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RVLVVDPNLVPHRERLEAAMPPGTEVLWHVAGVPEDELRKAEVFVGSRFTAEMARLAENLRLLHPAAAGT DKIDLSALSADVLVANTFHHERSIAEYVVGAAVMLRRDFLTQDARLRDGVWASSVYDSTVPQPSTLADAH VGFVGFGHIGRHTWKLLQVFGCTAAAVTGSGRVADDAGLAWVDDTGKLERLMRECDVVVVSAPLNRHTEG MIGAAELKALGPDGVLINVGRGPLVQERALYDALAGGAIKAAAVDVWYRYPADGTGCAPSDLPFATLPGI LMTPHTSGVTTDTFKGRVDDVAANVGRLQNGEPLRNLVPH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1016 | - | - | 100% (321) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
| M. vanbaalenii PYR-1 | Mvan_0404 | - | 9e-28 | 31.89% (323) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
| M. vanbaalenii PYR-1 | Mvan_2128 | - | 2e-22 | 30.19% (265) | D-3-phosphoglycerate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3020c | serA1 | 5e-22 | 30.26% (304) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0334 | - | 8e-27 | 32.34% (303) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv2996c | serA1 | 5e-22 | 30.26% (304) | D-3-phosphoglycerate dehydrogenase |
| M. leprae Br4923 | MLBr_01692 | serA | 6e-20 | 28.99% (307) | D-3-phosphoglycerate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4334 | - | 5e-24 | 29.24% (301) | 2-hydroxyacid dehydrogenase |
| M. marinum M | MMAR_1715 | serA1 | 2e-21 | 27.30% (304) | D-3-phosphoglycerate dehydrogenase SerA1 |
| M. avium 104 | MAV_3847 | serA | 2e-23 | 29.61% (304) | D-3-phosphoglycerate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6115 | - | 1e-114 | 64.40% (323) | phosphoglycerate dehydrogenase |
| M. thermoresistible (build 8) | TH_2037 | serA | 3e-26 | 30.97% (310) | PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) |
| M. ulcerans Agy99 | MUL_1952 | serA1 | 1e-21 | 27.30% (304) | D-3-phosphoglycerate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3020c|M.bovis_AF2122/97 ---------MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAV
Rv2996c|M.tuberculosis_H37Rv ---------MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAV
MLBr_01692|M.leprae_Br4923 ---------MDLPVVLIADKLAQSTVAALGDQVEVRWVDGPDRTKLLAAV
MMAR_1715|M.marinum_M ---------MNLPVVLIADKLAQSTVAALGDQVEVRWVDGPDREKLLAAV
MUL_1952|M.ulcerans_Agy99 ---------MNLPVVLIADKLAQSTVAALGDQVEVRWVDGPDREKLLAAV
MAV_3847|M.avium_104 ---------MNLPVVLIADKLAESTVAALGDQVEVRWVDGPDREKLLAAV
TH_2037|M.thermoresistible__bu ---------VSLPVVLIADKLAESTVAALGDQVEVRWVDGPDREKLLAAV
Mflv_0334|M.gilvum_PYR-GCK ---------MRVLAHFLPGPKVTEFLSPHTDWLDIRYCAEDDDETFYREL
MAB_4334|M.abscessus_ATCC_1997 MSLSGENHRVRVLAHFPSGPRVLEQLAPHADWLDVRFCAEDDDNTFYAEL
Mvan_1016|M.vanbaalenii_PYR-1 ---------MRVLVVDPNLVPHRERLEAAMPPGTEVLWHVAGVP--EDEL
MSMEG_6115|M.smegmatis_MC2_155 ---------MHVLVADAHLLPHRSRLEAALPAGVTVCWREPGDSRILDDL
: : . . : . . :
Mb3020c|M.bovis_AF2122/97 PEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLV
Rv2996c|M.tuberculosis_H37Rv PEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLV
MLBr_01692|M.leprae_Br4923 PEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLV
MMAR_1715|M.marinum_M PEADALLVRSATTVDAEVLAAATKLKIVARAGVGLDNVDVDAATTRGVLV
MUL_1952|M.ulcerans_Agy99 PEADALLVRSATTVDAEVLAAATKLKIVARAGVGLDNVDVDAATTRGVLV
MAV_3847|M.avium_104 PEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATERGVLV
TH_2037|M.thermoresistible__bu ADADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVEAATARGVLV
Mflv_0334|M.gilvum_PYR-GCK PDAEVIWH-VLRPISGDDLSKAPKLRLVHKLGAGVNTVDVDTATARGIAV
MAB_4334|M.abscessus_ATCC_1997 PGADVLWH-VLRPLSADDVAKGERLRLIHKFGAGVNTIALDAAVEHGVAV
Mvan_1016|M.vanbaalenii_PYR-1 RKAEVFVG---SRFTAEMARLAENLRLLHPAAAGTDKIDLSALSADVLVA
MSMEG_6115|M.smegmatis_MC2_155 PEADVYVG---SRFTADMAAVAHRLRLIHVNGAGTDKIDFAHLRADTLVA
*:. . .: . .*::: ..* :.: . : .
Mb3020c|M.bovis_AF2122/97 VNAPTSNIHSAAEHALALLLAASRQIPAADASLR-EHTWKRSSFSG--TE
Rv2996c|M.tuberculosis_H37Rv VNAPTSNIHSAAEHALALLLAASRQIPAADASLR-EHTWKRSSFSG--TE
MLBr_01692|M.leprae_Br4923 VNAPTSNIHSAAEHALALLLAASRQIAEADASLR-AHIWKRSSFSG--TE
MMAR_1715|M.marinum_M VNAPTSNIHSAAEHAMALLLAAARQIPAADASLR-EHTWKRSSFSG--AE
MUL_1952|M.ulcerans_Agy99 VNAPTSNIHSAAEHAMALLLAAARQIPAADASLR-EHTWKRSSFSG--AE
MAV_3847|M.avium_104 VNAPTSNIHSAAEHALALLLAAAREIPAADASLR-EHTWKRSSFSG--TE
TH_2037|M.thermoresistible__bu VNAPTSNIHSAAEHAIALLLAAARQIPAADATLR-QRTWKRSEFSG--VE
Mflv_0334|M.gilvum_PYR-GCK ANMPGANAPSVAEGTLLLMLAALRRLPELDRATRTGNGWPSDPTLG--ES
MAB_4334|M.abscessus_ATCC_1997 ANMPGANAPSVAEGALLLMLAALRQLPRLDRDIRSGNGWPTDQSLG--ES
Mvan_1016|M.vanbaalenii_PYR-1 N--TFHHERSIAEYVVGAAVMLRRDFLTQDARLR-DGVWASSVYDSTVPQ
MSMEG_6115|M.smegmatis_MC2_155 N--TFHHEQSIAEYIAGAAVLLRRDFLAQDRALR-TGRWATPGYDRQIPQ
. : * ** : * : * * * .
Mb3020c|M.bovis_AF2122/97 IFGK---TVGVVGLGRIGQLVAQRIAAFGAYVVAYDPY---VSPARAAQL
Rv2996c|M.tuberculosis_H37Rv IFGK---TVGVVGLGRIGQLVAQRIAAFGAYVVAYDPY---VSPARAAQL
MLBr_01692|M.leprae_Br4923 IFGK---TVGVVGLGRIGQLVAARIAAFGAHVIAYDPY---VAPARAAQL
MMAR_1715|M.marinum_M IFGK---TVGVVGLGRIGQLVAQRVEAFGAHVVAYDPY---VSPARAAQL
MUL_1952|M.ulcerans_Agy99 IFGK---TVGVVGLGRIGQLVAQRVEAFGAHVVAYDPY---VSPARAAQL
MAV_3847|M.avium_104 IFGK---TVGVVGLGRIGQLVAQRLSAFGTHLIAYDPY---VSPARAAQL
TH_2037|M.thermoresistible__bu IYDK---TVGVVGLGRIGQLVAQRLAAFGTHLIAYDPY---VSPARAAQL
Mflv_0334|M.gilvum_PYR-GCK VRDLGGCTVGLVGYGNIAKQVERILLAIGAEVVHTSTR---DDGLPGWRT
MAB_4334|M.abscessus_ATCC_1997 VRDIGSCTIGLVGYGNIAKSLEKILLAMGATVLHTSTR---DDGTAGWRG
Mvan_1016|M.vanbaalenii_PYR-1 PSTLADAHVGFVGFGHIGRHTWKLLQVFGCTAAAVTGSGRVADDAG-LAW
MSMEG_6115|M.smegmatis_MC2_155 PRTLRDARIGYIGFGHIGRTSWKLLRAFGADAVAVTGTGRVDAAAEGLRW
:* :* *.*.: : .:*
Mb3020c|M.bovis_AF2122/97 GIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAAR
Rv2996c|M.tuberculosis_H37Rv GIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAAR
MLBr_01692|M.leprae_Br4923 GIELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAAR
MMAR_1715|M.marinum_M GIELLPLDDLLARADFISVHLPKTPETAGLLGKEALAKTKPGVIIVNAAR
MUL_1952|M.ulcerans_Agy99 GIELLPLDDLLARADFISVHLPKTPETAGLLGKEALAKTKPGVIIVNAAR
MAV_3847|M.avium_104 GIELLSLDELLARADFISVHLPKTPETAGLIDKDALAKTKPGVIIVNAAR
TH_2037|M.thermoresistible__bu GIELVDLDELLGRADIISVHLPKTPETAGLIGADALAKVKPGVIIVNAAR
Mflv_0334|M.gilvum_PYR-GCK ------LPDLLSESDIVSLHLPLTGATEGLLGRKALAQMKTDAVLVNTSR
MAB_4334|M.abscessus_ATCC_1997 ------LNDLLTSSDIVSLHLPLTEASTGMLDSAALNRMKPGSVLVNTSR
Mvan_1016|M.vanbaalenii_PYR-1 VDDTGKLERLMRECDVVVVSAPLNRHTEGMIGAAELKALGPDGVLINVGR
MSMEG_6115|M.smegmatis_MC2_155 AGDTGRLTALMTESDVVVVCAPLTERTVGMIGADELRALGPSGVLINVGR
: *: .*.: : * . : *::. * .. :::*..*
Mb3020c|M.bovis_AF2122/97 GGLVDEAALADAITGGHVRAAGLDVFATEPCT-------DSPLFELAQVV
Rv2996c|M.tuberculosis_H37Rv GGLVDEAALADAITGGHVRAAGLDVFATEPCT-------DSPLFELAQVV
MLBr_01692|M.leprae_Br4923 GGLVDEVALADAVRSGHVRAAGLDVFATEPCT-------DSPLFELSQVV
MMAR_1715|M.marinum_M GGLIDESALAEAITSGHVRGAGLDVFATEPCT-------DSPLFELPQVV
MUL_1952|M.ulcerans_Agy99 GGLIDESALAEAITSGYVRGAGLDVFATEPCT-------DSPLFELPQVV
MAV_3847|M.avium_104 GGLVDEAALADAVRSGHVRAAGLDVFSKEPCT-------DSPLFELPQVV
TH_2037|M.thermoresistible__bu GGLIDEQALADAIISGRVRAAGIDVFAKEPCT-------DSPLFDLPQVV
Mflv_0334|M.gilvum_PYR-GCK GAIVDEAALVDALRAGTLAAAGLDVFAVEPVPS------DNPLLGLPNVV
MAB_4334|M.abscessus_ATCC_1997 GAVVDEAALVNALQQGPLGAAGLDVFAQEPVSP------ENPLLALPNVV
Mvan_1016|M.vanbaalenii_PYR-1 GPLVQERALYDALAGGAIKAAAVDVWYRYPADGTGCAPSDLPFATLPGIL
MSMEG_6115|M.smegmatis_MC2_155 GPLVVESALYEALSAGTIAAAALDVWYRYPGPDGDGTPSDLPFDTLPNVL
* :: * ** :*: * : .*.:**: * : *: *. ::
Mb3020c|M.bovis_AF2122/97 VTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGVVNEEVAP
Rv2996c|M.tuberculosis_H37Rv VTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGVVNEEVAP
MLBr_01692|M.leprae_Br4923 VTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVDGGVVNEEVAP
MMAR_1715|M.marinum_M VTPHLGASTAEAQDRAGTDVAASVKLALAGEFVPDAVNIAGGAVNEEVAP
MUL_1952|M.ulcerans_Agy99 VTPHLGASTAEAQDRAGTDVAASVKLALAGEFVPDAVNIAGGAVNEEVAP
MAV_3847|M.avium_104 VTPHLGASTTEAQDRAGTDVAASVKLALAGEFVPDAVNVAGGTVNEEVAP
TH_2037|M.thermoresistible__bu VTPHLGASTVEAQDRAGTDVAASVKLALAGEFVPDAVNVGAGEVSEEVAP
Mflv_0334|M.gilvum_PYR-GCK LTPHVTWYTADTMRRYLEFALDNCERLRDGRALAHVVNDPSG--------
MAB_4334|M.abscessus_ATCC_1997 LTPHVTWFTADTMTRYLHHAIDNCRRIHEGMPLADRVR------------
Mvan_1016|M.vanbaalenii_PYR-1 MTPHTSGVTTDTFKGRVDDVAANVGRLQNGEPLRNLVPH-----------
MSMEG_6115|M.smegmatis_MC2_155 MTPHVSGVTADTFAARADDIAANIGRLQRGEPLVNQIDRMDRQSGHQLS-
:*** *.:: . * : . :
Mb3020c|M.bovis_AF2122/97 WLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSALRGLFSA
Rv2996c|M.tuberculosis_H37Rv WLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSALRGLFSA
MLBr_01692|M.leprae_Br4923 WLDLVCKLGVLVAALSDELPASLSVHVRGELASEDVEILRLSALRGLFST
MMAR_1715|M.marinum_M WLDLACKLGVLAAALSDEPPVSLSVQARGELASEDVEVLKLSALRGLFSA
MUL_1952|M.ulcerans_Agy99 WLDLACKLGVLAAALSDEPPVSLSVQAGGELASEDVEVLKLSALRGLFSA
MAV_3847|M.avium_104 WLDLVRKLGLLAATLSDGPPVSLSVQVRGELASEDVEVLKLSALRGLFSA
TH_2037|M.thermoresistible__bu WVDLARKLGLLVGTLSGEPTATLQVRVAGELASEDVEVLRLSALRGLFST
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4334|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1016|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6115|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 VIEDAVTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVGADGSVVT
Rv2996c|M.tuberculosis_H37Rv VIEDAVTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVGADGSVVT
MLBr_01692|M.leprae_Br4923 VIEDAVTFVNAPALAAERGVSAEITTGSESPNHRSVVDVRAVASDGSVVN
MMAR_1715|M.marinum_M VVEGPVTFVNAPALAAERGVSVEISKASESPNHRSVVDVRVVGADGSVVS
MUL_1952|M.ulcerans_Agy99 VVEGPVTFVNAPALAAERGVSVEISKASESPNHRSVVDVRVVGADGSVVS
MAV_3847|M.avium_104 VVEGPVTFVNAPALAEERGVTAEISTASESPNHRSVVDVRAVSHDGTVVN
TH_2037|M.thermoresistible__bu LTDQQVTYVNAPTLAAERGMQAELEKVSESPNYRSVVDVRAVSTDGTVTN
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4334|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1016|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6115|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 VSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIGTLLG
Rv2996c|M.tuberculosis_H37Rv VSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIGTLLG
MLBr_01692|M.leprae_Br4923 IAGTLSGPQLVQKIVQVNGRNFDLRAQGMNLVIRYVDQPGALGKIGTLLG
MMAR_1715|M.marinum_M VSGTLYGAQLTHKIVQINGRHFDLRAEGTNLIVNYVDQPGALGKIGTLLG
MUL_1952|M.ulcerans_Agy99 VSGTLYGAQLTHKIVQINGRHFDLRAEGTNLIVNYVDQPGALGKIGTLLG
MAV_3847|M.avium_104 VAGTLSGPQLVEKIVQINGRNFDLRARGINLVINYVDQPGALGKIGTLLG
TH_2037|M.thermoresistible__bu VAGTLSGPQQVEKIVQINGRNFDLRAEGVNLVMHYVDRPGALGKIGTLLG
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4334|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1016|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6115|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 TAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYKLEVV
Rv2996c|M.tuberculosis_H37Rv TAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYKLEVV
MLBr_01692|M.leprae_Br4923 AAGVNIQAAQLSEDTEGPGATILLRLDQDVPGDVRSAIVAAVSANKLEVV
MMAR_1715|M.marinum_M AAGVNIHAAQLSEDVEGPGATVLLRLDQDVPEDVRSAIAAAVGANRLEVV
MUL_1952|M.ulcerans_Agy99 AAGVNIHAAQLSEDVEGPGATVLLRLDQDVPEDVRSAIAAAVGANRLEVV
MAV_3847|M.avium_104 SAGVNIQAAQLSEDAEGPGATILLRLDQDVPADVRSAIGAAVGANKLEVV
TH_2037|M.thermoresistible__bu AADVNILAAQLSQDISGDGATLMLRVNRDVPADVRDAIGAAVGASTLEVV
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4334|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1016|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6115|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 DLS
Rv2996c|M.tuberculosis_H37Rv DLS
MLBr_01692|M.leprae_Br4923 NLS
MMAR_1715|M.marinum_M DLS
MUL_1952|M.ulcerans_Agy99 DLS
MAV_3847|M.avium_104 DLS
TH_2037|M.thermoresistible__bu DLS
Mflv_0334|M.gilvum_PYR-GCK ---
MAB_4334|M.abscessus_ATCC_1997 ---
Mvan_1016|M.vanbaalenii_PYR-1 ---
MSMEG_6115|M.smegmatis_MC2_155 ---