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CTACEWAPHFAAYGRRNPVTRRTALRAAAVTALAVTAAACATGPDSDTSVTSAASGAEAPDFVFHNGRVY TVTESAPWAEAVVVTGNSITFVGDNAAARALAGPDTEVIDLAGKLLMPGFVEGHIHPFLGSFLSTGVDLQ VPTRQDALNAIAAYATDKADGPVRGFGWRVDMFGPQGPTRTELDSVLPDRPGFFFAIDGHSMWANSKALE MAGISRDSEDPIPGFSYYVRDENGEPTGYVLEVDAVLGLVNAIEPISTDSMEQLLRAWLPKASEAGITSV FDAGVPPIGGDQGALIELYTNVESRGELPFRVVASYSVKSPPVDDAVAELTGIRDRISSDLVQVNVVKII GDGTQEGYTAWLLEPYADKPDSIGGSPFTDDQWRQLVREVDAAGFDVHIHACGERTARTALDSIEAAAKV NPARERRHTVAHLVYLEEPDSRRFGDLGVIAEFSANWFSADPDTVINLAARYGAPRKDNLYRIQDVLSSG GRVSLGTDWPAAGYFSTYKPLDSIQIGVTRQLIGDPAAEVLSPADQKLTVEQAVHANTLGAAYQLRLDGL VGSVETGKRADLIVVDRNIFEIDPHDIHSAAVTLTMMDGEIRHRV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2930 | - | - | 100% (606) | amidohydrolase 3 |
| M. gilvum PYR-GCK | Mflv_3116 | - | 1e-26 | 25.84% (538) | amidohydrolase 3 |
| M. gilvum PYR-GCK | Mflv_2885 | - | 2e-26 | 26.62% (571) | amidohydrolase 3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0567 | - | 2e-50 | 29.93% (558) | hypothetical protein Mb0567 |
| M. tuberculosis H37Rv | Rv0552 | - | 2e-50 | 29.93% (558) | hypothetical protein Rv0552 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2546 | - | 0.0 | 67.49% (606) | amidohydrolase |
| M. marinum M | MMAR_0898 | - | 6e-50 | 29.26% (557) | hypothetical protein MMAR_0898 |
| M. avium 104 | MAV_4591 | - | 5e-49 | 29.33% (549) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_4289 | - | 0.0 | 64.31% (608) | amidohydrolase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0651 | - | 2e-49 | 29.08% (557) | hypothetical protein MUL_0651 |
| M. vanbaalenii PYR-1 | Mvan_1184 | - | 3e-52 | 29.95% (551) | amidohydrolase 3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2930|M.gilvum_PYR-GCK MCTACEWAPHFAAYGRRNPVTRRTALRAAAVTALAVTAAACATGPDSDTS
MAB_2546|M.abscessus_ATCC_1997 MCTACEWAPHFAALSAKS--TRRTALRAAVALTLAAGAAACSAGTVPAPT
MSMEG_4289|M.smegmatis_MC2_155 MCTACEWAPHFTRPDADGPAPTRKPPRRS-----------------PEAT
Mb0567|M.bovis_AF2122/97 --------------------------------------------------
Rv0552|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0898|M.marinum_M --------------------------------------------------
MUL_0651|M.ulcerans_Agy99 --------------------------------------------------
MAV_4591|M.avium_104 --------------------------------------------------
Mvan_1184|M.vanbaalenii_PYR-1 ------------------------------------------------MT
Mflv_2930|M.gilvum_PYR-GCK VTSAASGAEAPDFVFHNGRVYTVTESAPWAEAVVVTGNSITFVGDNAAAR
MAB_2546|M.abscessus_ATCC_1997 TGSAGPQNTHADFVFRNGRVYTVAGPTEWAQAVAVQGNAITHVGDEAGAM
MSMEG_4289|M.smegmatis_MC2_155 AHRTGSADAHADFVFTNGRVHTVAGASPWAEAVAVRGNTITHVGRTAEVL
Mb0567|M.bovis_AF2122/97 -------MADADLVMT-GTVLTVDDARPTAEAIAVADGRVIAVGDRSEVA
Rv0552|M.tuberculosis_H37Rv -------MADADLVMT-GTVLTVDDARPTAEAIAVADGRVIAVGDRSEVA
MMAR_0898|M.marinum_M -------MADADVVIT-GTVLTVDDTRPTAEAIAVTDGRIVAVGDRSEVA
MUL_0651|M.ulcerans_Agy99 -------MADADVVIT-GTVLTVDDTRPTAEAIAVTDGRVVAVGDRSEVA
MAV_4591|M.avium_104 -----MHMGQADLVLT-GTVLTVDEARPTAEALAVADGRIVAVGTRAEIA
Mvan_1184|M.vanbaalenii_PYR-1 NDTEIAVLTAPPTLFTGGTIWTGRGD---TDAVLVDGGVVVALGDEARRR
. :: * : * ::*: * .. : :* :
Mflv_2930|M.gilvum_PYR-GCK ALAGPDTEVIDLAGKLLMPGFVEGHIHPFLGSFLSTG-----VDLQVPTR
MAB_2546|M.abscessus_ATCC_1997 ALVGPNTRVVDLAGRLLMPGFVEGHIHPFFGAFLSGG-----VNLQVSTK
MSMEG_4289|M.smegmatis_MC2_155 SAAGPRTRVIDLGGRLLMPGFVEGHTHPMLGAFLSHG-----VDLQVPTK
Mb0567|M.bovis_AF2122/97 GLVGANTRVIDLGAGCVMPGFVEAHGHPLLEAVVLSDRFVDIRPVTMRDA
Rv0552|M.tuberculosis_H37Rv GLVGANTRVIDLGAGCVMPGFVEAHGHPLLEAVVLSDRFVDIRPVTMRDA
MMAR_0898|M.marinum_M GLIGEGTRTIDLGSGCLMPGFVEAHGHPLMEAIVLSGRIVDIRPVTVRDS
MUL_0651|M.ulcerans_Agy99 GLIGEGTRTIDLGSGCLMPGFVEAHGHPLMEAIVLSGRIVDIRPVTVRDS
MAV_4591|M.avium_104 AHVGPHTQTVDIGDGCVMPGFVEAHGHPLMEAVALSDRIVDIRPVTLANA
Mvan_1184|M.vanbaalenii_PYR-1 ----GGAHHVDLDGGFLMPSFADGHAHPLYGGLEAVG----PPVRRCGSV
:. :*: :**.*.:.* **: .. .
Mflv_2930|M.gilvum_PYR-GCK QDALNAIAAYATDKADGPVRGFGWR-VDMFGPQGPTRTELDSVLPDRPGF
MAB_2546|M.abscessus_ATCC_1997 EAALAAIAKYAEENPVGPVRGFGWR-VDMFGPEGPTRQELDSVLPDRPGF
MSMEG_4289|M.smegmatis_MC2_155 DDALAAIAAHAEQHPEGVVRGFGWR-VDMFGPDGPSRADLDRVLPDRPGL
Mb0567|M.bovis_AF2122/97 DDVVAAIRGEVARRGPAGAYLVGWDPLLQSGLGEPTLTWLDSLAPNGPLV
Rv0552|M.tuberculosis_H37Rv DDVVAAIRGEVARRGPAGAYLVGWDPLLQSGLGEPTLTWLDSLAPNGPLV
MMAR_0898|M.marinum_M ERVVAEICREAGERGSAGAYLIGWDPLLQPGLPEPTLAWLDDIAPNGPLV
MUL_0651|M.ulcerans_Agy99 ERVVAEICREAGERGSAGAYLIGWDPLLQPGLPEPTLAWLDDIAPNGPLV
MAV_4591|M.avium_104 DDVVAAVKSEVGKRGEAGAYLNGWDPLLQQGLPQPTLAWLDDIAPDGPLV
Mvan_1184|M.vanbaalenii_PYR-1 DEIVRAVQRYAADHPDEDWIVGASYDSSLAPEGLFDARWLDAAVPDRPVV
: : : . . . ** *: * .
Mflv_2930|M.gilvum_PYR-GCK FFAIDGHSMWANSKALEMAGISRDSEDPIPGFSYYVRDENGEPTGYVLEV
MAB_2546|M.abscessus_ATCC_1997 FFAVDAHSMWANSKSLEVAGINRETPDPVPGFSYYAKDSHGEPTGFILEI
MSMEG_4289|M.smegmatis_MC2_155 FFAIDAHSMWANTAALQMAGIDRDTPDPVPGFSYFQRDADGEPTGYVLEV
Mb0567|M.bovis_AF2122/97 IIHNSGHKAYFNSHAAWLNGLTRDTADPKG--AKYGRDGNGELDGTAEEI
Rv0552|M.tuberculosis_H37Rv IIHNSGHKAYFNSHAAWLNGLTRDTADPKG--AKYGRDGNGELDGTAEEI
MMAR_0898|M.marinum_M IIHNSGHKAYFNTHAAWLNGLTRDTPDPKG--AKYGRDANGELDGTAEET
MUL_0651|M.ulcerans_Agy99 IIHNSGHKAYFNTHAAWLNGLTRDTPDPKG--AKYGRDANGELDGTAEET
MAV_4591|M.avium_104 IIHNSGHKAFFNSRAAQRHGLNRDTPDPKG--ARYGRDADGELDGTAEET
Mvan_1184|M.vanbaalenii_PYR-1 LRAWDYHTVWCNSAALQRAGITAETPEPVLG--EIPRRADGSPLGTLREW
: . *. : *: : *: :: :* : .*. * *
Mflv_2930|M.gilvum_PYR-GCK DAVLGLVNAIEPISTDSMEQLLRAWLPKASEAGITSVFDAGVPPIGGDQG
MAB_2546|M.abscessus_ATCC_1997 SAILDLVNAIEPVTAQSLQRALEDWLPNAAAAGITSVFDAGVPAVAS-QA
MSMEG_4289|M.smegmatis_MC2_155 NAVLGLVDAVEPISAPGMRRMLEGWLPAAAAAGITTVFDAGVPPVGGDQA
Mb0567|M.bovis_AF2122/97 GAILPLLAGVADP--SNFGAMLRAECARLNRAGLTTCSEMAFDPGYRPMV
Rv0552|M.tuberculosis_H37Rv GAILPLLAGVADP--SNFGAMLRAECARLNRAGLTTCSEMAFDPGYRPMV
MMAR_0898|M.marinum_M GAVLPLLAGVTDP--SNYPAMLRAECARLNRAGLTTCSEMAFDPGFRPLV
MUL_0651|M.ulcerans_Agy99 GAVLPLLAGVTDP--SNYPAMLRAECARLNRAGLTTCLEMAFDPGFRPLV
MAV_4591|M.avium_104 GAVFPLLDGAIDT--AGYPRMLHAECARLNRAGLTTCSEMAFDPRFRPMV
Mvan_1184|M.vanbaalenii_PYR-1 GATDLVMNAMPPRDEAVRVGALGTAADYYLSRGVTWVQDAWVEPADVATY
.* :: . * *:* : . .
Mflv_2930|M.gilvum_PYR-GCK ALIELYTNVESRGELPFRVVASYSVKSPP----VDDAVAELTGIRDRISS
MAB_2546|M.abscessus_ATCC_1997 ALIGLYGDIERRGRLPFRVVASYTVKAPP----FGDVVAKFAETRDQVST
MSMEG_4289|M.smegmatis_MC2_155 AMIALYADLDEAGALPFRVVASYAIKSPPPGGRFEDVLAQFRAARDSVGT
Mb0567|M.bovis_AF2122/97 EAVRAELTVR---------LCTYEISNAR----------MCTDATPGQGD
Rv0552|M.tuberculosis_H37Rv EAVRAELTVR---------LCTYEISNAR----------MCTDATPGQGD
MMAR_0898|M.marinum_M EQLRDELTVR---------LRTYEISNAQ----------LSTEASPGDGD
MUL_0651|M.ulcerans_Agy99 EQLRDELTVR---------LRTYEISNAQ----------LSTEASPGDGD
MAV_4591|M.avium_104 EQLRGQLTVR---------LRSYEISNPQ----------LRTDATPGEGD
Mvan_1184|M.vanbaalenii_PYR-1 VAAAGQGALRMR-------FNLALYADPRHFDAQVTQFAEQRALVEAARS
: . .
Mflv_2930|M.gilvum_PYR-GCK DLVQVNVVKIIGDGTQEGYTAWLLEPYAD---------KPDSIGGSPFTD
MAB_2546|M.abscessus_ATCC_1997 DLVRVGAVKIMGDGTQGGYTAWLIDPYAD---------KPDSIGTSPFTE
MSMEG_4289|M.smegmatis_MC2_155 DLVNVDVLKIVGDGTQGGYTAWLIEPYAD---------RPDSTGSSPFTE
Mb0567|M.bovis_AF2122/97 DMLRQVGIKIWVDGSPWVGNIDLTFPYLDTPATRAIGVPPGSRGCANYTR
Rv0552|M.tuberculosis_H37Rv DMLRQVGIKIWVDGSPWVGNIDLTFPYLDTPATRAIGVPPGSRGCANYTR
MMAR_0898|M.marinum_M DMLRQVGIKIWVDGSPWIGNIDLSFPYLDTAATRTIGVTPGSCGCANYTR
MUL_0651|M.ulcerans_Agy99 DMLRQVGIKIWVDGSPWIGNIDLSFPYLDTAATRTIGVTPGSCGCANYTR
MAV_4591|M.avium_104 DMLRQVGIKIWVDGSPWIGNIALSFPYLDTEATRTIGVTPGSCGCANYTT
Mvan_1184|M.vanbaalenii_PYR-1 PLLTAQTVKFFADGVVENETGALLAPYCTG--------LHDHAGQHNWEG
:: :*: ** . * ** . * :
Mflv_2930|M.gilvum_PYR-GCK DQWRQLVREVDAAGFDVHIHACGERTARTALDSIEAAAKVNPARERRHTV
MAB_2546|M.abscessus_ATCC_1997 QEWGELVGRIDSAGIDMHVHACGERTARVALDAFEAAIANNPARDRRHTV
MSMEG_4289|M.smegmatis_MC2_155 EQWHEMIGLFDAAGVNVHVHACGECTARVALDAIERAVAVNGPRDRRHTI
Mb0567|M.bovis_AF2122/97 EQLAEIVGAYFPRGWQIACHVHGDGGVDTILDVYEEALRRNPRDDHRLRL
Rv0552|M.tuberculosis_H37Rv EQLAEIVGAYFPRGWQIACHVHGDGGVDTILDVYEEALRRNPRDDHRLRL
MMAR_0898|M.marinum_M EQLAEIVGAYFPLGWPIACHVQGDAGVDTILDVYEEALRSNPRPDHRLRL
MUL_0651|M.ulcerans_Agy99 EQLAETVGAYFPLGWPIACHVQGDAGVDTTLDVYEEALRSNPRPDHRLRL
MAV_4591|M.avium_104 EQLREIVGAYFPLGWQLACHVQGDAGVDTILDVYEEALKRHPRDDHRLRL
Mvan_1184|M.vanbaalenii_PYR-1 ESLAEAARRVDELGLQIHIHAIGDAAVRQALDAIEYVAAQNGPRDRRAVI
:. : * : *. *: . ** * . : ::* :
Mflv_2930|M.gilvum_PYR-GCK AHLVYLEEPDSRRFGDLGVIAEFSANWFSADPDTVINLAARYGAPRKDNL
MAB_2546|M.abscessus_ATCC_1997 AHLIYVDDADSARFAKLGVVAQFSANWFSADPDTVVNMAARYGAPRKDNF
MSMEG_4289|M.smegmatis_MC2_155 AHLVFVDDADAARFAELGVVAQFSANWFSADPDTVQNMAARYGSPRKDHL
Mb0567|M.bovis_AF2122/97 EHVGAIRPDQLRRAAELGVTCSIFVDQIHYWGDVIV--DDLFGAQRGSRW
Rv0552|M.tuberculosis_H37Rv EHVGAIRPDQLRRAAELGVTCSIFVDQIHYWGDVIV--DDLFGAQRGSRW
MMAR_0898|M.marinum_M EHVGAIRPEQLRRAADLGVTCSIFVDQIHYWGDVIV--DGLFGPERGSRW
MUL_0651|M.ulcerans_Agy99 EHVGAIRPEQLRRAADLGVTCSIFVDQIHYWGDAIV--DGLFGPERGSRW
MAV_4591|M.avium_104 EHVGAIRPDQLQRAADLGVTCSIFVDQIHYWGDVLV--DGLFGEERGSRW
Mvan_1184|M.vanbaalenii_PYR-1 AHCQLVDRDDLDRFAALSVIPNMQPLWAQLDALMTVLTIPRLGADRADSQ
* : : * . *.* .: * * .
Mflv_2930|M.gilvum_PYR-GCK YRIQDVLSSGGRVSLGTDWPAAGYFSTYKPLDSIQIGVTRQLIGDPAAEV
MAB_2546|M.abscessus_ATCC_1997 YRIQDILRTGAHVALGTDWPAAGYFSTYKPLESIQIGVTRQLIGDPGAQV
MSMEG_4289|M.smegmatis_MC2_155 YRARDILRAGGRISLGTDWPAAGYFSTHKPLDAIEIAVTRQLIGDAHAPV
Mb0567|M.bovis_AF2122/97 MPAGSAVAAGMRISLHNDPPVT----PEEPLRNISVAATRVAPSGR----
Rv0552|M.tuberculosis_H37Rv MPAGSAVAAGMRISLHNDPPVT----PEEPLRNISVAATRVAPSGR----
MMAR_0898|M.marinum_M MPAGSAVATGMRISLHNDPPVT----PEEPLRNISVAATRVAPSGR----
MUL_0651|M.ulcerans_Agy99 MPAGSAVATGMRISLHNDPPVT----PEEPLRNISVAATRVAPSDR----
MAV_4591|M.avium_104 MPAGSAVATGMRISLHNDPPVT----PEEPLRNISVAATRKAPSGR----
Mvan_1184|M.vanbaalenii_PYR-1 YPIRTLDASGAPLAFGSDWPVS----SGAPLDGVAVAASRTTSDGD-PPG
:* ::: .* *.: . ** : :..:* ..
Mflv_2930|M.gilvum_PYR-GCK LSPADQKLTVEQAVHANTLGAAYQLRLDGLVGSVETGKRADLIVVDRNIF
MAB_2546|M.abscessus_ATCC_1997 LRPHDQKLSVAEAVRANTLGAAYQIRMDNKVGSVEVGKLADLIVLDRNIL
MSMEG_4289|M.smegmatis_MC2_155 LSPADQRLSVAEAVHANTLGAAYQLRLDDVVGSVEVGKRADLIVLDTDIF
Mb0567|M.bovis_AF2122/97 VLAPEERLTVEQAIRAQTIDAAWQLFAEDAIGSLQVGKYADMVVLSADPR
Rv0552|M.tuberculosis_H37Rv VLAPEERLTVEQAIRAQTIDAAWQLFAEDAIGSLQVGKYADMVVLSADPR
MMAR_0898|M.marinum_M VLAPEERLTVEQAIRAQTIDAAWQMFADDIIGSLEVGKYADMVVLSADPR
MUL_0651|M.ulcerans_Agy99 VLAPEERLTVEQAIRAQTIDAAWQMFADDIIGSLEVGKYADMVVLSADPR
MAV_4591|M.avium_104 VLAPEERLTVEQAIRAQTLDAAWQLFADDVIGSLEVGKYADLVVLSADPR
Mvan_1184|M.vanbaalenii_PYR-1 GWTPHEILPVERALTAYTAAVAHQAFAENTWGIIEPGFSADMVWLDRDPR
. .: *.* .*: * * .* * :. * :: * **:: :. :
Mflv_2930|M.gilvum_PYR-GCK EIDPHDIHSAAVTLTMMDGEIRHRV---------
MAB_2546|M.abscessus_ATCC_1997 ECDPQDIHTATVLMTMMNGQVRHELQGLKS----
MSMEG_4289|M.smegmatis_MC2_155 KIDPHDIHTAEVVLTMMDGRIRHDTSRVSDAAPR
Mb0567|M.bovis_AF2122/97 TVPPEQIADLAVRATFLAGRQVYRR---------
Rv0552|M.tuberculosis_H37Rv TVPPEQIADLAVRATFLAGRQVYRR---------
MMAR_0898|M.marinum_M TVPPEEIADLEVRATFLAGRQVYRK---------
MUL_0651|M.ulcerans_Agy99 TVPPEEIADLEVRATFLAGRQVYRK---------
MAV_4591|M.avium_104 AVPPERIADLQVRATYLAGRRVYPQ---------
Mvan_1184|M.vanbaalenii_PYR-1 LTPPLELPSTSVVGTYLRGTLASPS---------
* : * * : *