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MSLSGENHRVRVLAHFPSGPRVLEQLAPHADWLDVRFCAEDDDNTFYAELPGADVLWHVLRPLSADDVAK GERLRLIHKFGAGVNTIALDAAVEHGVAVANMPGANAPSVAEGALLLMLAALRQLPRLDRDIRSGNGWPT DQSLGESVRDIGSCTIGLVGYGNIAKSLEKILLAMGATVLHTSTRDDGTAGWRGLNDLLTSSDIVSLHLP LTEASTGMLDSAALNRMKPGSVLVNTSRGAVVDEAALVNALQQGPLGAAGLDVFAQEPVSPENPLLALPN VVLTPHVTWFTADTMTRYLHHAIDNCRRIHEGMPLADRVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4334 | - | - | 100% (320) | 2-hydroxyacid dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3304c | - | 1e-36 | 32.99% (288) | D-3-phosphoglycerate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0999 | - | 4e-29 | 30.07% (286) | formate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3020c | serA1 | 5e-41 | 36.46% (288) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0334 | - | 1e-128 | 71.01% (307) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv2996c | serA1 | 5e-41 | 36.46% (288) | D-3-phosphoglycerate dehydrogenase |
| M. leprae Br4923 | MLBr_01692 | serA | 2e-39 | 35.82% (282) | D-3-phosphoglycerate dehydrogenase |
| M. marinum M | MMAR_0531 | serA3 | 1e-121 | 67.73% (313) | D-3-phosphoglycerate dehydrogenase SerA3 |
| M. avium 104 | MAV_3847 | serA | 1e-40 | 35.84% (279) | D-3-phosphoglycerate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0604 | - | 1e-119 | 66.88% (311) | glyoxylate reductase |
| M. thermoresistible (build 8) | TH_3383 | - | 1e-122 | 66.14% (319) | PUTATIVE D-isomer specific 2-hydroxyacid dehydrogenase, |
| M. ulcerans Agy99 | MUL_1195 | serA3 | 1e-122 | 68.37% (313) | D-3-phosphoglycerate dehydrogenase SerA3 |
| M. vanbaalenii PYR-1 | Mvan_0404 | - | 1e-124 | 70.29% (313) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0334|M.gilvum_PYR-GCK --------------------------------MRVLAHFLPG---PKVTE
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------MRVLAHFVPGGPDSKVIE
MSMEG_0604|M.smegmatis_MC2_155 -----------------------MAVN--PGTVRVLAHFAPS---NTVLD
MMAR_0531|M.marinum_M -----------------------MN-----QPLRVLAHFVPG---EKVLE
MUL_1195|M.ulcerans_Agy99 -----------------------MN-----QPLRVLAHFVPG---EKVLE
TH_3383|M.thermoresistible__bu VDRPAVALSANRRRHCPGMLRGDMSGVNSRSALRVLAHFRPG---PKVLE
MAB_4334|M.abscessus_ATCC_1997 -----------------------MSLSGENHRVRVLAHFPSG---PRVLE
Mb3020c|M.bovis_AF2122/97 --------------------------------MSLPVVLIAD---KLAPS
Rv2996c|M.tuberculosis_H37Rv --------------------------------MSLPVVLIAD---KLAPS
MLBr_01692|M.leprae_Br4923 --------------------------------MDLPVVLIAD---KLAQS
MAV_3847|M.avium_104 --------------------------------MNLPVVLIAD---KLAES
: : . : .. . .
Mflv_0334|M.gilvum_PYR-GCK FLSPHTDWLDIRYCAEDDDETFYRELPDAEVIWH-VLRPISGDDLSKAPK
Mvan_0404|M.vanbaalenii_PYR-1 FLAPCRDWLDVRFCAEDDDDTFYRELADAEVIWH-VLRPLSGEDLARAPR
MSMEG_0604|M.smegmatis_MC2_155 FLAPHLDWLDVRFCGEEDDETFYRELGDADVLWH-VLRPITGDDLNRAPR
MMAR_0531|M.marinum_M FVAAQRDWLDIRWCAEDDDSGFYRELDHAEVIWH-VLRPLSGADLQRAPR
MUL_1195|M.ulcerans_Agy99 FVAAQRDWLDIRWCAEDDDSGFYRELDHAEVIWH-VLRPLSGADLQRAPR
TH_3383|M.thermoresistible__bu FLEPESGWLDVRFCDEDDDETFHRELPHAEVIWH-VLRPLSGEDLTRATR
MAB_4334|M.abscessus_ATCC_1997 QLAPHADWLDVRFCAEDDDNTFYAELPGADVLWH-VLRPLSADDVAKGER
Mb3020c|M.bovis_AF2122/97 TVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVLAAAPK
Rv2996c|M.tuberculosis_H37Rv TVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVLAAAPK
MLBr_01692|M.leprae_Br4923 TVAALGDQVEVRWVDGPDRTKLLAAVPEADALLVRSATTVDAEVLAAAPK
MAV_3847|M.avium_104 TVAALGDQVEVRWVDGPDREKLLAAVPEADALLVRSATTVDAEVLAAAPK
: . . :::*: * : : *:.: .: . : . :
Mflv_0334|M.gilvum_PYR-GCK LRLVHKLGAGVNTVDVDTATARGIAVANMPGANAPSVAEGTLLLMLAALR
Mvan_0404|M.vanbaalenii_PYR-1 LRLVHKLGAGVNTIDVDAATARGVAVANMPGANAESVAEGTLLLMLAALR
MSMEG_0604|M.smegmatis_MC2_155 LRLVHKLGAGVNTIDVETATQLGILVANMPGANAPSVAEGTVLLMLAALR
MMAR_0531|M.marinum_M LRLVQKLGAGVNTIDVATATKHGIAVANMPGANAPSVAEGTVLLMLAALR
MUL_1195|M.ulcerans_Agy99 LRLVQKLGAGVNTIDVATATKHGIAVANMPGANAPSVAEGTVLLMLAALR
TH_3383|M.thermoresistible__bu CRLVHKLGTGVNTIDVDTATERGIAVANMPGANAASVAEGTVMLMLAALR
MAB_4334|M.abscessus_ATCC_1997 LRLIHKFGAGVNTIALDAAVEHGVAVANMPGANAPSVAEGALLLMLAALR
Mb3020c|M.bovis_AF2122/97 LKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASR
Rv2996c|M.tuberculosis_H37Rv LKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASR
MLBr_01692|M.leprae_Br4923 LKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASR
MAV_3847|M.avium_104 LKIVARAGVGLDNVDVDAATERGVLVVNAPTSNIHSAAEHALALLLAAAR
::: : *.*::.: : :*. *: *.* * :* *.** :: *:*** *
Mflv_0334|M.gilvum_PYR-GCK RLPELDRATRTGNGWPSDPTLGESVRDLGGCTVGLVGYGNIAKQVERILL
Mvan_0404|M.vanbaalenii_PYR-1 RLPVLDRATREGRGWPSDPTLGETVRDIGGCTVGLVGYGNIAKQVERILV
MSMEG_0604|M.smegmatis_MC2_155 RLPQLDRATRAGRGWPTDPTLGDTVRDIGGCTVGLVGYGNVAKRVERIVL
MMAR_0531|M.marinum_M RLPELDAATRQGRGWPTDPQLGESVRDIGSCTVGLIGYGNIAKRVATIVS
MUL_1195|M.ulcerans_Agy99 RLPELDAATRQGRGWPTDPQLGESVRDIGSCTVGLIGYGNIAKRVATIVS
TH_3383|M.thermoresistible__bu RLVELDRATRAGTGWPTDPSLGETVRDIGGSTVGLIGYGNVARRVEQIVA
MAB_4334|M.abscessus_ATCC_1997 QLPRLDRDIRSGNGWPTDQSLGESVRDIGSCTIGLVGYGNIAKSLEKILL
Mb3020c|M.bovis_AF2122/97 QIPAADASLREHTWKRSSFSG----TEIFGKTVGVVGLGRIGQLVAQRIA
Rv2996c|M.tuberculosis_H37Rv QIPAADASLREHTWKRSSFSG----TEIFGKTVGVVGLGRIGQLVAQRIA
MLBr_01692|M.leprae_Br4923 QIAEADASLRAHIWKRSSFSG----TEIFGKTVGVVGLGRIGQLVAARIA
MAV_3847|M.avium_104 EIPAADASLREHTWKRSSFSG----TEIFGKTVGVVGLGRIGQLVAQRLS
.: * * :. :: . *:*::* *.:.: : :
Mflv_0334|M.gilvum_PYR-GCK AIGAE-VVHTSTRDDGLPGWR-----TLPDLLSESDIVSLHLPLTGATEG
Mvan_0404|M.vanbaalenii_PYR-1 AMGAD-VIHTSTRDDGSAGWR-----SLPDLLSACDIVSLHLPLTDATAG
MSMEG_0604|M.smegmatis_MC2_155 AMGAEQVLHTSTRDTGHPRWR-----NLPDLLAASDIVSLHLPLTDTSRG
MMAR_0531|M.marinum_M AMGAT-VLHTSTRDDGRPGWR-----PLPELLATSDIVSLHLPLTPHTDR
MUL_1195|M.ulcerans_Agy99 AMGAT-VLHTSTRDDGRPGWR-----PLPELLATSDIVSLHLPLTPHTDR
TH_3383|M.thermoresistible__bu AMGAE-VLHTSTADDGHPNWR-----PLNDLLARSDIVSIHVPLTEKTLG
MAB_4334|M.abscessus_ATCC_1997 AMGAT-VLHTSTRDDGTAGWR-----GLNDLLTSSDIVSLHLPLTEASTG
Mb3020c|M.bovis_AF2122/97 AFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAG
Rv2996c|M.tuberculosis_H37Rv AFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAG
MLBr_01692|M.leprae_Br4923 AFGAHVIAYDPYVAPARAAQLGIELMSFDDLLARADFISVHLPKTPETAG
MAV_3847|M.avium_104 AFGTHLIAYDPYVSPARAAQLGIELLSLDELLARADFISVHLPKTPETAG
*:*: : : . . . : :**: .*::*:*:* * :
Mflv_0334|M.gilvum_PYR-GCK LLGRKALAQMKTDAVLVNTSRGAIVDEAALVDALRAGTLAAAGLDVFAVE
Mvan_0404|M.vanbaalenii_PYR-1 LLGRDALARMKSDAVLVNTSRGPIVDEEALADALRTGKLAAAGLDVFAVE
MSMEG_0604|M.smegmatis_MC2_155 LLGPEAIAAMKPGAVLVNTARGPIVDEAALIEALRGGRLAAAGLDVFDTE
MMAR_0531|M.marinum_M LLDADALAQMKPNSLLINTSRGAVIDEDALVDALRSGSLAAAGLDVFAVE
MUL_1195|M.ulcerans_Agy99 LLDADALARMKPNSLLINTSRGAVVDEDALVDALRSGSLAAAGLDVFAVE
TH_3383|M.thermoresistible__bu LLDATALSRMKPAAVLVNTARGAIVDEIALTEALHARRLAAAGLDVFATE
MAB_4334|M.abscessus_ATCC_1997 MLDSAALNRMKPGSVLVNTSRGAVVDEAALVNALQQGPLGAAGLDVFAQE
Mb3020c|M.bovis_AF2122/97 LIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATE
Rv2996c|M.tuberculosis_H37Rv LIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATE
MLBr_01692|M.leprae_Br4923 LIDKEALAKTKPGVIIVNAARGGLVDEVALADAVRSGHVRAAGLDVFATE
MAV_3847|M.avium_104 LIDKDALAKTKPGVIIVNAARGGLVDEAALADAVRSGHVRAAGLDVFSKE
::. *: *. :::*::** ::** ** :*: : ******* *
Mflv_0334|M.gilvum_PYR-GCK PVPSDNPLLGLPNVVLTPHVTWYTADTMRRYLEFALDNCERLRDGRALAH
Mvan_0404|M.vanbaalenii_PYR-1 PVPADNPLLRLPNVVLTPHVTWYTADTMRRYLEFAVDNCERLRDGRNLVN
MSMEG_0604|M.smegmatis_MC2_155 PLPADHPLLGLDNVVLTPHVTWYTADTMRRYLSIGVENCRRIRDGEPLAH
MMAR_0531|M.marinum_M PVVPENPLLRLDNVVLTPHVTWYTVDTMRRYLTEAVDNCRRLRDGLSLAN
MUL_1195|M.ulcerans_Agy99 PVVPENPLLRLDNVVLTPHVTWYTVDTMRRYLTEAVDNCRRLRDGLSLAN
TH_3383|M.thermoresistible__bu PVRPNNPLLTLDNVVLTPHVSWYTVDTMRRYLTHAVDNCRRLRDGEQLAD
MAB_4334|M.abscessus_ATCC_1997 PVSPENPLLALPNVVLTPHVTWFTADTMTRYLHHAIDNCRRIHEGMPLAD
Mb3020c|M.bovis_AF2122/97 PCT-DSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPD
Rv2996c|M.tuberculosis_H37Rv PCT-DSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPD
MLBr_01692|M.leprae_Br4923 PCT-DSPLFELSQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPD
MAV_3847|M.avium_104 PCT-DSPLFELPQVVVTPHLGASTTEAQDRAGTDVAASVKLALAGEFVPD
* : **: * :**:***: *.:: * . . * : .
Mflv_0334|M.gilvum_PYR-GCK VVNDPSG-------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 VVNDVAG-------------------------------------------
MSMEG_0604|M.smegmatis_MC2_155 LVNEAR--------------------------------------------
MMAR_0531|M.marinum_M VVNCQADC------------------------------------------
MUL_1195|M.ulcerans_Agy99 AVNCQADC------------------------------------------
TH_3383|M.thermoresistible__bu VVNGITGRRPG---------------------------------------
MAB_4334|M.abscessus_ATCC_1997 RVR-----------------------------------------------
Mb3020c|M.bovis_AF2122/97 AVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEE
Rv2996c|M.tuberculosis_H37Rv AVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEE
MLBr_01692|M.leprae_Br4923 AVNVDGGVVNEEVAPWLDLVCKLGVLVAALSDELPASLSVHVRGELASED
MAV_3847|M.avium_104 AVNVAGGTVNEEVAPWLDLVRKLGLLAATLSDGPPVSLSVQVRGELASED
*.
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0604|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0531|M.marinum_M --------------------------------------------------
MUL_1195|M.ulcerans_Agy99 --------------------------------------------------
TH_3383|M.thermoresistible__bu --------------------------------------------------
MAB_4334|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 VEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGVTAEICKASESPNHRS
Rv2996c|M.tuberculosis_H37Rv VEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGVTAEICKASESPNHRS
MLBr_01692|M.leprae_Br4923 VEILRLSALRGLFSTVIEDAVTFVNAPALAAERGVSAEITTGSESPNHRS
MAV_3847|M.avium_104 VEVLKLSALRGLFSAVVEGPVTFVNAPALAEERGVTAEISTASESPNHRS
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0604|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0531|M.marinum_M --------------------------------------------------
MUL_1195|M.ulcerans_Agy99 --------------------------------------------------
TH_3383|M.thermoresistible__bu --------------------------------------------------
MAB_4334|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 VVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHY
Rv2996c|M.tuberculosis_H37Rv VVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHY
MLBr_01692|M.leprae_Br4923 VVDVRAVASDGSVVNIAGTLSGPQLVQKIVQVNGRNFDLRAQGMNLVIRY
MAV_3847|M.avium_104 VVDVRAVSHDGTVVNVAGTLSGPQLVEKIVQINGRNFDLRARGINLVINY
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0604|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0531|M.marinum_M --------------------------------------------------
MUL_1195|M.ulcerans_Agy99 --------------------------------------------------
TH_3383|M.thermoresistible__bu --------------------------------------------------
MAB_4334|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 VDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVR
Rv2996c|M.tuberculosis_H37Rv VDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVR
MLBr_01692|M.leprae_Br4923 VDQPGALGKIGTLLGAAGVNIQAAQLSEDTEGPGATILLRLDQDVPGDVR
MAV_3847|M.avium_104 VDQPGALGKIGTLLGSAGVNIQAAQLSEDAEGPGATILLRLDQDVPADVR
Mflv_0334|M.gilvum_PYR-GCK ------------------
Mvan_0404|M.vanbaalenii_PYR-1 ------------------
MSMEG_0604|M.smegmatis_MC2_155 ------------------
MMAR_0531|M.marinum_M ------------------
MUL_1195|M.ulcerans_Agy99 ------------------
TH_3383|M.thermoresistible__bu ------------------
MAB_4334|M.abscessus_ATCC_1997 ------------------
Mb3020c|M.bovis_AF2122/97 TAIAAAVDAYKLEVVDLS
Rv2996c|M.tuberculosis_H37Rv TAIAAAVDAYKLEVVDLS
MLBr_01692|M.leprae_Br4923 SAIVAAVSANKLEVVNLS
MAV_3847|M.avium_104 SAIGAAVGANKLEVVDLS