegmatis_MC2_155 VDPARPTAEALAVSGGQIVAVGDRADVAQWVGPDTDVRELGNSCVAPGFV
MAB_1868c|M.abscessus_ATCC_199 VDGHGTTTEALAVAQGKIAAVGSRQDVMRLRGAQTDVIELDGLALLPAFV
Mvan_3625|M.vanbaalenii_PYR-1 MADGAPRAQAVAVSGEKIVAVGSVDDCRAAL-PDAEVVDTGAAALAPGFI
Mflv_2885|M.gilvum_PYR-GCK MNADVPRAEAVAVSGDTIAAVGSVEECRRAL-PGAEVVDTGATVLAPGFV
: . ::*:**: : *** : : . : . : *.*:
Mb0567|M.bovis_AF2122/97 EAHGHPLLEAVVLSDRFVDIRPVTMRDADDVVAAIRGEVARRGP-AGAYL
Rv0552|M.tuberculosis_H37Rv EAHGHPLLEAVVLSDRFVDIRPVTMRDADDVVAAIRGEVARRGP-AGAYL
MMAR_0898|M.marinum_M EAHGHPLMEAIVLSGRIVDIRPVTVRDSERVVAEICREAGERGS-AGAYL
MUL_0651|M.ulcerans_Agy99 EAHGHPLMEAIVLSGRIVDIRPVTVRDSERVVAEICREAGERGS-AGAYL
MAV_4591|M.avium_104 EAHGHPLMEAVALSDRIVDIRPVTLANADDVVAAVKSEVGKRGE-AGAYL
MSMEG_1102|M.smegmatis_MC2_155 EAHGHPLMEAVAVSDRIVDIRPVTLGTADAVVDAIHAEVAKRGA-AGAYL
MAB_1868c|M.abscessus_ATCC_199 EAHSHPSQIAATLGPPAVDVRPFVVPTGQQVMQKLADTVRSTPKGTQVLL
Mvan_3625|M.vanbaalenii_PYR-1 EPHGHPLISGVATQAPARSIAPWDCPTWADVQTVFTDALATTDPDTPLWF
Mflv_2885|M.gilvum_PYR-GCK EPHGHPLISGIATQAPARSIAPWDCPSWADVLDVFAETLATSDPDTPLLF
*.*.** . . .: * * . : :
Mb0567|M.bovis_AF2122/97 VGWDPLLQSGLGEPTLTWLDSLAPNGPLVIIHNSGHKAYFNSHAAWLNGL
Rv0552|M.tuberculosis_H37Rv VGWDPLLQSGLGEPTLTWLDSLAPNGPLVIIHNSGHKAYFNSHAAWLNGL
MMAR_0898|M.marinum_M IGWDPLLQPGLPEPTLAWLDDIAPNGPLVIIHNSGHKAYFNTHAAWLNGL
MUL_0651|M.ulcerans_Agy99 IGWDPLLQPGLPEPTLAWLDDIAPNGPLVIIHNSGHKAYFNTHAAWLNGL
MAV_4591|M.avium_104 NGWDPLLQQGLPQPTLAWLDDIAPDGPLVIIHNSGHKAFFNSRAAQRHGL
MSMEG_1102|M.smegmatis_MC2_155 NGWDPLLQTGLPEPTLAWLDGIAPEHPLVILHNSGHKAFFNSAAARAAGL
MAB_1868c|M.abscessus_ATCC_199 YGIDVLLQPDLQLPTRTILDALAPDHPVIIVANSGHAAYANTASFRLAGI
Mvan_3625|M.vanbaalenii_PYR-1 AGYDALLH-GHPAPDAEELDGIFGDRVALLTDNSGHGIYFNSALIRSYGW
Mflv_2885|M.gilvum_PYR-GCK AGFDALLH-GHPKPHAAELDEIFGDRVALVTDNSGHGVYFNSALMRSYGW
* * **: . * ** : : :: **** : *: *
Mb0567|M.bovis_AF2122/97 TRDTA-DPKGAKYGRDGNGELDGTAEEIGAI----LPLLAGVADPSNFGA
Rv0552|M.tuberculosis_H37Rv TRDTA-DPKGAKYGRDGNGELDGTAEEIGAI----LPLLAGVADPSNFGA
MMAR_0898|M.marinum_M TRDTP-DPKGAKYGRDANGELDGTAEETGAV----LPLLAGVTDPSNYPA
MUL_0651|M.ulcerans_Agy99 TRDTP-DPKGAKYGRDANGELDGTAEETGAV----LPLLAGVTDPSNYPA
MAV_4591|M.avium_104 NRDTP-DPKGARYGRDADGELDGTAEETGAV----FPLLDGAIDTAGYPR
MSMEG_1102|M.smegmatis_MC2_155 TRDTP-DPKGAKYGRDANGDLDGTAEESAAV----FTLLGGAISVADYPA
MAB_1868c|M.abscessus_ATCC_199 TRDTP-NPVGAEYVHGPDGELTGEVREAAALTTLAMPYLRNVAEPNAFQN
Mvan_3625|M.vanbaalenii_PYR-1 DSEPPADPVASHYGRNADGSLTGQGFELPVVTAVTGPLMAKMGNP---LV
Mflv_2885|M.gilvum_PYR-GCK DTNPPADPVASHFGRNPDGSLDGQGFELPVVTAVTGPLMATLGNP---LV
:.. :* .:.: :. :*.* * * .: . : .
Mb0567|M.bovis_AF2122/97 MLRAECARLNRAGLTTCSEMAFDPG-----YRPMVEAVRAELTVRLCTYE
Rv0552|M.tuberculosis_H37Rv MLRAECARLNRAGLTTCSEMAFDPG-----YRPMVEAVRAELTVRLCTYE
MMAR_0898|M.marinum_M MLRAECARLNRAGLTTCSEMAFDPG-----FRPLVEQLRDELTVRLRTYE
MUL_0651|M.ulcerans_Agy99 MLRAECARLNRAGLTTCLEMAFDPG-----FRPLVEQLRDELTVRLRTYE
MAV_4591|M.avium_104 MLHAECARLNRAGLTTCSEMAFDPR-----FRPMVEQLRGQLTVRLRSYE
MSMEG_1102|M.smegmatis_MC2_155 MLRAECARLNRAGLTTCSEMAFDPM-----FRPLLANLHDHLTVRLRTYE
MAB_1868c|M.abscessus_ATCC_199 -LHWAFGQLAAVGIATASEHSYSAAQQGDLYRRMAADP--GVKLRIRAYE
Mvan_3625|M.vanbaalenii_PYR-1 SAAHYFALMARGGYTSTSDMTYDPKFAAG-YEALAAAP--SCPLRVSMWE
Mflv_2885|M.gilvum_PYR-GCK AAALYYAVMARGGYTSTSDMTYDPKFAAG-YEALAAAP--SCPLRVSMWE
. : * :: : ::.. :. : :*: :*
Mb0567|M.bovis_AF2122/97 ISNARMCTDATPGQG-----DDMLRQVGIKIWVDGSPWVGNIDLTFPYLD
Rv0552|M.tuberculosis_H37Rv ISNARMCTDATPGQG-----DDMLRQVGIKIWVDGSPWVGNIDLTFPYLD
MMAR_0898|M.marinum_M ISNAQLSTEASPGDG-----DDMLRQVGIKIWVDGSPWIGNIDLSFPYLD
MUL_0651|M.ulcerans_Agy99 ISNAQLSTEASPGDG-----DDMLRQVGIKIWVDGSPWIGNIDLSFPYLD
MAV_4591|M.avium_104 ISNPQLRTDATPGEG-----DDMLRQVGIKIWVDGSPWIGNIALSFPYLD
MSMEG_1102|M.smegmatis_MC2_155 MSTAALHTDAQPFEG-----DDVVRQVGIKIWVDGSPWIGNIDLTFPYLD
MAB_1868c|M.abscessus_ATCC_199 MGAPELAKDPTHVAGPAAGADQLFAQIGMKLWADGSPWQGNIFTSFPYLD
Mvan_3625|M.vanbaalenii_PYR-1 MSITDTYSDPATFAAG----EAWLTKAGVKLWTDGSPWVGNIAISFPYLD
Mflv_2885|M.gilvum_PYR-GCK VSTSDTYSEAVTFAAG----EASLTKTGVKLWTDGSPWVGNIAISFPYLD
:. . .:. . : . : *:*:*.***** *** :*****
Mb0567|M.bovis_AF2122/97 TPATRAIGVPPGSRG---CANYTREQLAEIVGAYFPRGWQIACHVHGDGG
Rv0552|M.tuberculosis_H37Rv TPATRAIGVPPGSRG---CANYTREQLAEIVGAYFPRGWQIACHVHGDGG
MMAR_0898|M.marinum_M TAATRTIGVTPGSCG---CANYTREQLAEIVGAYFPLGWPIACHVQGDAG
MUL_0651|M.ulcerans_Agy99 TAATRTIGVTPGSCG---CANYTREQLAETVGAYFPLGWPIACHVQGDAG
MAV_4591|M.avium_104 TEATRTIGVTPGSCG---CANYTTEQLREIVGAYFPLGWQLACHVQGDAG
MSMEG_1102|M.smegmatis_MC2_155 TDATRTIGVVPGSCG---HANYTPEQLAEIVDTYYPQGWQMACHVHGDAG
MAB_1868c|M.abscessus_ATCC_199 TAATRRMGLEPHHHG---GMNYTPAQVTELATAFIEQGWQLACHVHGDRA
Mvan_3625|M.vanbaalenii_PYR-1 TEATRTAGIDPATAGGTQSMNYSREQLDAILDRAAPAGWQMAFHANGDLA
Mflv_2885|M.gilvum_PYR-GCK SEATRTAGIDPATAGGAHSMNYSREQLDAILDKAAPAGWQMAFHANGDLA
: *** *: * * **: *: ** :* *.:** .
Mb0567|M.bovis_AF2122/97 VDTILDVYEEALRRN--PRDDHRLRLEHVGAIRPDQLRRAAELGVTCSIF
Rv0552|M.tuberculosis_H37Rv VDTILDVYEEALRRN--PRDDHRLRLEHVGAIRPDQLRRAAELGVTCSIF
MMAR_0898|M.marinum_M VDTILDVYEEALRSN--PRPDHRLRLEHVGAIRPEQLRRAADLGVTCSIF
MUL_0651|M.ulcerans_Agy99 VDTTLDVYEEALRSN--PRPDHRLRLEHVGAIRPEQLRRAADLGVTCSIF
MAV_4591|M.avium_104 VDTILDVYEEALKRH--PRDDHRLRLEHVGAIRPDQLQRAADLGVTCSIF
MSMEG_1102|M.smegmatis_MC2_155 VDTILDVYEKALRRW--PRDDHRLRLEHVGAITPEQLQRAHDLGVTCSLF
MAB_1868c|M.abscessus_ATCC_199 IDVVLDAYEKAQSP-----ASLRSRLEHVGAMTPAQFQRAARLGVHPSLF
Mvan_3625|M.vanbaalenii_PYR-1 LDLALDAYEDALTRHGLLGSDHRWRLEHCGAGTRAQFDRAARLGVHVSLA
Mflv_2885|M.gilvum_PYR-GCK LDLALDAYEDALTRHDLLGTDHRWRLEHCGAGTREHFDRAARLGVHVSLA
:* **.**.* . * **** ** :: ** *** *:
Mb0567|M.bovis_AF2122/97 VDQIHYWGDVIVDDLFGAQRGSRWMPAGSAVAAGMRISLHNDPPVTPEEP
Rv0552|M.tuberculosis_H37Rv VDQIHYWGDVIVDDLFGAQRGSRWMPAGSAVAAGMRISLHNDPPVTPEEP
MMAR_0898|M.marinum_M VDQIHYWGDVIVDGLFGPERGSRWMPAGSAVATGMRISLHNDPPVTPEEP
MUL_0651|M.ulcerans_Agy99 VDQIHYWGDAIVDGLFGPERGSRWMPAGSAVATGMRISLHNDPPVTPEEP
MAV_4591|M.avium_104 VDQIHYWGDVLVDGLFGEERGSRWMPAGSAVATGMRISLHNDPPVTPEEP
MSMEG_1102|M.smegmatis_MC2_155 VDQIHYWGDIIVDGLFGAERGERWMPVGSAVATGMRVSLHNDPPVTPEEP
MAB_1868c|M.abscessus_ATCC_199 IEHVYFWGDPLIDELFGQDHGAHWMSAKSALDAGLRISFHNDGNVSPPNP
Mvan_3625|M.vanbaalenii_PYR-1 PFQYYYWGDLLDGAMFDPEHGARWAAFGDAVASGACVSLHNDGSVSPPTP
Mflv_2885|M.gilvum_PYR-GCK PFQYYYWGDLLDGAIFDHEHGSRWAAFGDAVASGACVSLHNDGSVSPPTP
: ::*** : . :*. ::* :* . .*: :* :*:*** *:* *
Mb0567|M.bovis_AF2122/97 LRNISVAATRVAP-SGRVLAPEERLTVEQAIRAQTIDAAWQLFAEDAIGS
Rv0552|M.tuberculosis_H37Rv LRNISVAATRVAP-SGRVLAPEERLTVEQAIRAQTIDAAWQLFAEDAIGS
MMAR_0898|M.marinum_M LRNISVAATRVAP-SGRVLAPEERLTVEQAIRAQTIDAAWQMFADDIIGS
MUL_0651|M.ulcerans_Agy99 LRNISVAATRVAP-SDRVLAPEERLTVEQAIRAQTIDAAWQMFADDIIGS
MAV_4591|M.avium_104 LRNISVAATRKAP-SGRVLAPEERLTVEQAIRAQTLDAAWQLFADDVIGS
MSMEG_1102|M.smegmatis_MC2_155 LRNIAVAATRTAP-SGRVLAPEQRITVEQAIRAQTIDAAWQLFSDDVIGS
MAB_1868c|M.abscessus_ATCC_199 LGNIATAVTRTAKGSGRVLAPEQRISVTQAVRAQTIDAAWQLHLDNEVGS
Mvan_3625|M.vanbaalenii_PYR-1 VINIATAVTRRTR-DGGVHRPDQAITLDQAWRAQTIDAARTLHRDHLVGS
Mflv_2885|M.gilvum_PYR-GCK VVSIATTVTRRTR-GGGVHRPDQAITLDQAWRAQTIDAARTLRREHLIGS
: .*:.:.** : .. * *:: ::: ** ****:*** : :. :**
Mb0567|M.bovis_AF2122/97 LQVGKYADMVVLSADPRTVPPEQIAD-LAVRATFLAGRQVYRR-------
Rv0552|M.tuberculosis_H37Rv LQVGKYADMVVLSADPRTVPPEQIAD-LAVRATFLAGRQVYRR-------
MMAR_0898|M.marinum_M LEVGKYADMVVLSADPRTVPPEEIAD-LEVRATFLAGRQVYRK-------
MUL_0651|M.ulcerans_Agy99 LEVGKYADMVVLSADPRTVPPEEIAD-LEVRATFLAGRQVYRK-------
MAV_4591|M.avium_104 LEVGKYADLVVLSADPRAVPPERIAD-LQVRATYLAGRRVYPQ-------
MSMEG_1102|M.smegmatis_MC2_155 LEVGKYADLVVLSADPRATEPARIAD-LDVQATFLAGRQVYPALG-----
MAB_1868c|M.abscessus_ATCC_199 LEVGKYADLVVLSADPHAVDPQALRD-ISVRATYLAGRQTYAAPVG----
Mvan_3625|M.vanbaalenii_PYR-1 VEVGKLADFVELSADPWAVDPDALIDTVTVTGTWLGGRRIDLDEFLAAVG
Mflv_2885|M.gilvum_PYR-GCK IEAGKLADFVELSADPWAVAPESLIESVQVQGTWVGGRRVDLDEFLTEVG
::.** **:* ***** :. * : : : * .*::.**:
Mb0567|M.bovis_AF2122/97 -------------------
Rv0552|M.tuberculosis_H37Rv -------------------
MMAR_0898|M.marinum_M -------------------
MUL_0651|M.ulcerans_Agy99 -------------------
MAV_4591|M.avium_104 -------------------
MSMEG_1102|M.smegmatis_MC2_155 -------------------
MAB_1868c|M.abscessus_ATCC_199 -------------------
Mvan_3625|M.vanbaalenii_PYR-1 GADNAAHAHLAERNAKSCC
Mflv_2885|M.gilvum_PYR-GCK GADAAVHTHLGQRTTKNCC