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MTGTDHLITGATVLTMDPVTGAAPVTRSIRIRGGEITAVEPTLTAEPGEDVIDGRDRLVVPGYVNAHTHS WEALFRARLDNLPLEHWMLLSYPVLGLAPLSPDLIRLRSALVAIESLRNGVTTLVDDVLEIPGQTEEQLA AVFETYRDIGIRANISGHVMDRPFVAHFPFLADALDPAERRALDALTVCDTGDYLAYAQAAAARYRDYAD GRLRFMVGPSAPQRCSPELMVGLDELARRHDLEFHIHVLETRTQAVTGEEFYGKTMVEYLHSLGVLGEHV TIAHGIWLTDSDIEVLADTGASVSHNPISNLKLGSGIAPWRKLRDAGVNLGLGTDGMSSSDTARMSEVVK AAALLHKVTGPDYRRWPTAAEVLTAGTLGGARSARLGATVGSIEVGKRADLVIYDMTALAFTPRNAPELH LVYSENGSSIDTVMVDGRVVMTADRLTTIDERAVLDELQARGPELRRWQDHLETLNRSLLPAFDRQYRQV MSRAVPVDRFSGHGDCWLN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0863 | - | - | 100% (509) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_3150 | - | 3e-52 | 34.48% (464) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_3147 | - | 3e-46 | 33.26% (469) | amidohydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2937c | - | 2e-05 | 41.18% (51) | D-amino acid aminohydrolase |
| M. gilvum PYR-GCK | Mflv_2930 | - | 4e-06 | 25.27% (182) | amidohydrolase 3 |
| M. tuberculosis H37Rv | Rv2913c | - | 3e-05 | 41.18% (51) | D-amino acid aminohydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2927c | - | 3e-45 | 31.91% (470) | hydroxydechloroatrazine ethylaminohydrolase |
| M. marinum M | MMAR_2844 | - | 3e-38 | 30.12% (425) | metal-dependent hydrolase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1297 | - | 2e-43 | 31.12% (466) | hydroxydechloroatrazine ethylaminohydrolase |
| M. thermoresistible (build 8) | TH_3859 | - | 6e-22 | 26.84% (462) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_2914 | - | 1e-37 | 29.88% (425) | hydroxydechloroatrazine ethylaminohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2844|M.marinum_M -----------------MSTILLTLMLECRVPKLVIDRVSIAT---VDPK
MUL_2914|M.ulcerans_Agy99 -------------------------MLECRVPKLVIDRISIAT---VDPK
MSMEG_1297|M.smegmatis_MC2_155 ------------------------------MPRLVIDGAAIAT---VDAA
MAB_2927c|M.abscessus_ATCC_199 -----------------------------MNPITLIENVFAAT---VDKS
Mb2937c|M.bovis_AF2122/97 ---------------------MLAWRQLNDLEETVTYDVIIRDGLWFDGT
Rv2913c|M.tuberculosis_H37Rv ---------------------MLAWRQLNDLEETVTYDVIIRDGLWFDGT
Mvan_0863|M.vanbaalenii_PYR-1 ----------------------------MTGTDHLITGATVLT---MDPV
TH_3859|M.thermoresistible__bu ---------------------------------------VLAG----DPL
Mflv_2930|M.gilvum_PYR-GCK MCTACEWAPHFAAYGRRNPVTRRTALRAAAVTALAVTAAACATGPDSDTS
*
MMAR_2844|M.marinum_M A------------------------AEFSEGHIIVEDDLIVAVGDG----
MUL_2914|M.ulcerans_Agy99 A------------------------AEFSEGHIIVEDDLIVAVGDG----
MSMEG_1297|M.smegmatis_MC2_155 H------------------------TEHNRGYIVVDDNIITAVGAG----
MAB_2927c|M.abscessus_ATCC_199 R------------------------REIADARVVIEGGRIAAVLTAGENN
Mb2937c|M.bovis_AF2122/97 G------------------------NAPLTRTLGIRDGVVATVAAG----
Rv2913c|M.tuberculosis_H37Rv G------------------------NAPLTRTLGIRDGVVATVAAG----
Mvan_0863|M.vanbaalenii_PYR-1 TG-----------------------AAPVTRSIRIRGGEITAVEPT----
TH_3859|M.thermoresistible__bu T------------------------AHVRAADLLIEDGRVTAIESD----
Mflv_2930|M.gilvum_PYR-GCK VTSAASGAEAPDFVFHNGRVYTVTESAPWAEAVVVTGNSITFVGDN-AAA
: : .. :. :
MMAR_2844|M.marinum_M PAPEVPGATVIDGRGCLATPGLVNTHEHLYQWITRGYTQKGTLFQWLTEM
MUL_2914|M.ulcerans_Agy99 PAPEVPGATVIDGRGCLATPGLVNTHEHLYQWITRGHTQKGTLFQWLTEM
MSMEG_1297|M.smegmatis_MC2_155 PAPEVPGAQFIDARGCLATPGLVNTHHHLYQWITRGHAQDGTLFEWLTTL
MAB_2927c|M.abscessus_ATCC_199 PWQELPGVERVDGSGCLLTPGLVNTHHHLYQWITRGLAADHTLFQWLTAL
Mb2937c|M.bovis_AF2122/97 ALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTTV
Rv2913c|M.tuberculosis_H37Rv ALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTTV
Mvan_0863|M.vanbaalenii_PYR-1 -LTAEPGEDVIDGRDRLVVPGYVNAHTHSWEALFRARLDNLPLEHWMLLS
TH_3859|M.thermoresistible__bu --LAGVDAEIIDATGRWVLPGFVDTHRHLWQTTMRGLTANWNLKDYFWCI
Mflv_2930|M.gilvum_PYR-GCK RALAGPDTEVIDLAGKLLMPGFVEGHIHPFLGSFLSTGVDLQVPTRQDAL
:* . ** :: * * :
MMAR_2844|M.marinum_M YP-----------------VWGRLDAELEFAAASAG--------------
MUL_2914|M.ulcerans_Agy99 YP-----------------VWGRLDAELEFAAASAG--------------
MSMEG_1297|M.smegmatis_MC2_155 YP-----------------LWSHLDADLEYVAASAA--------------
MAB_2927c|M.abscessus_ATCC_199 YP-----------------VWQGIDADSLHVAAQGA--------------
Mb2937c|M.bovis_AF2122/97 LLGNCSLSTVYANSEDAADLFSRVEAVPREFVLGALRDNQTWSTPAEYIE
Rv2913c|M.tuberculosis_H37Rv LLGNCSLSTVYANSEDAADLFSRVEAVPREFVLGALRDNQTWSTPAEYIE
Mvan_0863|M.vanbaalenii_PYR-1 YP-----------------VLGLAPLSPDLIRLRSA--------------
TH_3859|M.thermoresistible__bu RS----------------HFAGLHDPDDVYGGQYAG--------------
Mflv_2930|M.gilvum_PYR-GCK NAIAAYATDKADG-----PVRGFGWRVDMFGPQGPTR-----------TE
.
MMAR_2844|M.marinum_M -LAGLALT-GCTTTMDHHYVFPHAGGDMLGAEIAAAKRIGVRFHPTRGSM
MUL_2914|M.ulcerans_Agy99 -LAGLALT-GCTTTMDHHYVFPHAGGDMLGAEIVAAKRIGVRFHPTRGSM
MSMEG_1297|M.smegmatis_MC2_155 -LAALALS-GCTTTTDHHYVFPRGGGDVLGAEIAAAQRIGLRFHPTRGSM
MAB_2927c|M.abscessus_ATCC_199 -LSWLALS-GCTTTTDHHYVFPSDAGDLLEAEIEAARQVGLRFDPTRGSM
Mb2937c|M.bovis_AF2122/97 AIDALPLG-PNVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAKMAKLL
Rv2913c|M.tuberculosis_H37Rv AIDALPLG-PNVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAKMAKLL
Mvan_0863|M.vanbaalenii_PYR-1 LVAIESLRNGVTTLVDDVLEIPGQTEEQLAAVFETYRDIGIRANISGHVM
TH_3859|M.thermoresistible__bu --GLDALVNGVTTTIDHSHITNSP--DHSDAAVRGLLDSGVRALWCYGFY
Mflv_2930|M.gilvum_PYR-GCK LDSVLPDRPGFFFAIDGHSMWANSKALEMAGISRDSEDPIPGFSYYVRDE
. .
MMAR_2844|M.marinum_M DLGVASGGLPPEHTVEDIDTILT------TCQDAVREHHDP--------T
MUL_2914|M.ulcerans_Agy99 DLGVASGGLPPEHTVEDIDTILT------TCQDAVREHHDP--------T
MSMEG_1297|M.smegmatis_MC2_155 DLGASAGGLPPDNVVEDIDAILA------AGQDAVGAHHDP--------S
MAB_2927c|M.abscessus_ATCC_199 DLGRSAGGLPPDGLVESIDTALE------ASDAAIARWHDP--------A
Mb2937c|M.bovis_AF2122/97 DEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRERRKLISVLRH
Rv2913c|M.tuberculosis_H37Rv DEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRERRKLISVLRH
Mvan_0863|M.vanbaalenii_PYR-1 DRPFVAHFPFLADALDPAERRALDALTVCDTGDYLAYAQAAAARYR--DY
TH_3859|M.thermoresistible__bu PSPQADPVFTTPQHRLDDARRVR---------STFFPTDDG--------L
Mflv_2930|M.gilvum_PYR-GCK NGEPTGYVLEVDAVLGLVNAIEP--ISTDSMEQLLRAWLPKASEAGITSV
.
MMAR_2844|M.marinum_M KGSMVQISLAPCSPFSVTGELMKQSALLARDLGVRLHTHLSETVEEDEFC
MUL_2914|M.ulcerans_Agy99 KGSMVQISLAPCSPFSVTGELMKQSALLARDLGVRLHTHLSETVEEDEFC
MSMEG_1297|M.smegmatis_MC2_155 FGSMCRIALAPCSPFSVSGELMRESAALARELGVRLHTHIAETTDEEQFC
MAB_2927c|M.abscessus_ATCC_199 PGAMVRIGLAPCSPFSVSADLLRQSALLARERGVRLHTHLAETKDESVYC
Mb2937c|M.bovis_AF2122/97 RGRILQSAPDVDNPVSALLFFLASSRIFNRRKGVRMSMLVSADAKSMPLA
Rv2913c|M.tuberculosis_H37Rv RGRILQSAPDVDNPVSALLFFLASSRIFNRRKGVRMSMLVSADAKSMPLA
Mvan_0863|M.vanbaalenii_PYR-1 ADGRLRFMVGPSAPQRCSPELMVGLDELARRHDLEFHIHVLETRTQAVTG
TH_3859|M.thermoresistible__bu VRMGVALTELGMQPFTETQRELQTAEDLAVP--VTMHTNCVWTRP-----
Mflv_2930|M.gilvum_PYR-GCK FDAGVPPIGGDQGALIELYTNVESRGELPFRVVASYSVKSPPVDDAVAEL
. : :
MMAR_2844|M.marinum_M LAQFGSRPVDYVESLGWLG--SDVWMAHCVHLSKGDIAKLAATGTG----
MUL_2914|M.ulcerans_Agy99 LAQFGSRPVDYVESLGWLG--SDVWMAHCVHLSKGYIAKLAATGTG----
MSMEG_1297|M.smegmatis_MC2_155 LERFGARPVDYVESLGWLG--DDVWFAHGVHLSASDIAKLAQTGTG----
MAB_2927c|M.abscessus_ATCC_199 AERFGCSPLDYMEELGWLG--PDVWFAHGVHFDDASIARLARTGTG----
Mb2937c|M.bovis_AF2122/97 VHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSDGIDLPVFEEFGAGTAAL
Rv2913c|M.tuberculosis_H37Rv VHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSDGIDLPVFEEFGAGTAAL
Mvan_0863|M.vanbaalenii_PYR-1 EEFYGKTMVEYLHSLGVLG--EHVTIAHGIWLTDSDIEVLADTGAS----
TH_3859|M.thermoresistible__bu ----EFHDVELYHRAGLLR--AGQIHSHANRCSDHELALLRDAGCA----
Mflv_2930|M.gilvum_PYR-GCK TGIRDRISSDLVQVNVVKIIGDGTQEGYTAWLLEPYADKPDSIGGS----
. . * .
MMAR_2844|M.marinum_M -------------------------------------------VAHCP--
MUL_2914|M.ulcerans_Agy99 -------------------------------------------VAHCP--
MSMEG_1297|M.smegmatis_MC2_155 -------------------------------------------VAHCP--
MAB_2927c|M.abscessus_ATCC_199 -------------------------------------------IAHCP--
Mb2937c|M.bovis_AF2122/97 HLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFHDAVIVECPDK
Rv2913c|M.tuberculosis_H37Rv HLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFHDAVIVECPDK
Mvan_0863|M.vanbaalenii_PYR-1 -------------------------------------------VSHNP--
TH_3859|M.thermoresistible__bu -------------------------------------------VSSTP--
Mflv_2930|M.gilvum_PYR-GCK -------------------------------------------PFTDDQW
MMAR_2844|M.marinum_M ----TSNGRFG--AGIAPIPELLAADVAVGLGVDGAG-AEHRGL------
MUL_2914|M.ulcerans_Agy99 ----TSNGRFG--AGIAPIPELLAADVAVGLGVDGAG-AEHRGL------
MSMEG_1297|M.smegmatis_MC2_155 ----SSNARLG--AGTAPIPELLAAGVPVGMGVDGVASNEHGGL------
MAB_2927c|M.abscessus_ATCC_199 ----TSNGRLG--AGIARVRELLAAGVPVGLGVDGAASNESGRL------
Mb2937c|M.bovis_AF2122/97 SLIGKSFGAIADERGLHPLDAFLDVLVDNGERNVRWTTIVANHR------
Rv2913c|M.tuberculosis_H37Rv SLIGKSFGAIADERGLHPLDAFLDVLVDNGERNVRWTTIVANHR------
Mvan_0863|M.vanbaalenii_PYR-1 ----ISNLKLG--SGIAPWRKLRDAGVNLGLGTDGMSSSDTARM------
TH_3859|M.thermoresistible__bu ----DTELQMG--CGRPVFRRALATGVTAGIGIDIVSNNSGDMFTAMRVL
Mflv_2930|M.gilvum_PYR-GCK RQLVREVDAAGFDVHIHACGERTARTALDSIEAAAKVNPARERRHTVAHL
. . .
MMAR_2844|M.marinum_M -----ANEMRQAALAARFRLG--PQALDAREALWMATVGGARCLGRDQD-
MUL_2914|M.ulcerans_Agy99 -----ANEMRQAALAARFRLG--PQALDAREALWMATVGGARCLGRDQD-
MSMEG_1297|M.smegmatis_MC2_155 -----GGELRQALLMARNRLG--PTAITARQVLQAGTIGGARCLGRDRE-
MAB_2927c|M.abscessus_ATCC_199 -----LEEAHQALLLARAVGG--PTALSTRTALELATLGGARLLGRSDE-
Mb2937c|M.bovis_AF2122/97 -----PNQLNKLAAEPSVHMG--FSDAGAHLRNMAFYNFGLRLLKRARDA
Rv2913c|M.tuberculosis_H37Rv -----PNQLNKLAAEPSVHMG--FSDAGAHLRNMAFYNFGLRLLKRARDA
Mvan_0863|M.vanbaalenii_PYR-1 -----SEVVKAAALLHKVTGPDYRRWPTAAEVLTAGTLGGARSARLGAT-
TH_3859|M.thermoresistible__bu MQHERGDALQPTLEESGLTAVAEPLPVTTRQILHAATLAGARALGLESV-
Mflv_2930|M.gilvum_PYR-GCK VYLEEPDSRRFGDLGVIAEFSANWFSADPDTVINLAARYGAPRKDNLYR-
. . *
MMAR_2844|M.marinum_M ----------------------------LGSLEVGKLADIALWQLDGLGH
MUL_2914|M.ulcerans_Agy99 ----------------------------LGSLEVGKLADIALWQLDGLGH
MSMEG_1297|M.smegmatis_MC2_155 ----------------------------LGSLEPGKLADMALWRVDGLGH
MAB_2927c|M.abscessus_ATCC_199 ----------------------------IGSIEVGKCADLVLWDLSTLGH
Mb2937c|M.bovis_AF2122/97 DRAGQPFLSIERAVYRLTGELAEWFGIGAGTLRQGDRADFAVIDPTHLDE
Rv2913c|M.tuberculosis_H37Rv DRAGQPFLSIERAVYRLTGELAEWFGIGAGTLRQGDRADFAVIDPTHLDE
Mvan_0863|M.vanbaalenii_PYR-1 ----------------------------VGSIEVGKRADLVIYDMTALAF
TH_3859|M.thermoresistible__bu ----------------------------CGSIDVGKSADLLLLRHDRLHM
Mflv_2930|M.gilvum_PYR-GCK ----------------------------IQDVLSSGGRVSLGTDWPAAGY
: .
MMAR_2844|M.marinum_M SDVEDPVWALIYG---------PPAPLRLLLVGGNTVVEDGELRTADTET
MUL_2914|M.ulcerans_Agy99 SDVEDPVWALIYG---------PPAPLRLLLVGGNTVVEDGELRTADTET
MSMEG_1297|M.smegmatis_MC2_155 ADIDDPVCALVFG---------PSAPLRLLLVNGVPVVADDELRTADTAT
MAB_2927c|M.abscessus_ATCC_199 SGIEDPVAAVILG---------EVPPIRRSWVGGRPIVADGQMLTVDTER
Mb2937c|M.bovis_AF2122/97 SVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGGTVVFRGGQFGGQFRDG
Rv2913c|M.tuberculosis_H37Rv SVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGGTVVFRGGQFGGQFRDG
Mvan_0863|M.vanbaalenii_PYR-1 TPRNAPELHLVYS--------ENGSSIDTVMVDGRVVMTADRLTTIDERA
TH_3859|M.thermoresistible__bu RPVIDDIDSIVLQ--------ATTRDIDRVLVAGRTVVQDGRLPAAVERR
Mflv_2930|M.gilvum_PYR-GCK FSTYKPLDSIQIG----VTRQLIGDPAAEVLSPADQKLTVEQAVHANTLG
: . . .
MMAR_2844|M.marinum_M LATDAKNAAVTLRERG----------------------------------
MUL_2914|M.ulcerans_Agy99 LATDAKNAAVTLRERG----------------------------------
MSMEG_1297|M.smegmatis_MC2_155 LAGDARDAARTLRARAGT--------------------------------
MAB_2927c|M.abscessus_ATCC_199 IAVAVRAAHHGLMNRER---------------------------------
Mb2937c|M.bovis_AF2122/97 YGQNVKSGRYLRAGELGAALSRSA--------------------------
Rv2913c|M.tuberculosis_H37Rv YGQNVKSGRYLRAGELGAALSRSA--------------------------
Mvan_0863|M.vanbaalenii_PYR-1 VLDELQARGPELRRWQDHLETLNRSLLPAFDRQYRQVMSRAVPVDRFSGH
TH_3859|M.thermoresistible__bu GVAAIEAAHSRLAERVAAVGGWKLAVPQGLMDQLGVTFHDNVANTPAQAN
Mflv_2930|M.gilvum_PYR-GCK AAYQLRLDGLVGSVETGKRADLIVVDRNIFEIDPHDIHSAAVTLTMMDGE
.
MMAR_2844|M.marinum_M ------
MUL_2914|M.ulcerans_Agy99 ------
MSMEG_1297|M.smegmatis_MC2_155 ------
MAB_2927c|M.abscessus_ATCC_199 ------
Mb2937c|M.bovis_AF2122/97 ------
Rv2913c|M.tuberculosis_H37Rv ------
Mvan_0863|M.vanbaalenii_PYR-1 GDCWLN
TH_3859|M.thermoresistible__bu S-----
Mflv_2930|M.gilvum_PYR-GCK IRHRV-