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TSAPVEDQGPRRAILGRLPRMYRADGSPIRVLLVDDERALTNLVKMALQYEGWEIDVAHDAAEAVDKYRA NTPDLLVLDIMLPDMDGLGVLARLRESGAYTPTLFLTARDSVADRVTGLTAGGDDYMTKPFSLEELVARL RGLLRRSAYLAPADDESLSVGDLTLDAASREVTRAGEPVSLTSTEFELLRLLMRNQRKALSRTDILRKVW DYDFGGRTSIVDLYVSYLRKKIDAGRDPMIHTVRGVGYMLRPAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2296 | - | - | 100% (255) | two component transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4429 | - | 5e-83 | 63.68% (234) | two component transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5175 | - | 9e-62 | 52.42% (227) | two component transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1062c | trcR | 1e-107 | 75.70% (251) | two component transcriptional regulator TRCR |
| M. gilvum PYR-GCK | Mflv_2266 | - | 3e-81 | 63.25% (234) | two component transcriptional regulator |
| M. tuberculosis H37Rv | Rv1033c | trcR | 1e-107 | 75.70% (251) | two component transcriptional regulator TRCR |
| M. leprae Br4923 | MLBr_00174 | - | 5e-58 | 48.66% (224) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_2581 | - | 6e-80 | 61.90% (231) | putative two component transcriptional regulatory protein |
| M. marinum M | MMAR_4455 | trcR | 1e-110 | 78.46% (246) | two-component transcriptional regulator TrcR |
| M. avium 104 | MAV_1176 | - | 1e-105 | 76.42% (246) | two component transcriptional regulator trcr |
| M. smegmatis MC2 155 | MSMEG_2916 | - | 1e-118 | 83.07% (254) | DNA-binding response regulator, PhoP family protein |
| M. thermoresistible (build 8) | TH_1732 | phoP | 2e-60 | 50.45% (224) | DNA-binding response regulator PhoP |
| M. ulcerans Agy99 | MUL_4624 | trcR | 1e-110 | 78.46% (246) | two component transcriptional regulator TrcR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2266|M.gilvum_PYR-GCK --MAHPQSDPEDPARVVMR------RADGSPIRVLVVDDEAVLAELMSMA
MAB_2581|M.abscessus_ATCC_1997 --MSDAASVSSEKARSSLR------RPDGSPVRVLVVDDERSLAELISMA
Mvan_2296|M.vanbaalenii_PYR-1 --MTSAPVEDQGPRRAILGRLPRMYRADGSPIRVLLVDDERALTNLVKMA
MSMEG_2916|M.smegmatis_MC2_155 --MTSAQLKNPRPRRAILGQLPRMYRPDGSPIRVLLVDDERALTNLVQMA
Mb1062c|M.bovis_AF2122/97 MTTMSGYTRSQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
Rv1033c|M.tuberculosis_H37Rv MTTMSGYTRSQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
MMAR_4455|M.marinum_M ---MTGSTRTQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
MUL_4624|M.ulcerans_Agy99 MKAMTGSTRTQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
MAV_1176|M.avium_104 ---MSGQSAAQRPRQAILGQLPRIYRADGSPIRVLLVDDEPALTNLVKMA
MLBr_00174|M.leprae_Br4923 -------------------------------MRILAVDDDRAVRESLRRS
TH_1732|M.thermoresistible__bu -----------------------------VAVRILVVDDDRAVRESLRRS
:*:* ***: : : : :
Mflv_2266|M.gilvum_PYR-GCK LRYEGWDISTAGDGATAIALARQNPPDVVVLDVMLPDMSGLEVLRTLREQ
MAB_2581|M.abscessus_ATCC_1997 LRYEGWEIHVAGDGMSAVKLARQVHPDIVVLDVMLPDVSGLEVLRQLRDL
Mvan_2296|M.vanbaalenii_PYR-1 LQYEGWEIDVAHDAAEAVDKYRANTPDLLVLDIMLPDMDGLGVLARLRES
MSMEG_2916|M.smegmatis_MC2_155 LQYEGWVIDVAHDAAQAVEKYRANLPDLLVLDIMLPDTDGLGVLEQIRSF
Mb1062c|M.bovis_AF2122/97 LHYEGWDVEVAHDGQEAIAKFDKVGPDVLVLDIMLPDVDGLEILRRVRES
Rv1033c|M.tuberculosis_H37Rv LHYEGWDVEVAHDGQEAIAKFDKVGPDVLVLDIMLPDVDGLEILRRVRES
MMAR_4455|M.marinum_M LHYEGWDVEIAHNGREAISKFDKISPDVLVLDIMLPDVDGLQILQRVRDS
MUL_4624|M.ulcerans_Agy99 LHYEGWDVEIAHNGREAISKFDKISPDVLVLDIMLPDVDGLQILQRVRDS
MAV_1176|M.avium_104 LHYEGWVVDIAHNGREAMAKFDRAAPDVLVLDIMLPDVDGLRILERVRQS
MLBr_00174|M.leprae_Br4923 LSFNGYSVELANDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRST
TH_1732|M.thermoresistible__bu LSFNGYSVELAEDGVEALDLIANDRPDAVVLDVMMPRLDGLEVCRQLRST
* ::*: : * :. *: ** :***:*:* .** : :*.
Mflv_2266|M.gilvum_PYR-GCK IPGLPLLLLTAKDSVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRT
MAB_2581|M.abscessus_ATCC_1997 YPGLPLLLLTAKDSLEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRT
Mvan_2296|M.vanbaalenii_PYR-1 GAYTPTLFLTARDSVADRVTGLTAGGDDYMTKPFSLEELVARLRGLLRRS
MSMEG_2916|M.smegmatis_MC2_155 GTYTPTLFLTARDSVADRVEGLTAGGDDYMTKPFSLEELVARLRGLLRRT
Mb1062c|M.bovis_AF2122/97 DVYTPTLFLTARDSVMDRVTGLTSGADDYMTKPFSLEELVARLRGLLRRS
Rv1033c|M.tuberculosis_H37Rv DVYTPTLFLTARDSVMDRVTGLTSGADDYMTKPFSLEELVARLRGLLRRS
MMAR_4455|M.marinum_M DAYTPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRRS
MUL_4624|M.ulcerans_Agy99 DAYTPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRRS
MAV_1176|M.avium_104 DAYTPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRRA
MLBr_00174|M.leprae_Br4923 GDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRT
TH_1732|M.thermoresistible__bu GDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARLRALLRRT
* *.***:**: :*: ** :*.***:.***::**:: *:*.****:
Mflv_2266|M.gilvum_PYR-GCK GVATATGGAKLVVGDLVLDEDSHEVTRGGDLITLTATEFELLRFMMRNAR
MAB_2581|M.abscessus_ATCC_1997 GIAGDSGDARLIVGDLVLDEDSHEVTRDGELINLTATEFELLRFMMRNNK
Mvan_2296|M.vanbaalenii_PYR-1 AYLAPADDESLSVGDLTLDAASREVTRAGEPVSLTSTEFELLRLLMRNQR
MSMEG_2916|M.smegmatis_MC2_155 AYLTPAADETLRVGDLTLDASSHTVTRGDTPIALTSTEFQLLRVLMRHPR
Mb1062c|M.bovis_AF2122/97 SHLERPADEALRVGDLTLDGASREVTRDGTPISLSSTEFELLRFLMRNPR
Rv1033c|M.tuberculosis_H37Rv SHLERPADEALRVGDLTLDGASREVTRDGTPISLSSTEFELLRFLMRNPR
MMAR_4455|M.marinum_M SHLAPPADESLKVGDLKLDAASREVTRGGTPISLSSTEFELLRFLMRNPR
MUL_4624|M.ulcerans_Agy99 SHLAPPADESLKVGDLKLDAASREVTRGGTPISLSSTEFELLRFLMRNPR
MAV_1176|M.avium_104 SQQPAPTAETLKVGDLVVDTASREVTRGDTPVSLSSTEFELLRFLMRNPR
MLBr_00174|M.leprae_Br4923 KPDDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANPR
TH_1732|M.thermoresistible__bu TPDDAADSQKLTFADLTLDPVTREVTRGNRQISLTRTEFALLELLIANPR
. : ..** :* :: *:* : *: *** **..:: : :
Mflv_2266|M.gilvum_PYR-GCK CVLSKAQILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREP-MIHTLRGA
MAB_2581|M.abscessus_ATCC_1997 RVLSKHQILDRVWSYDFGGRSNVVELYISYLRKKIDTGREP-MIHTLRGA
Mvan_2296|M.vanbaalenii_PYR-1 KALSRTDILRKVWDYDFGGRTSIVDLYVSYLRKKIDAGRDP-MIHTVRGV
MSMEG_2916|M.smegmatis_MC2_155 KALSRDDILRQVWEYDFGGRTSIVDLYVSYLRKKIDTGREP-MIHTVRGV
Mb1062c|M.bovis_AF2122/97 RALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDSDREP-MIHTVRGI
Rv1033c|M.tuberculosis_H37Rv RALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDSDREP-MIHTVRGI
MMAR_4455|M.marinum_M RALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDADREP-MIHTVRGI
MUL_4624|M.ulcerans_Agy99 RALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDADREP-MIHTVRGI
MAV_1176|M.avium_104 RALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDSGREP-MIHTVRGV
MLBr_00174|M.leprae_Br4923 RVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGV
TH_1732|M.thermoresistible__bu RVLSRSRILEEVWGFDFPTSGNALEVYIGYLRRKTEAEGEPRLIHTVRGV
.*:: ** .** :** . :::*:.***:* :: :. :***:**
Mflv_2266|M.gilvum_PYR-GCK GYVLKPAR-
MAB_2581|M.abscessus_ATCC_1997 GYVLKPAH-
Mvan_2296|M.vanbaalenii_PYR-1 GYMLRPAR-
MSMEG_2916|M.smegmatis_MC2_155 GYMLRPAD-
Mb1062c|M.bovis_AF2122/97 GYMLRPPE-
Rv1033c|M.tuberculosis_H37Rv GYMLRPPE-
MMAR_4455|M.marinum_M GYMLRPAE-
MUL_4624|M.ulcerans_Agy99 GYMLRPAE-
MAV_1176|M.avium_104 GYMLRPAE-
MLBr_00174|M.leprae_Br4923 GYVLRETPP
TH_1732|M.thermoresistible__bu GYVLRETPP
**:*: .