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LIADDDDVVRDVVRRYLERDGLEVCTAPNGSEALRLLGSRRIDVAVLDVMMPGPDGIALCRNLRKGGDYS VPVILLTALGEEQDRIAGLEAGADDYLTKPFSPRELALRVRSVLRRSPATGGVLPVDIRSGDLTVTTASR TVTMAGTPVSLTNREFDLLLFFLTHPDTVFTREDLLKQVWLWDFGDLSTVTVHVKRLRSKLGDRHRVQTV WGRGYMWTSGAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0885 | - | - | 100% (224) | two component transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4844 | - | 2e-40 | 42.79% (222) | two component transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2296 | - | 3e-39 | 40.91% (220) | two component transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1062c | trcR | 1e-39 | 41.36% (220) | two component transcriptional regulator TRCR |
| M. gilvum PYR-GCK | Mflv_0035 | - | 1e-104 | 84.30% (223) | two component transcriptional regulator |
| M. tuberculosis H37Rv | Rv1033c | trcR | 1e-39 | 41.36% (220) | two component transcriptional regulator TRCR |
| M. leprae Br4923 | MLBr_00174 | - | 1e-38 | 41.18% (221) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_1076 | - | 9e-39 | 40.72% (221) | two component response transcriptional regulatory protein MprA |
| M. marinum M | MMAR_4455 | trcR | 1e-39 | 40.91% (220) | two-component transcriptional regulator TrcR |
| M. avium 104 | MAV_1176 | - | 8e-40 | 40.91% (220) | two component transcriptional regulator trcr |
| M. smegmatis MC2 155 | MSMEG_0994 | resD | 1e-96 | 78.54% (219) | DNA-binding response regulator ResD |
| M. thermoresistible (build 8) | TH_1732 | phoP | 6e-39 | 40.72% (221) | DNA-binding response regulator PhoP |
| M. ulcerans Agy99 | MUL_4624 | trcR | 9e-40 | 40.91% (220) | two component transcriptional regulator TrcR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1062c|M.bovis_AF2122/97 MTTMSGYTRSQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
Rv1033c|M.tuberculosis_H37Rv MTTMSGYTRSQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
MMAR_4455|M.marinum_M ---MTGSTRTQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
MUL_4624|M.ulcerans_Agy99 MKAMTGSTRTQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
MAV_1176|M.avium_104 ---MSGQSAAQRPRQAILGQLPRIYRADGSPIRVLLVDDEPALTNLVKMA
MLBr_00174|M.leprae_Br4923 -------------------------------MRILAVDDDRAVRESLRRS
TH_1732|M.thermoresistible__bu -----------------------------VAVRILVVDDDRAVRESLRRS
MAB_1076|M.abscessus_ATCC_1997 -----------------------------MPVRILVVDDDRAVRESLRRS
Mvan_0885|M.vanbaalenii_PYR-1 ---------------------------------MLIADDDDVVRDVVRRY
Mflv_0035|M.gilvum_PYR-GCK -----------------------------MVTRVLIADDDGVVRDVVRRY
MSMEG_0994|M.smegmatis_MC2_155 ------------------------------MPRVLIADDDTVVRDVVRRY
:* .**: .: : ::
Mb1062c|M.bovis_AF2122/97 LHYEGWDVEVAHDGQEAIAKFDKVGPDVLVLDIMLPDVDGLEILRRVRES
Rv1033c|M.tuberculosis_H37Rv LHYEGWDVEVAHDGQEAIAKFDKVGPDVLVLDIMLPDVDGLEILRRVRES
MMAR_4455|M.marinum_M LHYEGWDVEIAHNGREAISKFDKISPDVLVLDIMLPDVDGLQILQRVRDS
MUL_4624|M.ulcerans_Agy99 LHYEGWDVEIAHNGREAISKFDKISPDVLVLDIMLPDVDGLQILQRVRDS
MAV_1176|M.avium_104 LHYEGWVVDIAHNGREAMAKFDRAAPDVLVLDIMLPDVDGLRILERVRQS
MLBr_00174|M.leprae_Br4923 LSFNGYSVELANDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRST
TH_1732|M.thermoresistible__bu LSFNGYSVELAEDGVEALDLIANDRPDAVVLDVMMPRLDGLEVCRQLRST
MAB_1076|M.abscessus_ATCC_1997 LSFNGYSVDLAEDGVDALNVIANDRPDALVLDVMMPKLDGLEVCRRLRST
Mvan_0885|M.vanbaalenii_PYR-1 LERDGLEVCTAPNGSEALRLLGSRRIDVAVLDVMMPGPDGIALCRNLRKG
Mflv_0035|M.gilvum_PYR-GCK LERDGLEVSTAHDGNEALRLLSSQRIDVAVLDVMMPGPDGMALCRRLRQN
MSMEG_0994|M.smegmatis_MC2_155 LERDGLDVTIAHDGSEALRLLESEQLDVAVLDVMMPGPDGLSLCRELRKY
* :* * * :* :*: . *. ***:*:* **: : ..:*.
Mb1062c|M.bovis_AF2122/97 DVY-TPTLFLTARDSVMDRVTGLTSGADDYMTKPFSLEELVARLRGLLRR
Rv1033c|M.tuberculosis_H37Rv DVY-TPTLFLTARDSVMDRVTGLTSGADDYMTKPFSLEELVARLRGLLRR
MMAR_4455|M.marinum_M DAY-TPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRR
MUL_4624|M.ulcerans_Agy99 DAY-TPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRR
MAV_1176|M.avium_104 DAY-TPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRR
MLBr_00174|M.leprae_Br4923 GDD-LPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRR
TH_1732|M.thermoresistible__bu GDD-LPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRR
MAB_1076|M.abscessus_ATCC_1997 GDD-LPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRR
Mvan_0885|M.vanbaalenii_PYR-1 GDYSVPVILLTALGEEQDRIAGLEAGADDYLTKPFSPRELALRVRSVLRR
Mflv_0035|M.gilvum_PYR-GCK GHYSVPVILLTALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRR
MSMEG_0994|M.smegmatis_MC2_155 GDYRLPVILLTALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRR
. * :.*** .. :*::** :*****:.***: .** *:*.:***
Mb1062c|M.bovis_AF2122/97 SSHLERPADEALRVGDLTLDGASREVTRDGTPISLSSTEFELLRFLMRNP
Rv1033c|M.tuberculosis_H37Rv SSHLERPADEALRVGDLTLDGASREVTRDGTPISLSSTEFELLRFLMRNP
MMAR_4455|M.marinum_M SSHLAPPADESLKVGDLKLDAASREVTRGGTPISLSSTEFELLRFLMRNP
MUL_4624|M.ulcerans_Agy99 SSHLAPPADESLKVGDLKLDAASREVTRGGTPISLSSTEFELLRFLMRNP
MAV_1176|M.avium_104 ASQQPAPTAETLKVGDLVVDTASREVTRGDTPVSLSSTEFELLRFLMRNP
MLBr_00174|M.leprae_Br4923 TKPDDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANP
TH_1732|M.thermoresistible__bu TTPDDAADSQKLTFADLTLDPVTREVTRGNRQISLTRTEFALLELLIANP
MAB_1076|M.abscessus_ATCC_1997 TTIDESADAATLSFGDLTLDPVTREVHRGTRSISLTRTEFALLEMLMANP
Mvan_0885|M.vanbaalenii_PYR-1 SPATGGVLPVDIRSGDLTVTTASRTVTMAGTPVSLTNREFDLLLFFLTHP
Mflv_0035|M.gilvum_PYR-GCK SPASIAAHPVDITSGDLTVSTASRSATVGGRTVSLTNREFDLLLFFLTHA
MSMEG_0994|M.smegmatis_MC2_155 TSGLTTPAPAELTVGELRVSTASRSVTLSGRPVNLTNREFDLLVFFLTHT
: : .:* : .:* . :.*: ** ** ::: :.
Mb1062c|M.bovis_AF2122/97 RRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDSDREP-MIHTVRG
Rv1033c|M.tuberculosis_H37Rv RRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDSDREP-MIHTVRG
MMAR_4455|M.marinum_M RRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDADREP-MIHTVRG
MUL_4624|M.ulcerans_Agy99 RRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDADREP-MIHTVRG
MAV_1176|M.avium_104 RRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDSGREP-MIHTVRG
MLBr_00174|M.leprae_Br4923 RRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRG
TH_1732|M.thermoresistible__bu RRVLSRSRILEEVWGFDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRG
MAB_1076|M.abscessus_ATCC_1997 RRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGELRLIHTVRG
Mvan_0885|M.vanbaalenii_PYR-1 DTVFTREDLLKQVWLWDFG-DLSTVTVHVKRLRSKLGDRHR---VQTVWG
Mflv_0035|M.gilvum_PYR-GCK GTVYTREDLLKEVWHWDFG-DLSTVTVHVKRLRSKLGDRHR---VQTVWG
MSMEG_0994|M.smegmatis_MC2_155 DTVFSREDLLKRVWRWDFG-DLSTVTVHVKRLRSKLGTHHR---VQTVWG
. :* :*..** :** . : ::: ** * . ::** *
Mb1062c|M.bovis_AF2122/97 IGYMLR--------PPE--
Rv1033c|M.tuberculosis_H37Rv IGYMLR--------PPE--
MMAR_4455|M.marinum_M IGYMLR--------PAE--
MUL_4624|M.ulcerans_Agy99 IGYMLR--------PAE--
MAV_1176|M.avium_104 VGYMLR--------PAE--
MLBr_00174|M.leprae_Br4923 VGYVLR--------ETPP-
TH_1732|M.thermoresistible__bu VGYVLR--------ETPP-
MAB_1076|M.abscessus_ATCC_1997 VGYVLR--------ETPP-
Mvan_0885|M.vanbaalenii_PYR-1 RGYMWT--------SGAAG
Mflv_0035|M.gilvum_PYR-GCK RGYMWAPDEASPGQPDAAG
MSMEG_0994|M.smegmatis_MC2_155 RGYLWS---------GQP-
**: