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VTGDADAIYTNGDIVTVDDEQPIAEAVAVKDGRIVAVGAHDDVVRENLGPHTRRVDLAGNTLLPGFIDPH SHYINALTVANQVNVFAPPAGPAADVEAIVAELKKFRDARDIADGEIIMAYGYDETVMPDGRTLHREDLD ADFPNNPVLVGHVSLHGAVLNSAAMQKFGISADTETPPGGVIVRKEGSTEPDGLIMETAFLPIFASLPKP TPEQEVQWSIAGQLLYAAVGITTAHEGLTHAADIALLRRAAAGGVDIIDVIAYPFILELDEVLPENPADT FGTYHNRLKLGGVKITLDGSPQGRTAFFTTPYLADGPGGEKNWSGELPFSQETVNGWFKRVYDLGLPLNI HANGDGAIDVLLAAHEYAAADDPTKDRHTTVIHSQFVRRDQLAKYVEYNLIPSLFTEHAFYFGDTHVRLR GKEQAHFLSPMRAAIDMGLRPTNHTDFNVTPLDQMFVLWTAVNRVSRSGEVIGADQRVTAVEALKAITIN AAYQYSEEQSKGSITVGKLADLVIVDNNPLTVDPMKLKDIAVLETIKEGRTVYREPATQSS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0894 | - | - | 100% (551) | metal-dependent hydrolase |
| M. ulcerans Agy99 | MUL_0651 | - | 8e-56 | 31.12% (556) | hypothetical protein MUL_0651 |
| M. ulcerans Agy99 | MUL_2270 | - | 5e-13 | 23.13% (536) | hypothetical protein MUL_2270 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0567 | - | 4e-56 | 31.24% (557) | hypothetical protein Mb0567 |
| M. gilvum PYR-GCK | Mflv_2930 | - | 2e-38 | 27.45% (561) | amidohydrolase 3 |
| M. tuberculosis H37Rv | Rv0552 | - | 4e-56 | 31.24% (557) | hypothetical protein Rv0552 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1868c | - | 3e-61 | 33.51% (561) | hypothetical protein MAB_1868c |
| M. marinum M | MMAR_1131 | - | 0.0 | 98.73% (551) | metal-dependent hydrolase |
| M. avium 104 | MAV_4591 | - | 2e-52 | 29.64% (560) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_1102 | - | 3e-46 | 29.14% (549) | twin-arginine translocation pathway signal |
| M. thermoresistible (build 8) | TH_2847 | - | 1e-06 | 42.65% (68) | PUTATIVE Amidohydrolase 3 |
| M. vanbaalenii PYR-1 | Mvan_1184 | - | 9e-37 | 28.36% (550) | amidohydrolase 3 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0894|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1131|M.marinum_M --------------------------------------------------
Mb0567|M.bovis_AF2122/97 --------------------------------------------------
Rv0552|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4591|M.avium_104 --------------------------------------------------
MSMEG_1102|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1868c|M.abscessus_ATCC_199 ----------------------MSINRRQFVVGGAAATAATTGLAALAGC
Mflv_2930|M.gilvum_PYR-GCK MCTACEWAPHFAAYGRRNPVTRRTALRAAAVTALAVTAAACATGPDSDTS
Mvan_1184|M.vanbaalenii_PYR-1 ------------------------------------------------MT
TH_2847|M.thermoresistible__bu --------------------------------------------------
MUL_0894|M.ulcerans_Agy99 ------MTGDADAIYTNGDIVTVDDEQPIAEAVAVKDGRIVAVGAHDDVV
MMAR_1131|M.marinum_M ------MTGDADAIYTNGDIVTVDDEQPIAEAVAVKDGRIVAVGAHDDVV
Mb0567|M.bovis_AF2122/97 -------MADADLVMTG-TVLTVDDARPTAEAIAVADGRVIAVGDRSEVA
Rv0552|M.tuberculosis_H37Rv -------MADADLVMTG-TVLTVDDARPTAEAIAVADGRVIAVGDRSEVA
MAV_4591|M.avium_104 -----MHMGQADLVLTG-TVLTVDEARPTAEALAVADGRIVAVGTRAEIA
MSMEG_1102|M.smegmatis_MC2_155 -------MPAADLVFYG-TVMTVDPARPTAEALAVSGGQIVAVGDRADVA
MAB_1868c|M.abscessus_ATCC_199 GHDTTDPDTGADLIFVGGPVVTVDGHGTTTEALAVAQGKIAAVGSRQDVM
Mflv_2930|M.gilvum_PYR-GCK VTSAASGAEAPDFVFHNGRVYTVTESAPWAEAVVVTGNSITFVGDNAAAR
Mvan_1184|M.vanbaalenii_PYR-1 NDTEIAVLTAPPTLFTGGTIWTGRGD---TDAVLVDGGVVVALGDEARRR
TH_2847|M.thermoresistible__bu --------MTFDLVIRNGTIVDGLGGEPFTGDVAVADGVIVAVGTADGSG
: . : : : * . : :*
MUL_0894|M.ulcerans_Agy99 RENLGPHTRRVDLAGNTLLPGFIDPHSHYINALTVANQVNVFAPPAGPAA
MMAR_1131|M.marinum_M REHLGPHTRRVDLAGNTLLPGFIDPHSHYINALTVANQVNVFAPPAGPAA
Mb0567|M.bovis_AF2122/97 -GLVGANTRVIDLGAGCVMPGFVEAHGHPLLEAVVLSDRFVDIRPVTMRD
Rv0552|M.tuberculosis_H37Rv -GLVGANTRVIDLGAGCVMPGFVEAHGHPLLEAVVLSDRFVDIRPVTMRD
MAV_4591|M.avium_104 -AHVGPHTQTVDIGDGCVMPGFVEAHGHPLMEAVALSDRIVDIRPVTLAN
MSMEG_1102|M.smegmatis_MC2_155 -QWVGPDTDVRELGNSCVAPGFVEAHGHPLMEAVAVSDRIVDIRPVTLGT
MAB_1868c|M.abscessus_ATCC_199 -RLRGAQTDVIELDGLALLPAFVEAHSHPSQIAATLGPPAVDVRPFVVPT
Mflv_2930|M.gilvum_PYR-GCK -ALAGPDTEVIDLAGKLLMPGFVEGHIHPFLGSFLSTG--VDLQVPTRQD
Mvan_1184|M.vanbaalenii_PYR-1 -----GGAHHVDLDGGFLMPSFADGHAHPLYGGLEAVG----PPVRRCGS
TH_2847|M.thermoresistible__bu -------RREIDATGLLVTPGFIDLHTHYDGQSIWSDRLNPSSAHGVTTA
: : *.* : * *
MUL_0894|M.ulcerans_Agy99 DVEAIVAELKKFRDARDIADGEIIMAYG-----YDETVMPDGRTLHREDL
MMAR_1131|M.marinum_M DVEAIVAELKKFRDARDIADGEIIMAYG-----YDETVMPDGRTLHREDL
Mb0567|M.bovis_AF2122/97 ADDVVAAIRGEVARRGP----AGAYLVG-----WDPLLQSGLGEPTLTWL
Rv0552|M.tuberculosis_H37Rv ADDVVAAIRGEVARRGP----AGAYLVG-----WDPLLQSGLGEPTLTWL
MAV_4591|M.avium_104 ADDVVAAVKSEVGKRGE----AGAYLNG-----WDPLLQQGLPQPTLAWL
MSMEG_1102|M.smegmatis_MC2_155 ADAVVDAIHAEVAKRGA----AGAYLNG-----WDPLLQTGLPEPTLAWL
MAB_1868c|M.abscessus_ATCC_199 GQQVMQKLADTVRSTPKG---TQVLLYG-----IDVLLQPDLQLPTRTIL
Mflv_2930|M.gilvum_PYR-GCK ALNAIAAYATDKADG-------PVRGFG-----WRVDMFGP-QGPTRTEL
Mvan_1184|M.vanbaalenii_PYR-1 VDEIVRAVQRYAADHPDE---DWIVGAS-----YDSSLAPEGLFDAR-WL
TH_2847|M.thermoresistible__bu LMGNCGVGFAPCRPEDHDVLVDVMAGVEDIPGVVMAEGLPWTWETFPQYL
*
MUL_0894|M.ulcerans_Agy99 DADFPNNPVLVGHVSLHGAVLNSAAMQKFGISADTETPPG--GVIVRKEG
MMAR_1131|M.marinum_M DADFPNNPVLVGHVSLHGAVLNSAAMQKFGISADTETPPG--GVIVRKEG
Mb0567|M.bovis_AF2122/97 DSLAPNGPLVIIHNSGHKAYFNSHAAWLNGLTRDTADPKG--AKYGRDGN
Rv0552|M.tuberculosis_H37Rv DSLAPNGPLVIIHNSGHKAYFNSHAAWLNGLTRDTADPKG--AKYGRDGN
MAV_4591|M.avium_104 DDIAPDGPLVIIHNSGHKAFFNSRAAQRHGLNRDTPDPKG--ARYGRDAD
MSMEG_1102|M.smegmatis_MC2_155 DGIAPEHPLVILHNSGHKAFFNSAAARAAGLTRDTPDPKG--AKYGRDAN
MAB_1868c|M.abscessus_ATCC_199 DALAPDHPVIIVANSGHAAYANTASFRLAGITRDTPNPVG--AEYVHGPD
Mflv_2930|M.gilvum_PYR-GCK DSVLPDRPGFFFAIDGHSMWANSKALEMAGISRDSEDPIPGFSYYVRDEN
Mvan_1184|M.vanbaalenii_PYR-1 DAAVPDRPVVLRAWDYHTVWCNSAALQRAGITAETPEPVLG--EIPRRAD
TH_2847|M.thermoresistible__bu DAVASRPRDIDVAAYLPHSPLRVYVMGRRGVDREPATPDDLERMRALAAE
* . . . *: :. *
MUL_0894|M.ulcerans_Agy99 STEPDGLIMETAFLPIFASLPKP--TPEQE-VQWSIAGQLLYAAVGITTA
MMAR_1131|M.marinum_M STEPDGLIMETAFLPIFASLPKP--TPEQE-VQWSIAGQLLYAAVGITTA
Mb0567|M.bovis_AF2122/97 GELDGTAEEIGAILPLLAGVADP--SNFG---AMLRAECARLNRAGLTTC
Rv0552|M.tuberculosis_H37Rv GELDGTAEEIGAILPLLAGVADP--SNFG---AMLRAECARLNRAGLTTC
MAV_4591|M.avium_104 GELDGTAEETGAVFPLLDGAIDT--AGYP---RMLHAECARLNRAGLTTC
MSMEG_1102|M.smegmatis_MC2_155 GDLDGTAEESAAVFTLLGGAISV--ADYP---AMLRAECARLNRAGLTTC
MAB_1868c|M.abscessus_ATCC_199 GELTGEVREAAALTTLAMPYLRN--VAEPNAFQNLHWAFGQLAAVGIATA
Mflv_2930|M.gilvum_PYR-GCK GEPTGYVLEVDAVLGLVN-AIEP--ISTDSMEQLLRAWLPKASEAGITSV
Mvan_1184|M.vanbaalenii_PYR-1 GSPLGTLREWGATD-LVMNAMPP--RDEAVRVGALGTAADYYLSRGVTWV
TH_2847|M.thermoresistible__bu AVAAGALGFASSRFALHKTESGSPIPTYDAAQEEIAAIARGVADAGGGLL
. . : : *
MUL_0894|M.ulcerans_Agy99 HEGLTHAAD----IALLRRAAAGGVDIIDVIAYPFILELDEVLPENPADT
MMAR_1131|M.marinum_M HEGLTHAAD----VALLRRAAAGGADLIDVIAYPFILELDEVLPENPADT
Mb0567|M.bovis_AF2122/97 SEMAFDPG---------YRPMVEAVRAELTVRLCTYEISNARMCTDATPG
Rv0552|M.tuberculosis_H37Rv SEMAFDPG---------YRPMVEAVRAELTVRLCTYEISNARMCTDATPG
MAV_4591|M.avium_104 SEMAFDPR---------FRPMVEQLRGQLTVRLRSYEISNPQLRTDATPG
MSMEG_1102|M.smegmatis_MC2_155 SEMAFDPM---------FRPLLANLHDHLTVRLRTYEMSTAALHTDAQPF
MAB_1868c|M.abscessus_ATCC_199 SEHSYSAAQ----QGDLYRRMAADP--GVKLRIRAYEMGAPELAKDPTHV
Mflv_2930|M.gilvum_PYR-GCK FDAGVPPIGGDQGALIELYTNVESRGELPFRVVASYSVKSPPVDDAVAEL
Mvan_1184|M.vanbaalenii_PYR-1 QDAWVEPAD---VATYVAAAGQGALRMRFNLALYADPRHFDAQVTQFAEQ
TH_2847|M.thermoresistible__bu QFVPDIPAGGYESVLRQVFEVGAETGLPVTFSLLTGNAGEPTWPQALNLV
.
MUL_0894|M.ulcerans_Agy99 FG----TYHNRLKLGGVKITLDGSPQGRTAFFTTPYLADGP----GGEKN
MMAR_1131|M.marinum_M FG----TYHNRLKLGGVKITLDGSPQGRTAFFTAPYLADGP----GGEKN
Mb0567|M.bovis_AF2122/97 QG------DDMLRQVGIKIWVDGSPWVGNIDLTFPYLDTPATRAIGVPPG
Rv0552|M.tuberculosis_H37Rv QG------DDMLRQVGIKIWVDGSPWVGNIDLTFPYLDTPATRAIGVPPG
MAV_4591|M.avium_104 EG------DDMLRQVGIKIWVDGSPWIGNIALSFPYLDTEATRTIGVTPG
MSMEG_1102|M.smegmatis_MC2_155 EG------DDVVRQVGIKIWVDGSPWIGNIDLTFPYLDTDATRTIGVVPG
MAB_1868c|M.abscessus_ATCC_199 AGPAA-GADQLFAQIGMKLWADGSPWQGNIFTSFPYLDTAATRRMGLEPH
Mflv_2930|M.gilvum_PYR-GCK TGIRDRISSDLVQVNVVKIIGDGTQEGYTAWLLEPYADKPD---------
Mvan_1184|M.vanbaalenii_PYR-1 RALVEAARSPLLTAQTVKFFADGVVENETGALLAPYCTGLH--------D
TH_2847|M.thermoresistible__bu EKFNAAAGGAAPAVTAQVFPRPIGMVMSLELSANPFVMYPSYREIAGLPL
: *:
MUL_0894|M.ulcerans_Agy99 WSGELPFSQETVNGWFKRVYDLG--LPLNIHANGDGAIDVLLAAHEYAAA
MMAR_1131|M.marinum_M WSGELPFSQETVNGWFKRVYDLG--LPLNIHANGDGAIDVLLAAHEYAAA
Mb0567|M.bovis_AF2122/97 SRGCANYTREQLAEIVGAYFPRG--WQIACHVHGDGGVDTILDVYEEALR
Rv0552|M.tuberculosis_H37Rv SRGCANYTREQLAEIVGAYFPRG--WQIACHVHGDGGVDTILDVYEEALR
MAV_4591|M.avium_104 SCGCANYTTEQLREIVGAYFPLG--WQLACHVQGDAGVDTILDVYEEALK
MSMEG_1102|M.smegmatis_MC2_155 SCGHANYTPEQLAEIVDTYYPQG--WQMACHVHGDAGVDTILDVYEKALR
MAB_1868c|M.abscessus_ATCC_199 HHGGMNYTPAQVTELATAFIEQG--WQLACHVHGDRAIDVVLDAYEKAQS
Mflv_2930|M.gilvum_PYR-GCK SIGGSPFTDDQWRQLVREVDAAG--FDVHIHACGERTARTALDSIEAAAK
Mvan_1184|M.vanbaalenii_PYR-1 HAGQHNWEGESLAEAARRVDELG--LQIHIHAIGDAAVRQALDAIEYVAA
TH_2847|M.thermoresistible__bu PQQVAEMRKPEVRERILNDKPAGDGHPLFFMTQAWDWIYPLGEQPDYEPD
* : . . :
MUL_0894|M.ulcerans_Agy99 DDPTKDRHTTVIHSQFVRRDQLAKYVEYN------LIPSLFTEHAFYFGD
MMAR_1131|M.marinum_M DDPTKDRHTTVIHSQFVRRDQLAKYVEYN------LIPSLFTEHAFYFGD
Mb0567|M.bovis_AF2122/97 RNPRDDHRLRLEHVGAIRPDQLRRAAELG------VTCSIFVDQIHYWGD
Rv0552|M.tuberculosis_H37Rv RNPRDDHRLRLEHVGAIRPDQLRRAAELG------VTCSIFVDQIHYWGD
MAV_4591|M.avium_104 RHPRDDHRLRLEHVGAIRPDQLQRAADLG------VTCSIFVDQIHYWGD
MSMEG_1102|M.smegmatis_MC2_155 RWPRDDHRLRLEHVGAITPEQLQRAHDLG------VTCSLFVDQIHYWGD
MAB_1868c|M.abscessus_ATCC_199 P---ASLRSRLEHVGAMTPAQFQRAARLG------VHPSLFIEHVYFWGD
Mflv_2930|M.gilvum_PYR-GCK VNPARERRHTVAHLVYLEEPDSRRFGDLG------VIAEFSANWFSADPD
Mvan_1184|M.vanbaalenii_PYR-1 QNGPRDRRAVIAHCQLVDRDDLDRFAALS------VIPNMQPLWAQLDAL
TH_2847|M.thermoresistible__bu ASTSIAARARARGVSPLEEAYDRLLDDDGHAMLLIAMGNYENNSLDTVGQ
: : . .
MUL_0894|M.ulcerans_Agy99 THVR---LRGKEQA-HFLSPMRAAIDMGLRPTNHTDFNVT----PLDQMF
MMAR_1131|M.marinum_M THVR---LRGKEQA-HFLSPMRAAIDMGLRPTNHTDFNVT----PLDQMF
Mb0567|M.bovis_AF2122/97 VIVDD--LFGAQRG-SRWMPAGSAVAAGMRISLHNDPPVT----PEEPLR
Rv0552|M.tuberculosis_H37Rv VIVDD--LFGAQRG-SRWMPAGSAVAAGMRISLHNDPPVT----PEEPLR
MAV_4591|M.avium_104 VLVDG--LFGEERG-SRWMPAGSAVATGMRISLHNDPPVT----PEEPLR
MSMEG_1102|M.smegmatis_MC2_155 IIVDG--LFGAERG-ERWMPVGSAVATGMRVSLHNDPPVT----PEEPLR
MAB_1868c|M.abscessus_ATCC_199 PLIDE--LFGQDHG-AHWMSAKSALDAGLRISFHNDGNVS----PPNPLG
Mflv_2930|M.gilvum_PYR-GCK TVINLAARYGAPRK-DNLYRIQDVLSSGGRVSLGTDWPAAGYFSTYKPLD
Mvan_1184|M.vanbaalenii_PYR-1 MTVLTIPRLGADRA-DSQYPIRTLDASGAPLAFGSDWPVS----SGAPLD
TH_2847|M.thermoresistible__bu WMRRDDVVLGLGDGGAHYGMICDASYPTFLLAHWARDRASGRLTVAEAVR
* : .: :
MUL_0894|M.ulcerans_Agy99 VLWTAVNRVSR----SGEVIGADQRVTAVEALKAITINAAYQYSEEQSKG
MMAR_1131|M.marinum_M VLWTAVNRVSR----SGEVIGADQRVTALEALKAITINAAYQYSEEQSKG
Mb0567|M.bovis_AF2122/97 NISVAATRVAP----SGRVLAPEERLTVEQAIRAQTIDAAWQLFAEDAIG
Rv0552|M.tuberculosis_H37Rv NISVAATRVAP----SGRVLAPEERLTVEQAIRAQTIDAAWQLFAEDAIG
MAV_4591|M.avium_104 NISVAATRKAP----SGRVLAPEERLTVEQAIRAQTLDAAWQLFADDVIG
MSMEG_1102|M.smegmatis_MC2_155 NIAVAATRTAP----SGRVLAPEQRITVEQAIRAQTIDAAWQLFSDDVIG
MAB_1868c|M.abscessus_ATCC_199 NIATAVTRTAKG---SGRVLAPEQRISVTQAVRAQTIDAAWQLHLDNEVG
Mflv_2930|M.gilvum_PYR-GCK SIQIGVTRQLIGDPAAEVLSPADQKLTVEQAVHANTLGAAYQLRLDGLVG
Mvan_1184|M.vanbaalenii_PYR-1 GVAVAASRTTSDG-DPPGGWTPHEILPVERALTAYTAAVAHQAFAENTWG
TH_2847|M.thermoresistible__bu ALTSVPARVAGFG-DRGRIAVGYKADLNVIDHAALRLHRPVILHDLPSGG
: * : * . *
MUL_0894|M.ulcerans_Agy99 SITVGKLADLVIVDNNPLTVDPMKLKDIAVLETIKEGRTVYREPATQSS
MMAR_1131|M.marinum_M SITVGKLADLVIVDNNPLTVDPMKLKDIAVLETIKEGRTIYREPATQSS
Mb0567|M.bovis_AF2122/97 SLQVGKYADMVVLSADPRTVPPEQIADLAVRATFLAGRQVYRR------
Rv0552|M.tuberculosis_H37Rv SLQVGKYADMVVLSADPRTVPPEQIADLAVRATFLAGRQVYRR------
MAV_4591|M.avium_104 SLEVGKYADLVVLSADPRAVPPERIADLQVRATYLAGRRVYPQ------
MSMEG_1102|M.smegmatis_MC2_155 SLEVGKYADLVVLSADPRATEPARIADLDVQATFLAGRQVYPALG----
MAB_1868c|M.abscessus_ATCC_199 SLEVGKYADLVVLSADPHAVDPQALRDISVRATYLAGRQTYAAPVG---
Mflv_2930|M.gilvum_PYR-GCK SVETGKRADLIVVDRNIFEIDPHDIHSAAVTLTMMDGEIRHRV------
Mvan_1184|M.vanbaalenii_PYR-1 IIEPGFSADMVWLDRDPRLTPPLELPSTSVVGTYLRGTLASPS------
TH_2847|M.thermoresistible__bu RRLDQRADGYVATVVSGHIIAENGVPTDARPGTLVRGRQPAPKVAG---
. : . : * *